• 제목/요약/키워드: Informed Culture

검색결과 60건 처리시간 0.025초

의약품 허가외사용 관리 체계 발전 방안 (Development of Regulation System for Off-Label Drug Use)

  • 이인향;서미경;이영숙;계승희;김현아;이숙향
    • 약학회지
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    • 제58권2호
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    • pp.112-124
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    • 2014
  • This study aimed to develop a regulation system for off-label drug use to secure the safe use of marketed drugs. We searched governmental documents for national and global regulating systems of off-label drug uses and a body of academic literature to explore current regulating trends. We included European Union, United Kingdom, United States of America, Australia and Japan, and critically reviewed the regulation of off-label drug use in four issues, which were a regulatory structure, safety control before and after off-label use, and information management. The findings of the present investigation called for several measures in off-label drug uses: enhancing prescribers' self-regulation, providing up-to-date information to prescribers for evidence-based practice and to patients for their informed consent, making evidence with scientific rigor, building an official registering process for off-label use in good quality and extending the role of pharmaceutical industry in pharmacovigilance. At last, we proposed a new system so as to regulate and evaluate off-label drug uses both at national and institutional level. In the new system, we suggested a clear-cut definition for clinical evidence that applicants would submit. We newly introduced an official 'Off-Label Drug Use Report' to evaluate the safety and clinical efficacy of a given off-label drug use. In addition, we developed an algorism of the regulation of off-label drug use within an institution to help set up the culture of evidence-based practices in off-label drug uses.

지역 미술과 권력 (Regional Art and Power)

  • 박영택
    • 미술이론과 현장
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    • 제3호
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    • pp.35-50
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    • 2005
  • For us, any regional art exist? Almost all art events today take place mostly in Seoul. Concentrating on the reinforcement of its power, the regional art world remains isolated without any connection with the Seoul art community. It is completely closed off from the central art scene. The regional art world seems to consider that more helpful in consolidating its status. It is in real sense suffering the absence of art criticism and art media, lack of an understanding of art and backwardness of art education. Many regional artists are dreaming of moving out from their domain, aspiring to be a member of the central art world. They make an effort to assimilate into a refined, modern style of the central art circle, rather than striving to create works imbued with regionality and locality. As the artists living in the provinces, the characteristics of their district should be above all else reflected in their art. Although they are less informed about the latest trend of culture and art, their art has to be something passionately and obstinately embodying the intrinsic quality of their regions. They have to find a practical solution more positively, instead of merely complaining about the poor condition of the regional art community. There is the need to bring about a turnabout in our awareness that regional art is confined to any limit and cannot be in the center of the entire art world. What' s most significant is to dissolve factionalism and not to depend on school ties or regional networks. As a reaction against authoritarianism, regional art has to put emphasis on attaining its originality. For this, regional art should respect regional tradition, history and background and break away from an old convention of wielding power.

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이찬 시의 낭만성과 비극성 (The Romance and Tragedy in Lee Chan's Poetry)

  • 유성호
    • 비교문화연구
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    • 제19권
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    • pp.127-147
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    • 2010
  • Lee Chan's early poems were defined as the world of romance. His second-term poems were defined as proletarian poetry and poems written in prison when he made the romance as the core point through longing and desire for lost world. Maximizing the romance was proletarian poetry. His third-term poems were feelings of the northern countries called the spirit of Lee Chan's poems. He recognized the emotion of diaspora as the tragedy in these poems. It was remarkable time that the poet's tragedy observing and expressing the reality of colony. Afterward he wrote poems related inside withdrawal and war cooperation, finally he wrote poem after defecting to North Korea. Lee Chan showed the romance of desire in early poems and proletarian poems. Then he indicated acute scenery of the tragedy in the late 1930s' poems. In heavy situation, he moved from pro-Japanese literature to North Korean literature. However he didn't throw introspected self-reflection language to himself each his changing. But through several form of garden, he clearly showed consistent of maximizing his utopia sense. The time Lee Chan experienced was an icon which intensively indicated several features of deformed modern Korean poetic history. He was a unique poet who expressed various traces of modern Korean poetry in short time step by step. His path informed that he was a special poet who stepped the trace of many modern Korean poetry's extremes such as romantic poetry, proletarian poetry, prison poetry, pro-Japanese poetry and North Korean poetry. Likewise we can call his life as a grudge return. Because he left hometown, experienced the light and darkness of modern times and returned his hometown.

