• International Journal of Oral Biology
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• v.41 no.2
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• pp.63-68
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• 2016

The aim of this study was to investigate the effect of n-3 polyunsaturated fatty acids (PUFAs) on eruptive movement during tooth development. Sprague-Dawley (SD) rat pups were randomly divided into two groups; control group and experimental group. The experimental group was administered daily with n-3 PUFA by intraperitoneal (IP) injection. After 10 days postpartum, rat pups were sacrificed to evaluate the effect of n-3 PUFA on eruptive tooth movement. Histological analyses were by hematoxylin-eosin (H&E) staining. Tartrate-resistant acid phosphatase (TRAP) assay was performed to compare the osteoclast distribution in the bone matrix above the developing molar teeth. Incisor teeth eruptions were noticeably observed in IP group, as compared to control group. Rat pups in IP group showed faster tooth eruption on day 8 after birth. Through histological analyses, IP group showed thinner bone matrix and more osteoclasts above the $1^{st}$ molar teeth, as compared to control group. TRAP assay showed significantly stronger stained pattern that the osteoclast above the $1^{st}$ molar teeth in IP group, as compared to control group. The results suggested that n-3 PUFA could affect osteoclastic activity involved in bony remodeling during eruptive tooth movement.

• Transactions of the Korean Society of Automotive Engineers
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• v.22 no.2
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• pp.91-99
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• 2014

The common-rail injectors are the most critical component of the CRDI diesel engines that dominantly affect engine performances through high pressure injection with exact control. Thus, from now on the advanced combustion technologies for common-rail diesel injection engine require high performance fuel injectors. Accordingly, the previous studies on the numerical and experimental analysis of the diesel injector have focused on a optimum geometry to induce proper injection rate. In this study, computational predictions of performance of the diesel injector have been performed to evaluate internal flow characteristics for various needle lift and the spray pattern at the nozzle exit. To our knowledge, three-dimensional computational fluid dynamics (CFD) model of the internal flow passage of an entire injector duct including injection and return routes has never been studied. In this study, major design parameters concerning internal routes in the injector are optimized by using a CFD analysis and Response Surface Method (RSM). The computational prediction of the internal flow characteristics of the common-rail diesel injector was carried out by using STAR-CCM+7.06 code. In this work, computations were carried out under the assumption that the internal flow passage is a steady-state condition at the maximum needle lift. The design parameters are optimized by using the L16 orthogonal array and polynomial regression, local-approximation characteristics of RSM. Meanwhile, the optimum values are confirmed to be valid in 95% confidence and 5% significance level through analysis of variance (ANOVA). In addition, optimal design and prototype design were confirmed by calculating the injection quantities, resulting in the improvement of the injection performance by more than 54%.

• Korean Journal of Poultry Science
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• v.22 no.2
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• pp.85-95
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• 1995

This study was conducted to investigate the immune response of layers fed diets supplemented with excess micronutrients, i.e., vitamin A, methionine, Zn, Cu, and Fe to the inoculation of Newcastle disease vaccine(NDV) or infectious bronchitis vaccine(IBV). The antibody titer against the NDV increased immediately after the inoculation and stayed high during the next 6 wk. On the other hand, The antibody titer against the IBV increased after 4 wk of inoculation The IgM level increased rapidly after 1 wk of NDV inoculation, however, it decreased after 5 wk of inoculation. The IgA displayed similar pattern to that of IgM in response to NDV inoculation. The pattern of IgM change after IBV inoculation was similar to that when layers were treated with NDV. However, IgA level changed earlier than did IgM. The IgG response to the NDV and IBV was very weak compared to the other immune responses. The excess supplementation of micronutrients to the diets of layers inoculated with NDV elicited favorable antibody titer and immune response compared to the layers fed the control diet. The excess Zn, however, allowed the layers to have higher antibody titer for the 4-wk period after NDV injection: after that they showed no effect of extra-Zn. The immune responses of layers fed excess vitamin A, Cu, methionine, and Fe were markedly higher in IgA and IgG than the control layers. The excess Zn, however, did not bring about any favorable result. No difference was detected in IgG level between control and micronutrients-treated groups.

