• The Journal of the Korea Contents Association
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• v.16 no.9
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• pp.473-481
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• 2016

Adverse drug reactions(ADRs) were caused by dexran 40 in patient with ischemic stroke and related 22 patients reported to formal ADRs at Jesus Hospital in Jeonju. This study was aimed to search ADRs related factors, type and the degree associated with dextran 40. Adverse Effects of Dextran 40 is including marked hypotension, nausea, dyspnea, generalized urticaria, fever and pulmonary edema. The average hospitalization period was 20 days and it was extended 26.8%. ADRs of Dextran 40 to incidence is 12.4%, and 9 persons(28.1%), itching, rash was 7 people (21.9%). Dextran induced ADRs reaction may be reported on early injection period and first time shot, but adverse drug reactions occurred after 4 days in 4 patients(18.2%). US FDA has recommanded that Dextran 1 significantly reduces the incidence of severe ADRs in USA. Because low molecular weighted dextran 1 prevented dextran molecules from combined Ig G completely. In Korea. Generally not yet introduced dextran 1, active use dextran 1 is able to be a good way in order to reduce ADRs of dextran 40.

• Journal of The Korean Society of Clinical Toxicology
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• v.9 no.2
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• pp.105-108
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• 2011

Aconitine is an anti-inflammatory agent with therapeutic uses in oriental medicine as an analgesic and for treatment of stroke. Because of its sodium channel effect, aconitine can promote undesirable, wide complex tachyarrhythmia. If tachycardia develops during use of aconitine, class Ia and class III anti arrhythmic drugs can be utilized for treatment. However there are no single anti-arrhythmia agents which are uniformly effective. We report a case, characterized by wide complex tachyarrhythmia and severe hypotension, which was successfully treated by simultaneous injections of amiodarone and lidocaine. A 59-year-old woman exhibiting clinical signs of drowsiness as a result of ingesting 6 g of aconitine, was admitted to the emergency department. Initially, wide complex tachyarrhythmia (ventricular tachycardia and pulse rate of 180 beats/min) and severe hypotension (blood pressure of 53/26 mmHg) was observed. After simultaneous injection of amiodarone and lidocaine, the patient's rhythm pattern changed to an accelerated junctional rhythm with ventricular premature complex. Two hours later, the patient's heart pattern became a sinus rhythm. As demonstrated by this case, simultaneous injections of amiodarone and lidocaine can be useful in treating ventricular arrhythmia induced by aconitine.

• Journal of Acupuncture Research
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• v.25 no.1
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• pp.1-14
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• 2008

Objectives : Delayed neuronal death(DND) of pyramidal neuronsin the CA1 regions of the hippocampus has been extensively studied following global brain ischemia, whereas little is known about DND in this highly vulnerable brain region after focal brain ischemia. The aim of the present study was to investigate the effect of Gastrodiae Elata(GA) pharmacopuncture on hippocampal neuronal apoptosis in rats with focal brain ischemic injury. Materials and methods : The neuroprotective effects of water extracts of GA were investigated in middle cerebral artery occlusion(MCAo) of Sprague-Dawley(SD) rats. Seventy-five healthy SD ratswere randomly divided into five groups following MCAo : control group with focal ischemia, saline injection group, pharmacopuncture group GA-1($0.0007mg/m{\ell}/g$), pharmacopuncture group GA-2($0.00035mg/m{\ell}/g$), pharmacopuncture group GA-3($0.00014mg/m{\ell}/g$). Results : The intensity of mGluR5 increased in the GA-1 group. The intensity of Bax and the Bax/Bcl-2 ratio decreased in the GA-1 group. The intensity of Bcl-2 increased in all the GA groups. The density of neurons stained by Cresyl violet and ChAT increased in the GA-1 group. Conclusions : Our study suggests that GA pharmacopuncture at $GB_{20}$ showed anti-apoptotic and neuroprotective effects on cholinergic neuronsin focal cerebral ischemia caused by stroke in SD rats.

• Journal of Advanced Marine Engineering and Technology
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• v.38 no.9
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• pp.1051-1056
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• 2014

Nitrous oxide ($N_2O$) is naturally generated from biological activity, such as bacteria's material exchange. However, recent $N_2O$ concentration in the atmosphere has being increased by the human activities such as industrial growth. One of factors to increase $N_2O$ concentration in the atmosphere is a $N_2O$ emission caused by the combustion of marine fuel oils. The marine transportation presently handles over 99 percent of the international freight cargoes and the number of ship is continuously increasing with increment of cargoes. In this study, author conducted a series of the experimental investigations on which combustion of fuels containing different element concentrations used in a 4-stroke marine diesel engine affect $N_2O$ emissions in the exhaust gas. Moreover, it is assessed on the extent to which fuel combustion patterns in the combustion chamber affect $N_2O$ emissions.

