• 한국농공학회지
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• 제30권3호
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• pp.58-68
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• 1988

Most of the Korean watersheds are mountaineous and consist of various soil types and land uses And seldom watersheds are found to have long term hydrologic records. The SNUA, a hydrologic watershed model was developed to meet the unique characteristics of Korean watershed and simulate the storm hydrographs from a small mountaineous watershed. Also the applicability of the model was tested by comparing the simulated storm hydrographs and the observed from Dochuk watershed, Gwangjugun, Kyunggido The conclusions obtained in this study could be summarized as follows ; 1. The model includes the simulation of interception, evaporation and infiltration for land surface hydrologic cycle on the single storm basis and the flow routing features for both overland and channel systems. 2. Net rainfall is estimated from the continuous computation of water balance at the surface of interception storage accounting for the rainfall intensities and the evaporation losses at each time step. 3. Excess rainfall is calculated by the abstraction of infiltration loss estimated by the Green and Ainpt Model from the net rainfall. 4. A momentum equation in the form of kinematic wave representation is solved by the finite differential method to obtain the runoff rate at the exit of the watershed. 5. The developed SNUA Model is a type of distributed and event model that considers the spatial distribution of the watershed parameters and simulates the hydrograph on a single storm basis. 6. The results of verification test show that the simulated peak flows agree with the observed in the occurence time but have relative enors in the range of 5.4-40.6% in various flow rates and also show that the simulated total runoff have 6.9-32% of relative errors against the observed. 7. To improve the applicability of the model, it was thought that more studies like the application test to the other watersheds of various types or the addition of the other hydrologk components describing subsurface storages are needed.

• 한국환경과학회지
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• 제23권2호
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• pp.207-218
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• 2014

A ventilation model was developed for predicting the air change per hour(ACH) in buildings and the airflow rates between zones of a multi-room building. In this model, the important parameters used in the calculation of airflow are wind velocity, wind direction, terrain effect, shielding effect by surrounding buildings, the effect of the window type and insect screening, etc. Also, the resulting set of mass balance equations required for the process of calculation of airflow rates are solved using a Conte-De Boor method. When this model was applied to the building which had been tested by Chandra et al.(1983), the comparison of predicted results by this study with measured results by Chandra et al. indicated that their variations were within -10%~+12%. Also, this model was applied to a building with five zones. As a result, when the wind velocity and direction did not change, terrain characteristics influenced the largest and window types influenced the least on building ventilation among terrain characteristics, local shieldings, and window types. Except for easterly and westerly winds, the ACH increased depending on wind velocity. The wind direction had influence on the airflow rates and directions through openings in building. Thus, this model can be available for predicting the airflow rates within buildings, and the results of this study can be useful for the quantification of airflow that is essential to the research of indoor air quality(temperature, humidity, or contaminant concentration) as well as to the design of building with high energy efficiency.

• 한국지반신소재학회논문집
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• 제7권4호
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• pp.9-18
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• 2008

우리나라에서는 강우로 인한 얕은 사면파괴 형태를 흔하게 볼 수 있다. 즉, 강우시 발생하는 사면의 얕은 파괴는 지표로 침투하는 강우에 의한 포화깊이 증가에 의해 발생한다. 본 연구에서는 침투가 사면 표면이 안정에 미치는 영향을 평가하기 위해 한계평형법을 이용하는 무한사면 해석방법을 적용하였다. 재현기간에 따른 강우강도와 지속기간이 고려되는 임의의 강우에 의해 유발되는 얕은 사면파괴의 가능성을 평가하기 위해서 일차원 침투모델인 Green-Ampt 모델에 바탕을 둔 침투능에 따른 침투깊이를 산정한 Pradel & Raad 방법을 이용하였다. 즉, 이론해에 의한 결과와 비교하기 위하여 동일한 조건으로 SEEP/W를 통한 수치해석을 수행하였다. 결과, 화강풍화토의 함수특성곡선을 이용하여 불포화사면의 강도정수를 추정하여 계산된 불포화 지반의 해석이 기존 포화사면의 해석에 비하여 보다 정확한 결과임을 알 수 있었다.

