• Advances in concrete construction
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• v.13 no.4
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• pp.291-305
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• 2022

The present investigation deals with the production of the innovative lightweight fly ash angular aggregates (FAA) first time in India using local class 'F' fly ash, its characterization, and exploring the potential for its utilization as alternative coarse aggregates in structural concrete applications. Two types of aggregates are manufactured using two different kinds of binders. The manufacturing process involves mixing fly ash, binder, and water, followed by the briquetting process, sintering and crushing them into suitable size aggregates. Tests are conducted on fly ash angular aggregates to measure their physical properties such as crushing value, impact value, specific gravity, water absorption, bulk density, and percentage of voids. Study shows that the physical parameters are significantly enhanced as compared to commercially available fly ash pellets (FAP). The developed FAA are used in concrete vis-à-vis conventional granite aggregates and FAP to determine their compressive, split tensile and flexural strengths. Although being lightweight, the strength parameters for concrete containing FAA are well compared with conventional concrete. This might be due to the high pozzolanic reaction between fly ash angular aggregates and cement paste. Also, RCC beams are cast and the load-deflection behaviour and ultimate load carrying capacity signify that FAA can be suitably used for RCC construction. Hence, the utilization of fly ash as angular aggregates can reduce the dead load of the structure and at the same time serves as a solution for fly ash disposal and mineral depletion problem.

• BMB Reports
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• v.55 no.6
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• pp.251-258
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• 2022

Innovative genome editing techniques developed in recent decades have revolutionized the biomedical research field. Liver is the most favored target organ for genome editing owing to its ability to regenerate. The regenerative capacity of the liver enables ex vivo gene editing in which the mutated gene in hepatocytes isolated from the animal model of genetic disease is repaired. The edited hepatocytes are injected back into the animal to mitigate the disease. Furthermore, the liver is considered as the easiest target organ for gene editing as it absorbs almost all foreign molecules. The mRNA vaccines, which have been developed to manage the COVID-19 pandemic, have provided a novel gene editing strategy using Cas mRNA. A single injection of gene editing components with Cas mRNA is reported to be efficient in the treatment of patients with genetic liver diseases. In this review, we first discuss previously reported gene editing tools and cases managed using them, as well as liver diseases caused by genetic mutations. Next, we summarize the recent successes of ex vivo and in vivo gene editing approaches in ameliorating liver diseases in animals and humans.

• Advances in aircraft and spacecraft science
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• v.9 no.6
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• pp.525-536
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• 2022

The current state of telecommunications infrastructure in the Arctic does not allow providing a wide range of required services for people, businesses and other categories, which necessitates the use of non-traditional approaches to its organization. The paper proposes an innovative approach to building a combined communication network based on tethered high-altitude platform station (HAPS) located at an altitude of 1-7 km and connected via radio channels with terrestrial and satellite communication networks. Network configuration and composition of telecommunication equipment placed on HAPS and located on the terrestrial and satellite segment of the network was justified. The availability of modern equipment and the distributed structure of such an integrated network will allow, unlike existing networks (Iridium, Gonets, etc.), to organize personal mobile communications, data transmission and broadband Internet up to 100 Mbps access for mobile and fixed subscribers, rapid transmission of information from Internet of Things (IoT) sensors and unmanned aerial vehicles (UAV). A substantiation of the possibility of achieving high network capacity in various paths is presented: inter-platform radio links, subscriber radio links, HAPS feeder lines - terrestrial network gateway, HAPS radio links - satellite retransmitter (SR), etc. The economic efficiency of the proposed solution is assessed.

