• Bulletin of the Korean Chemical Society
• /
• v.35 no.7
• /
• pp.2097-2108
• /
• 2014

Chemical feature based quantitative pharmacophore models were generated using the HypoGen module implemented in DS2.5. The best hypothesis, Hypo1, which was characterized by the highest correlation coefficient (0.96), the highest cost difference (61.60) and the lowest RMSD (0.74), consisted of one hydrogen bond acceptor, one hydrogen bond donor, one hydrophobic and one ring aromatic. The reliability of Hypo1 was validated on the basis of cost analysis, test set, Fischer's randomization method and GH test method. The validated Hypo1 was used as a 3D search query to identify novel inhibitors. The screened molecules were further refined by employing ADMET, docking studies and visual inspection. Three compounds with novel scaffolds were selected as the most promising candidates for the designing of Mcl-1 antagonists. Finally, a 10 ns molecular dynamics simulation was carried out on the complex of receptor and the retrieved ligand to demonstrate that the binding mode was stable during the MD simulation.

• The Transactions of the Korean Institute of Electrical Engineers P
• /
• v.65 no.2
• /
• pp.101-107
• /
• 2016

The main target in this paper is the localization of VME Type EPSM in Generator Exciter(EX2100) System. Developed EPSM has the compatibility with the existing product in the structure and shape and electrical feature and so on, but it has a much improved capacity and reliability in comparison with origin company product. this paper, to improve these functions, put emphasis on protection, monitoring, power capacity increase(over 120%), an enlarged scale of input voltage supply, AC/DC dual voltage use and so on. After manufacturing product localization, it was carried out several tests for the performance and reliability verification of developed product. These tests were performed in Authorized Inspection Agency(KTL) and field application test and maker self-test were additionally performed. Finally, the results of all tests were "success".

• Transactions of the Korean Society of Mechanical Engineers A
• /
• v.27 no.11
• /
• pp.1933-1940
• /
• 2003

Recently, the importance of plant maintenance(PM) was highly raised to provide efficient plant operation which highly affects the productivity. For this reason, a number of engineering methodologies, such as risk-based inspection(RBI), fitness for service guidelines(FFS), plant lifecycle management(PLM), have been applied to improve the plant operation efficiency. Also, a network-based business operation system, which is called ERP(Enterprise Resource Planning), has been introduced in the field of plant maintenance. However, there was no attempt to connect engineering methodologies to the ERP PM system. In this paper, a knowledge-based information system for the plant operation of steel making company has been proposed. This system which is named as K-VRS(Knowledge-based Virtual Reality System), provides a connection between ERP plant maintenance module and knowledge-based engineering methodologies, and thus, enables network-based highly effective plant maintenance process. The developed system is expected to play a great role for more efficient and safer plant maintenance.

• Transactions of the Korean Society of Mechanical Engineers A
• /
• v.32 no.12
• /
• pp.1102-1106
• /
• 2008

Microfluidics deals with the behavior, precise control and manipulation of fluids at a micro scale. It has become increasingly prevalent in various applications such as biomedical applications (diagnostics, therapeutics, and cell/tissue engineering), inkjet head, and fuel cells etc. The issue of inspection and characterization of microfluidics has emerged as a major consideration in design, fabrication, and detection of microfluidic devices. In this paper, we characterize a diffusion based mixing in Y-microchannel using a fluorescent optical scanner based on a DVD pick-up module, which is widely used in optical storages. Using fluorescent dye, we measure the fluorescent intensity that represents the mixing patterns in Y-microchannel. We also compare these experimental results with computational fluid dynamics (CFD) simulation ones. It is shown that the proposed optical scanner can be used as an alternative measurement system with high performance and cost-effectiveness, compared to conventional optical tools such as epifluorescent microscopes using high resolution CCD camera and confocal microscopes with photomultiplier (PMT) detectors.

• Proceedings of the Korean Society of Precision Engineering Conference
• /
• 2002.10a
• /
• pp.147-150
• /
• 2002

A light guide panel is an element of the LCD backlight module that is often used for the display of compact electronic devices. In this study, a laser marking system is proposed to fabricate light guide panel, which can be replaced of other manufacturing methods such as silk printing, stamping, and v-cutting methods. The objectives of this research are the establishment of laser marking system, evaluation of laser marking parameters, understanding marking process, application to PMMA, reliability test and quality inspection. A 50W $CO_2$ laser (CW) was used to perform different experiments in which, the influence of some processing parameters (average power, scanning speed) on the geometry and quality of groove pattern was studied. The width of the etched grooves increases with increasing a laser power and decreasing a scan speed. In order to analyze surface characteristics and optical properties (luminance, uniformity), SEM photography and BM7 (luminance measuring system) were used. As a result, the optimal conditions of the process parameters were determined.

