• IMMUNE NETWORK
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• v.13 no.2
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• pp.70-74
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• 2013

L-ascorbic acid (vitamin C) is one of the well-known antiviral agents, especially to influenza virus. Since the in vivo antiviral effect is still controversial, we investigated whether vitamin C could regulate influenza virus infection in vivo by using Gulo (-/-) mice, which cannot synthesize vitamin C like humans. First, we found that vitamin C-insufficient Gulo (-/-) mice expired within 1 week after intranasal inoculation of influenza virus (H3N2/Hongkong). Viral titers in the lung of vitamin C-insufficient Gulo (-/-) mice were definitely increased but production of anti-viral cytokine, interferon (IFN)-${\alpha}/{\beta}$, was decreased. On the contrary, the infiltration of inflammatory cells into the lung and production of pro-inflammatory cytokines, tumor necrosis factor (TNF)-${\alpha}$ and interleukin (IL)-${\alpha}/{\beta}$, were increased in the lung. Taken together, vitamin C shows in vivo antiviral immune responses at the early time of infection, especially against influenza virus, through increased production of IFN-${\alpha}/{\beta}$.

• Journal of Periodontal and Implant Science
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• v.37 no.4
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• pp.839-848
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• 2007

Purpose: Various kinds of biodegradable membranes are currently used in dental clinics. And the frequency and the necessity of their usage are increasing due to their numerous advantages. Therefore it is important to understand the difference of various membranes and histological reaction against implanted membranes. Materials and Methods: Biodegradable membranes of $Biogide^{(R)}$, $Resolute^{(R)}$, and $Tutodent^{(R)}$ were cut into small pieces by $1.0{\times}0.5cm$. The membranes were implanted 1.5cm apart from each other under the epithelium on the skull of 18 Sprague Dawley rats. The animals were sacrificed at 3, 7, and 14 days after surgical procedure. The specimens were examined by histological analysis. Results: 1. Early period after implantation of the membranes showed connective tissues surrounding membranes and there were a few inflammatory cells present. 2. In $Biogide^{(R)}$ and $Tutodent^{(R)}$ specimens, inflammatory cells and surrounding tissues were shown to infiltrate from outside with slight density difference inside. In $Resolute^{(R)}$ specimens, membranes were fragmented. Inflammatory cells and connective tissues were also observed inside. 3. In $Resolute^{(R)}$ specimen, giant cells were present which implicates that foreign body reaction has occurred. 4. $Biogide^{(R)}$ had lower integrity than other membranes and is not enough to be used alone in defect area. However, $Resolute^{(R)}$ had superior firmness than others. $Tutodent^{(R)}$ had middle level of integrity. Conclusion: This experimental model enabled to observe early inflammatory reactions and morphological changes of materials and can be used to develop and evaluate the efficacy of biodegradable membranes. Duplication of standardized human oral environment will be required in future experiments.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.38 no.3
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• pp.211-222
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• 2020

The purpose of this study is to derive a plan to improve the standard of survey cost, which is a system for estimating survey cost operated by the National Geographic Information Institute. The current standard has not been revised significantly since the initial enactment. However, in the situation where the survey industry is getting worse, the actualization of the standard is an urgent task for training engineers and industrial development. In this study, in order to break the problems of the standard and to derive improvement plan, we analyzed the outline, basic characteristics, and history of the standard and compared it with similar domestic ones. We collected opinions from the government and the industry through a survey, and verified labor cost and overhead rates. The conclusions are as follows. First, it is necessary to complement standard for production rate that directly affects direct cost, and to compensate for the missing items in the direct cost. Second, when compared with cost standards in foreign countries and cadastre field, the labor cost in survey field was found to be very low and improvement is needed. Third, the overhead rates were assessed to be appropriate, and the problem of improper overhead design should be coped with by strengthening education and promotion. Fourth, it is necessary to consider the introduction of deliberation committee or standard market price system for rapid response to new technologies.