• Journal of the Korean Society of Marine Environment & Safety
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• v.14 no.1
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• pp.83-87
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• 2008

We have a lot of interest in alternative fuels to provide energy independence from oil producing country and to reduce exhaust emissions for air pollution prevention. Biodiesel, which can be generated from natural renewable sources such as new or used vegetable oils or animal fats, may be used as fuel without change of engine structure in diesel engine of compression ignition engine. In this paper, the test results on specific fuel consumption and exhaust emissions of neat diesel oil and biodiesel blends(10 vol.% biodiesel and 20 vol.% biodiesel) were presented using four stroke, direct injection diesel engine. Especially this biodisel was produced from rape oil at our laboratory by ourselves. This study showed that specific fuel consumption and NOx emission were slightly increased, on the other hand CO emission and Soot were tolerably decreased more in the case of biodiesel blends than neat diesel oil.

• Proceedings of KOSOMES biannual meeting
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• 2007.11a
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• pp.133-137
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• 2007

An experimental study is conducted to evaluate and compare the use of BiodieseDI Fuel supplements at blend ratio of 10/90(BDF10) and 20/80(BDF20), in four stroke, direct injection diesel engine located at the authors' laboratory. especially this Biodiesel is produced from Rape oil at the authors' laboratory. The tests are conducted using each of the above fuel blends, in the engine working at a speed of 1800rpm and at a various loads. In each test, specific fuel consumption, exhaust emissions such as nitrogen oxides(NOx), carbon monoxide(CO) and Soot are measured. The results of investigation at various operating conditions are as follows (1) Specific fuel consumption is increased average 1.52%, maximum 1.84% at load 25% in case of BDF10, and average 1.98%, maximum 2.80% at load 25% in case of BDF20. (2) CO emission is decreased average 5.14%, maximum 6.09% at load 0% in case of BDF10, and average 7.75%, maximum 9.13% at load 0% in case of BDF 20. (3) NOx emission is increased average 2.97%, maximum 3.74% at load 0% in case of BDF10, and average 3.84%, maximum 4.67% at load 0% in case of BDF20. (4) Soot emission is decreased average 9.36%, maximum 10.85% at load 75% in case of BDF10, and average 11.99%, maximum 13.95% at load 75% in case of BDF20.

• Journal of Power System Engineering
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• v.19 no.3
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• pp.16-21
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• 2015

Nitrous oxide($N_2O$) concentration in the atmosphere has been constantly increased by the human activities with industrial growth after the industrial revolution. One of factors to increase $N_2O$ concentration in the atmosphere is the $N_2O$ emission caused by the combustion of marine fuel. Especially, a sulfur component included in marine fuel oils is known as increasing the $N_2O$ formation in diesel combustion. Form this point of view, $N_2O$ emission from a ship is not negligible. On the other hand, Exhaust gas recirculation(EGR) that have thermal, chemical and dilution effect is effective method for reducing the NOx emission. In this study, an author investigated $N_2O$ reduction by using EGR on a direct injection diesel engine. The test engine was a 4-stroke diesel engine with maximum output of 12 kW at 2600rpm, and operating condition of the engine was a fixed load of 75%. The experimental oil was a blend-fuel that were adjusted with sulfur ratio of 3.5%, and EGR ratio of 0%, 10%, 20% and 30%. In conclusion, diesel fuel that contained 3.5% sulfur component increased $SO_2$ emission in exhaust gas, and increment of EGR ratio reduced NO emission. Moreover, $N_2O$ emission was decreased as over 50% at EGR ratio of 10% and reduced 100% at EGR ratio of 30% compared with $N_2O$ emission of 0% EGR ratio.

