• Korean Journal of Clinical Oncology
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• v.9 no.2
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• pp.80-86
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• 2013

Purpose: Hypermethylation of human mut L homologue 1 (hMLH1) promoter region is known to cause sporadic microsatellite instability (MSI) colorectal cancers. 5,10-methylenetetrahydrofolate reductase (MTHFR) is the key enzyme in folate metabolism, acting as a methyl donor for DNA methylation. In this study, we investigate whether the polymorphism of MTHFR 677C>T plays a role in the alteration of the promoter-specific hypermethylation, predisposing to MSI colorectal cancers. Methods: Total of 487 sporadic colorectal cancer patients in CHA Bundang Medical Center were collected. MSI was identified when two or more are positive among five microsatellite markers (BAT25, BAT26, D17S250, D5S346, D2S123). The others were classified as microsatellite stable (MSS). Polymorphism of MTHFR 677C>T was genotyped by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: MSI was observed in 65 of 487 patients (12.73%). MSI colorectal cancers showed similar clinicopathological features with previously reported; younger age onset, right-sided preponderance, mucinous and poorly differentiated histology, lower stage, fewer lymph node metastases than MSS tumors (each P<0.05). The frequency of MTHFR 677TT genotype was 17.7% in the MSI group higher than 14.6% in the MSS group (P=0.17). Although not statistically significant, compared to the MTHFR 677CC referent, MTHFR 677 CT+TT genotype was more likely to have MSI than MSS (odds ratio, 1.81; 95% confidence interval, 0.94 to 3.68; P=0.06). Conclusion: This study demonstrated higher frequency of MTHFR 677TT genotype in MSI colorectal cancers. Furthermore, individuals with MTHFR 677CT+TT variant type might potentially develop MSI rather than MSS colorectal cancers.

• Journal of Electrical Engineering and Technology
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• v.10 no.5
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• pp.1989-2000
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• 2015

In this paper, digital peak current mode control for single phase H-bridge inverters is developed and implemented. The digital peak current mode control is achieved by directly controlling the PWM signals by cycle-by-cycle current limitation. Unlike the DC-DC converter where the output voltage always remains in the positive region, the output of DC-AC inverter flips from positive to negative region continuously. Therefore, when the inverter operates in negative region, the control should be changed to valley current mode control. Thus, a novel control logic circuit is required for the function and need to be analyzed for the hardware to track the sinusoidal reference in both regions. The problem of sub-harmonic instability which is inherent with peak current mode control is also addressed, and then proposes the digital slope compensation in constant-sloped external ramp to suppress the oscillation. For unipolar PWM switching method, an adaptive slope compensation in digital manner is also proposed. In this paper, the operating principles and design guidelines of the proposed scheme are presented, along with the performance analysis and numerical simulation. Also, a 200W inverter hardware prototype has been implemented for experimental verification of the proposed controller scheme.

• Journal of Advanced Marine Engineering and Technology
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• v.39 no.10
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• pp.1017-1022
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• 2015

Specific hydrodynamic characteristic of pump-turbine during the start and load rejection process of generating mode causes anomalous increase of water pressure, along with large machine vibration, called "S" characteristic. The aim of this study is to understand and explain the hydrodynamic performance of pump-turbine at "S" characteristic region by using a model of pump-turbine system. The operation in the condition of runway and low discharge in a typical "S" characteristic curve may become unstable and complex flow appears at the passage of guide vane and impeller. Therefore, velocity and pressure distribution are investigated to give an all-sided explanation of the formation and phenomenon of this characteristic, with the assistance of velocity triangle analysis at the impeller inlet. From this study, the internal flow and pressure fluctuation at the normal, runway and low discharge points are explored, giving a deep description of hydrodynamic characteristic when the pump-turbine system operates with "S" characteristic.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.28 no.5
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• pp.554-562
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• 2004

An empirical relationship between parameters from SP curves and tensile properties has been systematically investigated by experimental tests and FEM simulations. A series of SP and tensile tests were performed. SP tests were also simulated by FE analysis with various tensile properties. It was found that the yield loads(Py) and the maximum loads( $P_{MAX}$) in SP curves were linearly related with the yield strength($\sigma$$_{o}$) and the tensile strength($\sigma$$_{UTS}$), respectively. The yield loads defined from the intersection point of two lines tangent to the elastic bending region and plastic bending region showed better relation to the yield strength than those from offset line. The maximum loads in SP curves showing plastic instability region was linearly related with the tensile strengths. The slope of SP curves in simulation results had a close correlation with the hardening coefficient and hardening strength as well.l.l.l.

