• Archives of Reconstructive Microsurgery
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• 제3권1호
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• pp.40-44
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• 1994

Microsurgery has advanced beyond its nascent stages reaching success rates of 90% to 95%. However, this means that even in the best circumstances, 5% to 10% of free flaps and replants fail. Almost all failures are due to vessel thrombosis, resulting in ischemia of the transplanted tissue. Many attemps have been undertaken to treat and reverse its effects. Zdeblick and colleagues noted an improvement in the viability of amputated limbs replanted after an extended period of ischemia following intraarterial infusion of urokinase. Subsequent studies have investigated many modalities of urokinase administration in various animal models by differing ischemic periods. These studies, however, have failed to establish a definitive, generally accepted protocol for administration of urokinase in the salvage of tissue subjected to prolonged ischemia. Our clinical observations suggest that a bolus of urokinase delivered under pressure may increase the thromoblytic effect of the drug, probably by means of increased delivery to microvasculature. We intend to investigate the role of selective pressure perfusion of ischemic flaps as a new means for increasing the effectiveness of urokinase in the treatment of the "no-reflow" phenomenon. A total of 32 male New Zealand rabbits were used and divided into the four groups according to the method of infusion. After 12 hours of ischemia the flaps were injected with Hartmann's solution or with urokinase and the percent survival of the flap was determined at 7 days following flap reperfusion. As the result, the flap survival rate was highest in the pressure injection of urokinase group.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제16권6호
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• pp.1935-1952
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• 2022

Consumer innovativeness plays a vital role in explaining consumer dynamics, such as adoption, usage, and behavioral intention, in the new world of disruptive online media. This empirical study aimed to examine the importance of consumer innovativeness and digital literacy in the adoption and expansion of new technology-based media services, focusing on OTT services. Extending the theory of adoption of new technologies by innovators to new media environment centered on OTT services, it examines the influence of the four dimensions of motivated consumer innovativeness on OTT service usage. The Korea Media Panel Data of 2019, where overall ICT usage and media consumption of a broad panel of respondents was collected, was used for the analysis. From the data of 10,864 respondents, 4,031 (37.1%) were found to have experience in using OTT services. To clarify the mediating effect of digital literacy on the correlations between cognitive innovativeness of consumers and their use of OTT services, Process Macro Model 4 was used. The bootstrap method was applied to reveal that all four dimensions of consumer innovativeness have a significant indirect effect on new media usage through digital literacy, thus indicating how digital literacy plays an important role in the spread of new digital services in addition to consumer innovativeness. The findings are important in that they can help in the efforts to introduce new technologies to the public and educate them to improve their digital literacy so that they can enjoy the complete experience of using these new digital products.

• The Korean Journal of Pain
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• 제13권1호
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• pp.44-48
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• 2000

Background: The continuous epidural analgesia is a popular method in the management of postoperative pain. However, the exact regimen for the optimal analgesia is still in dispute. In this study, we evaluated the effect of an initial loading dose prior to the continuous epidural infusion after a brief surgery, which may have some residual effects of local anesthetics that is used for the intraoperative epidural anesthesia. Methods: Seventy five patients required epidural anesthesia with 15 ml of 2% mepivacaine for the perianal surgery were randomly divided into three groups: Group 1, being the control group (n=25) did not received postoperative epidural pain control. But, group 2 (n=25) and 3 (n=25) received continuous epidural analgesia with local anesthetics and morphine immediately after surgery. In Group 2, the patients received continuous epidural infusion without initial loading dose. In Group 3, the patients received initial loading dose (1% mepivacaine 6 ml and morphine 1 mg) and followed by continuous epidural infusion. We evaluated the number of patients who needed adjuvant analgesics, the pain score, and incidence of side effects for the postoperative 48 hours. Results: At postoperative 12 hours, in group 3, the two variables, the number of patients who needed analgesics and the pain score showed a statistical significance with low scores compared with group 1 and 2. At postoperative 24 and 48 hours, the two variables indicated above did not show any differences in group 2 and 3. The incidence of side effects is not different among the three groups. Conclusions: The loading dose prior to continuous epidural infusion is necessary after a brief surgery which may have some residual effects of local anesthetics that is used for the intraoperative epidural anesthesia.

