• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2008년도 춘계종합학술대회 A
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• pp.401-404
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• 2008

인간과 마찬가지로 가축도 체온의 변화로부터 질병의 유무를 판별할 수 있는 정보를 제공한다. 그 중 소의 경우, 유열, 중독, 설사, 식체, 만성장염, 감기, 폐렴, 탄저병 등의 질병을 예측 할 수 있다. 따라서 주기적으로 체온을 측정하고 분석함으로써 질병을 조기 발견하고 빠르게 대처하여 손실을 최소화 할 수 있는 가축용 체온 측정 시스템을 제안한다. 또한 이 시스템은 주기적인 자동 측정과 위험 상태 알림 기능을 갖추고 있으므로 줄어드는 인력에 대한 대안과 가축의 품질 관리에 유용하게 사용될 수 있을 것이다.

• 동아시아식생활학회지
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• 제19권1호
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• pp.116-129
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• 2009

The study was conducted to evaluate consumer awareness of the risk elements associated with foods and their information search behavior regarding food safety. The data were collected from 504 adult consumers living in Seoul, Busan, Incheon, Daegu, Daejeon, and Gwangju through a self-administered questionnaire on August, 2006. Frequency analyses, t tests, one-way analysis of variance, and Duncan's multiple range comparison tests were conducted to analyze the responses using SPSS v. 14.0. The levels of recognition of consumers regarding each risk element were generally low. Many respondents answered that they obtained information regarding food safety from TV/radio/newspapers and family/relatives/friends/neighbors. The respondents also indicated that they had strong confidence in the information from family/relatives/friends/neighbors. Additionally, most respondents required information regarding heavy metal contamination, endoctrine disruptors, and avian influenza.

• Pediatric Infection and Vaccine
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• 제21권1호
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• pp.22-28
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• 2014

목적: 임상적으로 중증 세균성 감염과 바이러스성 질환의 감별이 어려운 어린 영아에서 호흡기 바이러스를 검출하고 이것과 연관된 임상적 위험인자를 분석하였다. 방법: 2011년 9월부터 2012년 8월까지 생후 90일 이하 영아 중 패혈증을 포함한 감염성 질환이 의심된 227명을 대상으로 비인두 검체를 채취하였으며 임상적 특성에 대한 후향적 연구를 시행하였다. 채취한 검체 내 호흡기 바이러스의 검출은 real-time PCR 검사를 통해 측정되었다. 결과: 총 157명(69.2%)의 영아에서 한 가지 이상의 호흡기 바이러스가 검출되었다. 빈도는 RSV (75명), RV (42명), influenza virus (18명), parainfluenza virus (15명), human metapneumovirus (9명), coronavirus (9명), adenovirus (4명), bocavirus (3명) 순이었다. 이 중 24명(10.6%)에서 세균성 감염을 진단하였다. 기침, 호흡기 질환의 가족력이 있는 경우 혹은 가을/겨울 철에 호흡기 바이러스가 의미있게 높은 빈도로 검출되었으며 로지스틱 회귀분석에서도 같은 경향을 확인하였다. 가을과 겨울에는 세균성 감염 환자보다 그렇지 않은 환자에서 호흡기 바이러스 검출이 유의하게 많은 것을 알 수 있었다. 결론: 호흡기 바이러스는 감염성 질환이 의심되어 입원한 어린 영아의 중요한 병원체이며 그 검출률은 호흡기 증상, 가을/겨울철 발생, 호흡기 증상의 가족력이 있는 환자에서 유의하게 높았다.

• Pediatric Infection and Vaccine
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• 제25권1호
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• pp.8-16
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• 2018

