• 대한세포병리학회지
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• 제8권2호
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• pp.143-149
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• 1997

Salivary duct carcinoma is rare high grade adenocarcinoma, arising from larger excretory duct in major salivary gland, resembling the ductal carcinoma of the breast histologically. We report a case of salivary duct carcinoma of left parotid gland in which fine needle aspiration cytology was performed. Cytologic examination revealed 1) moderate cellularity, 2) flat sheets or three dimensional, tightly cohesive clusters on the necrotic background, 3) sometimes cribriform or papillary configuration, 4) polygonal or cuboidal cells with moderate anisonucleosis with abundant, granular and eosinophilic cytoplasm, 5) round to oval nuclei with irregular chromatin clumps, and 6) 1 or 2 inconspicuous nucleoli. Histologically, the tumor is mainly composed of cribriform intraductal component with central comedonecrosis, and small foci of infiltrating component including well differentiated ductal structures or irregular sheets in a desmoplastic stroma.

• 대한세포병리학회지
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• 제3권2호
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• pp.52-59
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• 1992

A number of studies have shown the value of fine needle aspiration cytology for the diagnosis of breast lesions, but reports on the comparison of cytologic and histologic variations of breast cancers are few. We reviewed histologically proven 106 breast aspirates with an emphasis on the cytology of ductal carcinomas and of an area of uncertain atypia. Positive and negative predictive values of breast aspiration cytology were 100% On review of the cases originally diagnosed as atypia of uncertain nature (19 %), features more suggestive of malignancy or benignancy were recognizable in most underdiagnosed cases and a half of overdiagnosed cases, respectively. However, indistinguishable atypism also remained. Thirty seven cases out of 53 infiltrating duct carcinomas revealed malignant cytology, with variations in background, cellularity, morphology of cell groups, and extent of isolated tumor cells. When classifying the infiltrating duct carcinomas into scirrhous, solid-tubular, and papillotubular types, scirrhous type frequently appeared as irregularly shaped tight or loose cell clusters, and solid-tubular type as round-margined cell balls.

• Asian Pacific Journal of Cancer Prevention
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• 제17권3호
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• pp.1393-1397
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• 2016

Background: Breast cancer is the most common cancer and the first cause of cancer death in women worldwide, with infiltrating duct carcinoma as the most common morphology. This study aimed to investigate trend of breast cancer incidence by age groups and histological changes in Iranian women between 2003 and 2008. Materials and Methods: This is analytic study, carried out based on re-analysis of the Cancer Registry Center report of health deputy for women's breast cancer in Iran during a 6-year period (2003-2008). Statistical analysis for incidence time trends and morphology change percentage carried out joinpoint regression analysis using the software Joinpoint Regression Program. Results: A total of 36,340 cases were reported for Iranian women in the six years. Analytical trend showed an increasing incidence trend with significant annual percentage change (APC) of 15.2 (CI: 11.6 to 18.8). The lowest and highest significant increased trend were related to age groups of 40 to 44 years and above 85 years, respectively; with APCs of 13.0 and 25.1, respectively. Of total cases, 78.7% of cases were infiltrating duct carcinoma, decreasing from 82.0% in 2003 to 76.6% in 2008, which was significant with an APC equal to -1.76 (CI:-2.7 to -0.8). Conclusions: The incidence trend of breast cancer is rising in Iranian women. The highest incidence was observed in the age groups 45-65 and 80-85. In conclusion, to reduce breast cancer incidence and its burden, preventive and screening programs for breast cancer, especially in young women, are recommended in Iran.

• Asian Pacific Journal of Cancer Prevention
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• 제17권4호
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• pp.2195-2198
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• 2016

Background: Breast cancer is the most prevalent malignancy among women with wide differences in clinical profile from region to region. The present study aimed to describe the profile of breast cancer patients attending a tertiary care hospital in Marathwada region of Western India. Materials and Methods: In this descriptive retrospective study, we reviewed records of pathologically diagnosed patients of breast cancer managed at our center from years 2009 to 2015. Data with respect to demographic status, detailed past, medical, familial and personal history, findings of clinical examination and histological features were obtained. Patients were staged according to the Tumor Node Metastasis (TNM) system. Results: Among 260 cases, mean age of presentation was 52.6, with average age of menarche of 11.3 and menopause of 52.6 years. The majority of patients were from urban regions and were postmenopausal (64.3%). Main clinical features presentation were breast lumps. Most patients were in stage II and had infiltrating duct carcinomas. Conclusions: Most common risk factors for breast cancer observed are increasing age, low parity and obesity. Breast cancer was more prevalent among postmenopausal women presenting in stage II with infiltating duct carcinoma in our region of India.

