• Title/Summary/Keyword: Innovation in S&T

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Cladophora glomerata Kützing extract exhibits antioxidant, anti-inflammation, and anti-nitrosative stress against impairment of renal organic anion transport in an in vivo study

  • Atcharaporn Ontawong;Chaliya J. Aida;Pornpun Vivithanaporn;Doungporn Amornlerdpiso;Chutima S. Vaddhanaphuti
    • Nutrition Research and Practice
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    • v.18 no.5
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    • pp.633-646
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    • 2024
  • BACKGROUND/OBJECTIVES: Cladophora glomerata extract (CGE), rich in polyphenols, was reported to exhibit antidiabetic and renoprotective effects by modulating the functions of protein kinases-mediated organic anion transporter 1 (Oat1) and 3 (Oat3) in rats with type 2 diabetes mellitus (T2DM). Nevertheless, the antioxidant effects of CGE on such renoprotection have not been investigated. This study examined the mechanisms involved in the antioxidant effects of CGE on renal organic anion transport function in an in vivo study. MATERIALS/METHODS: Diabetes was induced in the rats through a high-fat diet combined with a single dose of 40 mg/kg body weight (BW) streptozotocin. Subsequently, normal-diet rats were supplemented with a vehicle or 1,000 mg/kg BW of CGE, while T2DM rats were supplemented with a vehicle, CGE, or 200 mg/kg BW of vitamin C for 12 weeks. The study evaluated the general characteristics of T2DM and renal oxidative stress markers. The renal organic transport function was assessed by measuring the para-aminohippurate (PAH) uptake using renal cortical slices and renal inflammatory cytokine expression in the normal diet (ND) and ND + CGE treated groups. RESULTS: CGE supplementation significantly reduced hyperglycemia, hypertriglyceridemia, insulin resistance, and renal lipid peroxidation in T2DM rats. This was accompanied by the normalization of high expressions of renal glutathione peroxidase and nuclear factor kappa B by CGE and vitamin C. The renal anti-inflammation of CGE was evidenced by the reduction of tumor necrosis factor-1α and interleukin-1β. CGE directly blunted sodium nitroprusside-induced renal oxidative/nitrosative stresses and mediated the PAH uptake in the normally treated CGE in rats was particularly noteworthy. These data also correlated with reduced nitric oxide production, highlighting the potential of CGE as a therapeutic agent for managing T2DM-related renal complications. CONCLUSION: These findings suggest that CGE has antidiabetic effects and directly prevents diabetic nephropathy through oxidative/nitrosative stress pathways.

High-performance 94 GHz MMIC Low Noise Amplifier using Metamorphic HEMTs (Metamorphic HEMT를 이용한 우수한 성능의 94 GHz MMIC 저잡음 증폭기)

  • Kim, Sung-Chan;An, Dan;Rhee, Jin-Koo
    • Journal of the Institute of Electronics Engineers of Korea SD
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    • v.45 no.8
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    • pp.48-53
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    • 2008
  • In this paper, we developed the MMIC low noise amplifier using 100 nm metamorphic HEMTs technology in combination with coplanar circuit topology for 94 GHz applications. The $100nm\times60{\mu}m$ MHEMT devices for the MMIC LNA exhibited DC characteristics with a drain current density of 655 mA/mm, an extrinsic transconductance of 720 mS/mm. The current gain cutoff frequency $(f_T)$ and maximum oscillation frequency $(f_{max})$ were 195 GHz and 305 GHz, respectively. The realized MMIC LNA represented $S_{21}$ gain of 14.8 dB and noise figure of 4.6 dB at 94 GHz with an over-all chip size of $1.8mm\times1.48mm$.

