• The Korean Journal of Physiology and Pharmacology
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• 제10권2호
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• pp.85-94
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• 2006

A splanchic artery occlusion for 90 min followed by reperfusion of the mesenteric circulation resulted in a severe form of circulatory shock, characterized by endothelial dysfunction, severe hypotension, marked intestinal tissue injury, and a high mortality rate. The effect of defibrotide, a complex of single-stranded polydeoxyribonucleotides having antithrombotic effect, was investigated in a model of splanchnic artery occlusion (SAO) shock in urethane anesthetized rats. Occlusion of the superior mesenteric artery for 90 min produced a severe shock state, resulting in a fatal outcome within 120 min of reperfusion in many rats. Defibrotide (10 mg/kg body weight) 10 min prior to reperfusion significantly improved mean arterial blood pressure in comparison to vehicle treated rats (p＜0.05). Defibrotide treatment also significantly attenuated in the increase of plasma amino nitrogen concentration, intestinal myeloperoxidase activity, intestinal lipid peroxidation, infiltration of neutrophils in intestine and thrombin induced adherence of neutrophils to superior mesentric artery segments. Superoxide anion and hydrogen peroxide production in $1{\mu}M$ formylmethionylleucylphenylalanine (fMLP)-activated PMNs was inhibited by defibrotide in a dose-dependent fashion. Defibrotide effectively scavenged hydrogen peroxide, but not hydroxyl radical. Treatment of SAO rats with defibrotide inhibited tumor necrosis factor-${\alpha}$, and interleukin-1${\beta}$ productions in blood in comparison with untreated rats. These results suggest that defibrotide partly provides beneficial effects by preserving endothelial function, attenuating neutrophil accumulation, and antioxidant in the ischemic reperfused splanchnic circulation

• 한국농공학회논문집
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• 제59권6호
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• pp.29-37
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• 2017

In this study, we analyzed the impacts of land surface characteristics on spatially and temporally distributed soil moisture values at the Yongdam and Soyang-river dam watersheds in 2014 and 2015. The soil moisture, NDVI (Normalized Difference Vegetation Index) and temperature values at the spatio-temporal scales were estimated using satellite-based MODIS (MODerate Resolution Imaging Spectroradiometer) products. Then the Pearson correlations between soil moisture and land surface characteristics (NDVI, temperature and DEM-digital elevation model) were estimated and analyzed, respectively. Overall, the monthly soil moisture values at the time step were highly influenced by the precipitation amounts. Also, the results showed that the soil moisture has the strong correlation with DEM while the temperature was inversely correlated with the soil moisture. However the monthly correlations between NDVI and soil moisture were highly varied along the time step. These findings indicated that water loss near the land surface are highly occurred by soil and plant activities as evapotranspiration and infiltration during the no/less precipitation period. But the high precipitation amounts reduce the impacts of land surface characteristics because of saturated condition of land surface. Thus these results demonstrated that soil moisture values are highly correlated with land surface characteristics. Our findings can be useful for water resources/environmental management, agricultural drought, etc.

• Restorative Dentistry and Endodontics
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• 제19권1호
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• pp.45-63
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• 1994

128 freshly extracted human molars were used to study the interaction between dentinal smear layer removal with various agents, and the shear bond strength of a light cured glass ionomer cement to dentin. It was proposed that the removal of smear layers using acidic cleaners followed by incorporation of Fe mordant with dentin could enhanced the infiltration of monomer component in light curing glass ionomer cement and resulted in a high bond strength. For the first treatment process for removal of smear layers on the surfaces of dentin, 50 % citric acid, 10% maleic acid and 10 % phosphoric acid were used, and for the second treatment process, 15% ferric chloride, 6.8% ferric oxalate or 30% potassium oxalate were used. Distilled water was used as a control. After double sequential treatment on dentin, a light curing glass ionomer cement was bonded to dentin. After being immersed in water at 31'C for 24 hours, shear bond strengths were measured Instron testing machine(Model No.4202, USA). Surface changes were also observed using SEM (Hitachi, S-2300, Japan) after treatment process with each agents. The following conclusions were drawn : 1. Dentin surface cleaned with maleic acid and treated with ferric oxalate showed the highest bond strength with light curing glass ionomer cement. 2. Bond strengths of glass ionomer cement to dentin treated with maleic acid or citric acid were the highest, and that treated with phosphoric acid showed the lowest. 3. The effect of ferric oxalate on shear bond strength to dentin was always higher than that of ferric chloride. 4. The smear layers were clearly removed and the orifices of dentinal tubules were opened widely by the citric acid, maleic acid and phosphoric acid. 5. The orifices of dentinal tubules opened after using the first solution were closed with the treatment of ferric chloride. 6. The precipitate like crystals were formed on dentin surfaces and tubules, but a significant decrease in bond strength of glass ionomer cement to dentin surface treated with potassium oxalate.

