• Journal of Ginseng Research
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• 제39권1호
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• pp.38-45
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• 2015

Background: Korean ginseng is a well-known medicinal herb that has been widely used in traditional medicine to treat various diseases, including asthma. Ginseng can be classified as white ginseng (WG) or red ginseng (RG), according to processing conditions. In this study, the authors compared the efficacies of these two ginseng types in a mouse model of acute asthma. Methods: To produce the acute asthma model, BALB/c mice were sensitized with ovalbumin (OVA) and aluminum hydroxide, and then challenged with OVA. WG and RG extracts were administered to mice orally. The influences of WG and RG on airway hyperresponsiveness (AHR), immune cell distributions in bronchoalveolar lavage fluid (BALF), and OVA-specific immunoglobulin E (IgE), IgG1, and IgG2a in serum were investigated. Cytokine production by lymphocytes isolated from peribronchial lymph nodes and histopathological changes was also examined. Results: In OVA-sensitized mice, both WG and RG reduced AHR and suppressed immune cell infiltration in bronchoalveolar regions. BALF OVA-specific IgE levels were significantly lower in RG-treated OVAsensitized mice than in the OVA-sensitized control group. WG and RG also suppressed inflammatory cytokine production by peribronchial lymphocytes. Histopathological findings showed reduced inflammatory cell infiltration and airway remodeling (e.g., epithelial hyperplasia) in WG- and RG-treated OVA mice compared with OVA controls. Conclusion: In this study, WG and RG showed antiasthmatic effects in an OVA-sensitized mouse model, and the efficacies of RG were found to be better than those of WG.

• Toxicological Research
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• 제24권4호
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• pp.273-280
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• 2008

The single intratracheal instillation (ITI) of bleomycin (BLM) is a widely used method for inducing experimental pulmonary fibrosis in rat model. In the present study, pulmonary function tests (PFTs) of tidal volume ($V_T$), minute volume ($V_M$), and respiratory frequency ($F_R$) have been applied to study their possibility as a tool to monitor the progress of BLM-induced lung injury in rat model. Rats were treated with a single ITI of BLM (2.5 mg/kg) or saline (control). Animals were euthanized at 3, 7, 14, 21, and 28 days post-ITI. Lung toxicity effects were evaluated by inflammatory cell count, lactate dehydrogenase (LDH) activity in the bronchoalveolar lavage fluid (BALF), and light microscopic examination of lung injury. The PFT parameters were measured immediately before the animals were sacrificed. BLM treatment induced significant cellular changes in BALF-increase in number of total cells, neutrophils, and lymphocytes along with sustained increase in number of macrophages compared to the controls at days 3, 7, and 14. BALF LDH level was significantly increased compared to that in the controls up to day 14. On day 3, infiltration of neutrophils was observed in the alveolar spaces. These changes developed into marked peribronchiolar and interstitial infiltration by inflammatory cells, and extensive thickening of the interalveolar septa on day 7. At 14, 21, and 28 days, mild peribronchiolar fibrosis was observed along with inflammatory cell infiltration. The results of PFT show significant consistencies compared to the results of other toxicity tests. These data demonstrate that the most suitable time point for assessing lung fibrosis in this model is 14 days post-ITI of BLM based on the observation of fibrosis at 14, 21, and 28 days. Further, the progress of lung injury can be traced by monitoring the PFT parameters of $F_R$, $V_T$, and $V_M$.

• Journal of Radiation Protection and Research
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• 제28권3호
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• pp.239-245
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• 2003

Every nuclear power plant measured concentrations of tritium in groundwater and surface water around the plants periodically. It was not easy to predict the tritium concentration only with these measurement data in case of various release scenarios. KAERI developed a new approach to find the relationship between the tritium release rate and tritium concentration in the environment. The approach was based upon a dynamic compartment model. In this paper the dynamic compartment model was modified to predict the tritium behavior more accurately. The mechanisms considered for the transfer of tritium between the compartments were evaporation, groundwater flow, infiltration, runoff, and hydrodynamic dispersion. Time dependent source terms of the compartment model were introduced to refine the release scenarios. Also, transfer coefficients between the compartments were obtained using realistic geographical data. In order to illustrate the model various release scenarios were developed, and the change of tritium concentration in groundwater and surface water around the nuclear power plants was estimated.