Research on A Comprehensive Study on Building a Zero Knowledge Proof System Model (영지식 증명 시스템 구축 연구)

  • Sunghyuck Hong
    • Advanced Industrial SCIence
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    • v.3 no.3
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    • pp.8-13
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    • 2024
  • Zero Knowledge Proof (ZKP) is an innovative decentralized technology designed to enhance the privacy and security of virtual currency transactions. By ensuring that only the necessary information is disclosed by the transaction provider, ZKP protects the confidentiality of all parties involved. This ensures that both the identity of the transacting parties and the transaction value remain confidential.ZKP not only provides a robust privacy function by concealing the identities and values involved in blockchain transactions but also facilitates the exchange of money between parties without the need to verify each other's identity. This anonymity feature is crucial in promoting trust and security in financial transactions, making ZKP a pivotal technology in the realm of virtual currencies. In the context of the Fourth Industrial Revolution, the application of ZKP contributes significantly to the comprehensive and stable development of financial services. It fosters a trustworthy user environment by ensuring that transaction privacy is maintained, thereby encouraging broader adoption of virtual currencies. By integrating ZKP, financial services can achieve a higher level of security and trust, essential for the continued growth and innovation within the sector.

Innovation Capability and Sustainable Competitive Advantage: An Entrepreneurial Marketing Perspective

  • TEGUH, Sriwidadi;HARTIWI, Prabowo;RIDHO, Bramulya Ikhsan;BACHTIAR, Simamora H.;SYNTHIA, Atas Sari;NOOR, Hazlina Ahmad
    • The Journal of Asian Finance, Economics and Business
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    • v.8 no.5
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    • pp.127-134
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    • 2021
  • This study aims to determine the role of innovative capabilities as a mediator in analyzing entrepreneurial marketing's effect on sustainable competitive advantage in food and beverage micro-, small-, and medium- enterprises (MSMEs). Data was obtained from a food and beverage store manager in Tangerang City, comprising 119 samples. Furthermore, the G⁎Power, a tool used to calculate statistical power analysis for various t-tests, F tests, χ2 tests, z tests, and several exact tests, was used to determine the number of research samples, the α error probability of 5%, and 3 variables. The data collection method used questionnaires with Likert Scale 1-5 to indicate strongly disagree to strongly agree. To analyze data, we used Path Analysis supported by SmartPLS statistics software. Path analysis is a form of multiple regression statistical analysis that is used to evaluate causal models by examining the relationships between a dependent variable and two or more independent variables. It aims to provide estimates of the magnitude and significance of hypothesized causal connections between sets of variables. The data processing process took place in two stages, namely the estimation model testing with validity and reliability, and the structural model testing to decide the impact or correlation between variables utilizing the t-test. The result showed a positive and significant effect of entrepreneurial marketing to innovative capability and competitive advantage through the innovative capability of MSMEs.

An Exploration For Future Emerging Technologies by Science Mapping and a Dynamic Portfolio Setting for Government R&D Strategy (과학지도 작성을 통한 미래기술 발굴 및 정부R&D의 동적 투자방향성 설정 연구)

  • Yang, He-Young;Son, Suk-Ho;Han, Min-Kyu;Han, Jong-Min;Yim, Hyun
    • Journal of Technology Innovation
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    • v.19 no.3
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    • pp.1-29
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    • 2011
  • Korean government built "2040 Science and Technology Future Vision" in order to show positive future scenarios and suggest a long-term guideline for a progress in science and technology. The S&T Future Vision was built based on an analysis of global megatrends and a prospect of domestic social change. After building S&T Future Vision, the "Government R&E Strategy"s was established as a follow-up action plan. The Government R&D Strategy consists of lists of future emerging technologies for future leadership, government R&D investment status and investment portfolio plans. Exploring future emerging technologies aggressively and making a governmental R&D strategic policy are requirements for national competitiveness, leadership in the world. Therefore search and selection for future emerging technologies is getting more and more important recently. Generally qualitative methodologies have been used such as expert-panel discussion method and portfolio analysis with expert valuation method in order to explore future technologies. These experts-based qualitative methodologies are well defined but lacking in some objectivity because size of expert-panels has limitations. We suggest a quantitative methodology, science mapping method to compensate this shortcoming in this study. There is another limitation related governmental R&D strategy which is that general R&D portfolios are static until a point of technology realization. We also propose a dynamic R&D investment portfolio which present different portfolios at a intermediate point and a point of technology realization. We expect this try with science mapping method and a dynamic R&D portfolio could strengthen strategic aspect of government R&D policy.

