• Title/Summary/Keyword: Integrated Channel

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A Study About Biochip Combined with Micro Mixer and Reactor for DNA Ligation (마이크로 혼합기와 반응기로 구성된 DNA 결찰용 바이오칩에 관한 연구)

  • Kang, Do-Hyoung;Ahn, Yoo-Min;Hwang, Seung-Yong
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.32 no.8
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    • pp.624-632
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    • 2008
  • In this research, we developed new PDMS-glass based microbiochip consisted of the micromixer and microreactor for DNA ligation. The micromixer was composed of a straight channel integrated with nozzles and pillars, and the microreactor was composed of a serpentine channel. We coated the PDMS chip surface with the 0.25wt.% PVP solution to prevent the bubble generation which was caused by the hydrophobicity of the PDMS. The new micomixer was passive type and the mixing was enhanced by a convective diffusion using the nozzle and pillar. The 10.33mm long micromixer showed the good mixing efficiency of 87.7% at 500 l/min flow rate. We could perform the DNA ligation successfully in the microbiochip, and the ligation time was shortened from 4 hours in conventional laboratory method to 5 min in the microbiochip.

디지털 오디오 방송의 기술 동향

  • 최진욱;이영진;서종수
    • The Proceeding of the Korean Institute of Electromagnetic Engineering and Science
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    • v.11 no.3
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    • pp.45-55
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    • 2000
  • DAB(Digital Audio Broadcasting)는 기존 아날로 그 방식 AM과 FM 라디오 방송의 한계와 문제점을 극복하고 CD 수준 음질의 오디오를 포함한 다양한 멀티미디어 서비스를 제공하는 차세대 라디오 방송이다. DAB는 전송 주파수 대역에 따라 기존의 FM/AM 대역과 다른 새로운 대역을 사용하는 Out-of-Band 방식과 기존의 FM/AM 대역을 사용하는 In-Band 방식으로 분류할 수 있다. Out-of-Band 방식으로는 유럽의 Eureka-147과 일본의 협대역 ISDB-T(Integrated Services Digital Broadcasting-Terrestrial) 방식이 있으며, In-Band 방식은 미국의 USADR(USA Digital Radio)사와 LDR(Lucent Digital Radio)사가 개발하고 있는 IBOC(In-Band On Channel) 방식과 국내 한국전자통신연구원(ETRI)에서 개발 중인 IBAC(In-Band Adjacent Channel) 방식이 있다. 본 고에서는 DAB의 전송 주파수 대역에 따른 방식별 특성을 고찰하고 유럽, 일본, 미국과 국내에서 상용화 서비스 또는 개발되고 있는 DAB 시스템의 기술동향을 분석 한다.

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Application of the "Law of the Wall" to Predict the Heat Transfer for Turbulent flow in a Rod Bundle (봉다발의 열전달 예측을 위한 "벽면의 법칙(Law of the Wall)" 적용)

  • 김내현
    • Transactions of the Korean Society of Mechanical Engineers
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    • v.16 no.11
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    • pp.2111-2118
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    • 1992
  • In this study, an analytic model is developed to predict Nusselt numbers for turbulent flow in a rod bundle. Flow channel area is divided into several element channels, and simple algebraic equations of universal velocity and temperature profiles are integrated over each element channel. The integral equations are then added to yield an analytic expression for the nusselt number of a rod bundle. The analytic model reasonably predicts the available heat transfer data.

A design of an improved GMSK quadrature modulator for digital cellular system (디지털 셀룰라 시스템을 위한 개선된 GMSK 직교 변조기의 설계)

  • 송영준;한영열
    • Journal of the Korean Institute of Telematics and Electronics A
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    • v.33A no.6
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    • pp.32-41
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    • 1996
  • We propose the improved GMSK (gaussian-filtered minimum shift keying) quadrature modulator using the FIR(finite impulse response )filter whose coefficients are obtained form the differnce of phase response, and design its ASIC (applicaton specific integrated circuit) which can be used for GSM (global system for mobile communication) digital cellular system and DCS 1800 (digital cellular system at 1800MHz) personal communication system. Input data become quantized I and Q channel 10 bit signal through cosine and sine ROM mapping after being filtered by the FIR filter whose normalized bandwidth is 0.3 and designed by considering intersymbol interference as well as sampling ratio. These two signals become the GMSK modulated I and Q channel signal through DAC (digital-to-analog converter) and 7th order analog chebyshev LPF(low pass filter) respectively. The difference between the ideal analog signal and its digitized signal is analyzed in terms of sampling noise, quantization noise, truncation noise and coefficient noise. And the effect of the LPF following the DAC is considered. The ASIC design of the GMSK quadrature modulator is also confirmed by an experiment.

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A Study on a In-mold Packaging Process using Injection Molding (사출성형을 이용한 마이크로 채널의 패키징 공정에 관한 연구)

  • Lee, Kwan-Hee;Park, Duck-Soo;Yoon, Jae-Sung;Yoo, Yeong-Eun;Choi, Doo-Sun;Kim, Sun-Kyoung
    • Proceedings of the KSME Conference
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    • 2008.11a
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    • pp.1821-1824
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    • 2008
  • A novel in-mold packaging process has been developed to manufacture devices with closed channels. In this unified process, fabrication of open channels and forming the rigid cover on top of them are sequentially integrated in the same mold. The entire process is comprised of two phases. In the first phase, the open channels are fabricated under an exquisitely controlled temperature and pressure using the conventional micro injection molding technology. In the second phase, the closed channels are fabricated by conducting the injection molding process using the molded structure with the open channels as a mold insert. As a result, the in-mold technology can eliminate the bonding processes such as heating, ultrasonic or chemical processes for cohesion between the channel and the cover, which have been required in conventional methods.