• 대한기관식도과학회지
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• 제14권2호
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• pp.43-47
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• 2008

Background : Anti-reflux procedures treat gastroesophageal reflux (GER) disease. It is known that gastroesophageal reflux is likelyrelated to the increased incidence of chronic rejection in lung transplantation recipients. Because experimental animal studies areto verify this, we have tried to make an animal model of GER in a rat. Material and Methods : Using the SD rats weighing 250-300 g, we surgically induced gastroesophageal reflux and measured the gastrostomy time under anesthesia. Of three groups, Group I was the control, Group II had lower esophageal and anterior myotomy, and Group III had lower esophageal and anterior myotomy plusdiaphragmatic crural myotomy.The animals were scarified, and lung biopsies and histological examinations were performed 1 week, 2 weeks, 4 weeks, 8 weeks and 3 months after gastroesophageal reflux surgery. Results : Baseline animals (n=5) had no GER after charcoal instillation through a gastrostomy tube in Group I. Charcoal-laden macrophages were observed in GroupsII and III. To determine evidence of GER evidence, charcoal was instillated through the gastrostomy tube in group III. In contrast, Group II demonstrated severe neurophil infiltration in the bronchioles and alveolar walls after procedure. After 12 weeks, we observed the disappearance of neurophil, lymphocyte and histiocyte infiltration, and also occasional focal bronchopneumonia and bronchitis. Group III demonstrated neurophil and basophil infiltration in the bronchioles and alveolar walls which was more severe than that in Group II. Interstitial fibrotic changes were observed in Group III.Conclusion : The purpose of our gastroesophageal reflux model was to find evidence of aspiration. There was more evidence of aspiration in Group II than in either of theother two groups.

• 한방안이비인후피부과학회지
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• 제32권2호
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• pp.1-10
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• 2019

Objectives : The objective of present study is to evaluate anti-inflammatory and anti-allergic effects of Perilla(Perilla frutescens; Labiatae, PF), the roots of Peucedanum praeruptorum(PP) and the root of Scutellaria baicalensis(SB) in vitro and anti-asthmatic effects of mixture of PF, PP and SB(PS) on ovalbumin (OVA)-induced asthma in BALB/c mice. Methods : Anti-inflammatory and anti-allergic effects were observed on the lipopolysaccharide(LPS) treated RAW 264.7 cells through Nitric Oxide(NO) production and RBL-2H3 cells through ${\beta}$-hexosaminidase. Anti-asthmatic effects were observed on the number of inflammatory cells in bronchoalveolar lavage fluid(BALF) and the level of IgE in serum on OVA-induced BALB/c mice. Results : The treatment of PF, PP and SB(12.5, 25, 50, $100{\mu}g/m{\ell}$) resulted in a significant inhibition of NO production in RAW 264.7 cells and mast cell degranulation in RBL-2H3 cells. Oral administration of PS(400mg/kg/day) resulted in a significant reduction in the numbers of eosinophils in BALF and level of IgE in serum. Conclusion : The oral administration of PS is effective in ameliorating the eosinophilic infiltration in vivo and thus can be a good therapeutic candidate for allergic asthma.

• 한국지반공학회논문집
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• 제31권2호
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• pp.5-11
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• 2015

비탈면의 안정성은 강우지속시간, 확률강우강도, 지반의 불포화특성, 지반강도 등에 의해 영향을 받는다. 최근 비탈면안정성 해석은 지반의 침투특성을 고려한 불포화해석을 수행하고 있으며, 불포화 토사비탈면에 대한 연구는 시간변화에 따라 지반의 변형과 응력분포해석을 고려할 수 있도록 하는 방향으로 진행되고 있다. 그러나 이와는 별개로 불포화사면의 침투특성은 강우강도나 지속시간 뿐만 아니라 비탈면의 지형여건과 녹화상태에 따라서도 침투정도가 다르지만, 이에 대한 영향은 고려하지 않고 있다. 본 연구에서는 비탈면경사 및 표면상태에 따른 침투를 고려하기 위하여 토양의 수리특성을 고려한 모형을 사용하고, 토사비탈면에 대한 불포화해석을 수행하여 비탈면 경사에 따른 영향을 파악하였다. 연구결과 비탈면 안정해석시 동일한 강우조건 하에서도 비탈면경사에 따른 침투율이 고려되어야 할 필요성을 제시하였다.

• 대한토목학회논문집
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• 제33권2호
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• pp.559-571
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• 2013

최근에 불투수층의 증가로 인하여 지표면의 저류량이 감소하고 첨두유출과 전체 지표면유출은 증가하고 있다. 첨두유출량의 증가와 빠른 도달시간으로 인하여 도시유역의 홍수 피해가 증가하고 있다. 또한 토양으로 침투되는 강우량이 감소하여 지하수위가 하강한다. 그러므로 도시하천의 건천화가 진행되어 유역의 물 순환이 악화된다. 따라서 본 연구에서는 건천화 문제를 감소시킬 수 있는 방안중 하나인 투수성 포장의 침투실험을 통하여 투수효과를 정량적으로 분석 및 평가하였다. 또한 SWMM 모형을 창원천 및 남천 유역에 적용하여 침투실험에서 얻어진 투수계수를 이용하여 투수성 포장의 물순환 영향을 분석하였다.

