• 동의생리병리학회지
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• 제36권6호
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• pp.229-234
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• 2022

Lung cancer is the leading cause of cancer-related deaths worldwide. Indigo Naturalis (IN) is a dark blue powder obtained by processing leaves or stems of indigo plants, its anticancer effects have been reported in several studies. However, the pharmacological mechanism of IN in small cell lung cancer (SCLC) is not elucidated. In this study, to investigate the anticancer efficacy of IN for SCLC, we presented potential active ingredients, SCLC-related targets, and pharmacological mechanisms of IN that are expected to have anticancer activity for SCLC using a network pharmacological analysis. The phytochemical compounds of IN have been collected through TCMSP, SymMap, or HPLC documents. The active ingredients of IN such as indirubin, indican, isatin, and tryptanthrin were selected through ADME parameters or literature investigations for each compound. Using the Compounds, Disease-Target associations Databases, 124 common targets of IN and SCLC were obtained. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) Pathway enrichment analysis was carried out. GO biological processes are associated with response to xenobiotic stimulus, positive regulation of protein phosphorylation, regulation of mitotic cell cycle, and regulation of apoptotic signaling pathway. KEGG disease pathways included Gastric cancer, Bladder cancer, SCLC, and Melanoma. The main anticancer targets of the IN for SCLC were analyzed in 14 targets, including BCL2, MYC, and TP53. In conclusion, the results of this study based on the network pharmacology of IN can provide important data for the effective prevention and treatment of SCLC.

• 농약과학회지
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• 제19권3호
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• pp.241-247
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• 2015

본 연구는 농약 제조수입회사에서 등록한 제조처방에 따라 농약을 유통판매하고 있는지의 동일성을 확인함에 있어서 FT-NIR의 적용 가능성을 알아보고자 하였다. 농약 등록용으로 제출된 시료와 유통 중인 농약 83점의 스펙트럼 간 상관관계를 조사하였다. 그리고 유효성분과 제형이 동일한 유통농약 23점의 스펙트럼 간 상관관계를 조사하였다. 또한, 유효성분이 다른 유통농약 68점의 스펙트럼 간 상관관계도 조사하였다. 등록용으로 제출된 시료와 유통 중인 농약 83점의 1차 미분 스펙트럼 간 상관관계 값은 95.86~100%로 나타났다. 상관관계 값 한계치를 Standard Deviation of Population에서 주로 적용하는 95%에는 모두 적합으로 판정될 수 있을 것이다. 한편, 농약의 유효성분과 제형은 동일한 유통농약 23점의 1차 미분 스펙트럼 간 상관관계 값은 29.09~99.83%로 나타났다. 99.0%이상 높이 나온 3점은 제조사는 다르지만 유효성분과 제형 및 사용된 부자재까지 같은 농약임을 확인할 수 있었다. 3점을 제외한 나머지는 95% 미만으로 나타났다. 농약의 유효성분이 다른 68점의 스펙트럼 간 상관관계 값이 2.00~93.70%까지 다양하게 나왔다. 상관관계 값이 93.70%처럼 높게 나타난 것은 농약의 유효성분은 다르지만 사용된 부자재의 유사성에 기인한 것으로 추정된다. 동일성 판별 상관관계 값의 한계치 95%를 적용하면 모두 부적합으로 판정될 수 있을 것이다. 따라서 본 결과를 토대로 등록 농약과 유통 중인 농약의 동일성을 정성적으로 판별하는데 있어서 FT-NIR의 활용 가능성이 확인되었다.

• 식품과학과 산업
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• 제55권1호
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• pp.2-22
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• 2022

Near-infrared spectroscopy (NIRS) is one of the representative non-destructive and eco-friendly analysis methods used for rapid analysis of various ingredients in the food industry. To develop analysis model with NIRS, Chemometrics are applied after pre-treatment of spectrum. Many studies have been reviewed on the analysis of general and functional components for agricultural and livestock products. In the case of livestock products, some studies have been conducted for on-line analysis. This study investigated results on various samples and component applying near-infrared spectroscopy. Furthermore, the results according to sample condition were compared. It was confirmed that NIRS is applied to various fields in the food industry.