• Journal of Distribution Science
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• v.21 no.4
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• pp.47-56
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• 2023

Purpose: the research aims to analyze the impact of the distribution of knowledge through online learning on the intellectual potential of PhD students and produce recommendations for policy to improve intellectual capacity. During the literature review, it was determined that a large number of studies examined the impact of online learning on the quality of education at different levels. Research design, data and methodology: the research methodology is based on subjective assessment and studying the students' opinions. The basis of the study was a comprehensive analysis of primary data obtained through a sociological survey of PhD students. 324 respondents from humanitarian, medical and natural faculties participated in the survey. Results: the study revealed that online learning helps increase students' intellectual potential. PhD students had a positive attitude towards the transition from traditional education to online learning. It should be noted that, according to the results, the most popular gadgets were laptops and smartphones, which were characterized by high mobility and ease of use. Based on the obtained results, recommendations were developed for the formation of online learning with a focus on increasing students' intellectual potential. Conclusions: based on the results of the assessment of educational and innovative potential, policy recommendations and further research in this area were proposed.

• Steel and Composite Structures
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• v.45 no.3
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• pp.455-466
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• 2022

Despite the considerable lateral stiffness and strength of the Concentrically Braced Frame (CBF), it suffers from low ductility and low seismic dissipating energy capacity. The buckling of the diagonal members of the CBF systems under cyclic loading ended up to the shortcoming against seismic loading. Comprehensive researches have been performing to achieve helpful approaches to prevent the buckling of the diagonal member. Among the recommended ideas, metallic damper revealed a better success than other ideas to enhance the behavior of CBFs. While metallic dampers improve the behavior of the CBF system, they increase constructional costs. Therefore, in this paper, a new steel damper with flexural mechanism is proposed, which is investigated experimentally and numerically. Also, a parametrical revision was carried out to evaluate the effect of thickness, slenderness ratio, angle of the main plate, and height of the main plates on the proposed damper. For the parametrical study, 45 finite element models were analyzed and considered. Experimental results, as well as the numerical results, indicated that the proposed damper enjoys a stable hysteresis loop without any degradation up to a high rotation equal to around 31% that is significantly considerable. Moreover, it showed a suitable performance in case of ductility and energy dissipating. Besides, the necessary formulas to design the damper, the required relations were proposed to design the elements outside the damper to ensure the damper acts as a ductile fuse.

• Steel and Composite Structures
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• v.45 no.2
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• pp.231-248
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• 2022

Hybrid Steel-Trussed Concrete Beam (HSTCB) is structural typology suitable for light industrialization. HSTCBs usually cover long span with small depths, which lead to significant amount of longitudinal rebars. The latter make beam-column joints more prone to damage due to earthquake-induced cyclic actions. This phenomenon can be avoided using friction-based BCCs. Friction devices at Beam-to-Column Connections (BCCs) have become promising solutions to reduce the damage experienced by structural members during severe earthquakes. Few solutions have been developed for cast-in-place Reinforced Concrete (RC) and steel-concrete composite Moment Resisting Frames (MRFs), because of the difficulty of designing cost-effective damage-proof connections. This paper proposes a friction-based BCC for RC MRFs made with HSTCBs. Firstly, the proposed connection is described, and its innovative characteristics are emphasized. Secondly, the design method of the connection is outlined. A detailed 3D FE model representative of a beam-column joint fitted with the proposed connection is developed. Several monotonic and cyclic analyses are performed, investigating different design moment values. Lastly, the numerical results are discussed, which demonstrate the efficiency of the proposed solution in preventing damage to RC members, and in ensuring satisfactory dissipative capacity.

• Steel and Composite Structures
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• v.49 no.4
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• pp.393-405
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• 2023

In this paper, the energy absorption capability of a novel cruciform composite lattice structure was evaluated through the simulation of compression tests. For this purpose, several test samples of Polylactic acid cellular reinforced with continuous glass fibers were prepared for compression testing using the additive manufacturing method of material extrusion. Using a conventional path design for material extrusion, multiple debonding is probable to be occurred at the joint regions of adjacent cells. Therefore, an innovative printing path design was proposed for the cruciform lattice structure. Afterwards, quasistatic compression tests were performed to evaluate the energy absorption behaviour of this structure. A finite element model based on local material property degradation was then developed to verify the experimental test and extend the virtual test method. Accordingly, different combinations of unit cells' dimensions using the design of the experiment were numerically proposed to obtain the optimal configuration in terms of the total absorbed energy. Having brilliant energy absorption properties, the studied cruciform lattice with its optimized unit cell dimensions can be used as an energy absorber in crashworthiness applications. Finally, a cellular structure will be suitable with optimal behavior in crush load efficiency and high energy absorption.