• Asian Pacific Journal of Cancer Prevention
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• 제14권6호
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• pp.3815-3817
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• 2013

Background: Breast cancer is a common cancer worldwide. With the establishment of Thailand's population-based cancer registry and availability of complete data from 2002-2011, it is of interest to investigate the epidemiologic and clinic-pathological profiles of breast cancer based on the population-based registry data. Methods: The data of all breast cancer patients in the registry for the period of 2002-2011 were included. All medical records of the patients diagnosed from documents of National Cancer Registry of Thailand were retrieved and the following information abstracted: age, clinical characteristics, and histological variables. Thailand census data for the period of 2002-2011 were used to provide the general population's statistics on age, gender, and other related demographic factors. Results: Over the 10 year-period, 7,711 breast cancer cases were included. The disease incidence under age 40 years was relatively low (4.13/$10^5$) while the incidence in the age groups 40 and older was very high (39.2/$10^5$). The vast majority of breast cancer cases (88.8%) were diagnosed by histology as primary lesions in the breast. The most common of patients with breast cancer (36.4%) had regional lymph node involvement and the most common of histopathology diagnosed in patients (84.2%) was an infiltrating duct carcinoma. Conclusions: This study showed a high incidence of breast cancer in older subjects, and high rate of breast cancer in Thailand. Future studies should explore clinical and molecular disease patterns.

• 대한방사선기술학회지:방사선기술과학
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• 제30권4호
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• pp.357-363
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• 2007

본 연구는 2005년 통계청의 전국 인구비율에 대한 발표를 기준으로 노인 인구 비율이 가장 낮고 광역도시 중 유방암의 조발생률과 연령표준화발생률이 가장 낮은 지역을 중심으로 외래에 내원하여 검사한 유방촬영술과 유방초음파 검사에서 질환별 발생빈도와 검사 분포를 조사하였다. 연중 유방검사 빈도는 7월과 8월에서 가장 많은 검진을 한 것으로 조사되었으며, 연령별 분포는 40대가 39.8%, 30대가 32.4%의 순으로 조사되었다. 외래에 내원하여 검진한 환자 중 질환별 분포는 유방초음파 검사에서 43%가 비정상 소견을 보였다. 그 중 치밀조직과 소결절이 21.5%, 섬유낭종이 8.3%의 순으로 진단 소견을 보였다. 유방촬영술에서는 치밀조직과 소결절이 41.3%, 양성석회화가 6.4%의 순으로 조사되었다. 검사 유형별 조사에서는 유방초음파 검사가 8개 질환으로 세분되어 판독되었고 유방촬영술은 6개 질환에서 진단 소견을 보여 구체적인 질환의 명시가 부족한 것으로 나타났다. 이 지역에서 외래 진료로 유방검사를 실시한 검사자 중 46%가 비정상 소견을 보인 것으로 나타났다.

• 대한핵의학회지
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• 제33권1호
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• pp.76-83
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• 1999