일본인의 종교심의 구조 - 학생들의 의식조사에서 알 수 있는 것 - (The structure of the Japanese religious mind: Some observations taken from research surveys on the religious attitudes of college students)

  • 井上順孝;佐佐充昭
    • 대순사상논총
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    • 제18권
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    • pp.149-164
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    • 2004
  • Various social surveys conducted by mass media and government agencies in recent years in Japan suggest that the percentage of those who believe in religion are between twenty and thirty percent. However, more than seventy percent of Japanese visit Shinto shrines or Buddhist temples during the New year period. Although there are varying interpretations on whether Japanese people are religious or not, detailed research shows the existence of certain religious tendencies among Japanese. I base my estimates on research surveys of college students covering a period of almost ten years. It is helpful for understanding the religiosity of the Japanese to differentiate between "clear-cut religion" and "peripheral religious phenomena." The exact boundary between these two categories, however, is difficult to clearly demarcate. "Clear-cut religion" refers here phenomena which are directly related to established religious organizations such as shrine Shinto, Buddhist sects, or Christianity. "Peripheral religious phenomena" covers such phenomena as fortune telling, mystical phenomena, religious customs and similar matters. It is often said that the younger generations are less concerned with religion. Our seven surveys questioning several thousand college students, conducted between 1995 and 2001, show that only between six and seven percent of the students state that they believe in religion. Additionally, the extent of negative attitudes toward religion quite remarkable. On the other hand, students who take part in conventional ritual such as a New year's visit to a shrine or temple and visiting the graves of ancestors amount to about fifty percentage. In spite of the prevailing negative attitude toward religious groups, these students have apparently kept a certain level of interest in religious customs. Moreover, they show a relatively strong interest in fortune telling, mystical phenomena, or supernatural phenomena. The exact degree of a positive attitude toward peripheral religious phenomena differs according to the level of being informed on these matters. As a whole, they largely rely on information gained from their families and local communities. Therefore, we can conclude that there is a degree of transmission of religious culture among younger generations.

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Psychometric testing of the Chinese version of the Perinatal Infant Care Social Support tool: a methodological study

  • Feiyan Yi;Sukhee Ahn;Miyeon Park
    • 여성건강간호학회지
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    • 제30권2호
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    • pp.128-139
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    • 2024
  • Purpose: This study aimed to translate the Perinatal Infant Care Social Support (PICSS) instrument into Chinese and to verify the reliability and validity of the translated version. Methods: This study used a cross-sectional design to examine the reliability and validity of the Chinese version of the PICSS (C-PICSS). A cohort of 150 first-time mothers in China participated, attending hospital follow-up care at 6 weeks postpartum. Data were collected after obtaining informed consent from the mothers. Results: The majority of mothers were aged between 20 and 29 years, with a mean age of 26.25 (±3.90) years. An item analysis of the 19 items in the C-PICSS showed that all items had an item-total score correlation above 0.2. This resulted in a Kaiser-Meyer-Olkin value of 0.92 and a significant Bartlett's test of sphericity (χ2=1,778.65, p<.001), confirming the suitability of the data for factor analysis. Correlation analyses revealed a strong positive relationship between infant care social support and general social support (r=.62, p<.001), and a negative relationship between infant care social support and postpartum depression (r=-. 38, p<.001). Higher scores for infant care social support were associated with reporting positive relationships with their husbands (t=3.72, p<.001) and high levels of spousal involvement (t=4.09, p<.001). In terms of structural support, spouses were identified as the primary source. Conclusion: The research results indicate that C-PICSS is reliable and valid as an indicator of social support for infant care among Chinese mothers.

VENGEANCE, VIOLENCE, VAMPIRES: Dark Humour in the Films of Park Chan-wook

  • Hughes, Jessica
    • 비교문화연구
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    • 제28권
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    • pp.17-36
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    • 2012
  • This essay places the South Korean film Thirst (2009) within Park Chan-wook's oeuvre as a filmmaker notorious for graphic depictions of violence and revenge. Park's use of dark humour in his films, which is emphasized in Thirst perhaps more than ever, allows for a more self-aware depiction of violence, where both the viewer and the protagonist are awakened to the futility of revenge. This ultimately paints his characters as fascinatingly crazy - simultaneously heroes, villains, and victims. Film theorist Wes D. Gehring's three themes of dark humour ('man as beast,' 'the absurdity of the world,' and 'the omnipresence of death') become most obvious in Park's most recent film, which pays closer attention to character development through narrative detail. Rather than portraying the characters as sentimental, dark humour depicts their misfortunes in an alternative way, allowing for consideration of such taboo subjects as religion, adultery, and death/suicide. These issues are further tackled through Thirst's portrayal of its vampire protagonist, which ultimately de-mystifies the traditional vampire figure. While this character has more often been associated with romance, exoticism and the mystical powers of the supernatural, Thirst takes relatively little from the demons of Nosferatu (Murnau, 1922) and various other Dracula adaptations, nor the romantic figures of Interview with the Vampire (Jordan, 1994), and Twilight (Hardwicke, 2008). Instead, it is part of a much smaller group of contemporary vampire films, which are rather informed by a postmodern reconfiguration of the monster. Thus, this paper examines Thirst as an important contribution to the global and hybrid nature of those films in which postmodern vampires are sympathetic and de-mystified, exhibiting symptoms stemming from a natural illness or misfortune. Park's undertaking of a vampire film allows for a complex balance between narrative and visuals through his focus on the Western implications of this myth within Korean cinema. This combination of international references and traditional Korean culture marks it as highly conscious of New Korean Cinema's focus on globalization. With Thirst, Park successfully unites familiar images of the vampire hunting and feeding, with more stylistically distinct, grotesque images of violence and revenge. In this sense, dark humour highlights the less charming aspects of the vampire struggling to survive, most effective in scenes depicting the protagonist feeding from his friend's IV in the hospital, and sitting in the sunlight, slowly turning to ash, in the final minutes of the film. The international appeal of Park's style, combining conventions of the horror/thriller genre with his own mixture of dark humour and non-linear narrative, is epitomized in Thirst, which underscores South Korea's growing global interest with its overt international framework. Furthermore, he portrayal of the vampire as a sympathetic figure allows for a shift away from the conventional focus on myth and the exotic, toward a renewed construction of the vampire in terms of its contribution to generic hybridization and cultural adaptation.