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A Study on the Diffusion Factor of e-finance (e-Finance의 확산요인에 관한 연구)

  • Kim, Min-Ho;Song, Chae-Hun;Song, Sun-Yok;Cha, Sun-Kwon
    • International Commerce and Information Review
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    • v.4 no.2
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    • pp.253-277
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    • 2002
  • Nowaday, the advanced technology in information and communication has been leading the dramatic change of transaction paradigm expansion from physical basis to electronic one. As we know, financial services support most of financial exchange between two business parties. So the expansion of electronic transaction paradigm affects to every financial institutions which provide financial services. Thus, financial institutions have accepted e-Finance systems and providing internet financial services to live in the competition. The purpose of this study is to contribute the qualitative enhancement of its customer service, rapid diffusion and accurate strategy establishment for e-Finance industry in the user side. Through the literature review and factor and reliability analysis, this study selects six diffusion factors such as efficiency of perceived e-Finance, reliability and safety of e-Finance in perceived e-Finance itself's characteristic; confidence, technical factors and the customer service quality of e-Finance system in perception on e-Finance System; inclination to innovation in the personal characteristic. According to result of hypothesis verification by using logistics regression analysis, technical factors and the customer service quality of e-Finance system in perception on e-Finance System and inclination to innovation in the personal characteristic gave statistically positive effect to the diffusion decision at the significant level 0.05 and 0.01. However efficiency of perceived e-Finance, reliability and safety of e-Finance in perceived e-Finance itself's characteristic didn't affect to diffusion decision and confidence of e-Finance system in perception on e-Finance System didn't have any statistical significancy. This study can be used as a basic material for the forward empirical study of diffusion factors in the user side and be able to apply to company and government policy making or embodiment, determination for customer service quality degree of financial institutions. But this study has some limitations like didn't touch satisfaction factors and its effect, only deal domestic customers and didn't use multi-regression analysis.

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A Study on the Collaboration Types of Knowledge Creation in Korean Government-supported Research Institutes of S&T: Focusing on Openness and Diversity (과학기술계 출연연구기관의 지식창출 협력유형 분석에 관한 연구: 개방성과 다양성 중심으로)

  • Park, Joohyoung;Lee, Heesang
    • Journal of Korea Technology Innovation Society
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    • v.17 no.3
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    • pp.563-583
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    • 2014
  • We classified collaboration types of Government-supported Research Institutes (GRIs) in Korea to make a creation knowledge with the openness and the diversity. The openness is described to collaboration dependence and leading intensity, and the diversity is expressed to collaboration diversity and collaboration concentration. We suggest four taxonomy models explained in terms of the openness and the diversity with country level and institute level. This study uses 39,507 papers in SCOUPS DB that include author(s) affiliated to 26 GRIs. It concludes that many GRIs is classified to the type of multilateral collaboration follower in institute level and to the type of global network player in country level from the perspective of openness. In the aspect of diversity, many GRIs is concentrated to the collaboration type of picky eater or monophagous in institute level and to the multinatioal asymmetry type or non-multinational asymmetry type in country level. It is necessary for GRIs to lead collaboration and to transfer inhouse R&D institutes with high performance to be competitive institutes which make high quality knowledge.