• Journal of Plant Biotechnology
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• v.49 no.1
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• pp.39-45
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• 2022

Conserved domains are defined as recurring units in molecular evolution and are commonly used to interpret the molecular function and biochemical structure of proteins. Herein, the ADP-glucose pyrophosphorylase (AGPase) amino acid sequences of three species of the Ipomoea genus [Ipomoea trifida, I. triloba, and I. batatas (L.) Lam. (sweetpotato)] were identified to investigate their physicochemical and biochemical characteristics. The molecular weight, isoelectric point, instability index, and grand average of hyropathy markedly differed among the three species. The aliphatic index values of sweetpotato AGPase proteins were higher in the small subunit than in the large subunit. The AGPase proteins from sweetpotato were found to contain an LbH_G1P_AT_C domain in the C-terminal region and various domains (NTP_transferase, ADP_Glucose_PP, or Glyco_tranf_GTA) in the N-terminal region. Conversely, most of its two relatives (I. trifida and I. triloba) were found to only contain the NTP_transferase domain in the N-terminal region. These findings suggested that these conserved domains were species-specific and related to the subunit types of AGPase proteins. The study may enable research on the AGPase-related specific characteristics of sweetpotatoes that do not exist in the other two species, such as starch metabolism and tuberization mechanism.

• Journal of the Korean earth science society
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• v.41 no.3
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• pp.222-237
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• 2020

A heavy (93 mm hr^-1) rainfall event accompanied by lightning occurred over Gangneung in the Yeongdong region of South Korea on August 6, 2018. This study investigated the underlying mechanism for the heavy rainfall event by using COMS satellite cloud products, surface- and upper-level weather charts, ECMWF reanalysis data, and radiosonde data. The COMS satellite cloud products showed rainfall exceeding 10 mm hr^-1, with the lowest cloud-top temperature of approximately -65℃ and high cloud optical thickness of approximately 20-25. The radiosonde data showed the existence of strong vertical wind shear between the upper and lower cloud layers. Furthermore, a strong inversion in the equivalent potential temperature was observed at a pressure altitude of 700 hPa. In addition, there was a highly developed cloud layer at a height of 13 km, corresponding with the vertical analysis of the ECMWF data. This demonstrated the increased atmospheric instability induced by the vertical differences in equivalent potential temperature in the Yeongdong region. Consequently, cold, dry air was trapped within relatively warm, humid air in the upper atmosphere over the East Sea and adjacent Yeongdong region. This caused unstable atmospheric conditions that led to rapidly developing convective clouds and heavy rainfall over Gangneung.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.2
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• pp.387-396
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• 2018

This study examined the instability factor of real income and net profits of Chung-yang Green Pepper Farm through an analysis of the operating costs. Furthermore, this paper suggests a plan for stabilizing the price by shipment adjustments resulting from an analysis of the price elasticity by A Linear Approximated Inverse Almost Ideal Demand System (LA/IAIDS). The income instability factor of the farm based on an analysis of the operating costs was attributed to the unexpected loading of utility expenses and collapse of the price due to oversupply at a specific point in time. On the other hand, this is insufficient to completely explain the income instability factor of Chung-yang Green Pepper Farm because a price collapse does not include the monthly price changes. An analysis of the price and scale flexibility of Chung-yang Green Pepper Farm by monthly data showed that annual farm net yield increases by 1.21% due to a 2.21% increase in price if the shipment quantity is reduced to 1% a year. In summary, a plan that supports the farm price received through declining shipments in winter is effective in stabilizing the income of farms. Because Chung-yang Green Pepper in Gyeongnam region has an especially high market share of 82.5%, the prices and income of Gyeongnam Chung-yang Green Pepper farms can be stabilized effectively if they form an association of producers around the Gyeongnam region and adjust the shipment.