• Journal of Ginseng Research
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• 제47권5호
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• pp.672-680
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• 2023

Background: Korean Red Ginseng (KRG), the steamed root of Panax ginseng, has pharmacological activities for immunological and neurodegenerative disorders. But, the role of KRGE in multiple sclerosis (MS) remains unclear. Purpose: To determine whether KRG extract (KRGE) could inhibit demyelination in corpus callosum (CC) of cuprizone (CPZ)-induced murine model of MS Methods: Male adult mice were fed with a standard chow diet or a chow diet supplemented with 0.2% (w/w) CPZ ad libitum for six weeks to induce demyelination while were simultaneously administered with distilled water (DW) alone or KRGE-DW (0.004%, 0.02 and 0.1% of KRGE) by drinking. Results: Administration with KRGE-DW alleviated demyelination and oligodendrocyte degeneration associated with inhibition of infiltration and activation of resident microglia and monocyte-derived macrophages as well as downregulation of proinflammatory mediators in the CC of CPZ-fed mice. KRGE-DW also attenuated the level of infiltration of Th1 and Th17) cells, in line with inhibited Mrna expression of IFN-γ and IL-17, respectively, in the CC. These positive effects of KRGE-DW mitigated behavioral dysfunction based on elevated plus maze and the rotarod tests. Conclusion: The results strongly suggest that KRGE-DW may inhibit CPZ-induced demyelination due to its oligodendroglial protective and anti-inflammatory activities by inhibiting infiltration/activation of immune cells. Thus, KRGE might have potential in therapeutic intervention for MS.

• The Plant Pathology Journal
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• 제24권3호
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• pp.296-304
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• 2008

The transient and rapid expression system of a foreign protein in planta is a very useful technique in biotechnology application. We have investigated optimum condition of Agrobacterium-infiltration technique in which expression level of foreign proteins were maximized without detrimental effects on plants using GFP and Cucumber mosaic virus 2b protein, which is known as an enhancer of gene expression and a suppressor of post-transcriptional gene silencing(PTGS). The optimum expression level of both RNA and protein of GFP with minimum leaf impairment was obtained at $OD_{600}$=0.2 of Agrobactrium inocula. The steady-state levels of GFP RNA and protein generally peaked at 3 and 7 days post-infiltration(dpi), respectively. In the presence of 2b, both the magnitude and duration of GFP expression was highly increased and we could detect GFP level until 17 dpi. On the other hands, the 2b-mediated higher accumulation of foreign proteins resulted in the repression of normal leaf growth, possibly due to the limitation of supply of energy or materials required for growth maintenance. Using this Agrobacterium-infiltration system with 2b and GFP, we tested a hypothesis for the threshold model of PTGS initiation. Four GFP transgenic lines of N. benthamiana, which shows different expression level of GFP were tested to determine the threshold level for PTGS initiation. Agrobacterium-infiltration of GFP into those GFP-transgenic plants resulted in the co-silencing of the transgenic GFP. It was found that very low concentration of Agrobacterium with GFP and GFP+2b($OD_{600}$=0.002-0.02) which could not phenotypically induce an additive GFP expression, was enough to trigger PTGS pathway in all GFP transgenic plants. This strongly indicates that each GFP-transgenic plant should be expressing the transgenic GFP at its own pre-determined level and there was no buffer zone of additive GFP-expression to the threshold. In other words, the PTGS seems to be immediately activated as a self-defensive mechanism if an internal balance of gene expression is broken.

• 한국수자원학회논문집
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• 제41권2호
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• pp.127-135
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• 2008

하수관거 개량사업의 주된 목적은 Inflow/Infiltration (I/I)를 제거 및 통수능력 확보이다. 최근 노후 하수관거의 개 보수 및 신설 사업이 활발히 이루어지고 있으나 현재의 사업들은 관거 데이터의 부족, 유량 및 수질 자료의 장기적인 측정 미비 등으로 인하여 효율적인 사업을 진행시키기에 무리가 있다. 본 연구에서는 하수관거 개량사업을 보다 효율적으로 진행시키기 위하여 Rehabilitation Weighting Model (RWM)과 Rehabilitation Priority Model (RPM)로 구성된 의사결정모형을 개발하였다. RWM은 시간 및 예산상의 제약으로 인하여 주요 지점에서만 관측되는 I/I를 상류의 각 관거별로 I/I를 산정하며, 관거별 I/I는 Analytic Hierarchy Process (AHP)를 통하여 산정된 8개 결함항목별 가중치에 따라서 결정된다. RPM은 Genetic Algorithm (GA)를 이용하여 소유역별 최적개량우선순위를 산정한다. 이것은 공사 기간 중 발생하는 I/I를 최소화시키기 위한 소유역별 공사 순서를 설정함으로써 하수처리장의 처리비용을 절감시킴으로써 하수관거 개량사업의 효율적인 시행을 위한 판단 기준을 제시해준다.