• Genomics & Informatics
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• v.16 no.4
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• pp.29.1-29.5
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• 2018

Hybrid capture-based targeted sequencing is being used increasingly for genomic variant profiling in tumor patients. Unique molecular index (UMI) technology has recently been developed and helps to increase the accuracy of variant calling by minimizing polymerase chain reaction biases and sequencing errors. However, UMI-adopted targeted sequencing data analysis is slightly different from the methods for other types of omics data, and its pipeline for variant calling is still being optimized in various study groups for their own purposes. Due to this provincial usage of tools, our group built an analysis pipeline for global application to many studies of targeted sequencing generated with different methods. First, we generated hybrid capture-based data using genomic DNA extracted from tumor tissues of colorectal cancer patients. Sequencing libraries were prepared and pooled together, and an 8-plexed capture library was processed to the enrichment step before 150-bp paired-end sequencing with Illumina HiSeq series. For the analysis, we evaluated several published tools. We focused mainly on the compatibility of the input and output of each tool. Finally, our laboratory built an analysis pipeline specialized for UMI-adopted data. Through this pipeline, we were able to estimate even on-target rates and filtered consensus reads for more accurate variant calling. These results suggest the potential of our analysis pipeline in the precise examination of the quality and efficiency of conducted experiments.

• Nuclear Engineering and Technology
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• v.51 no.2
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• pp.561-572
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• 2019

In the design criterion for the nuclear power plant piping system, the limit state of the piping against an earthquake is assumed to be plastic collapse. The failure of a common piping system, however, means the leakage caused by the cracks. Therefore, for the seismic fragility analysis of a nuclear power plant, a method capable of quantitatively expressing the failure of an actual piping system is required. In this study, it was conducted to propose a quantitative failure criterion for piping system, which is required for the seismic fragility analysis of nuclear power plants against critical accidents. The in-plane cyclic loading test was conducted to propose a quantitative failure criterion for steel pipe elbows in the nuclear power plant piping system. Nonlinear analysis was conducted using a finite element model, and the results were compared with the test results to verify the effectiveness of the finite element model. The collapse load point derived from the experiment and analysis results and the damage index based on the stress-strain relationship were defined as failure criteria, and seismic fragility analysis was conducted for the piping system of the BNL (Brookhaven National Laboratory) - NRC (Nuclear Regulatory Commission) benchmark model.

• Journal of The Korean Association of Information Education
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• v.13 no.2
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• pp.127-134
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• 2009

As wireless-internet and mobile computer revitalizes, various teaching and learning strategies are appearing. In this study, we suggest a new integrated teaching method in u-learning environment effectively. First of all, to apply information technique to education effectively, we grasped various educational factors centered on learners. And then, we categorized them into contents, time and space as three vital factors and analyzed. Next, by combining the important factors, we suggested the new integrated teaching and learning strategy. We also operated personalized the integrated teaching for elementary school students and verified the effect. As a result, we learned that the integrated teaching was effective in the area of higher-level thinking presented as an effectiveness index, learning motivation and self-directed learning. That is, this study will promote excellence in education centered on learners in the hereafter u-learning environment and support general integrated education effectively.

• Journal of Biosystems Engineering
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• v.37 no.4
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• pp.215-224
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• 2012

Purpose: This study was conducted to classify the energy efficiency of 131 tractor models tested during from 2006 to 2010 in Korea. Methods: Four sub-indexes were developed using the fuel consumptions at 60% and 90% of rated speed with partial loads and at pull speeds of 3.0 km/h and 7.5 km/h with maximum drawbar pull. Weighting factors of the sub-indexes were also considered to reflect the characteristics of tractor's actual working hours in Korea. Four sub-indexes were integrated into a classification index. Using the developed classification index, a five-classification system was made on the basis of normal distribution of tractors over the classification range. Percentage of $1^{st}$ grade interval was expected to be close to 15%, $2^{nd}$ grade 20%, $3^{rd}$ grade 30%, $4^{th}$ grade 20%, $5^{th}$ grade 15%. Results: Number of $1^{st}$ grade was 21, $2^{nd}$ grade 23, $3^{rd}$ grade 39, $4^{th}$ grade 33, $5^{th}$ grade 15 among 131 models. Conclusions: Classification index was developed by integrating four sub-indexes. By the classification method using developed index, distribution of classified tractors was acceptable for practical application.

• Proceedings of the Korea Contents Association Conference
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• 2007.11a
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• pp.468-472
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• 2007

There are many measuring tools to evaluate individual's scientific productivity using scientific articles based on bibliometrics. Especially succeeding discussions are accomplished at an trial for individual's scientific productivity after Hirsch's 2005 proposal using h-index. And there are many succeeding discussions and applications to evaluate journals, articles and qualitative level of researchers using h-index, g-index. But these indices have a same indices without regard to first author or other co-author if a article has a same number of citations. This research aims to propose K-index integrated between these indices and author rank.