목적: 본 연구는 바이러스성 크루프로 입원하는 환아의 임상적 및 역학적 특성을 분석하여 원인 바이러스 감염에 따른 중증도를 평가하고자 하였다. 방법: 2013년 5월부터 2016년 12월까지 원주세브란스기독병원 소아청소년과에 바이러스성 크루프로 입원한 10세 이하 환아 중 비강인두도말 검체 채취 및 다중 역전사중합효소연쇄반응 검사를 하여 호흡기 바이러스가 검출된 302명을 대상으로 의무기록을 후향적으로 검토하였다. 바이러스성 크루프의 중 증도를 평가하기 위하여 Westley의 점수제를 사용하였다. 결과: 전체 302명 중 중증 바이러스성 크루프로 입원한 환아는 149명(49.3%)이었으며, 이 중 남아가 88명, 여아가 61명으로 남녀 비는 1.44:1이었다. Parainfluenza virus가 110예(48.7%)로 거의 절반에 가까운 빈도를 보였으며, 이후로 influenza virus (15.5%), human rhinovirus (11.9%), respiratory syncytial virus (10.2%) 순이었다. 중증 바이러스성 크루프와 원인 바이러스와의 연관성에 대한 분석에서는 parainfluenza virus 2형에서만 위험도가 의미 있게 높은 것으로 나타났다. Parainfluenza virus 2형은 연령에 따라서는 발병 빈도에 차이가 없었으나 여름, 가을에 상대적으로 더 높은 감염 빈도를 보였다. 결론: 본 연구에서 중증 바이러스성 크루프와 연관이 있었던 바이러스는 parainfluenza virus 2형이 유일하였다. 추후 전향적, 다기관 연구 및 추가적인 변수들을 복합적으로 고려하여 원인 바이러스 감염에 따른 중증도를 재확인하고, 원인 바이러스에 대한 지역별, 시기별, 연령별 분석이 필요하다.

• Journal of Information Science Theory and Practice
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• 제1권1호
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• pp.42-53
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• 2013

Timely access to quality healthcare information during an outbreak plays an important role in curtailing its spread. The aim of this study was to investigate the information needs and seeking behavior of the general public in Singapore during the H1N1 pandemic. A pre-tested questionnaire was used for data collection. The convenience snowball sampling method was used and 260 working adults and tertiary-level students participated in this study. The most crucial information needs of a majority of the participants were: symptoms of H1N1, causes of the infection, preventive measures, and possible treatments. Data analysis also revealed that mass media such as television, newspapers, and radio were most frequently used for seeking the needed information. The use of human information sources was also quite high while only a small number of the respondents accessed online news and healthcare websites. About three-quarters of the participants indicated that the gathered information helped them to stay vigilant and take necessary precautionary measures. A major problem identified by the participants in using H1N1 information was the lack of understanding of certain terms used in public communications. This paper suggests certain measures for strengthening health information communication during future outbreaks.

• Tuberculosis and Respiratory Diseases
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• 제73권1호
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• pp.1-10
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• 2012

Care of patients with sepsis has improved over the last decade. However, in the recent two years, there was no significant progress in the development of a new drug for critically ill patients. In January 2011, it was announced that the worldwide phase 3 randomized trial of a novel anti-Toll-like receptor-4 compound, eritoran tetrasodium, had failed to demonstrate an improvement in the mortality of patients with severe sepsis. In October 2011, Xigris (drotrecogin alfa, a recombinant activated protein C) was withdrawn from the market following the failure of its worldwide trial that had attempted to demonstrate improved outcome. These announcements were disappointing. The recent failure of 2 promising drugs to further reduce mortality suggests that new approaches are needed. A study was published showing that sepsis can be associated to a state of immunosuppression and loss of immune function in human. However, the timing, incidence, and nature of the immunosuppression remain poorly characterized, especially in humans. This emphasizes the need for a better understanding of sepsis as well as new therapeutic strategies. Many clinical experiences of the extracorporeal membrane oxygenator (ECMO) treatment for adult acute respiratory distress syndrome (ARDS) patients, which is caused by the H1N1 influenza A virus, were reported. The use of ECMO in severe respiratory failure, particularly in the treatment of adult ARDS, is occurring more commonly.

• International Journal of Advanced Culture Technology
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• 제10권4호
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• pp.316-321
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• 2022

Since 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread rapidly, infecting millions of people worldwide. On March 11, 2020, the World Health Organization declared coronavirus disease (COVID-19) a pandemic owing to the worldwide spread of SARS-CoV-2, which created an unprecedented burden on the global healthcare system. In this context, there are increasing concerns regarding co-infections with other respiratory viruses, such as the influenza virus. In this study, clinical data of patients infected with SARS-CoV-2 and other respiratory viruses were compared with patients infected with SARS-CoV-2 alone. The hematology and blood biochemistry results of 178 patients infected with SARS-CoV-2 , who were tested on admission, were retrospectively reviewed. In patients with SARS-CoV-2 and adenovirus co-infection, C-reactive protein levels were elevated on admission, whereas lactate dehydrogenase (LDH), prothrombin time, international normalized ratio, activated partial thromboplastin clotting time, and bilirubin values were all within the normal range. Moreover, patients with SARS-CoV-2 and human bocavirus co-infection had low LDH and high bilirubin levels on admission. These findings reveal the clinical features of respiratory virus and SARS-CoV-2 co-infections and support the development of appropriate approaches for treating patients with SARS-CoV-2 and other respiratory virus co-infections.

