• Asian Pacific Journal of Cancer Prevention
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• v.14 no.6
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• pp.3669-3676
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• 2013

Faithful transmission of genetic information depends on accurate chromosome segregation as cells exit from mitosis, and errors in chromosomal segregation are catastrophic and may lead to aneuploidy which is the hallmark of cancer. In eukaryotes, an elaborate molecular control system ensures proper orchestration of events at mitotic exit. Phosphorylation of specific tyrosyl residues is a major control mechanism for cellular proliferation and the activities of protein tyrosine kinases and phosphatases must be integrated. Although mitotic kinases are well characterized, phosphatases involved in mitosis remain largely elusive. Here we identify a novel variant of mouse protein tyrosine phosphatase containing domain 1 (Ptpcd1), that we named Ptpcd2. Ptpcd1 is a Cdc14 related centrosomal phosphatase. Our newly identified Ptpcd2 shared a significant homology to yeast Cdc14p (34.1%) and other Cdc14 family of phosphatases. By subcellular fractionation Ptpcd2 was found to be enriched in the cytoplasm and nuclear pellets with catalytic phosphatase activity. By means of immunofluorescence, Ptpcd2 was spatiotemporally regulated in a cell cycle dependent manner with cytoplasmic abundance during mitosis, followed by nuclear localization during interphase. Overexpression of Ptpcd2 induced mitotic exit with decreased levels of some mitotic markers. Moreover, Ptpcd2 failed to colocalize with the centrosomal marker ${\gamma}$-tubulin, suggesting it as a non-centrosomal protein. Taken together, Ptpcd2 phosphatase appears a non-centrosomal variant of Ptpcd1 with probable mitotic functions. The identification of this new phosphatase suggests the existence of an interacting phosphatase network that controls mammalian mitosis and provides new drug targets for anticancer modalities.

• Journal of Biomedical Engineering Research
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• v.27 no.2
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• pp.78-82
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• 2006

The ventricular assist device(VAD) helps to reduce the overload against the patient's native heart(NH). The pulsatile VAD pumps out the ventricular blood to the aorta with pulsatile flow. If the VAD pulsates simultaneously with the NH, the ventricle of the NH could confronts abnormally elevated aortic pressure, and this could deteriorate the ventricle rather than assist to recover it. Thus counterpulsation algorithms to avoid copulsation have been adopted by many VADs, but these methods utilize electrocardiography or arterial pressure signals, which may have difficulties to acquire consistently for a long period. In this study, the copulsation estimation algorithm for the counterpulsation is developed using the VAD outlet pressure signal. The VAD outlet pressure signal is good to maintain for a long time and the sensor part could be integrated to the VAD as a built-in module. From the VAD outlet pressure signal and its pump rate information calculated with Fast Fourier Transform, pulse peaks by the VAD and the NH were extracted and the next copulsation time at which the VAD and the NH would pulsate simultaneously was estimated. This estimation algorithm was implemented by using PC MATLAB software and tested for various pump rate conditions with mock circulation system. For each condition, the copulsation time was estimated successfully. Consequently, the results showed the possibility to use the outlet cannula pressure signal in the copulsation estimation.

• Journal of The Korean Association of Information Education
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• v.9 no.2
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• pp.167-176
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• 2005

It has been an important agenda to acquire effective decision making procedure for various issues occurred in education area. As an example, when it comes for the ministry of education to make a decision on such an issue that proper investment, to enhance information of education area, in national wide elementary schools, an effective decision making procedure will aid to establish right way of investment. Currently, the questionnaires gathered from school teachers or the related professional consultants are the only resources in order for making such a critical and important decision. Recently, however, educational, medical, and financial industries are looking forward the best decision making method integrated with rapidly upgraded modern IT technologies using the various resources and tools which they already possess. With this subject in mind, in this paper we present a generic decision making model applying ADALINE neural network. The model can be easily adapted to various problems arising in education area. We proved the model through simulations with realistic sample data.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2008.10a
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• pp.357-360
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• 2008

Vital sign monitoring system using IEEE 502.IS.4 based wireless sensor network(WSN) is designed and developed on mobile environment and sensor node platform. WSN and CDMA are integrated to create a wide coverage to support various environments like inside and outside. We developed query processor to use selective any devices(ECG, Blood pressure and sugar module) and control of the self-organizing network of sensor nodes in a wireless sensor network. Vital sign from wireless medical any devices are analysed in cell phone first for real time signal analyses and the abnormal vital signs are sent and save to hospital server for detail signal processing. wireless signal traffic in wireless sensor network environment or data communication inside the cell phone is reduced.

• Management & Information Systems Review
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• v.32 no.3
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• pp.247-261
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• 2013

Recently, the smart phone, a carrying along terminal connection technology such as Galaxytap/iPad etc. evolves, and supply is increasing rapidly, is included for smart phone because various sensor technologies are developed and service application that is acted in terminal with this is accompanied and grow. Continuously 4 generation to 3 Gs, Wibro Wireless network technology of communications a LTE technology from that is constructed, environment for Ubiquitous realization is being constructed fast. Therefore, in this paper it can inquire state of electronic, furniture devices through apartment complex web server and gear that control groove network at smart phone, and control, and confirms home state prevention of crimes state, and video inquiry of position that CCTV is placed in apartment complex was available. And it proposed integrated smart apartment with parking system and medical system using RFID system in ubiquitous environment.