• 한국농공학회지
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• 제30권2호
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• pp.95-104
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• 1988

This study refers to the development of a hydrologic model simulating daily inflow and release rates for inigation reservoirs. A daily - based model is needed for adequate operation of an irrigation reservoir sufficing the water demand for paddy fields which is closely related to meteorological conditions. And the objective of this study is to develop a reservoir release rate model and then to calibrata the parameters. The release rates model considers daily water demands , water supply for transplanting, minmum release for maintaining canal flow, and maxirnun and regular flooding depth for determining effective rainfall on paddy fields. Each of the factors in the model was regarded as a lumped pararuter representing the average condition of a whole irrigated area. The water demand was estimated form the potential evapotranspiration by Penman method, the effective rainfall, and the infiltration on paddy fields. The release model was found to be capable of adequately simulating daily reservoir releases based on meteorological data.

• 한국해양환경ㆍ에너지학회지
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• 제11권4호
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• pp.227-231
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• 2008

본 연구에서는 연안사질 조간대에 표착된 기름의 방제를 위한 화학적 방제법의 적용 가능성을 파악하기 위해서 사질 조간대에서 유처리분산제의 살포에 의한 해수침투량의 변화 및 표착유의 거동을 검토하는 것을 목적으로 하여, 모의 조간대 실험장치를 이용하여 실험을 실시하였다. 파도에너지가 비교적 작은 사질 조간대에서 표착된 원유에 의해서 해수의 침투량이 감소되었으나, 분산제를 살포함으로 인해 해수침투량이 약 30% 증가되는 것을 알 수 있었다. 사질 조간대에 표착한 원유는 토양표층 2 cm부분에서 가장 농도가 높은 경향을 나타내었으며, 유화분산제를 살포하였을 경우 침투된 기름이 작은 입자로 분산되어 토양중으로 분산되었다. 따라서 표착된 원유에 분산제를 살포함으로 인해 저서생물의 생존에 필수적인 용존산소, 영양염, 유기물 등의 공급이 회복되어 저서생물에게 생존에 긍정적인 영향을 미칠 것으로 판단된다. 또한 표착된 기름에 유처리분산제를 살포함으로 인해 표착된 기름이 작은 유적으로 분산되어 비 표면적의 증대로 인한 기름분해 미생물의 분해가 촉진되어 표착유의 처리에 효과적일 것으로 사료된다.

• 한국농공학회논문집
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• 제48권1호
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• pp.71-79
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• 2006

In Korea, most landslides occurred during the rainy season and had a shallow failure plane parallel to the slope. For these types of rainfall-induced failures, the most important factor triggering slope unstability is decrease in the matric suction of unsaturated soils with increasing saturation depth by rainfall infiltration. The saturation depth was readily estimated using modified Green-Ampt model proposed by Chu et al. (Chu Model) at present. But Chu Model involves some problems for application, because water-redistribution phenomena were not effected. So the modified Chu Model (MCGAM) which reflect water redistribution phono mens was developed. The results showed that the MCGAM had a better agreement with measured volumetric water contents than existing Chu Model.

• 대한한의학방제학회지
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• 제21권1호
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• pp.131-141
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• 2013

Objectives : This study was performed to assess the ameliorative effects of Gagam-GongJin-dan (WSY-1075) composited with Corni Fructus, Angelica gigantis Radix, Lycii Fructus, Ginseng Radix, Cervi parvum Cornu and Cinnamomi Cortex in contact dermatitis animal model. Methods : WSY-1075 was orally administrated the various concentrations (50-400 mg/kg, body weight/day) with one time per day for 10 days from 4 days after DNFB sensitization. We investigated ameliorative effects of WST-1075 on the scratching behavior, skin clinical serverity and inflammatory mediators in 2,4-dinitrofluorobenzene (DNFB)-induced contact dermatitis mice. Results : The orally administration of WSY-1075 (400 mg/kg) inhibited the scratching behavior induced by sensitization and challenge with DNFB. WSY-1075 (200 mg/kg or 400 mg/kg) administration also reduced the skin damage, inflammatory mediators, mast cell infiltration induced by DNFB. Moreover, WSY-1075 (above 200 mg/kg) administration inhibited the serum levels of IgE and IL-4 in DNFB-induced contact dermatitis mice. Conclusions : These results suggest that WSY-1075 administration (200 mg/kg or 400 mg/kg) has the ameliorative effects on the scratching behavior, the clinical signs, mast cell infiltration and inflammatory mediators in DNFB-induced contact dermatitis animal model mice.