• Korean Journal of Veterinary Research
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• v.39 no.2
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• pp.267-275
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• 1999

Bovine somatotropin is known to improve the growth rate and lactation in cattle. In this study, we examined the concentration-time profiles of a sustained-release formulation of bovine somatotropin (BST) and insulin-like growth factor-1 (IGF-1) in plasma and milk in cows. In addition, the possible effect of co-administrated vitamin ADE complex on the pharmacokinetic parameters of BST and IGF-1 was evaluated. 1. Plasma BST and IGF-1 levels reached the peak at 12~24 and 48 hours after the administration of BST, and plasma half-lives ranged 100 to 137 and 201 to 310 hours, respectively. To 8th day after administration, BST and IGF-1 levels in milk were not significantly different from the control levels. 2. Plasma BST levels showed cyclic pattern with high concentrations in early stage after each injection and following gradual declining during repeated administrations at 2 week intervals, while plasma IGF-1 levels in treated animals did not show such a cyclic pattern, but remained higher than the control levels. 3. Milk BST and IGF-1 levels during repeated treatments were not significantly different from the control levels. 4. Co-administration of vitamin ADE complex yielded slightly increased AUC of plasma BST for high dose group, but such effect was not evident in the IGF-1 levels. Co-administration of ADE complex tended to increase plasma BST levels and decrease the elimination half-life of IGF-1. 5. These results suggest that the BST formulation tested is one of the ideal sustained-release formulation for long term use in dairy industry. As for the co-administration of vitamin ADE complex, the benefit of co-administration with BST is needed to be further evaluated.

• Journal of Advanced Marine Engineering and Technology
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• v.28 no.3
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• pp.475-481
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• 2004

Recently it is strongly required on lower fuel consumption. lower exhaust emission, higher engine performance. and social demands in a spark ignition gasoline engine. In this study. the experimental engine used at test. it has been modified the lean burn gasoline engine. and used the programmable engine management system, and connected the controller circuit which is designed for the engine control. At the parametric study of the engine experiment, it has been controlled with fuel injection, ignition timing. swirl mode, equivalence ratio engine dynamometer load and speed as the important factors governing the engine performance adaptively. It has been found the combustion characteristics to overcome the hysteresis phenomena between normal and lean air-fuel mixing ranges. by mean of the look-up table set up the mapping values. at the optimum conditions during the engine operation. As the result, it is found that the strength of the swirl flow with the variation of engine speed and load is effective on combustion characteristics to reduce the bandwidth of the hysteresis regions. The results show that mass fraction burned and heat release rate pattern with crank angle are reduced much rather, and brake specific fuel consumption is also reduced simultaneously.

• The Transactions of the Korean Institute of Electrical Engineers B
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• v.53 no.11
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• pp.664-670
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• 2004

This paper presents a new velocity estimation strategy of a non-salient permanent magnet synchronous motor (PMSM) drive without high frequency signal injection or special PWM pattern. This approach is based on the d-axis current regulator output voltage of the drive system that has the information of rotor position error. The rotor velocity can be estimated through a rotor position tracking PI controller that controls the position error to zero. For zero and low speed operation, PI controller gains of rotor position tracking controller have a variable structure according to the estimated rotor velocity. In order to boost the bandwidth of PI controller around zero speed, a loop recovery technique is applied to the control system. The proposed method only requires the flux linkage of permanent magnet and is insensitive to the parameter estimation error and variation. The designers can easily determine the possible operating range with a desired bandwidth and perform the vector control even at low speeds. The experimental results show the satisfactory operation of the proposed sensorless algorithm under rated load conditions.