• Journal of Sasang Constitutional Medicine
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• v.13 no.2
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• pp.165-176
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• 2001

This study demonstrates the effects of Yanggyuksanhwa-Tang, Sasang constitutional herb prescription reported its clinical effect on the stroke of the So-yang In(少陽人), on the cerebral blood flow changes induced by nitro L-arginine methyl ester (L-NAME) treatment and ischemic brain damage induced by the middle cerebral artery occlusion (MCAO) in the rats. The changes of the arterial blood pressure, cerebral blood flow, and the diameter of the pial artery were measured in rats treated with L-NAME. And the changes of the infarct size, volume, and plasma tumor necrosis factor alpha ($TNF-{\alpha}$) levels were measured in the rats that the middle cerebral artery has been occluded by the intraluminal suture thread method. Yanggyuksanhwa-Tang was administered by the i.v. injection on the L-NAME treated rats, by the i.o. administration on the MCAO rats. The results is 1. The changes of the arterial blood pressure was not different statistically between in the L-NAME treated control group and in the Yanggyuksanhwa-Tang administered group. 2. Increase in the cerebral blood flow induced by L-NAME treatment was attenuated in the Yanggyuksanhwa-Tang administered group significantly (P<0.05) as compared with the L-NAME treated control group. 3. Decrease in the diameter of the pial artery induced by L-NAME treatment was attenuated about 18% in the Yanggyuksanhwa-Tang administered group as compared with the L-NAME treated control group. 4. Ischemic damaged infarct areas were decreased significantly (P<0.05) in the interaural 12mm, 10mm, and 6mm brain sections of the Yanggyuksanhwa-Tang administered group as compared the MCA occluded control group. 5. Total ischemic infarct volume was decreased significantly (P<0.05) in the Yanggyuksanhwa-Tang administered group as compared the MCA occluded control group. 6. Plasma $TNF-{\alpha}$ levels were decreased significantly (P<0.01) in the Yanggyuksanhwa-Tang administered group as compared the MCA occluded control group.

• International Journal of Automotive Technology
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• v.6 no.5
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• pp.437-444
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• 2005

Unburned hydrocarbon (UBHC) emissions from gasoline engines remain a primary engineering research and development concern due to stricter emission regulations. Gasoline engines produce more UBHC emissions during cold start and warm-up than during any other stage of operation, because of insufficient fuel-air mixing, particularly in view of the additional fuel enrichment used for early starting. Impingement of fuel droplets on the cylinder wall is a major source of UBHC and a concern for oil dilution. This paper describes an experimental study that was carried out to investigate the distribution and 'footprint' of fuel droplets impinging on the cylinder wall during the intake stroke under engine starting conditions. Injectors having different targeting and atomization characteristics were used in a 4-Valve engine with optical access to the intake port and combustion chamber. The spray and targeting performance were characterized using high-speed visualization and Phase Doppler Interferometry techniques. The fuel droplets impinging on the port, cylinder wall and piston top were characterized using a color imaging technique during simulated engine start-up from room temperature. Highly absorbent filter paper was placed around the circumference of the cylinder liner and on the piston top to collect fuel droplets during the intake strokes. A small amount of colored dye, which dissolves completely in gasoline, was used as the tracer. Color density on the paper, which is correlated with the amount of fuel deposited and its distribution on the cylinder wall, was measured using image analysis. The results show that by comparing the locations of the wetted footprints and their color intensities, the influence of fuel injection and engine conditions can be qualitatively and quantitatively examined. Fast FID measurements of UBHC were also performed on the engine for correlation to the mixture formation results.

• Journal of Advanced Marine Engineering and Technology
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• v.19 no.1
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• pp.60-70
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• 1995

In the field of marine transportation the energy saving is one of the most important factors for profit. In order to reduce the fuel oil consumption the ship's propulsion efficiency must be increased as much as possible. The propulsion efficiency depends upon a combination of an engine and a propeller. The propeller has better efficiency as lower rotational speed. This situation led the engine manufacturers to design the engine that has lower speed, longer stroke and a small number of cylinders. Consequently the variation of rotational torque became larger than before because of the longer delay-time in the fuel oil injection process and an increased output per cylinder. As this new trends the conventional mechanical-hydrualic governors for engine speed control have been replaced by digital speed controllers which adopted the PID control or the optimal control algorithm. But these control algorithms have not enough robustness to suppress the variation of the delay-time and the parameter pertubation. In this paper we consider the delay-time and the perturbation of engine parameters as the modeling uncetainties. Next we design the controller which has zero offset in steady state engine speed, based on the two-degree-of-freedom control theory and $\mu$-synthesis. Thd validity of the controller is investigated through the response simulation. We use a personal computer and an analog computer as the digital controller and the engine (plant) part respectively. And, we certify that the designed controller maintains its performance even though the engine parameters may vary.