• Pediatric Infection and Vaccine
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• 제29권3호
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• pp.155-160
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• 2022

코로나19로 확진된 소아와 청소년은 대개 경한 증상을 나타내며 SARS-CoV-2 감염으로 인한 다기관 기능부전은 매우 드물다. 저자들은 코로나19 예방접종을 완료한 16세 청소년에게서 발생한 다기관을 침범한 심한 SARS-CoV-2 감염에 대해 보고하고자 한다. 환자는 내원 당시 의식이 없었으며 심한 마비성장폐색증이 있었다. 혈액검사 상 심한 대사성 산증과 함께 림프구감소증, 혈소판감소증, 염증 수치 상승, 간수치 상승, 단백뇨와 혈뇨가 동반된 급성 신손상의 증거가 있었다. 환자의 상태는 렘데시비르와 덱사메타손 투여와 함께 점차 호전되었다. 코로나19 확진 2주 후에 환자는 다기관염증증후군을 짧게 경험하였으나 특별한 합병증 없이 퇴원하였다.

• Pediatric Infection and Vaccine
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• 제31권1호
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• pp.140-146
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• 2024

소아 다기관 염증 증후군(multisystem inflammatory syndrome in children, MIS-C)은 코로나바이러스감염증-19 (코로나 19; coronavirus disease 2019, COVID-19)의 드문 합병증으로 심장, 폐, 신장, 소화관 및 신경계를 포함한 다기관 손상을 일으킨다. 코로나19 팬데믹 이후 MIS-C 사례가 증가함에 따라 MIS-C에 대한 적절한 치료의 중요성이 강조되고 있다. anakinra, infliximab, 스테로이드와 같은 면역 조절제는 MIS-C에 대한 intravenous immunoglobulin (IVIG)의 1차 치료에 대한 추가 요법으로 고려되지만 cytomegalovirus (CMV), Epstein-Barr 바이러스 및 결핵과 같은 2차 감염을 유발할 소지가 있다. 저자들 MIS-C로 IVIG, steroid 및 infliximab을 투여한 환자에서 동반된 CMV 감염으로 인하여 약 한달간 지속되는 발열이 발생한 3세 남아의 증례 1례를 처음으로 보고하였다.

• Pediatric Infection and Vaccine
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• 제31권1호
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• pp.136-139
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• 2024

횡문근융해증(rhabdomyolysis) 근육세포의 파괴에 따라 근세포 내 물질이 세포 외부액과 혈액으로 방출되어 증상이 나타나며, 주로 외상, 근효소 결핍, 감염, 전해질 불균형, 약물, 내분비 질환 등에 의해 유발될 수 있다. 본 연구에서는 SARS-CoV-2 감염이 확인된 7세 남아에서 나타난 횡문근융해증 사례를 보고하고자 한다. 또한, 질병 스펙트럼, 치료 및 결과를 확인하기 위한 체계적인 문헌 고찰을 수행하였다. 검색 결과, 코로나19 감염 후 7건의 횡문근융해증 보고 사례를 확인하였다. 그 중 5건은 발열이 있었으며 크레아틴 키나제(creatine phosphokinase, CK)는 3,717에서 274,664 IU/L 범위에 속하였다. 두 명은 중환자실에서 치료를 받았으며 두 명은 신장 대체 요법을 받았으며 한 명을 제외하고 모두 생존하였다. 코로나19 감염 후 횡문근융해증이 나타날 수 있으며, 근육 통증을 호소하는 소아에서의 소변 색상의 철저한 검사 및 혈액 검사를 통한 근육 효소의 평가가 진단과 치료에 도움이 될 수 있다.

• 한국산업보건학회지
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• 제30권2호
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• pp.109-123
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• 2020

Objectives: The aims of this study were to review the standards and key components of the standards for disposable masks in Korea, the US, EU, Japan, and China and to evaluate the appropriateness of disposable masks during a virus pandemic. Methods: We reviewed the standards in the above countries and compared their key elements for each standard. For the second purpose, systemic paper gathering using key words like 'mask', 'respirator' 'virus', and 'coronavirus' in the PubMed search engine was performed. Fifty-three papers were selected and reviewed in regard to the appropriateness of test protocols with sodium chloride(NaCl) particles for virus filtration and the effectiveness against viruses. Results: The standards for masks are largely divided into two categories: US standards and EU standards. In Korea, the Ministry of Employment and Labor adapted the EU standards for workers and the Health Masks adopted the Ministry of Employment and Labor standards by the Ministry of Food and Drug Safety. Regarding airborne viral infections, WHO emphasizes only droplet infection, while many studies have shown that small particles enter the air through coughing or sneezing, which increases the possibility of airborne infection. Compared to other particles, various factors such as airborne viability and the ability to replicate the virus in the body are further involved in the virus's airborne infection rate. Airborne infection is classified into absolute air infection, preferential air infection, and opportunistic air infection. The NaCl-certified N95 mask showed good filtration efficiency against viruses and NaCl particles were proved to be a surrogate material for viruses. From this, KF94 is also expected to be effective in blocking viruses. Conclusion: The N95 test method could be used as a surrogate test method for virus filtration. N95-class masks have been found to effectively block viral infections in the air. However, surgical or medical masks are only partially effective against airborne virus infection though they could effectively block large droplet infection. However, most studies considered in this study targeted N95 in foreign countries and studies on masks actually used in Korea are very limited, so studies on microorganisms and reuse on domestic masks should be conducted in the future.