• 한국식품영양학회지
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• 제14권5호
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• pp.467-478
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• 2001

This study was focused on the sanitary analysis of hazard factors and the establishment of critical control points on hamburger by the microbiological investigation. The degree of microorganic pollution on the ingredients and equipments for hamburger manufacturing and the variation of microorganisms at storage time and temperatures were investigated. The magnitudes of total aerobic bacteria In hamburger were highly detected to be in the order of resting placed in expressway > convenience stores > fast food stores, and coliforms were lowly detected as convenience stores > fast food stores > resting places in expressway. In investigation of basic ingredients, the degree of microorganic pollution showed highly on patty. cabbage and cucumber. In investigated result of mocroorganic distribution at the various phases in hamburger manufacturing, total aerobic bacteria counts were detected over 5.5$\times$10$^2$ CFU/g, and coliforms counts were detected over 2.0$\times$10$^2$ CFU/g. In investigated result of microorganic distribution on the instruments and equipments for hamburger manugacturing, total aerobic bacteria counts were detected over 10$\^$5/ CFU/100cm2 and coliforms counts were detected over 10$^2$CFU/100㎠. Staphylococcus aureus was detected at wagon and refrigerator. Salmonella spp. was detected at grinder and Vibrio parahaemolyticus was not detected. At various storage temperatures, total aerobic bacteria counts insreased 3.0$\times$10$^3$ CFU/g to 7.0$\times$10$^4$ CFU/g, 4.2$\times$10$\^$7/ CFU/g and 8.1$\times$10$\^$8/ CFU/g at 10$\^{C}$, 20$\^{C}$, 30$\^{C}$ after 48 hours respectively. coliform counts also increased 4.5$\times$10$^2$ CFU/g to 2.2$\times$10$^3$ CFU/g, 5.4$\times$10$\^$5/ CFU/g, 4.5$\times$10$\^$6/ CFU/g at 10$\^{C}$, 20$\^{C}$, 30$\^{C}$ after 48 hours respectively. The establishment of critical control point CCP was divided into CCP1 and CCP2 by the removing level of hazard factor, and then CCP1 was established on basic ingredients, and CCP2 was established on the phases of mixing, pouring, packaging, transporting and preserving.

• 한국조리학회지
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• 제22권5호
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• pp.200-213
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• 2016

본 연구는 전통한식당과 서양식 레스토랑의 음식품질의 차이점을 비교한 다음 서양식음식에 비하여 선호도가 점점 떨어지는 우리 전통음식이 가지는 부족한 부분을 파악하여 국내 외식시장에서 우리 전통음식을 활성화를 하고자 하는데 기초자료를 제공할 뿐만 아니라, 농 어촌에서 생산되는 식재료 판매량을 증가시켜 농 어촌경재를 활성화 하고자 하였다. 본 연구를 위해서 서양식 레스토랑 음식품질 및 전통한식당 음식품질 요인분석을 실시하였고, 이에 대한 각각의 중요도와 만족도를 파악하기 위하여 IPA 분석을 실시하였다. 서양식 레스토랑과 전통한식당의 IPA 분석결과, 지역특산물 식자재 사용 정도, 건강식 음식, 세트음식의 가짓수 등은 공통적으로 1사분면에 포함되어지기 때문에 향후 한정식당을 운영하는 메뉴 기획자는 지역에서 명성이 나 있는 조리장이 지역특산물을 이용한 전통음식과 조미료를 사용하지 않는 맛이 우수한 건강식 음식이 개발되어야할 것이며, 또한, 인구통계적 특성을 고려하여 40대의 300~400만원 수입의 동료 또는 친구들과 함께 할 수 있는 기존에 제공되는 음식보다 푸짐하게 제공되어야 할 것이다.

• 한국식품영양학회지
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• 제28권1호
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• pp.9-15
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• 2015

This study was conducted to improve the quality of Wanja-jeon, a Korean traditional food utilizing beef. Antioxidative evaluation of the ingredients in Wanja-jeon showed that soybean powder was highest in DPPH, ABTS radical scavenging activities and in reducing power among the food ingredients tested. Since soybean powder demonstrated high antioxidative activity, beef was replaced with soybean powder in Wanja-jeon to increase the antioxidative activity. All antioxidative activities such as DPPH and ABTS radical scavenging activities as well as reducing power increased with increases in the amount of soybean powder replacing beef. In texture analysis, the hardness, chewiness and brittleness of Wanja-jeon were highest when beef was replaced with 20% soybean powder, whereas the springiness and cohesiveness of the Wanja-jeon were highest with 50% of the beef replaced with soybean powder. The Hunter's color L and b values were highest in Wanja-jeon with 50% soybean powder replacing beef, while the a value of the color was highest in Wanja-jeon with 30% soybean replacing beef.

