• Journal of Korean Medicine Rehabilitation
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• v.18 no.1
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• pp.75-94
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• 2008

Objectives : This study was to investigate the effects of GCP treatment on the monosodium iodoacetate-induced osteoarthritis in rats. Methods : Arthritis was induced by injection of Monosodium lodoacetate(0.5mg) into knee joints of rats. Arthritic rats were divided into control(n=8) and treated(n=8) group. Control group was taken distilled water for 20 days. Treated group was taken extracts of GCP by oraly for same duration. Normal group(n=8) was injected with normal saline and was taken distilled water for 20 days. Body weight was measured at 0, 5, 10, 15, 20 days after injection. Macroscopic examination and histopathological study on articular cartilage of knee joint were operated at 20 days after injection. Proteoglycan(PG) content of articular cartilages of knee joint was represented by safranine O staining, was measured at 20 days injection. Tumor necrosis $factor-{\alpha}$, $Interleukin-1{\beta}$, Interleukin-6 in synovial fluid were measured with ELISA kit at 20 days after injection. Immunohistochemical staining of COX-2, iNOS in knee joints were observed at 20 days after injection. Results : 1. Body weight of the treated group increased compare with control group at 20 days after injection. 2. Macroscopically, degree of osteoarthritis in the treated group were evaluated compared with the control group. 3. PG content in articular cartilage of the treated group was significantly increased compared with the control group. 4. Histopathologically, osteoarthritic scores of the treated group was significantly decreased compared with the control group. 5. $TNF-{\alpha}$ content in synovial fluid of the treated group was decreased compared with the control group. 6. $IL-1{\beta}$ content in synovial fluid of the treated group was significantly decreased compared with the control group. 7. Positive reaction of COX-2 in chondrocytes and synovial membrane of the treated group was faint compared with the control group. Conclusions : On the basis of these results, we concluded that GCP has inhibiting effects on the $IL-1{\beta}$ and COX-2 secretion of chondrocytes and synovial membrane in Monosodium lodoacetate-Induced osteoarthritis model of rats.

• Journal of Institute of Control, Robotics and Systems
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• v.4 no.2
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• pp.163-169
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• 1998

In this paper, we design an optimal model following ${\mu}-$synthesis control system for fuel-injection of diesel engine which has robust performance and satisfactory command tracking performance in spite of uncertainties of the system. To do this, we give gain and dynamics parameters to the weighting functions and apply genetic algorithm with reference model to the optimal determination of the weighting functions that are given by the D-K iteration method which can design ${\mu}-$synthesis controller in the state space. These weighting functions are optimized simultaneously in the search domain which guarantees the robust performance of the system. The ${\mu}-$synthesis control system for fuel-injection designed by the above method has not only the robust performance but also a better command tracking performance than those of the ${\mu}-$synthesis control system designed by trial-and-error method. The effectiveness of this ${\mu}-$synthesis control system for fuel-injection is verified by computer simulation.

• Journal of the Korean Geosynthetics Society
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• v.19 no.4
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• pp.11-20
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• 2020

This study introduced the compact grouting method that can be used for improving soft ground and restoring buildings with unequal subsidence. The pump used in the traditional compact grouting method is a system that injects one hole each, which reduces the construction efficiency, and the analog injection method manually manages the construction by field workers, making it difficult to manage consistent quality. Pump and quality control system were developed to solve problems in existing construction. Since field supervisor determines amount of injected materials by using analog equipment and controls manually, it is difficult to manage consistent quality of construction. Therefore, the quality control system was developed in order to solve that problem. The quality control system consists of automatic mixing system of injection materials, multiple simultaneous injection pumps, and injection management monitoring system. Performance of the quality control system was verified through on-site testing, and ground improvement performance was verified through quality testing after testing and testing of the compact grouting method. Therefore, it is expected that the integrated quality control system developed will improve the quality assurance and efficiency and stability of construction at sites where construction and quality verification are difficult.

• The Korea Journal of Herbology
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• v.24 no.3
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• pp.79-86
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• 2009

Objectives : The present study investigated Inflammatory effect of Coptidis Rhizoma in lipopolysaccharideexposed rats and Raw 264.7 cells. Methods： The plasma concentration of IL-1$\beta$, IL-6 and TNF-$\alpha$ peaked at 5 h after LPS injection, and the values of the Coptidis Rhizoma extract groups were lower than those of the control group. In the increment of cytokines concentration at 2 h and 5 h after LPS injection, the Coptidis Rhizoma groups were lower than that of control group. The plasma concentration of IL-10 peaked at 5 h after LPS injection, and the values of the Coptidis Rhizoma extract groups were higher than those of the control group. In the increment of cytokines concentration at 2 h and 5 h after LPS injection, the Coptidis Rhizoma groups were higher than that of control group. Liver cytokines measurement was done at 5 h after LPS injection. The concentration of liver IL-1$\beta$ and IL-6 in the Coptidis Rhizoma groups was lower than that of the control group. The concentrations of liver TNF-$\alpha$, and IL-10 showed no significant differences among all the treatment groups. Results： In the studies of lipopolysaccharide-exposed Raw 264.7 cells, the concentration of IL-1$\beta$, IL-6 and TNF-$\alpha$ in the lipopolysaccharide-exposed cells groups was higher than that of control group (normal group), and in the lipopolysaccharide-exposed cells groups, these values showed a tendency to decrease in the Coptidis Rhizoma groups. The concentration of IL-10 in the lipopolysaccharide-exposed cells groups was higher than that of control group (normal group), and in the lipopolysaccharide-exposed cells groups, the values showed a tendency to increase in the Coptidis Rhizoma groups. Conclusions： These results indicate that the Coptidis Rhizoma extracts have an functional material for Inflammatory activities.