• 기본간호학회지
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• 제9권2호
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• pp.323-334
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• 2002

Purpose: This study was designed to verify preemptive effects of intravenous patient-controlled analgesia (IV-PCA) infusion on postoperative pain in women having a total abdominal hysterectomy. Method: The research design was a nonequivalent control group post test only design. The participants in this study were 50 women who were scheduled for a total abdominal hysterectomy at a University affiliated Hospital in Suwon, Korea. The subjects were divided into two groups. For the experimental group, IV-PCA infusion was started before the skin incision and for the control group. IV-PCA infusion was started after the skin was closed. Each group was evaluated in terms of pain score by the visual analogue scale (VAS) and the number of times they pushed the button for IV-PCA at postoperative hours 1, 2, 3, 6, 12, and 24. The data were collected from July 1 to December 10, 2001. Collected data was analyzed by SPSS/PC + program. Result: 1. There was no difference between the two groups, over six points for the number of times the control button for IV-PCA was used. Group differences and interaction effect were not significant. 2. There was no significant difference in pain scores between the two groups, over seven time points. A significant interaction effect was observed between groups and measurement Points in time. 3. There was a significant difference in the requirements for additional analgesia between the two groups, 32% of the control group received additional analgesia. Conclusion: Preemptive analgesics administration may have a better effect in relieving postoperative pain than the usual analgesic treatment which is started after surgery.

• Journal of Yeungnam Medical Science
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• 제10권1호
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• pp.135-143
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• 1993

Bacteroides fragilis의 임상 분리균주 45주의 cefaclor, ciprofloxacin, imipenem의 3종 항균제에 대한 감수성 검사를 기존의 한천 평판희석법과 최근 새로이 개발된 E-test (AB Biodisk, Slona, Sweden)법으로, brain heart infusion, Mueller-Hinton, Wilkins Chalgren 한천 배지 3종류를 사용하여 균의 최소발육 억제 농도 (MIC : Minimal Inhibitory Concentration)의 결과를 비교, 관찰하였으며 5종의 quinolone 제제 (ciprofloxacin, enoxacin, norfloxacin, ofloxacin, pefloxacin)에 대한 Bacteroides fragilis group 60주의 시험관내 감수성 검사를 한천 평판 희석법으로 실시하여 다음과 같은 결과를 얻었다. 한천 평판 희석법에서 관찰된 MIC를 기준으로 E-test MIC의 결과를 비교하면 실험균주 90.3%가 한천 평판희석법의 MIC (within${\pm}$1 dilution)와 일치하여 E-test가 B. fragilis의 항균제 감수성 검사법에 한 종류로 유용한 것으로 생각되며 사용된 배지에 따른 감수성상의 양상은 큰 차이를 관찰할 수 없었으며 B. gragilis의 항균제 감수성 검사용 기본 배지로 brain heart infusion배지와 Wilkins Chalgren배지는 적합하나 Mueller-Hinton배지는 부적합 한것으로 나타났다. Bacteroides fragilis group 60주에 대한 5종의 quinolone제제에 대한 감수성상은 ofloxacin을 제외한 약재에 대해 대부분 내성을 띄었으며 균종간의 감수성상의 두드러진 차이는 관찰되지 않았다.

• Journal of the Korean Wood Science and Technology
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• 제48권4호
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• pp.513-526
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• 2020

The existing preservation methods are difficult to be applied to a large dimension log which is needed for making traditional wooden ship 'Jalur' in Riau Province. Novel techniques to provide the use of readily available species to replace traditional species alternative were investigated. These included infusion and a combination of injection and bandage-wrapping methods for preserving living trees of Balam (Macaranga conifera (Rchb.f. & Zoll.) Müll.Arg.) and Bintangor (Calophyllum soulattri Burm.f.). Water-based boron compounds were applied as wood preservatives. In total, 18 discs from the bottom, middle, and top of four trees and two controls were used. Trees undergoing treatment were also used to see how wood anatomical structure might affect the boron penetration. The overall aim was to identify the best method for use in Jalur manufacturing. The results showed that in infused Balam tree where the hose position for the preservative intake was deep (10-15 cm from the bark), no boron compound was observed in the outer sapwood. Combination of injection and bandage-wrapping method gave higher percentage of boron penetration at bottom and middle of Balam tree. However, infused Bintangor showed 100% boron penetration. The larger vessel diameter, the absence of tyloses, and the simple perforation plates in Bintangor wood were likely to have contributed to the higher penetration of boron. The combination of bandage-wrapping and infusion, or alternatively by infusing the living trees close to the bark, and at as low as position in the stem gives better protection when treatments are applied to living trees.

