• Journal of Life Science
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• v.29 no.4
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• pp.447-454
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• 2019

Fat accumulation in adipocytes occurs through the process of adipogenesis in which preadipocytes differentiate into adipocytes. Obesity is a metabolic disorder caused by excessive accumulation of fat in the body, which increases the incidence of cardiovascular diseases, hypertension, type 2 diabetes, hyperlipidemia, and various cancers. Recently, inhibition of adipocyte differentiation was shown to be a potential antiobesity strategy. In this study, the inhibitory effect of dichloromethane fractions from Illicium verum Hooker fil. water extract on the differentiation of 3T3-L1 preadipocytes to adipocytes was investigated. Dichloromethane fractions from I. verum Hooker fil. significantly inhibited adipocyte differentiation when applied during the adipocyte differentiation process, as assessed by measuring fat accumulation using Oil-red O staining. In addition, dichloromethane fractions from I. verum Hooker fil. reduced important adipogenic transcription factors, such as CCAAT/enhancer binding protein ${\alpha}$ ($C/EBP{\alpha}$), $C/EBP{\beta}$, and peroxisome proliferator activated receptor ${\gamma}$ ($PPAR{\gamma}$). The expression of FAS and LPL, which are terminal differentiation markers of mature adipocytes, was also reduced in the 3T3-L1 adipocytes treated with dichloromethane fractions from I. verum Hooker fil. In addition, the treatment significantly inhibited mitotic clonal expansion, which is essential for adipocyte differentiation, by arresting the G1 phase of the cell cycle. Taken together, these results suggest that dichloromethane fractions from I. verum Hooker fil. may be a natural material with antiobesity effects.

• The Korean Journal of Franchise Management
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• v.8 no.4
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• pp.43-54
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• 2017

Purpose - Recently, the meaning and importance of entrepreneurship has been emphasized in order to achieve innovation-led economic growth through entrepreneurship. Various forms of entrepreneurship education have been established centering on universities, and the scale of the entrepreneurship support programs of the government and the private sector has been increasing. Entrepreneurial education can enhance entrepreneurship and promote entrepreneurial intention. The purpose of this study is to examine the effect of experience of entrepreneuship education and social awareness of entrepreneurship on entrepreneurial intention through entrepreneurship, focusing on women who were relatively alienated from entrepreneurial activities. This study will provide suggestions for women's entrepreneurship in the future. Research design, data, and methodology - Recently, the meaning and importance of entrepreneurship has been emphasized in order to achieve innovation-led economic growth through entrepreneurship. Various forms of entrepreneurship education have been established centering on universities, and the scale of the entrepreneurship support programs of the government and the private sector has been increasing. Entrepreneurial education can enhance entrepreneurship and promote entrepreneurial intention. The purpose of this study is to examine the effect of experience of entrepreneuship education and social awareness of entrepreneurship on entrepreneurial intention through entrepreneurship, focusing on women who were relatively alienated from entrepreneurial activities. This study will provide suggestions for women's entrepreneurship in the future. Result - Recently, the meaning and importance of entrepreneurship has been emphasized in order to achieve innovation-led economic growth through entrepreneurship. Various forms of entrepreneurship education have been established centering on universities, and the scale of the entrepreneurship support programs of the government and the private sector has been increasing. Entrepreneurial education can enhance entrepreneurship and promote entrepreneurial intention. The purpose of this study is to examine the effect of experience of entrepreneuship education and social awareness of entrepreneurship on entrepreneurial intention through entrepreneurship, focusing on women who were relatively alienated from entrepreneurial activities. This study will provide suggestions for women's entrepreneurship in the future. Conclusions - Although women's economic activity is increasing, women's activities in the field of business start-up are still passive. The purpose of this study is to examine the effect of entrepreneurship on entrepreneuship education and the social perception of entrepreneurship. As a result, we found that social awareness, entrepreneurship education, and entrepreneurship all had a significant influence on the intention of entrepreneurship. Positive social atmosphere for entrepreneurship induces interest in entrepreneurship education and forms a virtuous cycle structure that fosters entrepreneurship through entrepreneuship education. In addition, the introduction of diverse programs that encourage entrepreneurship should enhance the attractiveness of promising talent to enter the entrepreneurial market.

• The Journal of Information Technology
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• v.6 no.3
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• pp.75-85
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• 2003

It is highly required to evaluate the economic value of technology in many decision making of the technology management area, for example, technology acquisition, transfer, and investments. Also evaluating the performance of R&D objectively is very important subject in the public side. So, developing the objective technology evaluation system has much usefulness in practice. In many studies, the patent information has been suggested to the valid measurement for evaluation of technology. The purpose of this study is to explore the validity of patent information as a measurement of technology evaluation.

