• Journal of Life Science
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• 제9권2호
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• pp.5-8
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• 1999

We isolated a sphingonyelinase (SMase) inhibitor, which would be a potential reagent to regulate cell proliferation, oncogenesis, and inflammation, from a strain of Streptomyces sp.. In this paper, we report the optimal conditions for the production of SMase inhibitor, designed as sphinin, from Streptomyces sp. F50970. The optimal carbon and nitrogen source were 1% soluble starch and 0.05%-0.15% trypton. Most of monosaccharides and high concentration of soluble starch above 1.0% caused falling of pH and sphinin production. Zn2+, Cu2+, Fe2+, Mn2+, and Co2+inhibited cell growth and the production of sphinin. Inorganic phosphate promoted the sphinin production. Optimal initial pH for the production of sphinin was 7.5-8.0. Addition of CaCO3 to the medium resulted in an increase of inhibitor production. Based on these results, we designed a fermentation medium for the production of a SMase inhibitor, sphinin, from Streptomyces sp. F50970.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2000년도 봄 학술발표회 논문집
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• pp.710-713
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• 2000

The corrosion protection methods of reinforcing steel in concrete are the various methods such as increasing thickness of cover concrete, using of reinforcing bars coated with epoxy, dosage of corrosion inhibitor as concrete admixture, cathodic protection method and etc. The most economical method of them will be the corrosion protection method using corrosion inhibitor as concrete admixture. Therefore, the purpose of this research is to investigate the performance of corrosion protection of ordinary strength and high strength concrete using corrosion inhibitor, respectively. For this purpose, after manufacturing ordinary strength and high strength concrete with and without corrosion inhibitor, the accelerated corrosion tests for reinforcing steel were conducted according to the periodic cycles (140 day) of wetting ($65^{\circ}C$, 90% R.H.) and drying period ($15^{\circ}C$, 65% R.H.). As a result, th high strength concrete using corrosion inhibitor showed an excellent performance of corrosion protection.

• 한국균학회지
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• 제44권4호
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• pp.314-317
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• 2016

To develop a new anti-dementia acetylcholinesterase (AChE) inhibitor from edible mushrooms, AChE inhibitory activities were determined on water and ethanol extracts of various edible mushrooms from oriental medicine markets and agriculture markets. As a result, the 70% ethanol extract from Pholiota adiposa fruiting body had the highest AChE inhibitory activity of 30.6, and its water extract also had an AChE inhibitory activity of 23.8%. Therefore, we finally selected P. adiposa as a potent anti-dementia AChE inhibitor-containing mushroom. The AChE inhibitor of P. adiposa was maximally extracted when its fruiting body was treated with water for 3hr at $70^{\circ}C$ and 70% ethanol for 12 hr at $70^{\circ}C$, respectively.

• 미생물학회지
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• 제28권3호
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• pp.264-267
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• 1990

The objectives of the current studies were to establish the optimal conditions for the production of extracellular protease inhibitor in a strain of Streptomyces fradiae. As results, it was found that cell specific growth rate was very critical for the production of protease inhibitor and the optimum specific growth rate was found to be 0.05 h$^{-1}$ . Dissolved oxygen tension and pH were also important to regulate the inhibitor production. The inhibitory mode of the purified inhibitor to .alpha.-chymotrypsin was found to be competitive (K$_{i}$=5.5*10$^{-7}$ M). One mole of inhibitor could bind two moles of .alpha.-chymotrypsin and the complex has very low dissociation constant.t.

• International journal of thyroidology
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• 제11권2호
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• pp.75-77
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• 2018

Tyrosine kinase inhibitor is known to prolong progression free survival in radioiodine refractory thyroid cancer patients. Fatigue/asthenia/malaise is one of most common adverse events by the tyrosine kinase inhibitor treatment, and management of the adverse event is important to keep the drug medication longer which is essential for the survival benefit. In the case report, a radioiodine refractory thyroid cancer patient receiving tyrosine kinase inhibitor experienced severe fatigue, and a pathologic fracture of right humerus occurred by slipping down which was tightly linked with the adverse event of the drug. The pathologic fracture was surgically well managed and the adverse event was well controlled by supportive managements combined with dose reduction of the tyrosine kinase inhibitor. The drug administration to the patient was kept more than 1 year without progression of the disease.

• 한국미생물·생명공학회지
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• 제16권5호
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• pp.398-401
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• 1988

$\beta$-lactamase을 저해하는 물질을 생성하는 방선균의 일균주를 토양에서 분리하였다. 분리된 균으로부터 $\beta$-lactamase 저해물질을 생산하는 조건을 검토하였고, 아울러 배양액에서부터 동 물질을 분리정제하여 그 특성의 일부를 조사하였다. 그 결과 이 물질은 $\beta$-lactam ring을 가지고 있지 않았으며, $\beta$-lactam 항생물질에 대한 내성을 나타내는 E. coli 내성균주에 강한 항생력을 나타냄을 알았다.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2021년도 가을 학술논문 발표대회
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• pp.32-33
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• 2021

The corrosion of the embedded steel rebars and the consequent deterioration of the reinforced concrete structure has become a challenging concern to the construction industries for the fiscal deficit. However, corrosion inhibitors are potential and being widely used for corrosion mitigation to solve such problems. This study has been focused on the mixed type of corrosion inhibitor where one component of the corrosion inhibitor is organic and another one is inorganic material. 0.1 (M) triethanolamine (TEA) and 0.01 (M) sodium hexametaphosphate (SHMP) have been mixed in distilled water to produce the mixed inhibitor. Studies of the steel rebar corrosion in chloride contaminated (3.5 wt.% NaCl) concrete pore (CCCP) solution has been conducted using different concentrations of corrosion inhibitor. Electrochemical impedance spectroscopy (EIS) method is involved to understand the corrosion behaviour of the steel rebars at different exposure durations.

• Bulletin of the Korean Chemical Society
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• 제33권9호
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• pp.3142-3144
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• 2012

• Bulletin of the Korean Chemical Society
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• 제34권12호
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• pp.3912-3914
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• 2013

• Bulletin of the Korean Chemical Society
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• 제33권12호
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• pp.4277-4279
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• 2012