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A Study on the Signal Analysis of Loose Parts Monitoring System (LPMS 신호분석 연구)

  • Lee, Sang-Guk
    • Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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    • 2014.10a
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    • pp.839-841
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    • 2014
  • The Nuclear Steam Supply System(NSSS) is designed to provide an integrated approach that includes areas of monitoring relevant to the integrity of the NSSS. LPMS is designed to function as an alarm system by providing sensor channel alarms for the associated subsystems. LPMS is equipped to provide analysis tools for new alarm events, historical events and for historical periodically stored channel data (e.g. waveforms) for most channels. This paper is intended to introduce the diagnosis principle and abnormal symptom of loose parts monitoring system as a monitoring tool in Nuclear Steam Supply System. And also, we are going to introduce signal analysis program in order to perform the actual diagnosis in power plants.

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Development of Next Generation Biochip Using Indicator-free DNA (비수식화 DNA를 이용한 차세대형 바이오칩의 개발)

  • Choi, Yong-Sung;Moon, Jong-Dae;Lee, Kyung-Sup
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 2006.05a
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    • pp.71-73
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    • 2006
  • This research aims to develop a multiple channel electrochemical DNA chip using micro- fabrication technology. At first, we fabricated a high integrated type DNA chip array by lithography technology. Several probe DNAs consisting of thiol group at their 5-end were immobilized on the gold electrodes. Then target DNAs were hybridized by an electrical force. Redox peak of cyclic-voltammogram showed a difference between target DNA and mismatched DNA in the anodic peak current. Therefore. it is able to detect a various genes electrochemically after immobilization of a various probe DNA and hybridization of label-free DNA on the electrodes simultaneously. It suggested that this DNA chip could recognize the sequence specific genes.

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Efficient Computation of Two-Phase Flow by Eulerian-Lagrangian Method Using Separate grids for the Particles and Flow Field (Eulerian-Lagrangian 방법에서 입자 및 유동 격자계 분리를 통한 2상 유동의 효율적 계산)

  • Pak S. I.;Lee J K.;Chang K. S.
    • 한국전산유체공학회:학술대회논문집
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    • 2003.08a
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    • pp.43-48
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    • 2003
  • When the Eulerian-Lagrangian method is used to analyze the particle laden two-phase flow, a large number of particles should be used to obtain statistically meaningful solutions. Then it takes too much time to track the particles and to average the particle properties in the numerical analysis of two-phase flow. The purpose of this paper is to reduce the computation time by means of a set of particle gird separate to the flow grid. Particle motion equation here is the simplified B-B-O equation, which is integrated to get the particle trajectories. Particle turbulent dispersion, wall collision, and wall roughness effects are considered but the two-way coupling effects between gas and particles are neglected. Particle laden 2-D channel flow is solved and it is shown that the computational efficiency is indeed improved by using the current method

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Generation of Fine Droplets in a Simple Microchannel (유체 소자를 이용한 미세 액적 생성)

  • Kim, Su-Dong;Kim, Young-Won;Yoo, Jung-Yul
    • Proceedings of the KSME Conference
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    • 2008.11b
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    • pp.2658-2663
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    • 2008
  • In the present study, we designed a microfluidic flatform that generates monodisperse droplets with diameters ranging from hundreds of nanometers to several micrometers. To generate fine droplets, T-junction and flow-focusing geometry are integrated into the microfluidic channel. Relatively large aqueous droplets are generated at the upstream T-junction and transported toward the flow-focusing geometry, where each droplet is broken up into the targeted size by the action of viscous stresses. Because the droplet prior to rupture blocks the straight channel that leads to the flow-focusing geometry, it moves very slowly by the pressure difference applied between the advancing and receding regions of the moving droplet. This configuration enables very low flow rate of inner fluid and higher flow rate ratio between inner and outer fluids at the flow-focusing region. It is shown that the present microfluidic device can generate droplets with diameters about 1 micrometer size and standard deviation less than 3%.

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Fabrication and Characteristics of Thermopneumatic-Actuated Polydimethylsiloxane Microvalve (열공압 방식의 Polydimethylsiloxane 마이크로 밸브의 제작 및 특성)

  • 김진호;조주현;한경희;김영호;김한수;김용상
    • The Transactions of the Korean Institute of Electrical Engineers C
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    • v.53 no.4
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    • pp.231-236
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    • 2004
  • A normally open thermopneumaticc-actuated microvalve has been fabricated and their properties are investigated. The advantages of the proposed microvalve are of the low cost fabrication process and the transparent optical property using polydimethylsiloxane (PDMS) and indium tin oxide (ITO) glass. The fabricated microvalves with in-channel configuration are easily integrated with other microfluidic devices on the same substrate. The fabrication process of thermopneumatic-actuated microvalvesusing PDMS is very simple and its performance is very suitable for a disposable lab-on-a-chip. The PDMS membrane deflection increases and the flow rates of the microchannel with microvalvels decrease as the applied power to the ITO heater increases. The powers at flow-off are dependent on the membrane thickness and the applied inlet pressure but are independent of the channel width of microvalves. The flow rate is well controlled by the switching function of ITO heater and the closing/opening times are around 20 sec and 25 sec, respectively.