• Korean Journal of Materials Research
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• v.16 no.11
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• pp.698-704
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• 2006

In this study, the effect of chill layers occurred in shot sleeve on the molten metal filling was analyzed through computer simulation. The behavior of chill layers with temperature variation of shot sleeve set from 200 to $280^{\circ}C$ was also investigated. The simulation results showed the chill layers set in the in-gates during the injection process change the main filling direction and cause turbulent flow pattern, resulting in porosities inside the castings. The amount of chill layers with the increasing temperature of shot sleeve was considerably reduced. Particularly, at the setting temperature of $280^{\circ}C$ by heat control unit, the biggest reduction in chill layers, excellent trimmed surface and the highest density were achieved, suggesting that as the optimal sleeve condition in aluminum high pressure diecasting, especially for highly complex parts like valve body.

• The Korean Journal of Pain
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• v.14 no.1
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• pp.83-92
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• 2001

Background: This study was undertaken to observe the functional changes of the hind limb and histopathological changes in the sciatic nerve after an injection of alcohol or phenol, which are commonly used neurolytic agents, highlighting the time of recovery. Methods: Forty-eight Sprague-Dawley rats weighing 200-300 g were used for the experiment. Histopathological changes under the electron microscope, were observed in the distal part of the sciatic nerve, into which 0.1 ml of alcohol or phenol was injected. This was severed in 3 rats of each group at 10 minutes, 1 hour, 24 hours, 3 days, 1, 2, 4 and 6 weeks later. The functional changes in the hind limbs were observed for 6 weeks by noting their walking pattern. Results: Following the injection of alcohol or phenol into the right sciatic nerve, the right hind limb showed a severe pronounced motor weakness and obvious gait changes. About 2 weeks later, gradual improvement of gait changes began, and after 6 weeks, the motor weakness and gait changes were no longer perceptible in both groups. The findings of any histopathological change were similar in both alcohol or phenol groups. At 10 minutes after injection, destructive lesions were confined to the unmyelinated fibers and the myelin sheath of small the myelinated fibers. On the 3rd day and at 1 week, pathologic changes in axonal fibers and Schwann cells were in being phagocytized in spite of myelin restitution. From 2 to 4 weeks, axonal regeneration and remyelination appeared at the same time a myelin disintegration and axonolysis. At 6 weeks, neural regeneration was similar to that of the contralateral control group. Conclusions: These results suggest that functional and histopathological changes, after injection of neurolytics into the peripheral nerves, are quite similar in both alcohol and phenol groups. The progression of functional and histopathological changes become more obvious according to the time interval following the injection. Consequently, side effects that develop following the use of alcohol or phenol may begin to improve around the time that nerve regeneration occurs, i.e., two to four weeks later.

• Journal of Biomedical Engineering Research
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• v.22 no.6
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• pp.503-510
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• 2001

In this paper. we describe a 32-channel bioimpedance measurement system It consists of 32 independent constant current sources of 50 kHz sinusoid. The amplitude of each current source can be adjusted using a 12-bit MDAC. After we applied a pattern of injection currents through 32 current injection electrodes. we measured induced boundary voltages using a variable-gain narrow-band instrumentation amplifier. a Phase-sensitive demodulator. and a 12-bit ADC. The system is interfaced to a PC for the control and data acquisition. We used the system to detect anomalies with different resistivity values in a saline Phantom with 290mm diameter The accuracy of the developed system was estimated as 2.42% and we found that anomalies larger than 8mm in diameter can be detected. We Plan to improve the accuracy by using a digital oscillator improved current sources by feedback control, Phase-sensitive A/D conversion. etc. to detect anomalies smaller than 1mm in diameter.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.47 no.5
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• pp.1-8
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• 2010

Clients require easy to use of product and operating and industry safety according to the change of a market and a factory. For overcoming it, this paper developed controller of take-out robots that take high speed and superprecision and supplement a week point as use the system based on network. development controller classify teaching pendant and center server PC. Center server PC service the information about all process to supervisor. Teaching pendant is the bridge that service various faculties such as control, user recognition, metallic pattern operation to the user using injection molding. The controller development for taking out injection molded body classify software and hardware. The development of software is divided into three step which is application program, user interface and device driver. the simple device driver is not classified and included in application program. The hardware induce the touch panel and wireless network and construct the effective process control and internet connection. The inject ion cycle of existing system was five second but advanced system has the inner four cycle, process efficiency and product operation through wireless network.