연령이 고려된 양쪽 귀의 가청대역 청력측정에 관한 연구 (On the Audible Band Hearing Measurement of Both Ears Considering Age)

  • 김봉영;배명진
    • 문화기술의 융합
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    • 제7권1호
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    • pp.570-575
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    • 2021
  • 인간은 오감을 풍요롭게 느끼면서 생활하기 때문에 인간의 행복한 삶을 영위하기 위해서는 청력이 손상되지 않도록 주의하여야 한다. 생활환경에서 입게 되는 청력손상은 특정 주파수대역이 먼저 손상되는 부분대역에서 청력손상이 일반적이다. 그러나 청력손상의 초기 통증이 별로 나타나지 않아서 그 증세를 초기단계에는 알아내기가 어렵다. 본 연구에서는 간단한 어플 등을 통해 손쉽고 빠르게 청력손상을 자가 측정할 수 있는 고속 측정법을 제안하였다. 이 방법은 voice soub-band별 이득 보상된 pure tone 9개를 번갈아 양쪽 귀에 들려줌으로써 자신의 청력손상을 스스로 고속 판별하게 된다. 1인당 27초 동안 18번의 톤 펄스를 들려주었을 때, 12명의 피험자들 중에서 1명이 부분청력손상 의심자로 확인되었다. 그리고 피험자들에게 들린 횟수 청력판별법을 알려주니, 실험참가자들 스스로가 자신의 청력손상여부를 바로 판별해 내었다. 이러한 측정방법은 스마트 폰으로 27초 내에 양쪽 귀의 청력을 간단히 판단함으로서 병원에서는 10분 이상 소요되었던 청력측정이 비교적 정확하게 이루어져서, 시간과 비용을 줄이면서 청력건강을 유지할 수 있음을 파악하였다.

사람의 제대 및 양막유래 줄기세포의 간세포로의 분화 (Hepatogenic Potential of Umbilical Cord Derived-Stem Cells and Human Amnion Derived-Stem Cells)

  • 김지영;이윤정;박세아;강현미;김경식;조동제;김해권
    • Clinical and Experimental Reproductive Medicine
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    • 제35권4호
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    • pp.247-265
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    • 2008
  • 목 적: 사람의 제대유래 줄기세포 (HUC)와 양막유래 줄기세포 (HAM)를 간유사세포로 분화 시키고자 하였다. 연구방법: 산모의 동의아래 만삭 정상 산모로부터 양막 및 제대를 얻고 줄기세포를 분리, 배양하였다. 분리된 세포의 줄기세포로서의 특성을 규명하기 위하여 RT-PCR, 세포면역화학 분석 그리고 중배엽성세포로의 분화능 실험을 하였다. 또한 이들 줄기세포를 분화 배양액에서 간유사세포로 분화 유도 후, 간세포 특이 유전자 발현, 알부민 ELISA, 알부민에 대한 면역블로팅 및 세포면역화학염색 그리고 PAS 염색을 시행하였다. 결 과: 사람의 양막 및 제대로부터 세포를 분리하여 줄기세포로서의 특성을 조사하고, 이들 세포의 지방세포, 연골세포, 골아세포로의 분화능력을 확인하였다. 동일한 분화 배양액에서 HUC과 HAM을 간유사세포로 분화시킨 결과 HUC이 모든 조건에서 HAM보다 알부민과 요소를 더 많이 합성 분비하였다. 간유사세포로의 분화능력이 더 좋은 것으로 나타난 HUC을 가지고 최적의 분화를 유도한 결과 $1.2{\pm}0.8\;{\mu}g/mL$의 알부민을 합성 분비하였고, $8.9{\pm}1.2\;mg/dL$의 요소를 합성 분비하였다. 결 론: HUC과 HAM 모두 알부민을 분비하는 간유사세포로 분화할 수 있었으며, HUC이 더 잘 유도되는 것으로 관찰되었다. 이러한 결과로써 HUC과 HAM을 간질환 환자의 간세포 이식 치료에 필요한 세포치료제로써 이용할 수 있을 것으로 생각된다.

