• Proceedings of the Korea Technology Innovation Society Conference
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• 2013.10a
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• pp.518-531
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• 2013

• Korea Journal of Hospital Management
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• v.14 no.2
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• pp.75-98
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• 2009

As the organizational environments are changing, organizational innovation has become a critical success factor for the healthcare organizations. Although there are lots of successful innovation cases in other industries, healthcare organization's management innovation cases are rare in Korea. This case study is focused on successful change process of a Maeumsarang psychiatric hospital. Main findings are: (a) virtuous cycle of healthcare service innovation and organizational innovation, (b) intensive training and learning, (c) usage of external resources, (d) high commitment HRM system, (e) CEO leadership, and (f) synchronization of planning and execution. Based on these findings, managerial implications are derived and future research directions are proposed.

• Journal of Korea Technology Innovation Society
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• v.8 no.3
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• pp.1027-1059
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• 2005

The purpose of this paper is to analyze the dynamic characteristics of innovation sources such as scientific knowledges, processing technologies and user's needs in advanced metals technology. The journal articles data of four advanced materials are analyzed; amorphous metals, superplastic materials, shape memory alloys and aluminum-lithium alloy. Some regularities are found from the analysis of the four materials. The innovation proceeds through close interactions among the innovation sources. As the innovation proceeds, the relative importance of each source changes: scientific knowledge initiates the innovation and becomes the most important source in the first phase, then the processing technologies increase importance in the second phase, and then scientific knowledge, again, becomes the leading factor of innovation. Scientific knowledge and processing technology take turns leading the innovation. The impacts of users' needs to the innovation increase more and more as innovation proceeds. The results of analysis imply to the policy makers that emphasis of policy, and therefore the allocation of sources for innovation, should vary along the phases in the life cycle of advanced metals technology.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.44 no.3
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• pp.240-247
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• 2021

As competition among companies has intensified and the life cycle of products has been shortened, strong innovation is needed to meet consumers' needs. In addition, it is necessary to shorten the life cycle of the product and reduce the time required for technology development for the competitive advantage of the product. In particular, venture companies where new technologies and ideas are important require more innovative capabilities than others companies. Therefore, this study analyzed the impact of technology innovation capabilities (product development process capability, human resource capability and financial capability) on sales by technology development for small and medium venture companies and analyzed moderating effect of technology development period on the relationship between technology innovation capabilities and sales by technology development. The data of 'Small and Medium Business Technology Statistics' collected by the government every year were used for analysis. Technology-intensive ventures were extracted from this data. In addition, the moderating effect was analyzed through hierarchical regression analysis. This study shows that product planning capability, test capability, and R&D expenditure have a positive impact on sales by technology development. In this study, the product development period showed a positive moderating effect on product development capability and sales performance. On the other hand, the product development period showed a negative moderating effect on R&D expenditure and sales by technology development.

• Journal of Technology Innovation
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• v.2 no.1
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• pp.256-276
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• 1994

This paper aims at identifying the desirable R'||'&'||'D life cycle related to government-industry cooperative R'||'&'||'D. It is based on a case study associated with the relationship between cooperation and cooperation in information in information communications sector. It presents three types of R'||'&'||'D life cycle to achieve a technological enhancement as high as possible with limited resources. The first case of R'||'&'||'D project is of "advanced type". In the generic technology phase, government takes a leading role jointly in R'||'&'||'D activities, but, in after the applied research phase, the domestic firms take the lead. This kind of cooperation can be made when competition between domestic firms is highly intense, and the technological knowledges of participating firms are at internationally competitive levels. The second type of "less-advanced type"; the firms of a country(more often a small country) lag behind in technology level, and the penetration of foreign firms in the market is limited. In this case, government takes full charge of R'||'&'||'D activities up to the applied research phase, due to the low technology level and insufficient financial resources of private firms. Lastly, this paper presents and R'||'&'||'D life cycle of "strategic" type. This applies to the case in which domestic firm with less financial resources make an attempt to increase their technological knowledges while the government, in turn, contributes to strengthen the international competitiveness of domestic industry.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 1994.04a
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• pp.516-516
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• 1994

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.9
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• pp.3805-3810
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• 2015

Arsenic trioxide (ATO) has been found to exert anti-cancer activity in various human malignancies. However, the molecular mechanisms by which ATO inhibits tumorigenesis are not fully elucidated. In the current study, we explored the molecular basis of ATO-mediated tumor growth inhibition in pancreatic cancer cells. We used multiple approaches such as MTT assay, wound healing assay, Transwell invasion assay, annexin V-FITC, cell cycle analysis, RT-PCR and Western blotting to achieve our goal. We found that ATO treatment effectively caused cell growth inhibition, suppressed clonogenic potential and induced G2-M cell cycle arrest and apoptosis in pancreatic cancer cells. Moreover, we observed a significant down-regulation of Skp2 after treatment with ATO. Furthermore, we revealed that ATO regulated Skp2 downstream genes such as FOXO1 and p53. These findings demonstrate that inhibition of Skp2 could be a novel strategy for the treatment of pancreatic cancer by ATO.

• Journal of Contemporary Eastern Asia
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• v.13 no.1
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• pp.57-68
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• 2014

This paper positions the triple-Helix as a meso-level notion, an epicycle in a grander circle of technological change, institutional change, and psychological change. Because of the differing speeds of these several kinds of change, speed is proposed as a high-level system metric. This implies that what we commonly call bridging agencies or facilitators - lawyers, venture capitalists, incubators, etc. - are better called buffering agencies, as they help to engage entities changing at different speeds. They use human judgment as well as information technologies to choose feasible timing for these engagements. The paper highlights implications for thinking about innovation diffusion: The grand cycle of socio-technical change means we should, rather, think in terms of innovation reinforcement, or a circle of innovation.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.35 no.2
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• pp.220-227
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• 2012

The case company has driven the six sigma innovation programme company wide for the last seven years without any stop in spite of the CEO change. There was neither any benchmark nor the sufficient number of internal experts during the initial stage of driving six sigma. However, the company raised a lot of innovation experts such as MBB, BB and GB, thereby successfully changed the way of employees' doing work and reaped an enormous amount of either visible or invisible performances as a result of implementing the six sigma innovation programme. This paper deals with both main activities undertaken at each stage of the innovation life cycle of six sigma and their performances in a ICT (Information Communication Technology) industry. The performances are described from the four aspects of a balanced score card (BSC) and finally some strategic implications suggested.

• Information Systems Review
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• v.19 no.1
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• pp.169-183
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• 2017

As global competition is heating up and product life cycle has been rapidly shortened, each company pursues a variety of competitive technology innovations through different means of innovation. In this study, we assume that open innovation can be a shift motive of the technology innovation paradigm of small and medium enterprises (SMEs) being beyond the limitations of R&D within a company. We analyze the process and content of open innovation and performance. In addition, we identify the problems generated in the open innovation process and analyze the ways to strengthen open innovation. This study is based on the investigations into the technological competitiveness of local SMEs. The innovation ecosystem is analyzed from the perspective of product/service innovation, organizational innovation, and marketing innovation. Situational analysis is presented on the relationship between the innovation capabilities of information and communication technology SMEs and innovation performance.