• The KIPS Transactions:PartD
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• v.11D no.2
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• pp.351-360
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• 2004

Most mobile agents are migrated to many mobile agent systems by the sequential node migration method. However. in this case, if some problems such as host's fault or obstacle etc. happened, mobile agent falls infinity walt or orphan states. Therefore, it is difficult to get an expectation effect as use of other distribution technologies because the required time for networking between nodes increases. And so, many researches have been performed to solve this problems. However, most of methods decide node migration based on passive routing table or detour hosts which have some problems. Actually, the researches for reducing the total required time for networking are insufficient yet. In this paper, to reduce the required time for networking of mobile agent we design an active routing table based on the information of implemented objects which are registered in the meta-table of naming agent. And also, for user's keyword, we propose an replication model that replicates many agent object according to the information and number of object references corresponding to meta-table. Replicated objects are migrated to mobile agent systems in parallel and it provides minimized required time for networking.

• Biomolecules & Therapeutics
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• v.7 no.1
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• pp.59-65
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• 1999

A bioequivalence study of the Dong Wha Cisapril tablets(Dong Wha Pharm. Ind. Co., Ltd.) to the Prepulsid tablets(Janssen Korea Ltd.), formulations of cisapride, was conducted. Twenty four healthy Korean male subjects received each formulation at the dose of 5 mg as cisapride in a 2$\times$2 crossover study. There was a 1-week washout period between the doses. Plasma concentrations of cisapride were monitored by an LC/MS method for over a period of 36 h after each administration. AUC(area under the plasma concentration- time curve from time zero to infinity) was calculated by the linear trapezoidal and extrapolation method. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma drug concentration-time data. Analysis of variance (ANOVA) revealed that there are no differences in AUC, $C_{max}$ and $T_{max}$ between the formulations. The apparent differences between the formulations in these parameters were all far less than 20% (i.e., 6.8, -6.6 and 1.8% for AUC, $C_{max}$ and $T_{max}$, respectively). Minimum detectable differences(%) at $\alpha$=0.05 and 1-$\beta$=0.8 were all less than 20% in these parameters between the formulations (i.e., 16.5, 11.4 and 16.4% for AUC, $C_{max}$ and $T_{max}$, respectively). The 90% confidence intervals for these parameters were also within 20% (i.e., -2.9~ 16.4, -13.2~0.1 and -7.8~ 11.4% for AUC, $C_{max}$ and $T_{max}$, respectively). These results satisfy the bioequivalence criteria of the Korea Food and Drug Administration (KFDA) guidelines (No. 98-51). Therefore, these results indicate that the two formulations of cisapride are bioequivalent and, thus, may be prescribed interchangeably.hangeably.y.hangeably.

• Journal of the Korean Society for Railway
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• v.17 no.5
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• pp.342-348
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• 2014

Contact between wheel and rail leads to the creep phenomenon. Linear creep theory, assuming linear increase in the creep force vs creep, results in a critical speed at which the vibration of a railway vehicle goes to infinity. However, the actual creep force converges to a limited value, so that the vibration of a railway vehicle cannot increase indefinitely. In this study, the dynamics of a railway vehicle is investigated with a 6 DOF bogie model includingthe nonlinear creep curves of Vermeulen, Polach, and a newly calculated creep curve with strip theory. Strip theory considers the profiles of the wheel and rail. The results show that the vibration of a railway vehicle results in a limit-cycle over a specific running speed, and this limit-cycle becomes smaller as the slope of the creep-curve steepens. Moreover, a hunting phenomenon is caused due to flange contact, which restricts the magnitude of the limit-cycle.