• Journal of radiological science and technology
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• v.27 no.4
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• pp.61-66
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• 2004

In order to improve an efficiency of education and acquisition of PACS administor in Radiological technologist, we implement an e-Learing databank system providing more efficiently provide medical questions set for the integrated education and PACS administor without the limitation of time and space based on XML that is the standard of exchange and transmission of Web documents via Internet. The proposed system is composed of administration module and user module. The former supports some functions: a creation, classification, and management of Radiological question set. Our system can elevate ability of learning and interchange of information among Radiological technologist making preparation of PACS administor for Radiological technologist examination. Finally, our system can maximize an effectiveness of education by evaluating and training users individually with various level according to the user's ability of learning and realization.

• The KIPS Transactions:PartA
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• v.19A no.1
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• pp.51-60
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• 2012

IC(Integrated circuits)card, generally be named smard card, embedded MPU(Micro Processor Unit) of small-size, memory, EEPROM, Card Operating System(COS) and security algorithm. The IC card is used in almost all industry such as a finance(credit, bank, stock etc.), a traffic, a communication, a medical, a electronic passport, a membership management and etc. Recently, a application field of IC card is on the increase by method for payments of T-commerce, as T-commerce is becoming a new growth engine of the broadcating industry by trend of broadcasting and telecommunication convergence, smart mechanization of TV. For example, we can pay in IC credit card(or IC cash card) on T-Commerce. or we can be provided TV banking service in IC cash card such as ATM. However, so far, T-commerce payment services have weakness in security such as storage and disclosure of card information as well as dropping sharply about custom ease because of taking advantage of card information input method using remote control. To solve this problem, This paper developed processing payment module for implementing TV electronic payment system using IC credit card payment standard, EMV.

• Investigative Magnetic Resonance Imaging
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• v.9 no.1
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• pp.2-8
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• 2005

Purpose : The purpose of this study was to implement a software to visualize tumor and its surrounding fiber tracts simultaneously using diffusion tensor imaging and examine the feasibility of our software for investigating the influence of tumor on its surrounding fiber connectivity. Material and Methods : MR examination including T1-weigted and diffusion tensor images of a patient with brain tumor was performed on a 3.0 T MRI unit. We used the skull-striped brain and segmented tumor images for volume/surface rendering and anatomical information from contrast-enhanced T1-weighted images. Diffusion tensor images for the white matter fiber-tractography were acquired using a SE-EPI with a diffusion scheme of 25 directions. Fiber-tractography was performed using the streamline and tensorline methods. To correct a spatial mismatch between T1-weighted and diffusion tensor images, they were coregistered using a SPM. Our software was implemented under window-based PC system. Results : We successfully implemented the integrated visualization of the fiber tracts with tube-like surfaces, cortical surface and the tumor with volume/surface renderings in a patient with brain tumor. Conclusion : Our result showed the feasibility of the integrated visualization of brain tumor and its surrounding fiber tracts. In addition, our implementation for integrated visualization can be utilized to navigate the brain for the quantitative analysis of fractional anisotropy to assess changes in the white matter tract integrity of edematic and peri-edematic regions in a number of tumor patients.

• The Journal of Pediatrics of Korean Medicine
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• v.34 no.3
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• pp.37-54
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• 2020

Objectives The purpose of this study is to analyze the treatment and treatment's effect for seizures disease in children by reviewing Korean clinical studies. Methods 13 articles which were published from August, 2002 to August, 2016 were obtained from the National discovery for science leader (NDSL), Research information sharing service (RISS), Google Scholar, and Oriental medicine advanced searching integrated system (OASIS) by using keyword 'Seizure', 'Convulsion', and 'Epilepsy'. Results Most of the study cases were with epilepsy children. The most frequently used herbal medicine was Gwakhyangjeonggi-san gami, and the most commonly used acupoints were LI4 and LR3. Treatment periods range from 13 days to 14 months, and all of the seizures were completely cured or relieved after the treatments. Conclusions This study shows that there are common symptoms and treatments for seizures in children. The reported different treatments can be used in primary medical care. Developing guideline standards of the seizure treatments can be possible with further studies.

• The Journal of Internal Korean Medicine
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• v.43 no.6
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• pp.1149-1161
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• 2022

Purpose: This systematic review was conducted to evaluate the clinical effects of Injinho-tang on hyperbilirubinemia in hepatobiliary disorders. Methods: We searched for randomized controlled clinical trials that had administered Injinho-tang as an intervention in the following medical databases: Public/Publisher MEDLINE (PubMed), Excerpta Medica dataBASE (EMBASE), Cochrane library, Research Information Sharing Service (RISS), ScienceON, Oriental Medicine Advanced Searching Integrated System (OASIS), and China National Knowledge Infrastructure (CNKI). Among the retrieved studies, only trials that met the inclusion criteria were selected, and serum total bilirubin values were extracted and analyzed from the finally selected trials. Results: The serum total bilirubin values of 1,302 patients with various hepatobiliary diseases were synthesized through a meta-analysis, which confirmed a decrease in serum total bilirubin of 21.03 𝜇mol/L (95% CI -29.58~-12.49, p<0.01) in the group administered with Injinho-tang compared with the control group. Conclusions: Injinho-tang is effective in alleviating hyperbilirubinemia in hepatobiliary diseases when administered with conventional treatment. However, the potential risk of bias, high heterogeneity among the included trials, and differences in herbal composition are limitations of the results of this meta-analysis.