• 대한화장품학회지
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• 제33권1호
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• pp.11-15
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• 2007

적정법은 화장품 원료 뿐 아니라 많은 화학물질의 분석 및 품질관리에서 많이 사용되는 방법으로 기기분석법이 발달하기 이전에는 대부분의 정량시험이 적정법에 의존하였다. 본 논문에서는 산화-환원 적정법을 이용한 화장품 분석의 이론 및 응용방법을 기술하였다. 대표적인 화장품 분석법으로 요오드가 및 브롬가 측정법을 이용한 원료의 불포화도 분석, 과망간산칼륨 또는 세륨염을 이용한 과산화수소 또는 기타 과산화물의 정량법, 자외선차단제 주성분으로 사용되는 티타늄다이옥사이드의 정량법이 있다.

• 대한본초학회지
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• 제27권4호
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• pp.17-23
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• 2012

Objectives : Schisandrae Fructus (SF) has traditionally been used to balance level of body fluid and to strengthen kidney function. It has been reported that the SF extract has antioxidant, hepatoprotective, neuroprotective and anticancer effects. This study investigated an antiproliferative effect of SF extract on PC-3 human prostate cancer cells and analyzed active ingredients of SF extract qualitatively and quantitatively. Methods : We examined the antiproliferative effect of SF extract with MTT assay, DAPI staining and annexin-V/7-AAD double staining. The active ingredients of SF extract were identified by using HPTLC and HPLC/DAD system. Results : SF-chloroform fraction inhibited growth of PC-3 cells and changed the morphology of nucleus in a dose dependent manner. A dose-dependent apoptotic cell death was also measured by flow cytometry analysis. It was analyzed that SF-chloroform fraction contained more schizandrin than other fractions by using HPTLC and HPLC/DAD system. Conclusions : These results suggest that SF extract and schizandrin may be a potential chemotherapeutic agent for the control of PC-3 human prostate cancer cells.

• 한국조리학회지
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• 제23권8호
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• pp.17-26
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• 2017

This study compared and analyzed the importance-satisfaction regarding the selection attributes of the convenience store focusing on PB lunch box for consumers of 20s and 30s. According to the research results, the importance of factors such as easy purchase, time reduction, convenient intake were found to be high among the selection attributes of the convenience store PB lunchbox and those of factors such as confirmation of food ingredients, nutrition, and new taste were found to be relatively low. In addition, factors with high satisfaction included easy purchase, convenient intake, time reduction, while factors with low satisfaction were confirmation of food ingredients, nutrition and hygiene. The results of the IPA analysis were as follows: The $1^{st}$ quadrant (Keep up the good work) included convenience, time reduction, easy purchase, convenient intake, convenient cooking method, and convenient packing container Etc. $2^{nd}$ quadrant (possible overkill) includes origin labeling and the 3rd quadrant (low priority) includes packing container design, convenient storage, consistency of quality and taste, good taste, moderate amount, new taste, one meal, moderate quantity and quality, inexpensive intake, and hygiene Etc. $4^{th}$ quadrant was found to include no corresponding factors.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2015년도 제46회 하계학술대회
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• pp.447-448
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• 2015

In order to looking for method of detecting inner fault of a 154kV GIT(Gas Insulated Transformer), it was considered that diagnosis partial discharge(PD) in UHF band and that analyze the ingredients of SF6 insulating gas. UHF PD diagnosis that is optimized to GIS was considered unsuitable through checking of inner part of a transformers which PD is detected excessively. The method analyzing the content of six kinds of gas(SOF2, SO2F2, etc)was decided through analysis of chemical degradation and combination process and discharge experiment. With the result applying this method to analyze the content of insulated gas of eighty five Gas Insulated Transformers.