• Archives of Plastic Surgery
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• 제45권1호
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• pp.14-22
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• 2018

Background Liposuction has become one of the most frequently performed procedures in the field of aesthetic surgery. Fat embolism syndrome after liposuction can easily be overlooked or underestimated; however, occasionally, fulminating fat embolism syndrome can develop and lead to a critical situation within 2-3 days after lipoplasty. Changes over time in the amount of circulating fat particles and the histology of major organs have not yet been studied. Methods This study was conducted using 18 male Sprague-Dawley rats aged 12 weeks and weighing 500-628 g (average, 562 g). Fifteen rats were used as the experimental group and 3 as the control group. Under general anesthesia, tumescent-technique liposuction was performed at the lateral flank areas and abdomen for 1 hour. Blood, lung, and brain tissue specimens were obtained at 1 hour, 1 day, and 2 days after the liposuction procedure. Results The average number of fat particles in the blood samples was 25,960/dL at 1 hour, 111,100/dL at 24 hours, and 21,780/dL at 48 hours. The differences between study groups were statistically significant. Both intravascular and extravascular fat particles with inflammation were seen in all 15 rats, as were inflammatory cell infiltration, hemorrhage, and consolidation with shrinkage of the lung alveoli. Conclusions These results imply that there is a strong possibility of fat embolism syndrome after liposuction in real clinical practice, and the first 24-48 hours after the operation were found to be the most important period for preventing pulmonary embolism and progression to fulminating fat embolism syndrome.

• Toxicological Research
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• 제33권4호
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• pp.325-332
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• 2017

3-Bromo-4,5-dihydroxybenzaldehyde (BDB) is a natural bromophenol compound that is most commonly isolated from red algae. The present study was designed to investigate the anti-inflammatory properties of BDB on atopic dermatitis (AD) in mice induced by 2,4-dinitrochlorobenzene (DNCB) and on lipopolysaccharide (LPS)-stimulated murine macrophages. BDB treatment (100 mg/kg) resulted in suppression of the development of AD symptoms compared with the control treatment (induction-only), as demonstrated by reduced immunoglobulin E levels in serum, smaller lymph nodes with reduced thickness and length, a decrease in ear edema, and reduced levels of inflammatory cell infiltration in the ears. In RAW 264.7 murine macrophages, BDB (12.5, 25, 50, and $100{\mu}M$) suppressed the production of interleukin-6, a proinflammatory cytokine, in a dose-dependent manner. BDB also had an inhibitory effect on the phosphorylation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-${\kappa}B$) and signal transducer and activator of transcription 1 (STAT1; Tyr 701), two major signaling molecules involved in cellular inflammation. Taken together, the results show that BDB treatment alleviates inflammatory responses in an atopic dermatitis mouse model and RAW 264.7 macrophages. These results suggest that BDB may be a useful therapeutic strategy for treating conditions involving allergic inflammation such as atopic dermatitis.