목적: 유방종괴의 악성과 양성을 구별하는 데 사용되고 있는 탈륨스캔의 조기스캔 및 지연스캔과 함께 Tc-99m MIBI 스캔을 시행하여 이들을 비교하였다. 대상 및 방법: 유방종괴를 호소한 환자 38명을 대상으로 탈륨의 조기스캔과 지연스캔 및 Tc-99m MIBI 스캔을 얻었다. 탈륨스캔은 74-111 MBq의 탈륨을 정맥주사한 후 10분과 3시간에 촬영을 하고, 이어서 555-740 MBq의 Tc-99m MIBI를 정맥주사하고 30분 후에 전면상과 측면상을 얻어 서로 비교하였다. 결과: 38명의 환자 중 23예가 악성 종양으로, 15예가 양성 종양이었다. 유방암 진단의 민감도와 특이도는 탈륨 조기스캔이 100% (23/23)와 73% (11/15), 탈륨 지연스캔이 82% (18/22)와 73% (l1/15), Tc-99m MIBI 스캔이 90% (18/20)와 83% (10/12)로서 탈륨 조기스캔의 민감도가 탈륨 지연스캔보다 유의하게 높았으나(p<0.05), 다른 지표의 유의한 차이는 없었다. 탈륨 조기스캔과 지연스캔에서 위양성을 보인 섬유선종 3예와 비정형 상피세포증식증 1예의 종괴의 크기는 음성으르 나온 11예의 양성 종양보다 유의하게 컸다(p<0.01). 액와부 림프절 전이의 진단적 민감도는 탈륨 조기스캔이 38% (5/13), 탈륨 지연스캔이 15% (2/13), Tc-99m MIBI 평면스캔이 58% (7/12), 단층영상이 67% (4/6)였다. Tc-99m MIBl 평면, 단층영상이 탈륨 지연스캔보다 높았다. 결론: 유방암 진단에서 탈륨의 조기스캔과 Tc-99m MIBI스캔은 진단능에서 차이가 없었으나 탈륨 지연스캔은 민감도가 낮았다. 액와부 림프절 전이의 진단에는 탈륨스캔보다 Tc-99m MIBI 스캔이 우수하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권11호
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• pp.4577-4581
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• 2015

Background: To explore the hospitalizations of breast cancer patients undergoing mastectomy, and to provide a basis for management, clinical prevention and treatment. Materials and Methods: We conducted an investigation by means of the retrospective survey and the medical records retrieval system, and made out the data of patients suffered from breast cancer in a hospital in Guangzhou from 2004 to 2013, including age, medical payment methods, pathological type, treatment, treatment results, complications, hospitalization days, cost and so on. Results: The average age of the inpatients was 50.14 years old. The main histologic types were infiltrating duct carcinoma (88.06%). The main surgery was modified radical mastectomy (80.41%). The cure rate was 90.80% during the 10 years. The main medical payment method was self-paying (57.28%). The average hospital stay was 13.51 days, and average hospitalization cost was RMB 23,083.66 yuan, proportion of drug fees up to 39.70%. Postoperative complication rate was 0.79%. The self-paying group was with the highest proportion of drug fees (P<0.05), while the free medical service group was with the longest hospitalization days (P<0.05). Conclusions: The payment methods significantly affected the proportion of drug fees and hospitalization days. The therapeutic effect was satisfactory with less complications and reasonable proportion of drug fees in our hospital.

• Asian Pacific Journal of Cancer Prevention
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• 제14권4호
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• pp.2231-2235
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• 2013

Background: Categorizing breast tumors based on the ER, PR and HER/Neu 2 receptor status is necessary in order to predict outcome and assist in management of breast cancer. Herfe we assessed this question in South Indian patients. Materials and Methods: A total of 619 formalin fixed paraffin embedded breast tumor tissues were collected from pathology archives after receipt of ethical clearance. With the help of primary and secondary conjugated antibodies, expression status of ER, PR and HER2/neu was determined. All the experimental data were assessed for correlations with histopathological features of tumors and clinical presentation of the subjects. Results: In the present study, the ages ranged from 20-87 years with a mean of $50.0{\pm}12.q$ years, and majority of the tumors (84%) were of infiltrating duct cell carcinoma type. Assessment of ER, PR and Her-2/neu expression showed that 46% were triple negative. Interestingly, an inverse relation between ER, PR and HER-2/neu was apparent in 41.2% (p<0.0001) of the tumors, of which 24.5% (p<0.0001) were ER and PR co-negative but HER-2 positive. Conclusions: ER and PR positive tumors are less common (i.e<30%) compared to HER-2/neu positive tumors (i.e>50%) in Indian breast cancer patients, underlining the need for effective diagnostic screening and specific therapeutic managements in order to improve the survival rate of patients in low resource countries such as India.