• Journal of the Korean Geotechnical Society
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• v.32 no.9
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• pp.51-62
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• 2016

Parametric studies for various site conditions by using 3d numerical model were carried out in order to estimate dynamic behavior of soil-pile-structure system in dry soil deposits. Proposed model was analyzed in time domain using FLAC3D which is commercial finite difference code to properly simulate nonlinear response of soil under strong earthquake. Mohr-Coulomb criterion was adopted as soil constitutive model. Soil nonlinearity was considered by adopting the hysteretic damping model, and an interface model which can simulate separation and slip between soil and pile was adopted. Simplified continuum modeling was used as boundary condition to reduce analysis time. Also, initial shear modulus and yield depth were appropriately determined for accurate simulation of system's nonlinear behavior. Parametric study was performed by varying weight of superstructure, pile length, pile head fixity, soil relative density with proposed numerical model. From the results of parametric study, it is identified that inertial force induced by superstructure is dominant on dynamic behavior of soil-pile-structure system and effect of kinematic force induced by soil movement was relatively small. Difference in dynamic behavior according to the pile length and pile head fixity was also numerically investigated.

• Journal of the Korea Convergence Society
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• v.11 no.3
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• pp.53-59
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• 2020

Initial response is important in marine oil spills, such as the Hebei Spirit oil spill, but it is very difficult to predict the movement of oil out of the ocean, where there are many variables. In order to solve this problem, the forecasting of oil spill has been carried out by expanding the particle prediction, which is an existing study that studies the movement of floats on the sea using the data of the float. In the ocean data format HDF5, the current and wind velocity data at a specific location were extracted using bilinear interpolation, and then the movement of numerous points was predicted by particles and the results were visualized using polygons and heat maps. In addition, we propose a spill oil particle matching algorithm to compensate for the lack of data and the difference between the spilled oil and movement. The spilled oil particle matching algorithm is an algorithm that tracks the movement of particles by granulating the appearance of surface oil spilled oil. The problem was segmented using principal component analysis and matched using genetic algorithm to the point where the variance of travel distance of effluent oil is minimized. As a result of verifying the effluent oil visualization data, it was confirmed that the particle matching algorithm using principal component analysis and genetic algorithm showed the best performance, and the mean data error was 3.2%.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.11
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• pp.7754-7760
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• 2015

The outer tie rod is one of the part of steering system, the optimization process was executed to find the lightweight design. The inner tie rod was considered in the optimum design of an outer tie rod. it could be closer to the test condition than in the case of considering outer tie rod only. The aluminum forging material was considered as a weight reduction proposal. The target of optimization was the shape of the minimum weight to resist at the load of buckling. RSM and Kriging interpolation method were applied as a optimization method to consider the nonlinear shape optimization problem. Then, 16.3%, 16.6% of weight reduction was obtained from the result comparing with that of the initial model. The results of meta model optimization was compared with that of finite element method. The error values of buckling load estimation were 2.6%, 2.04%. and those of weight estimation were 0.17%, 0.13%. Therefore, it seemed that the result of Kriging model could be obtained closer to optimum value than that of RSM model.

• Applied Microscopy
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• v.29 no.2
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• pp.189-193
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• 1999

The response of ameloblast to long term (3 weeks) exposure to fluoride was examined in continuously erupting mandibular incisors of pregnancy rats as compared to control rats receiving a similar diet (Teklad L-356) but no sodium fluoride in there drinking water. Rats were started on water containing 0 ppm, 100 ppm, 200 ppm, and 300 ppm NaF at the beginning of pregnancy. To examine on the ultrastructural changes of the ameloblast, electron microscopy was used. The results indicated that rat incisors expressed two major changes in normal amelogenesis that could be attributed to chronic fluoride treatment. The fluoride produces marked alteration in the fine structure of ameloblast from teeth of young rats, such as large confluent distensions of the endoplasmic reticulum and swelling of isolated mitochondria, in particular on the morphology of the rough-surfaced endoplasmic reticulum. A graded series of alterations to these organelles were produced, and the severity of the changes would seem to be dependent on dose and time. This experimental data suggested that exposure prolonged of animal to high level of fluoride appears to induce morphological changes in the normal appositional growth and initial mineralization of enamel created during amelogenesis.