• 생명과학회지
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• 제22권3호
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• pp.298-305
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• 2012

Lutein은 식물에서 발견되는 carotenoid 계열에 속하는 물질로 항산화 기능을 가지고 있는 것으로 널리 알려져 있지만, 호흡기 질환과 관련하여 아직까지 lutein의 효능과 작용 기작이 잘 알려져 있지 않다. Ovalbumin (OVA)으로 유도한 천식(asthma) 생쥐모델에서 lutein은 기도 과민성을 억제하였고, 기관지 폐포 세척액에서 OVA의 감작에 의하여 증가한 각종 염증성 지표들을 감소시켰다. 또한, OVA의 감작에 의하여 증가한 제2형 협조 T 세포(Th2 cell)의 증가된 반응을 약화시키는 결과를 볼 수 있었다. 본 실험에서 lutein이 ovalbumin (OVA)으로 유도한 천식 생쥐 모델에서 제 2형 협조 T세포의 싸이토카인과 유전자 발현을 조절할 수 있는 면역약리학적 기능을 할 수 있는 물질로서의 가능성이 있음을 확인할 수 있었다.

• 한국산학기술학회논문지
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• 제13권8호
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• pp.3307-3314
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• 2012

농어촌 주택 표준모델에 대한 연간 건물에너지요구량을 DesignBuilder를 사용하여 계산하였다. 실내설정온도, 외벽의 열관류율, 창호타입, 환기량을 변화시키며 건물의 설계/운영 변수들이 에너지요구량에 미치는 영향을 분석하였다. 건물의 크기와 상관없이 난방에너지요구량이 냉방에너지요구량보다 더 큰 것으로 나타났다. 단열재 두께를 증가시켜 외벽의 열관류율을 감소시키면 단열효과의 증가로 난방에너지요구량은 감소하지만 냉방에너지요구량이 증가한다. 하지만 외벽의 열관류율 조절을 통한 난방에너지요구량의 절감에는 한계가 있으므로 외부에 직접 노출된 외벽의 면적을 최소화하는 것이 더 효과적인 것으로 판단된다. 계산에 사용된 4가지 창호 중 일반 이중창호가 난방에너지요구량 측면에서 가장 유리한 것으로 나타났다. 침기량은 일정하게 유지하고 단위시간당 환기량을 증가시킨 경우 냉방에너지요구량은 큰 변화가 없었으나 난방에너지요구량이 증가하였다. 실내의 공기질이 만족되는 범위 내에서 환기량을 최소화하는 것이 연간 건물에너지요구량을 줄이는데 유리한 것으로 판단된다.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2011년도 학술발표회
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• pp.89-89
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• 2011

한 유역에서 유출 모형의 성공을 좌우할 수 있는 중요한 요소 중 하나는 강수 손실량(precipitation loss)을 결정하는 것이다. 손실량은 홍수 예측이나 수자원 평가를 위한 유출 모형의 주요 입력 자료가 된다. 만족할 만한 유출 모형을 구현하기 위해서는 손실량의 정확한 평가가 요구된다(Najafi, 2003). 총 강우량 중에서 손실량을 뺀 초과 강우량 또는 유효 강우량은 치수적 측면이든 이수적 측면에서 요구되는 직접 유출량(direct runoffs)에 상당하는 규모로서 유출 모형에서 매우 중요하다. 이제까지 많은 경우에 직접 유출되는 유효 강수량은 총강수량에서 주요 손실량 성분인 침투량을 감하여 산출하여 왔다. 이 때 침투량은 호우사상별로 적게는 유출량의 30%에서 많게는 100%까지 차지할 만큼 주요한 손실 성분으로 취급되었다(Chow, 1964 ; Singh, 1989). 침투량을 산정하기 위한 기존 모형내 포함되는 매개변수 값은 실용적으로 잘 정립되지 않았기 때문에 유출 모형에 실제 적용하는데 어려움이 있다. 한편 침투량 산정 모형 중에 Horton 모형은 가장 잘 알려져 있는 모형 중 하나이다(Horton, 1939 ; 1940). 후속 성과(Blake et al., 1968; Rawls et al., 1976)은 있었지만 모형내 매개변수 값을 결정해야 하는 실용상의 어려운 점이 있다(Singh, 1989). 그리고 국내 초과 강수량 산출 모형에 관한 연구사례가 다수(조홍제,1986; 남선우와 최은호, 1990; 정성원과 김승, 1991; 안태진 등, 2000; 박햇님과 조원철, 2002; 유주환, 2006) 있었지만 시간적으로 연속함수를 갖는 Horton 침투 모형을 실무적으로 이산화 하여 적용할 수 있도록 하는 방법의 절차 및 원칙이 제시되지 않아 유출 모형에 직접 적용하기 쉽지 않은 형편이다. 이에 본 발표에서는 한 유역에서 Horton 매개변수를 결정한 기존 연구(2006, 유주환)의 성과를 적용한 Horton 침투모형을 강수사상별 이산화한 시간별로 적용하는 절차와 적용 원칙을 소개하고자 한다.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2015년도 학술발표회
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• pp.456-456
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• 2015