• Journal of Yeungnam Medical Science
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• 제35권2호
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• pp.192-198
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• 2018

Background: Chronic inflammation can lower the seizure threshold and have influence on epileptogenesis. The components of red ginseng (RG) have anti-inflammatory effects. The abundance of peripherally derived immune cells in resected epileptic tissue suggests that the immune system is a potential target for anti-epileptogenic therapies. The present study used continuous electroencephalography (EEG) to evaluate the therapeutic efficacy of RG in intrahippocampal kainic acid (IHKA) animal model of temporal lobe epilepsy. Methods: Prolonged status epilepticus (SE) was induced in 7-week-old C57BL/6J mice via stereotaxic injection of kainic acid (KA, 150 nL; 1 mg/mL) into the right CA3/dorsal hippocampus. The animals were implanted electrodes and monitored for spontaneous seizures. Following the IHKA injections, one group received treatments of RG (250 mg/kg/day) for 4 weeks (RG group, n=7) while another group received valproic acid (VPA, 30 mg/kg/day) (VPA group, n=7). Laboratory findings and pathological results were assessed at D29 and continuous (24 h/week) EEG monitoring was used to evaluate high-voltage sharp waves on D7, D14, D21, and D28. Results: At D29, there were no differences between the groups in liver function test but RG group had higher blood urea nitrogen levels. Immunohistochemistry analyses revealed that RG reduced the infiltration of immune cells into the brain and EEG analyses showed that it had anticonvulsant effects. Conclusion: Repeated treatments with RG after IHKA-induced SE decreased immune cell infiltration into the brain and resulted in a marked decrease in electrographic seizures. RG had anticonvulsant effects that were similar to those of VPA without serious side effects.

• Composites Research
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• 제34권4호
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• pp.249-256
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• 2021

본 논문에서는 화학기상침투법(CVI) 공정으로 제작되는 탄소/탄소 복합재의 밀도화 과정을 수치해석적으로 연구하였다. 이를 위해 선행 연구에서 개발된 전산유체역학 모델과 반응로 내 주요 화학 반응 모델을 연계한 다중물리 수치해석 모델을 이용하여, 섬유 프리폼의 밀도와 공극률 변화를 다양한 측면에서 분석하였다. 특히 프리폼 주변 기체 유동의 형태에 따른 밀도화 변화를 알기 위해, 특정 형상의 구조물을 프리폼 주변에 배치시켜 유동을 변화시킨 후 프리폼의 밀도화를 계산하였다. 총 4가지 다른 형태의 구조물로 해석한 결과 프리폼 주변의 유동 형태 및 속도 분포를 구조물 형상으로 제어할 수 있었으며, 프리폼의 평균 밀도를 높이거나 밀도 편차를 감소시키는 것이 가능함을 확인하였다. 본 연구에서는 실제 산업 현장에서 사용되는 반응로와 공정 조건을 모델로 이용하였다.

• 한국수자원학회논문집
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• 제56권12호
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• pp.855-869
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• 2023

도심지의 잦은 홍수피해를 해결하기 위한 대책으로 저영향개발기법은 지속적으로 연구중에 있다. LID는 도시화의 영향으로 부터 물순환을 회복하기 위해 강우유출 지점에서 침투 및 저류를 기반으로 개발이전의 물순환 상태로 회복하기 위해 도입된 기술이다. 그 중 식생저류지는 LID 요소중 하나로 우수유출수의 침투 및 저류를 통해 유출량을 감소하고, 비점오염원 저감 효과를 가지고 있다. 식생저류지의 연구는 지속적으로 수행되었으나 소유역 규모에서의 정량적 성능연구는 부족한 실정이다. 본 연구에서는 정량적 수문해석을 할 수 있는 K-LIDM (Korea-Low Impact Development Model)을 활용하여 식생저류지 유역 구축을 통해 유출량 저감성능 분석을 수행하였다. 연구결과는 추후에 유역특성, 식생유형 및 토양상태 등 여러가지 변수들을 포함한 연구수행시 참고자료로 활용될 수 있을것으로 사료된다.