과학기술 비즈니스(S&T Business): 과학벨트(ISBB)의 역할

  • Lee, Won-Cheol;Choe, Jong-In
    • 한국벤처창업학회:학술대회논문집
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    • 2016.04a
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    • pp.70-78
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    • 2016
  • 기술사업화에 대한 중요성은 점점 강조되고 있지만 높은 기술 우수성이 항상 성공적인 비즈니스로 이어지는 것은 아니다. 또한, 기초연구 및 기술개발에 많은 투자를 하는 기업 역시 항상 높은 이윤 창출을 장담할 수는 없다. 이는 연구개발 수준이 상용화되기 어려운 단계에 존재하는 경우인 기술적인 문제와 기술이 사업화되는 시장이 불완전하여 합리적으로 작동하지 않는 시장측면의 문제 모두가 원인이 된다. 따라서 기초과학의 연구 성과를 바탕으로 이러한 시장의 불완전성 아래 연구 및 사업화 주체가 새로운 기술의 개발과 사업화를 성공적으로 수행하기 위해서는 외부의 파트너들과 제휴 및 협력 체계를 구축하여 자금이나 인력 등 필요한 자원을 효과적으로 확보하여 활용할 수 있어야 한다. 기존 연구에서는 기술에 대한 접근방법에 따라 연구개발(R&D) 관점, 기술경영(Management of Technology)관점, 기술혁신(Technology Innovation)관점으로 많은 연구가 이루어졌으나, 기술사업화(Technology Commercialization)관점의 연구는 많이 이루어지지 않고 있다. 본 연구에서는 기초과학을 연구하는 과정에서 필요한, 또는 실현 가능한 비즈니스를 살펴보고, 기술의 속성(암묵지, 기술가치의 객관화, 혁신 주체 간 정보의 비대칭 등)을 통해 시장의 불완전성을 이해하고자 한다. 또한, 기술이 사업화로 연결되지 않는 현상, 즉 '죽음의 계곡(Valley of Death)'을 탈피하는 것에 대한 적절한 대응방안으로써 기술사업화 협력요인을 포함하고 있는 과학기술 비즈니스의 성공요인과 함께 과학벨트의 역할을 중심으로 전략적 접근을 시도하고자 한다.

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Structural Properties of Social Network and Diffusion of Product WOM: A Sociocultural Approach (사회적 네트워크 구조특성과 제품구전의 확산: 사회문화적 접근)