• IE interfaces
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• v.18 no.4
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• pp.402-411
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• 2005

Secondary batteries with high performance are essential in widespread use of modern portable devices such as cellular phones and laptop computers. High energy density, long cycle life, and safety are some of important requirements for secondary battery. To achieve such characteristics, a mixing proportion of electrolyte solution ingredients in the battery should be carefully chosen. In this paper, using statistical design of mixture experiments (DOME), we attempt to find an optimum condition of designing the secondary battery. DOME has a distinct feature in that the experimental region is represented by simplex, rather than hypercube, because the sum of blend proportions should be unity. Several designs based upon this point have been proposed for mixture experiments. Among them, an extreme vertices design is employed in this paper because there are a couple of blend constraints to be considered. In order to investigate how the mixing proportion interacts with other manufacturing factors, a fractional factorial design is also included across the extreme vertices design. As a result, we find that the blend proportion of solution ingredients has a significant effect on battery performances. By simultaneously optimizing two battery capacities, this paper proposes an optimum blend proportion according to process factor settings.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.26 no.9
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• pp.40-46
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• 2012

The single-phase switched reluctance motor(SRM) has only one inductance variation and the positive torque is generated in the restricted section. So, it cannot be started by itself. To solve this problem, many researchers have addressed the several starting method for the single-phase SRM. This paper is focused on the torque characteristics of the single-phase SRM according to starting method. The four major starting method - permanent magnet, saturable stator pole, to grade the rotor, stepped rotor pole - is selected to analyze the torque characteristics. The analysis model of each starting method is designed to changed the pole shape or inserting other material in the basic model. The torque characteristics of each analysis model is obtained by using FEM analysis. The FEM analysis is performed at incremental rotor positions over half inductance cycle in any one pole with 250AT, 500AT, 750AT. The distortion factor of each analysis model is analyzed through the FFT to compare the distortion between basic model and four analysis model.

• KIPS Transactions on Computer and Communication Systems
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• v.5 no.1
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• pp.1-6
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• 2016

This paper focuses on algorithm innovation of NAND Flash Memory for enhancing cell lifetime. During flash memory read/write/erase, the voltage of a specific cell should be a valid voltage level. If not, we cannot read the data correctly. This type of interference/disturbance tends to be serious when program and erase operation will go on. This is because FN tunneling results in tunnel oxide damage due to increased trap site on repetitive high biased state. In order to resolve this problem, we make the cell degradation by reducing the amount of stress in terms of erase cell, resulting in minimizing the cell disturbance on erase verify.

• International Journal of Quality Innovation
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• v.8 no.2
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• pp.132-146
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• 2007

Constructing an effective production control policy is the most important issue in wafer fabrication factories. Most of researches focus on the input regulations of wafer fabrication. Although many of these policies have been proven to be effective for wafer fabrication manufacturing, in practical, there is a need to help operators decide which lots should be pulled in the right time and to develop a systematic way to alleviate the long queues at the bottleneck workstation. The purpose of this study is to construct a photolithography workstation dispatching rule (PADR). This dispatching rule considers several characteristics of wafer fabrication and influential factors. Then utilize the weights and threshold values to design a hierarchical priority rule. A simulation model is also constructed to demonstrate the effect of the PADR dispatching rule. The PADR performs better in throughput, yield rate, and mean cycle time than FIFO (First-In-First-Out) and SPT (Shortest Process Time).

• Journal of KIBIM
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• v.4 no.4
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• pp.1-12
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• 2014

As interest for visualization and real time processing of construction management information was heightened recently, a diversity of management tools have been developed and corresponding systems also have been changed. In the case of BIM(Building Information Modeling) which is being spotlighted as such kind of management tool, its outcome such as technical innovation and time saving through overseas success case, reducing effect of unnecessary work, and so forth has continuously been established. The BIM in which various information related with life cycle of project are managed with the base of 3D object is useful as an information management tool of construction project which becomes complex and large in its scale. The aim of this paper is analysis or reliability on BIM design for expressway. To solve these issues, this study analyzes the design document, road design handbook, guide. Also this paper performed analysis of reliability 2D vs. BIM quantity calculation. This pilot projects "BIM design at Daegu expressway Lot No.5" lays the foundation for future work on BIM based civil engineering design.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.14 no.5
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• pp.2022-2042
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• 2020

This research aims to contribute to the discipline of knowledge management (KM) in Higher Education (HE), and is conducted using the case of the study programme (SP) for Integrated Academic Studies (IAS) of Technics and Informatics (TI). A deduction-induction methodology is applied, using a Plan-Do-Check-Act (PDCA) approach to design a suitable KM concept for making improvements to the SP IAS TI on the standardisation platform. Based on the application of the International Classification of Standards (ICS), the research analyses the correlations and competences acquired during the courses within the accredited TI study programme of two-course studies. On the basis of the results of a comparative analysis of the developmental learning process and educational goals, it is shown that knowledge management in correlation with standardisation leads to the improvement of study programmes in the upcoming accreditation cycle on the standardisation platform. Frequent innovations within standardised thematic fields (daily, weekly, monthly, etc.) indicate the need for appropriate changes to the SP. The contribution to KM is through an original analysis of annual samples of more than 90,000 standardised sources in correlation with the TI study programme. Expert System (ES) modelling and the original results enable an analogous contribution to the future KM of other SPs.

• Korean Medical Education Review
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• v.16 no.1
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• pp.16-24
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• 2014

The development of information technology (IT) has led to changes in medical education. IT has been used for e-learning and e-teaching, e-assessment, e-logistics, and e-administration. Pusan National University School of Medicine has developed its own educational information system using IT to support students' learning and assessment and to manage curricular activities. Based on our experience, we propose six suggestions for designing new software, specifically regarding simplifying the design for users, communication with the programmer, a rapid cycle from design to implementation, orientation support for users, backup and security support, and obtaining patents. Collaborating with the Department of Medical Informatics within the School of Medicine has advantages, and an alliance among medical schools can simplify the development of software. In any case, curricular innovation should precede the introduction of technology because all technologies should support curricular goals.