주요 고농서를 통한 조성시대의 도작기술 발전 과정 영구 IV. 조선시대의 비곡종 및 경지관리 (Transition of Rice Culture Practices during Chosun Dynasty through Old References IV. Preparation of Seeds and Land)

  • 이숭겸;구자옥;이은웅;이홍석
    • 한국작물학회지
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    • 제36권6호
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    • pp.576-585
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    • 1991
  • 비곡종법은 중국의 $\ulcorner$범승지서$\lrcorner$부터 이미 확립 된 체계가 있어서 우리나라도 대부분 이를 인용하여 따르는 경향이 있었으며, 취종법은 비정상형의 종자를 선별해 버리고 우량종자를 선택하는 방식이었고, 선종법도 중국은 수선법을 따랐으나 우리나라는 풍선$\longrightarrow$절별$\longrightarrow$수선법을 창안발전시켰고, 최근에는 염수선이 첨가되었을 뿐, 모두가 완벽한 기술이었다. 종자흡습도 측정법이나 종자의 설즙 및 요분, 골즙처리법 등은 그 근간이 고대중국에서 유래된 것으로 우리나라의 농서들도 대체로 이를 인용하거나 다소의 가감을 통하여 수용하고 있었으나 이들 기술이 갖는 타당성은 합리성에 비하여 번거롭고 비현실적이며, 이는 우리나라 입지보다 중국의 한지, Alkali토양에서 오히려 수긍도가 높은 기술로 해석된다. 경지는 농사의 시작을 알리는 작업으로서 천지간에 기통하는 때를 기다려 시행한다는 고래 중국의 농업관을 거의 가감없이 선초부터 선말의 농서에까지 인용하고 있었다. 초경, 추경(혹은 춘경), 기경은 깊게하고 재경, 춘경(흑은 하경), 중경은 얕게 하며, 전자는 저수와 정지를 목적으로 하고 후자는 중경제초를 목적으로 하도록 기술분화 하고 있었다. 그러나 한전의 세역법에서 와 달리 상경하는 우리나라에서는 추경이 권장되고 있었으나 실제로 추경하지는 못하고 있었으며 이런 상황으로부터 시대를 경과하며 우리나라의 기경법은 녹비작물이용법, 엄경법, 분양법, 때에 따라서 건경법 등과 연계시켜 수행토록 종합처리법으로 발전을 이룩하였다. 뿐만 아니라 15세기까지는 새로운 산전과 연안지로의 경지확장을 위한 개간법을 지원하기 위한 농기구로서 윤목사용법이 창안되었고 17-18세기부터는 내외환으로 황무지화한 농경지를 대상으로 우선적으로 노동생산성을 제고시킴으로써 생산력까지 회복시키고자 하였으며, 이를 위하여 중국고대농법인 반종법과 소누법을 재인용 소개하여 왔으나 큰 성과는 불분명하며 드디어 선말에는 이에 대한 현실성을 평가하기에 이르렀다.

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Phytophthora cambivora KACC 40160으로부터 새로운 elicitin의 분리 (Purification of a New Elicitin from Phytopthora cambivora KACC40160)

  • 윤상홍;배신철;박인철;구본성;김용환;여윤수
    • Applied Biological Chemistry
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    • 제46권2호
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    • pp.79-83
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    • 2003
  • 난균류에 속하는 Phytophthora spp.와 pythium spp.에서 분비되는 단백질인 elicitin은 식물과 병원균과의 비친화적 관계에서 과민감반응을 유도하는 인자로 알려져 왔다. 국내에서 수집된 5종의 Phytophthora spp로부터 분리된 elicitin들은 무, 배추, 고추에서 과민감 반응을 유도 하였으나 오이, 토마토에서는 볼 수 없었다. 특히 지금까지 보고가 되지않은 P. cambivora KACC 40160균주의 배양액으로부터 ion exchange와 gel filtration을 이용하여 고추에 과민감반응을 유도하며 분자량이 10kDa인 새로운 elicitin을 순수분리 하여 cambivorein이라 명명 하였다. 분리된 cambivorein의 N-말단 아미노산 서열분석 결과 ${\beta}-isoform$의 특징인 13번째 아미노산이 Iysine을 가지고 있었으며 기존의 다른 종류의 elicitin과는 다른 아미노산으로 구성되어 있었다.