• Reproductive and Developmental Biology
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• v.33 no.3
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• pp.163-169
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• 2009

Many biological systems are regulated by an intricate set of feedback loops that oscillate with a circadian rhythm of roughly 24 h. This circadian clock mediates an increase in body temperature, heart rate, blood pressure, and cortisol secretion early in the day. Recent studies have shown changes in the amplitude of the circadian clock in the hearts and livers of streptozotocin (STZ)-treated rats. It is therefore important to examine the relationships between circadian clock genes and growth factors and their effects on diabetic phenomena in animal models as well as in human patients. In this study, we sought to determine whether diurnal variation in organ development and the regulation of metabolism, including growth and development during the juvenile period in rats, exists as a mechanism for anticipating and responding to the environment. Also, we examined the relationship between changes in growth factor expression in the liver and clock-controlled protein synthesis and turnover, which are important in cellular growth. Specifically, we assessed the expression patterns of several clock genes, including Per1, Per2, Clock, Bmal1, Cry1 and Cry2 and growth factors such as insulin-like growth factor (IGF)-1 and -2 and transforming growth factor (TGF)-${\beta}1$ in rats with STZ-induced diabetes. Growth factor and clock gene expression in the liver at 1 week post-induction was clearly increased compared to the level in control rats. In contrast, the expression patterns of the genes were similar to those observed after 5 weeks in the STZ-treated rats. The increase in gene expression is likely a compensatory change in response to the obstruction of insulin function during the initial phase of induction. However, as the period of induction was extended, the expression of the compensatory genes decreased to the control level. This is likely the result of decreased insulin secretion due to the destruction of beta cells in the pancreas by STZ.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.9
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• pp.6130-6141
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• 2015

This study was performed to elucidate the association of blood pressure and incidence of hypertension in response to changes in body mass index. A total of 28,249 industrial workers (male: 25,548, female: 2,701) who aged 30~69 years old, received regular medical check-up at least once per year from 2002 to 2012 (over 11 years) were included. In the analysis, the averages of blood pressure were stratified by BMI which was obtained from the initial examination results of each individual. In addition, averages of changes in blood pressure were analyzed by stratifying with changes in BMI over 10 years(from 2002); annual occurrence rates of high blood pressure, stratified per BMI, were further assessed in which patients were in normal ranges of blood pressure. As a result, the averages blood pressure over 10 years were more significantly elevating in the group of obesity compared to those of the low weight group as well as the normal weight group. Similarly, when it comes to the occurrence rates of high blood pressure, the group of higher BMI represented elevated risks compared to the groups of low BMI. In conclusion, the increase of BMI over 10 years(2002-20012) were significantly influenced on the increase of blood pressure.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.6 no.2
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• pp.187-201
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• 1996

This study was to evaluate the efficiency of diffusive monitor using activated carbon fiber(ACF, KF-1500) in measuring airborne organic solvents. The following characteristics were identified and studied as critical to the performance of diffusive monitor; recovery, sampling rate, face velocity, reverse diffusion and storage stability. For the evaluation of the performance of this monitor, MIBK, PCE, toluene were used as organic solvents. In the sampling rate experiments, eight kinds of solvents (n-hexane, MEK, DIBK, MCF, TCE, CB, xylene, cumene) as well as the above solvents were used. The results were as follows: 1. The desorption efficiencies(DE's) of ACF diffusive monitor ranged from 83 % to 101 %. In contrast, those of coconut shell charcoal ranged from 78 % to 102 %. Especially, the DE's of ACF for the polar solvents such as MEK were superior to those of charcoal. 2. Experimental sampling rates on ACF were average 42ml/min(37-46ml/min) for 11 organic solvents at $24{\pm}2^{\circ}C$, $50{\pm}5%RH$. However ideal sampling rates(DA/L) were 33 % higher than experimental sampling rates. 3. The initial response(15~16 min) of the testing monitor was 2 times higher than the actual concentration determined by the reference methods at $24{\pm}2^{\circ}C$, $8{\pm}5%RH$ and $80{\pm}5%RH$. Within 1 hours, the curve reached a linear horizontal line at low humidity condition. But sampling efficiencies decreased with respect to time at high humidity condition. And sampling efficiencies were higher at high humidity condition than low humidity condition for MIBK. 4. At very low velocity (less than 0.02 m/sec), the concentration of ACF diffusive monitor were poorly estimated. But ACF diffusive monitor were not affected at higher velocity(0.2 m/sec-0.6 m/sec). 5. There was no significant reverse diffusion when the ACF monitors were exposed to clean air for 2 hours after being exposed for 2 hours at the level of 1 TLV. 6. There was no significant sample loss during 3 weeks of storage at room temperature and 5 weeks of storage at refrigeration.