• 대한조선학회논문집
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• 제55권3호
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• pp.205-214
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• 2018

This paper deals with the experimental study on the hygrothermal ageing effect to the strength of Carbon Fiber Reinforced Plastics (CFRP) materials for marine leisure boat manufactured by vacuum assisted resin infusion method. The experiments performed consist of tensile, flexural and shear tests according to American Society for Testing and Materials (ASTM) and Korean Industrial Standards (KS) test methods. Test coupons are varied from uni-directional(UD, $0^{\circ}$, $90^{\circ}$), Bi-Directional (BD), and Double-Bias (DB) carbon fiber fabrics in conjunction with epoxy resin. The results of tensile test show that tensile strength reduces significantly while not the same degree of reduction is observed for elasticity modulus with respect to the existence of hygrothermal ageing effect. This implies that the tensile strain induced from external load holds steady values but ultimate strength values change widely under hygrothermal ageing effect. In case of the flexural test, $0^{\circ}$ UD shows more strength reduction than $90^{\circ}$ UD while BD has reduced values in both flexural strength and elasticity modulus under hygrothermal ageing effect. It is learned that the bending strain induced from external load and ultimate strength values are reduced with respect to hygrothermal ageing effect. Shear test performed only on DB materials, and the results show marginal reduction in ultimate strength and moderate reduction in elasticity modulus. This means that the shear strain varies more than ultimate shear strength with respect to hygrothermal ageing effect. The experiment conducted in this paper clearly demonstrates the differences in material properties of the CFRP for the consideration of hygrothermal ageing effect. Findings obtained from this experimental study can serve as a fundamental input data for the realistic structural responses of marine leisure boat built in CFRP materials.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1998년도 Proceedings of UNESCO-internetwork Cooperative Regional Seminar and Workshop on Bioassay Guided Isolation of Bioactive Substances from Natural Products and Microbial Products
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• pp.193-194
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• 1998

Recently, evaluation of brain transport of taurine which is possible to effect on Alzheimer's disease has investigated in rats. Also, internal carotid artery perfusion (ICAP) method is very useful for measuring of blood-brain barrier (BBB) permeability in rats. But ICAP has difficulties to evaluate of BBB permeability in mice especially. In the present study examines neuropharmaceutials permeability through the BBB in mice by common carotid artery perfusion (CCAP) method that modify ICAP method and require simple surgery. The external carotid artery (ECA) is cannulated with coagulating pterygopalatine artery (PPA) on ICAP method, while CCA is cannulated without coagulating PPA on CCAP method. The CCAP method require 4-5 fold higher infusion rate than ICAP method because an additional factor of 2 must be incorporated to adjust for fluid loss to the extracerebral circulation.

• Tuberculosis and Respiratory Diseases
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• 제40권5호
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• pp.474-482
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• 1993