• Journal of the Korean earth science society
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• v.44 no.2
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• pp.119-134
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• 2023

The synoptic, thermodynamic, and dynamic characteristics of a snowfall event that occurred in the Yeongdong region on March 1-2, 2021, were investigated. Surface weather charts, ERA5 reanalysis data, rawinsonde data, GK-2A satellite data, and WISSDOM data were used for analysis. The snow depth, exceeding 10 cm, was observed at four weather stations during the analysis period. The maximum snow depth (37.4 cm) occurred at Bukgangneung. According to the analysis of the weather charts, old and dry air was trapped within relatively warm, humid air in the upper atmosphere over the East Sea and adjacent Yeongdong region. This caused unstable atmospheric conditions that led to developing convective clouds and snowfall over Bukgangneung. In particular, based on the thermodynamic and kinematic vertical analysis, we suggest that strong winds attributable to the vertical gradient of potential temperature in the low layer and the development of convective instability due to cold advection played a significant role in the occurrence of snowfall in the Yeongdong region. These results were confirmed from the vertical analysis of the rawinsonde data.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.34 no.9
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• pp.859-866
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• 2010

Nonlinear dynamics of pulsating instability-diffusional-thermal instability with Lewis numbers sufficiently higher than unity-in counterflow diffusion flames, is numerically investigated by imposing a Damkohler number perturbation. The flame evolution exhibits three types of nonlinear behaviors, namely, decaying pulsating behavior, diverging behavior (which leads to extinction), and stable limit-cycle behavior. The stable limit-cycle behavior is observed in counterflow diffusion flames, but not in diffusion flames with a stagnant mixing layer. The critical value of the perturbed Damkohler number, which indicates the region where the three different flame behaviors can be observed, is obtained. A stable simple limit cycle, in which two supercritical Hopf bifurcations exist, is found in a narrow range of Damkohler numbers. As the flame temperature is increased, the stable simple limit cycle disappears and an unstable limit cycle corresponding to subcritical Hopf bifurcation appears. The period-doubling bifurcation is found to occur in a certain range of Damkohler numbers and temperatures, which leads to extend the lower boundary of supercritical Hopf bifurcation.

• Transactions of the Korean Society of Mechanical Engineers
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• v.17 no.1
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• pp.200-214
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• 1993

This paper presents the results of fluidelastic instability analysis performed for the U-tube bundle of a Westinghouse model 51 steam generator, one of the recirculating types designed at an early stage, in which the principal region of external cross-flow is associated with the U-bend portion of tube. The prerequisites for this analysis are detailed informations of the secondary side flow conditions in the steam generator and the free vibration behaviours of the U-tubes. In this study, the three-dimensional two-phase flow field in the steam generator has been calculated employing the ATHOS3 steam generator two-phase flow code and the ANSYS engineering analysis code has been used to calculate the free vibration responses of specific U tubes under consideration. The assessment of the potential instability for the suspect U-tubes, which is the final analysis process of the present work, has been accomplished by combining the secondary side velocity and density distributions obtained from the ATHOS3 prediction with the relative modal displacement and natural frequency data calculated using the ANSYS code. The damping of tubes in two-phase flow has been deduced from the existing experimental data by taking into account the secondary side void fraction effect. In operation of the steam generator, the tube support conditions at the tube-to-tube support plate intersections due to either tube denting degradation or deposition of tube support plate corrosion products or ingression of dregs. Thus, various hypothetical cases regarding the tube support conditions at the tube-to-tube support plate intersections have been considered to investigate the clamped support effects on the forced vibration response of the tube. Also, the effect of anti-vibration bars support in the curved portion of tube has been examined.