• Smart Structures and Systems
• /
• v.26 no.4
• /
• pp.533-544
• /
• 2020

Effective bridge maintenance reduces bridge operation costs and extends its service life. The possibility of storing bridge life-cycle data in a 3D parametric model of the bridge through Bridge Information Modeling (BrIM) provides new opportunities to enhance current practices of bridge maintenance management. This study develops a Decision Support System (DSS), namely BrDSS, which employs BrIM and an efficient optimization model for bridge maintenance planning. The BrIM model in BrDSS extracts basic data of elements required for the optimization process and visualizes the inspection data and the optimization results to the user to help in decision makings. In the optimization module of the DSS, the specifically formulated Genetic Algorithm (GA) eliminates the chances of producing infeasible solutions for faster convergence. The practicality of the presented DSS was explored by utilizing the DSS in the maintenance planning of a bridge under operation in the southwest of Iran.

• Journal of Institute of Control, Robotics and Systems
• /
• v.19 no.10
• /
• pp.915-920
• /
• 2013

Payload capacity and transition ability are essential for climbing robots to apply the robots to various applications such as inspection and exploration. This paper presents a new climbing robotic platform with multi-link structure of track-wheel modules to enhance payload capacity and transition ability, and its tracking controller design and experimental results. The compliances between track-wheel modules achieve stable internal and external transitions while the large adhesion area of the track-wheel module enhances the payload capacity of the robot. Kinematic model-based tracking controller is designed and implemented for autonomous internal transition, and the gains of the controller are optimized by experimental design. Experiments on the automatic internal transitions are performed and the results guarantee autonomous internal transition with little tracking error.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
• /
• 2017.05a
• /
• pp.379-382
• /
• 2017

Shipping and logistics safety, security system is strengthening worldwide, the development of shipping and logistics safety security core technology for national security logistics system construction has been carried out. In addition, it is necessary to localize the Array Detection System, which is a core component of the container search machine, to cope with the 100% pre-inspection of the container scheduled for 2018 in the United States. In this paper, we propose a test software program developed by using TI-RTOS (Texas Instruments - Real Time Operating System) with a test digital signal processing board which is developed self development.

• Proceedings of the KSME Conference
• /
• 2001.06b
• /
• pp.228-234
• /
• 2001

NTMS(Non-contact Tilted-angle Measuring System) is developed by using the principle that the magnetic field of an anisotropic magnet's inner space is uniform and it's possible to measure the strength of the magnetic field using a linear hall effect sensor. In order to implement the caliper system of the geometry PIG(Pipeline Inspection Gauge) which has high accuracy and proper output voltage of the hall sensor without additional driving module or a signal amplifier, it is necessary to consider the size of the magnet, the inner space and back-yoke and the position of pin-hole in the magnet. So the optimal design method of the caliper system is proposed through analysis of NTMS's magnetic field adopting a FEM(Finite Element Method). The experimental results show that the developed caliper system can be used for the geometry pig with good performances.

• The Journal of Korea Robotics Society
• /
• v.17 no.2
• /
• pp.238-244
• /
• 2022

Maintenance works of offshore wind turbines could take a longer time, which causes the reduction of their energy production efficiency, than those of onshore wind turbines owing to severe offshore environment. Subsequently, preventive maintenance measures are required to increase the production efficiency. Thus, we proposed a wheel-based Underwater Pole Climbing Robot (UPCR) platform, which was aimed at the periodic inspection and maintenance of the substructures of the offshore wind turbines, with three advantages: high speed, good mobility and low power consumption. In the proposed platform, a self-locking system using a gripper module was adopted for preventing slippery problem and a dual configuration was chosen for moving on a branched structure. As a result, the proposed robot was able to continuously climb, preserve it's position at the pole without consuming energy, and move from the pole to the other branched pole. The results of this research show that the UPCR has basic moving capabilities required for the underwater work for the substructures of the offshore wind turbines.