  • Yoon, Sung-Joon;Han, Hee-Eun
    • Journal of Distribution Research
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    • v.16 no.1
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    • pp.141-177
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    • 2011
  • I. Research Objectives: Most of the previous studies on diffusion have concentrated on efficacy of WOM communication with the use of variables at individual level (Iacobucci 1996; Midgley et al. 1992). However, there is a paucity of studies which investigated network's structural properties as antecedents of WOM from the perspective of consumers' sociocultural propensities. Against this research backbone, this study attempted to link the network's structural properties and consumer' WOM behavior on cross-national basis. The major research objective of this study was to examine the relationship between network properties and WOM by comparing Korean and Chinese consumers. Specific objectives of this research are threefold; firstly, it sought to examine whether network properties (i.e., tie strength, centrality, range) affect WOM (WOM intention and quality of WOM). Secondly, it aimed to explore the moderating effects of cutural orientation (uncertainty avoidance and individuality) on the relationship between network properties and WOM. Thirdly, it substantiates the role of innovativeness as antecedents to both network properties and WOM. II. Research Hypotheses: Based on the above research objectives, the study put forth the following research hypotheses to validate. ${\cdot}$ H 1-1 : The Strength of tie between two counterparts within network will positively influence WOM effectivenes ${\cdot}$ H 1-2 : The network centrality will positively influence the WOM effectiveness ${\cdot}$ H 1-3 : The network range will positively influence the WOM effectiveness ${\cdot}$ H 2-1 : The consumer's uncertainty avoidance tendency will moderate the relationship between network properties and WOM effectiveness ${\cdot}$ H 2-2 : The consumer's individualism tendency will moderate the relationship between network properties and WOM effectiveness ${\cdot}$ H 3-1 : The consumer's innovativeness will positively influence the social network properties ${\cdot}$ H 3-2 : The consumer's innovativeness will positively influence WOM effectiveness III. Methodology: Through a pilot study and back-translation, two versions of questionnaire were prepared, one in Korean and the other in Chinese. The chinese data were collected from the chinese students enrolled in language schools in Suwon city in Korea, while Korean data were collected from students taking classes in a major university in Seoul. A total of 277 questionnaire were used for analysis of Korean data and 212 for Chinese data. The reason why Chinese students living in Korea rather than in China were selected was based on two factors: one was to neutralize the differences (ie, retail channel availability) that may arise from living in separate countries and the second was to minimize the difference in communication venues such as internet accessibility and cell phone usability. SPSS 12.0 and AMOS 7.0 were used for analysis. IV. Results: Prior to hypothesis verification, mean differences between the two countries in terms of major constructs were performed with the following result; As for network properties (tie strength, centrality and range), Koreans showed higher scores in all three constructs. For cultural orientation traits, Koreans scored higher only on uncertainty avoidance trait than Chinese. As a result of verifying the first research objective, confirming the relationship between network properties and WOM effectiveness, on Korean side, tie strength(Beta=.116; t=1.785) and centrality (Beta=.499; t=6.776) significantly influenced on WOM intention, and similar finding was obtained for Chinese side, with tie strength (Beta=.246; t=3.544) and centrality (Beta=.247; t=3.538) being significant. However, with regard to WOM argument quality, Korean data yielded only centrality (Beta=.82; t=7.600) having a significant impact on WOM, whereas China showed both tie strength(Beat=.142; t=2.052) and centrality(Beta=.348; t=5.031) being influential. To answer for the second research objective addressing the moderating role of cultural orientation, moderated regression anaylsis was performed and the result showed that uncertainty avoidance moderated between network range and WOM intention for both Korea and China, But for Korea, the uncertainty avoidance moderated between tie strength and WOM quality, while for China it moderated between network range and WOM intention. And innovativeness moderated between tie strength and WOM intention for Korea but it moderated between network range and WOM intention for China. As a result of analysing for third research objective, we found that for Korea, innovativeness positively influenced centrality only (Beta=.546; t=10.808), while for China it influenced both tie strength (Beta=.203; t=2.998) and centrality(Beta=.518; t=8.782). But for both countries alike, the innovativeness influenced positively on WOM (WOM intention and WOM quality). V. Implications: The study yields the two practical implications. Firstly, the result suggests that companies targeting multinational customers need to identify segments which are susceptible to the positive WOM and WOM information based on individual traits such as uncertainty avoidance and individualism and based on that, develop marketing communication strategy. Secondly, the companies need to divide the market on Roger's five innovation stages and based on this information, enforce marketing strategy which utilizes social networking tools such as public media and WOM. For instance, innovator and early adopters, if provided with new product information, will be able to capitalize upon the network advantages and thus add informational value to network operations using SNS or corporate blog.

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Determinants of Firms' Standardization Activity: Evidence from the Korean Service Firms (기업의 표준화활동 결정요인 : 우리나라 서비스기업에 대한 실증연구)

  • Sung, Tae-Kyung
    • Management & Information Systems Review
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    • v.28 no.2
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    • pp.95-112
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    • 2009
  • The paper investigates the determinants of firm's standardization activity in the Korean service industry. Standardization variables as dependent ones are standardization management at the firm level, domestic standardization activity, and international standardization activity. The independent variables include innovative activities(R&D intensity and patent application), firm size, export ratio, network, and firm's organization characteristics. We estimated the logistic regression model, using the data from 102 Korean service firms. The empirical findings are as follows. First, R&D intensity has a positive effect on international standardization activity, but not on the standardization management at the firm level and domestic standardization activity. Second, patent application has a negative effect on the standardization management at the firm level. Third, firm size doesn't have any influence on firms' standardization activities in the service sector. Fourth, the level of chief executive officer's interest on standardization is a very important factor in determining firms' efforts to participate standardization process, regardless of types of standardization activity.

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