• Journal of IKEEE
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• v.26 no.1
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• pp.43-49
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• 2022

This paper compares the sensorless control performance according to the applied voltage waveform by injecting sinusoidal, triangular, and square waveform in the harmonic injection sensorless control method. By injecting various voltage shape waveform with a frequency of 1kHz, the error amount of the estimated angle for each waveform is compared and analyzed. For the experiment, the HILS(hardware in the loop simulation) system was used. The hardware is the control board, and the inverter and motor models implemented in Simulik are located in the real-time simulator. The control algorithm is implemented by the FPGA control board, which includes a PWM interrupt service routine with a frequency of 10 kHz, harmonic injection and position detection sensorless algorithm.

• Transactions of the Korean Society of Automotive Engineers
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• v.11 no.6
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• pp.37-43
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• 2003

The objective of this work is to investigate the effect of swirl, injection pressure and pilot injection on D.I. diesel combustion by using a transparent engine system. The test engine is equipped with common rail injection system to obtain high pressure and to control injection timing and duration. In this study, the combustion analysis and steady flow test were conducted to estimate the heat release rate from in-cylinder pressure. Soot distribution in diffusion flame according to swirl ratio, injection pressure and pilot injection was investigated by using LII technique. As the results, high injection pressure was found to shorten ignition delay as well as enhance peak pressure and heat release rate was greatly affected by injection timing and pilot injection. In addition, the results showed that the period of soot formation corresponded to the diffusion flame.

• Biotechnology and Bioprocess Engineering:BBE
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• v.9 no.3
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• pp.156-165
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• 2004

Concentrations of substrates, glucose, and ammionia in biological processes have been on-line monitored by using glucose-flow injection (FIA) and ammonia-FIA systems. Based on the on-line monitored data the concentrations of substrates have been controlled by an on-off controller, a PID controller, and a neural network (NN) based controller. A simulation program has been developed to test the control quality of each controller and to estimate the control parameters. The on-off controller often produced high oscillations at the set point due to its low robustness. The control quality of a PID controller could have been improved by a high analysis frequency and by a short residence time of sample in a FIA system. A NN-based controller with 3 layers has been developed, and a 3(input)-2(hidden)-1(output) network structure has been found to be optimal for the NN-based controller. The performance of the three controllers has been tested in a simulated process as well as in a cultivation process of Saccharomyces cerevisiae, and the performance has also been compared to simulation results. The NN-based controller with the 3-2-1 network structure was robust and stable against some disturbances, such as a sudden injection of distilled water into a biological process.

• Proceedings of the KIEE Conference
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• 1989.11a
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• pp.291-295
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• 1989

The conventional Optimized Injection Method is a good control technique but can't be applied to 3-phase a.e. line. In this paper, a new technique, Time-sharing Method based on basic principle of conventional Optimized Injection Method is introduced to hold the independence of each phase, and the structure of power circuit is improved to realize the new control method. By this scheme it is possible to simplify the control circuit and power circuit. The characteristic of the new control method are investigated and compared with conventional Optimized Injection Method by computer simulation.

• Journal of the Korean Society of Safety
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• v.10 no.4
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• pp.22-35
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• 1995

In this paper, an electronic control unit is developed using 16bit microcomputer for automobile engine. This system incorporate AFS(Air Flow Sensor) of Hot Wire type, DIS(Direct Ignition System), ISC(Idle Speed Control) system, CAS(Cranke Angle Sensor) and other peripheral device. This system includes hardware and software to facilitate precision control of both fuel injection and ignition timing. Especially, this controller consists of position signal(180 teeth) and 4 REF signals. Present system has maximum $720^{\circ}CA$ delay. But this system has maximum $180^{\circ}CA$. Thus, this system is able to precision control both fuel injection and ignition timing.

• 한국전산유체공학회:학술대회논문집
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• 2002.10a
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• pp.17-22
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• 2002

A numerical solution procedure has been developed to analyze the flow field resulted from the injection of a transverse jet through the divergent flap of a 2DCD nozzle for thrust vector control. The formulation employs the compressible Navier-Stokes equations in conservation law form and a two equation $\kappa-\omega$ turbulence model. Detailed numerical results are presented in this paper for the 2DCD nozzle over a range of secondary to primary injection mass flow ratios and nozzle pressure ratios.