• The Mathematical Education
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• v.57 no.4
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• pp.353-369
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• 2018

This study started with the following questions. Suppose that students do not accept various forms of geometric series tasks as the same task. Also, let's say that the approach was different for each task. Then, when they realize that they are the same task, how will students connect the different approaches? This study is a process of pro-actively confirming whether or not such a question can be made. For this purpose, three students in the second grade of high school participated in the teaching experiment. The results of this study are as follows. It also confirmed how the students think about the various types of tasks in the geometric series. For example, students have stated that the value is 1 in a series type of task. However, in the case of the 0.999... type of task, the value is expressed as less than 1. At this time, we examined only mathematical expressions of students approaching each task. The problem of reachability was not encountered because the task represented by the series symbol approaches the problem solved by procedural calculation. However, in the 0.999... type of task, a variety of expressions were observed that revealed problems with reachability. The analysis of students' expressions related to geometric series can provide important information for infinite concepts and limit conceptual research. The problems of this study may be discussed through related studies. Perhaps more advanced research may be based on the results of this study. Through these discussions, I expect that the contents of infinity in the school field will not be forced unilaterally because there is no mathematical error, but it will be an opportunity for students to think about the learning method in a natural way.

• Nuclear Engineering and Technology
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• v.54 no.1
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• pp.1-10
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• 2022

This study discusses the effect of using ²³²Th instead of ²³⁸U on the neutronic characteristics and the main operating parameters of the pressurized water reactor (PWR). MCNPX version 2.7 was used to compare the neutronic characteristics of UO₂ with (Th, ²³⁵U)O₂ and (Th, ²³³U) O₂. Firstly, the infinity multiplication factor (K_inf), thermal neutron flux, and power distribution have been studied for the investigated fuel types. Secondly, the effect of Gd₂O₃ and Er₂O₃ on the K_inf and on the radial thermal neutron flux and thermal power has been investigated to distinguish which of them is more suitable than the other in reactivity management. Thirdly, to illustrate the effectiveness of ²³²Th in decreasing the inventory of both the actinides and non-actinides, the concentration of plutonium (Pu) isotopes and minor actinides (MAs) has been simulated with the fuel burnup. Besides, due to their large thermal neutron absorption cross-section, the concentrations of ¹³⁵Xe, ¹⁴⁹Sm, and ¹⁵¹Sm with the fuel burnup have been investigated. Finally, the main safety parameters such as the reactivity worth of the control rods (ρ_CR), the effective delayed neutron fraction β_eff, and the Doppler reactivity coefficient (DRC) were calculated to determine to which extent these fuel types achieve the acceptable limits.

• Biomolecules & Therapeutics
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• v.30 no.6
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• pp.510-519
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• 2022

Tofacitinib, a Janus kinase 1 and 3 inhibitor, is mainly metabolized by CYP3A1/2 and CYP2C11 in the liver. The drug has been approved for the chronic treatment of severe ulcerative colitis, a chronic inflammatory bowel disease. This study investigated the pharmacokinetics of tofacitinib in rats with dextran sulfate sodium (DSS)-induced ulcerative colitis. After 1-min of intravenous infusion of tofacitinib (10 mg/kg), the area under the plasma concentration-time curves from time zero to time infinity (AUC) of tofacitinib significantly increased by 92.3%. The time-averaged total body clearance decreased significantly by 47.7% in DSS rats compared with control rats. After the oral administration of tofacitinib (20 mg/kg), the AUC increased by 85.5% in DSS rats. These results could be due to decreased intrinsic clearance of the drug caused by the reduction of CYP3A1/2 and CYP2C11 in the liver and intestine of DSS rats. In conclusion, ulcerative colitis inhibited CYP3A1/2 and CYP2C11 in the liver and intestines of DSS rats and slowed the metabolism of tofacitinib, resulting in increased plasma concentrations of tofacitinib in DSS rats.

• Advances in concrete construction
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• v.13 no.5
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• pp.385-394
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• 2022

Recently, an increasing number of cutting-edged studies have shown that designing a smart active control for real-time implementation requires piles of hard-work criteria in the design process, including performance controllers to reduce the tracking errors and tolerance to external interference and measure system disturbed perturbations. This article proposes an effective artificial-intelligence method using these rigorous criteria, which can be translated into general control plants for the management of civil engineering installations. To facilitate the calculation, an efficient solution process based on linear matrix (LMI) inequality has been introduced to verify the relevance of the proposed method, and extensive simulators have been carried out for the numerical constructive model in the seismic stimulation of the active rigidity. Additionally, a fuzzy model of the neural network based system (NN) is developed using an interconnected method for LDI (linear differential) representation determined for arbitrary dynamics. This expression is constructed with a nonlinear sector which converts the nonlinear model into a multiple linear deformation of the linear model and a new state sufficient to guarantee the asymptomatic stability of the Lyapunov function of the linear matrix inequality. In the control design, we incorporated H Infinity optimized development algorithm and performance analysis stability. Finally, there is a numerical practical example with simulations to show the results. The implication results in the RMS response with as well as without tuned mass damper (TMD) of the benchmark building under the external excitation, the El-Centro Earthquake, in which it also showed the simulation using evolved bat algorithmic LMI fuzzy controllers in term of RMS in acceleration and displacement of the building.