연구배경 : 조직형플라스미노겐활성체는 생리적인 플라스미노겐활성체이므로 혈전의 섬유소에 결합된 플라스미노겐만을 활성화시키는 특이성이 있다고 알려져 있지만, 폐색전증에서 치료목적으로 대량투여하는 경우에도 섬유소에 대한 특이성이 유지되어 전신적인 출혈경향을 유발하지 않는가에 대해서는 논란이 있다. 또한 동량의 약제를 투여하더라도 조직형플라스미노겐활성체의 투여시간에 따라 혈전의 용해효과가 달라진다고 보고되었지만, 이러한 경우에 혈액의 응고기전이 어떠한 영향을 받는지는 명확하지 않아 이를 규명해보고자 본 연구를 시행하였다. 방법 : 실험견에 자가혈병으로 대량의 폐색전증을 유발시킨후 대조군은 특이치료없이, $t-PA_{15}$ 군은 15분동안, 그리고 $t-PA_{180}$군은 3시간에 걸쳐, 조직형플라스미노겐활성체를 체중(kg)당 1mg씩 정맥투여하였다. 그리고 실험과정중 시간에 따라, 실험동물의 혈색소치, 적혈구용적, 백혈구수, 혈소판수, 프로트롬빈시간, 활성부분트롬보플라스틴시간, 섬유소원농도, 트롬빈시간, 플라스미노겐 및 ${\alpha}_2$-항플라스민의 농도, 제 V 및 VIII응고인자의 농도, 그리고 섬유소원분해산물의 농도를 측정하였다. 결과: 1) 일반혈액검사소견근 세 군간에 유의한 차이가 없었다. 그러나 실험과정중 혈색소치와 적혈구용적 및 혈소판수는 감소하고, 백혈구수는 계속 증가하는 경향을 보였다. 2) 프로트롬빈시간, 활성부분트롬보플라스틴시간 및 트롬빈시간은 $t-PA_{15}$군이 치료후 15분~60분 사이에, $t-PA_{180}$군은 치료후 30분~180분 사이에 연장되었다가 정상으로 회복되었다. 3) 섬유소원농도 ${\alpha}_2$-항플라스민의 농도, 제 V 및 VIII응고인자의 농도는 $t-PA_{15}$군 및 $t-PA_{180}$ 군에서 모두 감소하였으나 $t-PA_{15}$군은 $t-PA_{180}$군에 비해 조기에 회복되는 양상을 보였고 플라스미노겐의 농도는 급격히 증가하였다가 회복되는 양상을 보였다. 4) 섬유소원분해산물의 농도는 폐색전후 증가하였고, $t-PA_{15}$군 및 $t-PA_{180}$ 군에서는 조직형플라스미노겐활성체 투여후 더욱 증가하였는데 $t-PA_{180}$군에서 더 현저하였다. 결론 : 폐색전증에서 치료목적으로 대량의 조직형플라스미노겐활성체를 투여하는 경우, 약제의 투여시간이 180분일때보다는 투여시간이 15분일때 출혈이 발생할 가능성이 적다. 따라서 동량의 조직형플라스미노겐활성체를 투여하더라도 약제의 투여시간을 달리함으로써 출혈의 부작용을 줄일 수 있을 것이다.

• Journal of Dental Anesthesia and Pain Medicine
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• 제15권4호
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• pp.221-227
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• 2015

Background: Endotracheal intubation induces clinically adverse cardiovascular changes. Various pharmacological strategies for controlling these responses have been suggested with opioids being widely administered. In this study, the optimal effect-site concentration (Ce) of remifentanil for minimizing hemodynamic responses to fiberoptic nasotracheal intubation was evaluated. Methods: Thirty patients, aged 18-63 years, scheduled for elective surgery were included. Anesthesia was induced with a propofol and remifentanil infusion via target-controlled infusion (TCI). Remifentanil infusion was initiated at 3.0 ng/mL, and the response of each patient determined the Ce of remifentanil for the next patient by the Dixon up-and-down method at an interval of 0.5 ng/mL. Rocuronium was administered after propofol and remifentanil reached their preset Ce; 90 seconds later fiberoptic nasotracheal intubation was initiated. Non-invasive blood pressure and heart rate (HR) were measured at pre-induction, the time Ce was reached, immediately before and after intubation, and at 1 and 3 minutes after intubation. The up-and-down criteria comprised a 20% change in mean blood pressure and HR between just prior to intubation and 1 minute after intubation. Results: The median effective effect-site concentration ($EC_{50}$) of remifentanil was $3.11{\pm}0.38ng/mL$ by the Dixon's up-and-down method. From the probit analysis, the $EC_{50}$ of remifentanil was 3.43 ng/mL (95% confidence interval, 2.90-4.06 ng/mL). In PAVA, the EC50 and EC95 of remifentanil were 3.57 ng/mL (95% CI, 2.95-3.89) and 4.35 ng/mL (95% CI, 3.93-4.45). No remifentanil-related complications were observed. Conclusions: The $EC_{50}$ of remifentanil for minimizing the cardiovascular changes and side effects associated with fiberoptic nasotracheal intubation was 3.11-3.43 ng/mL during propofol TCI anesthesia with a Ce of 4 ug/mL.