• Clinical and Experimental Pediatrics
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• 제61권6호
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• pp.180-186
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• 2018

Purpose: Despite the availability of molecular methods, identification of the causative virus in children with acute respiratory infections (ARIs) has proven difficult as the same viruses are often detected in asymptomatic children. Methods: Multiplex reverse transcription polymerase chain reaction assays were performed to detect 15 common respiratory viruses in children under 15 years of age who were hospitalized with ARI between January 2013 and December 2015. Viral epidemiology and clinical profiles of single virus infections were evaluated. Results: Of 3,505 patients, viruses were identified in 2,424 (69.1%), with the assay revealing a single virus in 1,747 cases (49.8%). While major pathogens in single virus-positive cases differed according to age, human rhinovirus (hRV) was common in patients of all ages. Respiratory syncytial virus (RSV), influenza virus (IF), and human metapneumovirus (hMPV) were found to be seasonal pathogens, appearing from fall through winter and spring, whereas hRV and adenovirus (AdV) were detected in every season. Patients with ARIs caused by RSV and hRV were frequently afebrile and more commonly had wheezing compared with patients with other viral ARIs. Neutrophil-dominant inflammation was observed in ARIs caused by IF, AdV, and hRV, whereas lymphocyte-dominant inflammation was observed with RSV A, parainfluenza virus, and hMPV. Monocytosis was common with RSV and AdV, whereas eosinophilia was observed with hRV. Conclusion: In combination with viral identification, recognition of virus-specific clinical and laboratory patterns will expand our understanding of the epidemiology of viral ARIs and help us to establish more efficient therapeutic and preventive strategies.

• IMMUNE NETWORK
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• 제23권4호
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• pp.31.1-31.18
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• 2023

Evidence suggests that the human respiratory tract, as with the gastrointestinal tract, has evolved to its current state in association with commensal microbes. However, little is known about how the airway microbiome affects the development of airway immune system. Here, we uncover a previously unidentified mode of interaction between host airway immunity and a unique strain (AIT01) of Staphylococcus epidermidis, a predominant species of the nasal microbiome. Intranasal administration of AIT01 increased the population of neutrophils and monocytes in mouse lungs. The recruitment of these immune cells resulted in the protection of the murine host against infection by Pseudomonas aeruginosa, a pathogenic bacterium. Interestingly, an AIT01-secreted protein identified as GAPDH, a well-known bacterial moonlighting protein, mediated this protective effect. Intranasal delivery of the purified GAPDH conferred significant resistance against other Gram-negative pathogens (Klebsiella pneumoniae and Acinetobacter baumannii) and influenza A virus. Our findings demonstrate the potential of a native nasal microbe and its secretory protein to enhance innate immune defense against airway infections. These results offer a promising preventive measure, particularly relevant in the context of global pandemics.

• Pediatric Infection and Vaccine
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• 제18권1호
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• pp.61-67
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• 2011

목 적 : 본 연구는 소아에서 보카바이러스와 연관된 하기도 감염증의 역학적인 특성에 대해 알아보고자 하였다. 방 법: 2000년 3월부터 2005년 9월까지 서울대학교 병원과 분당 서울대학교병원에 하기도 감염증으로 입원한 658명의 소아에게서 비인두 흡입 검체를 채취하였다. 다중 역전사 중합효소 연쇄 반응을 이용하여 11종의 바이러스를 조사하였고, 의무기록을 후향적으로 분석하였다. 결 과:전체 호흡기바이러스는 658명의 환아 중 325명(49.4%)에서 검출되었다. 보카바이러스는 62명(9.4%)에서 검출되었으며, 3개월 이상 5세 미만에서 많았다. 보카바이러스가 중복감염이 확인된 것은 37.1%로, 전체 바이러스 양성 환자들의 중복감염률(12.3%)보다 의미 있게 높은 것으로 확인되었다(P =0.000). 또한 늦은 봄부터 이른 여름인 5월부터 7월에 많이 검출되었다. 결 론 : 보카바이러스는 국내에서 소아의 하기도 감염증에서 유병률이 높았고, 특히 늦은 봄부터 초여름에 유행하였다.