• Earthquakes and Structures
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• v.25 no.3
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• pp.187-198
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• 2023

Model Predictive Control (MPC) is an advanced control approach that uses the current states of the system model to predict its future behavior. In this article, according to the seismic dynamics of structural systems, the Predictive Functional Control (PFC) method is used to solve the control problem. Although conventional PFC is an efficient control method, its performance may be impaired due to problems such as uncertainty in the structure of state sensors and process equations, as well as actuator saturation. Therefore, it requires the utilization of appropriate estimation algorithms in order to accurately evaluate responses and implement actuator saturation. Accordingly, an extended PFC is presented based on the H-ifinity (H∞) filter (HPFC) while considering simultaneously the saturation actuator. Accordingly, an extended PFC is presented based on the H-ifinity (H∞) filter (HPFC) while considering the saturation actuator. Thus, the structural responses are formulated by two estimation models using the H∞ filter. First, the H∞ filter estimates responses using a performance bound (𝜃). Second, the H∞ filter is converted into a Kalman filter in a special case by considering the 𝜃 equal to zero. Therefore, the scheme based on the Kalman filter (KPFC) is considered a comparative model. The proposed method is evaluated through numerical studies on a building equipped with an Active Tuned Mass Damper (ATMD) under near and far-field earthquakes. Finally, HPFC is compared with classical (CPFC) and comparative (KPFC) schemes. The results show that HPFC has an acceptable efficiency in boosting the accuracy of CPFC and KPFC approaches under earthquakes, as well as maintaining a descending trend in structural responses.

• Journal of Information Technology Services
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• v.22 no.1
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• pp.75-93
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• 2023

The game industry has grown not only by combining them with various technologies also introducing new types of business models such as P2P, F2P, and P2W. Furthermore, games which implemented X2E model with blockchain technology are recently in the spotlight of the public attention. As domestic game companies have also prospect the blockchain games feasible, they are seeking ways to expand their global market share by strengthening the X2E model. Hence, by carrying this new business model out, it is expected to diversify their global revenue stream, which was previously confined to Asia region. This study analyzed the case of companies that have implemented the P2E and C2E models in order to suggest the direction of development for the game platform in Web 3.0 era. The cases of P2E game platform, which constitute of Axie Infinity and Mir 4, encompass the compensation structure, the stabilization mechanism of the in-game token economy, and future strategies regarding blockchain gaming. Likewise, the platform structure, business model, and future growth potential was discussed in terms of C2E scheme, focusing on the ZEPETO and Roblox cases. Based on the above case analysis, this study attempted to provide information on the current limitations and development directions of the P2E and C2E platforms. The current limitations in legal and industrial aspects should be addressed to facilitate the blooming of blockchain and P2E game industry. In addition, the necessity of not only social support also improvement on the technology and social stigma of full-time creators is ought to be emphasized in an effort to encourage the development of C2E platforms.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.26 no.6A
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• pp.1001-1011
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• 2006

It is a general agreement that exact statistical solutions can be found by a Monte Carlo technique. Due to difficulties, however, in the numerical generation of random fields, which satisfy not only the probabilistic distribution but the spectral characteristics as well, it is recognized as relatively difficult to find an exact response variability of a structural response. In this study, recognizing that the random field assumes a constant over the domain under consideration when the correlation distance tends to infinity, a semi-theoretical solution of response variability is proposed for general structures. In this procedure, the probability density function is directly used. It is particularly noteworthy that the proposed methodology provides response variability for virtually any type of probability density function, and has capability of considering correlations between multiple random variables.