• Journal of the Korean Society of Safety
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• v.30 no.5
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• pp.52-58
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• 2015

Although lots of safety inspection and precision safety diagnosis have been conducted on concrete retaining wall, there is no comprehensive analysis on the basis of the accumulated data associated with the statistic. Especially, the concentrated management is necessary on the evaluation items that cause critical damages for the efficient performance. In this regard, this study conducted a correlation analysis between the 18 condition evaluation items and defect index for the concrete retaining wall as well as how each item affects the final defect index as much as in the manual. As a result, correlation coefficient between sliding and overturning was 0.601, which means that they have a strong correlation, and the most influential item on defect index is the condition of drainage that scored the 0.750 correlation coefficient. In addition, as a result of regression analysis, the condition of drainage with the 0.683 correlation coefficient has a strong correlation with the defect index. If the condition evaluation items are integrated or readjusted based on the results of the statistical analysis in this study, the more efficient and accurate maintenance will be possible.

• Journal of East-West Nursing Research
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• v.20 no.2
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• pp.160-166
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• 2014

Purse: The purpose of this study was to examine the effect of a laughter therapy on mental health promoting like depression, laughing index of elderly. Methods: The study was conducted based on the non-equivalent control group pretest-posttest design. The participations included 12 older adults in the control group and 11 in the experiment group. Data was collected from October 1 to November 22, 2013. Experimental group participated in laughter therapy six times, once a week for 60 minutes of each session. Questionnaires were used to measure pretest and posttest levels of depression and laughing index. Results: At the end of six-week intervention, depression score (z=-2.95 p=.003) and laughter index score (z=-2.81 p=.005) was significantly decreased in the experimental group compared to the control group. Futhermore, there was a significant difference in the depression scores of the experiment group at the posttest, but no signigicant difference was found between the two groups. Conclusion: The study results suggest that the laughter therapy is an effective intervention to reduce the depression but helpful to enhance the laughing index. Therefore, it is expected that laughter therapy will serve as an emotional nursing intervention for elderly patients with depression.

• Journal of The Korean Astronomical Society
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• v.37 no.5
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• pp.315-322
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• 2004

Several arguments have been presented in the literature to support the connection between radio halos and cluster mergers. The spectral index distributions of the halos in A665 and A2163 provide a new strong confirmation of this connection, i.e. of the fact that the cluster merger plays an important role in the energy supply to the radio halos. Features of the spectral index (flattening and patches) are indication of a complex shape of the radiating electron spectrum, and are therefore in support of electron reacceleration models. Regions of flatter spectrum are found to be related to the recent merger. In the undisturbed cluster regions, instead, the spectrum steepens with the distance from the cluster center. The plot of the integrated spectral index of a sample of halos versus the cluster temperature indicates that clusters at higher temperature tend to host halos with flatter spectra. This correlation provides further evidence of the connection between radio emission and cluster mergers.

• Journal of the Korean BIBLIA Society for library and Information Science
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• v.8 no.1
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• pp.117-134
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• 1997

This study proves that the quoted legal text functions as the index which represents the contents of the text because of the characteristics of legal information, the automatic indexing in the secondary legal full-text databases can be possible without the assitance of the experts. In case of the establishment, amendment or repealing of law, change of words of index can be possible through revising the legal text quoted in the secondary legal full-text databases. Even when we dont input the full-text about retrospective documents, automatic indexing is also possible, and the establihment and the practice of expert knowledge and integrated databases are possible in case of the retrospective documents. This study indicates that it is necessary to have characteristic information the information experts recognize - that is to say, experimental and inherent knowledge only human being can have - built-in into the system rather than to approach the information system by the linguistic, statistic or structuralistic way, and it can be more essential and intelligent information system.

• Fire Science and Engineering
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• v.30 no.1
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• pp.81-85
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• 2016

Reasonable disaster prevention signs play an important role in guiding evacuation. Through the field investigation on disaster prevention signs in shelters and surrounding areas in Beijing, some problems were found in the using of sign system. Based on the principle of integrated design, evacuation and rescue requirements, it is necesssary to make further study on aspects such as, design of function, systematic consideration, humanization design, as well as the internationalization using. This paper presents an evaluation index system for disaster prevention signs. Such a system is very important for strengthening the independent guiding function of sign systems and improving evacuation efficiency. An effective connection could be realized between the internal environment of buildings, evacuation routes, and emergencey shelters.