최근 집중호우 및 돌발홍수로 인한 물관련 피해가 늘어감에 따라 도시화된 유역의 물관리 연구에 많은 초점이 모아지고 있다. 도시 유역의 물순환에 대한 하나의 해결방법으로 각광받고 있는 LID(Low Impact Development)에 관한 많은 연구가 이루어지고 있다. 본 연구에서는 법정행정구역도를 따라 온천천 유역을 각 동별로 나누어 LID를 설치하였을 때 적용 효과가 가시적으로 나타나는 소유역을 확인하기 위하여 SWMM 모형을 통해 시뮬레이션을 실시하였다. LID 요소기술로는 토지피복에 따라 주택지에는 옥상녹화, 도로에는 투수성포장을 설치하여 각 동별로 LID 적용 전 후에 대한 유출량, 침투량, 첨두유량, 유출계수 등을 비교 및 분석하는 연구를 수행하였다. 온천천 유역 14개 동에 대한 분석을 실시한 결과, 유출량 감소율의 경우 수민동(85.24%), 거제동(83.23%), 명장동(82.81%), 침투량 증가율은 수민동(162.8%), 안락동(105.1%), 복산동(71.03%) 순으로 하천 주변의 거주지가 밀집된 지역에 가시적인 효과가 나타났으며, 첨두유량 감소율은 청룡동(81.82%), 장전동(80.37%) 부곡동(79.39%) 순으로 소유역의 경사가 급한 지형에 효과가 좋은 것으로 나타났다. 유출계수 감소율은 유출량 감소율의 경우와 마찬가지로 나타났다. 도시 유역에 보다 나은 물순환을 위하여 LID 요소기술을 설치할 때 저감시키거나 증가시키려는 매개변수를 확실히 선정하는 것이 LID 효과를 극대화 할 수 있다는 점을 확인하였다.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2016년도 학술발표회
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• pp.202-202
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• 2016

Despite the potentially major influence of rainstorm patterns on the prediction of shallow landslides, this relationship has not yet received significant attention. In this study, five typical temporal rainstorm patterns with the same cumulative amount and intensity components comprising Advanced (A1 and A2), Centralized (C), and Delayed (D1 and D2) were designed based on a historical rainstorm event occurred in 2006 in Mt. Jinbu area. The patterns were incorporated as the hydrological conditions into the Transient Rainfall Infiltration and Grid-based Regional Slope-stability Model (TRIGRS), in order to assess their influences on pore pressure variation and changes in the stability of the covering soil layer in the study area. The results revealed that not only the cumulative rainfall thresholds necessary to initiate landslides, but also the rate at which the factor of safety (FS) decreases and the time required to reach the critical state, are governed by rainstorm pattern. The sooner the peak rainfall intensity occurs, the smaller the cumulative rainfall threshold, and the shorter the time until landslide occurrence. Left-skewed rainfall patterns were found to have a greater effect on landslide initiation. More specifically, among the five different patterns, the Advanced storm pattern (A1) produced the most critical state, as it resulted in the highest pore pressure across the entire area for the shortest duration; the severity of response was then followed by patterns A2, C, D1, and D2. Thus, it can be concluded that rainfall patterns have a significant effect on the cumulative rainfall threshold, the build-up of pore pressure, and the occurrence of shallow landslides, both in space and time.