• The Korean Journal of Physiology and Pharmacology
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• v.28 no.3
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• pp.197-207
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• 2024

The potential of tivozanib as a treatment for oral squamous cell carcinoma (OSCC) was explored in this study. We investigated the effects of tivozanib on OSCC using the Ca9-22 and CAL27 cell lines. OSCC is a highly prevalent cancer type with a significant risk of lymphatic metastasis and recurrence, which necessitates the development of innovative treatment approaches. Tivozanib, a vascular endothelial growth factor receptor inhibitor, has shown efficacy in inhibiting neovascularization in various cancer types but has not been thoroughly studied in OSCC. Our comprehensive assessment revealed that tivozanib effectively inhibited OSCC cells. This was accompanied by the suppression of Bcl-2, a reduction in matrix metalloproteinase levels, and the induction of intrinsic pathway-mediated apoptosis. Furthermore, tivozanib contributed to epithelial-to-mesenchymal transition (EMT) inhibition by increasing E-cadherin levels while decreasing N-cadherin levels. These findings highlight the substantial anticancer potential of tivozanib in OSCC and thus its promise as a therapeutic option. Beyond reducing cell viability and inducing apoptosis, the capacity of tivozanib to inhibit EMT and modulate key proteins presents the possibility of a paradigm shift in OSCC treatment.

• Structural Engineering and Mechanics
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• v.89 no.1
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• pp.93-102
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• 2024

Using negative Poisson's ratio materials, an innovative metallic-yielding damper is introduced for the first time in this study. Through the use of ABAQUS commercial software, a nonlinear finite element analysis is conducted to determine the performance of the proposed system. Mild steel plates with elliptical holes are used for these types of dampers, which dissipate energy through an inelastic deformation of the constitutive material. To assess the capability of the proposed damper, nonlinear quasi-static finite element analyses have been conducted on the damper with a variety of geometric parameters. According to the results, the proposed system is ductile and has a high capacity to dissipate energy. The proposed auxetic damper has a specific energy absorption of 910.8 J/kg and a ductility of 33.6. Therefore, this damper can dissipate a large amount of earthquake input energy without buckling by increasing the buckling load of the brace with its ductile behavior. In addition, it was found that by incorporating auxetic dampers in the steel frame, the frame was made harder, stronger, and ductile and its energy absorption increased by 300%.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.18 no.7
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• pp.2027-2046
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• 2024

Reconfigurable Intelligent Surface (RIS) is an innovative technique to precisely control the phase of incident signals with the help of low-cost passive reflective elements. It shows excellent potential in the sixth generation of mobile communication systems, which not only extends wireless coverage but also boosts channel capacity. Considering that multipath propagation and a high number of antennas are involved in RIS in assisted mega multiple-input multiple-output (MIMO) systems, it suffers from severe channel fading and multipath effects, which in turn lead to signal instability and degradation of transmission performance. To overcome this obstacle, this essay suggests an improved gradient optimization algorithm to dynamically and optimally adjust the phase of the reflective elements to counteract channel fading and multipath effects as a strategy. In order to overcome the optimization problem of falling into local minima, this paper proposes an adaptive learning rate algorithm based on Adagrad improvement, which searches for the global optimal solution more efficiently and improves the robustness of the optimization algorithm. The suggested technique helps to enhance the estimate of channel efficiency of RIS-assisted large MIMO systems, according to simulation results.