• 한국응급구조학회지
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• 제26권2호
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• pp.47-59
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• 2022

Purpose: This study aimed to survey coronavirus disease (COVID-19) related knowledge, preventive possibility, and preventive behaviors levels among college students and identify the correlation between these variables. Methods: An online survey was conducted among college students from October 25 to November 5, 2021. The data were analyzed by an independent t-test and Pearson's correlations. Results: A total of 344 college students participated. The correct answer rate for COVID-19 knowledge level was high, infection and preventive possibility levels were moderate, and the anxiety level was high. Infection possibility had a positive correlation with anxiety and preventive behaviors had a positive correlation with preventive possibility. Conclusion: The findings regarding COVID-19 perception can be used to develop appropriate health policies for infectious disease prevention behaviors in educational fields.

• 대한후두음성언어의학회지
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• 제33권3호
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• pp.183-187
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• 2022

Dysphonia is well known as one of the otolaryngological symptoms of coronavirus disease 2019 (COVID-19) infection. The vocal changes of the COVID-19 condition have been reported in terms of parameters of multi-dimensional voice assessment, including acoustic analysis, auditory-perceptual evaluation, and psychometric assessment. However, there has not been a daily followup study in patients with acute COVID-19 infection. In this study, a 41-year-old male performed daily voice recordings of vowel phonation and passage-reading tasks during the self-quarantine period of one week. Compared to the normal voice status of the prepandemic period, voice abnormalities peaked on day two after the diagnosis of COVID-19 infection and recovered after one week.

• Korean Journal of Radiology
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• 제21권7호
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• pp.851-858
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• 2020

Coronavirus disease 2019 (COVID-19) is a new infectious disease rapidly spreading around the world, raising global public health concerns. Radiological examinations play a crucial role in the early diagnosis and follow-up of COVID-19. Cross infection among patients and radiographers can occur in radiology departments due to the close and frequent contact of radiographers with confirmed or potentially infected patients in a relatively confined room during radiological workflow. This article outlines our experience in the emergency management procedure and infection control of the radiology department during the COVID-19 outbreak.

• 한국직업건강간호학회지
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• 제25권1호
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• pp.1-8
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• 2016

Purpose: The 2015 Korean Middle East Respiratory Syndrome Coronavirus (MERS-CoV) outbreaks resulted in 186 cases, with 8% (15 persons) of these being nurses. This study aimed to examine MERS-CoV infection status of clinical nurses and to evaluate perception for infection control. Methods: We investigated the MERS-CoV infection status of nurses using MERS-CoV press release data. We examined and analysed perception for Infection control of 121 nurses of the three MERS intensive therapeutic hospitals in July 2015. Results: One to six nurses per hospital in total 8 health care facilities were infected with MERS-CoV. They mainly had short clinical careers and were unaware of infection possibility. The personal and organizational infection control levels that nurses perceive were low and the relationship between two levels was statistically significant. Conclusion: For promoting health protection and infectious disease management competency of nurses, it is necessary to prepare institutional system for controlling infectious disease.

• Journal of Preventive Medicine and Public Health
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• 제54권4호
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• pp.245-250
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• 2021

Objectives: Jeju Province in Korea reported 627 coronavirus disease 2019 (COVID-19) cases between January 20, 2020, and March 31, 2021. This study analyzed the sources of infection among confirmed cases in Jeju Province, a self-governed island. Methods: The sources of infection were broadly categorized as follows: (1) infections from overseas (confirmed patients who reported travel overseas or contact with overseas travelers); (2) infections from outside Jeju Province (confirmed patients who had visited other provinces or had contact with individuals who had traveled to other provinces in Korea); and (3) unknown sources of infection (confirmed patients who were infected following contact with an infected person whose source of infection was unknown). The chi-square test was used to analyze the differences in the distributions of related variables for each source of infection. Results: Of the 627 confirmed cases, 38 (6.1%) were infections from overseas sources, 199 (31.7%) were from outside of Jeju Province, and 390 (62.2%) were from unknown sources. Jeju Province had no cases with an unknown source of infection during the first and second waves of the nationwide outbreak. Conclusions: Infections from overseas sources could be blocked from spreading to local communities in Jeju Province by conducting screening at the airport, along with the preemptive suspension of visa-free entry. In addition, considering the scale of the nationwide outbreak, measures must be established to delay outbreaks from unknown sources of infection caused by sources outside Jeju Province.

• Journal of Microbiology and Biotechnology
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• 제30권12호
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• pp.1843-1853
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• 2020

COVID-19, caused by the novel coronavirus SARS-CoV-2, has spread globally and caused serious social and economic problems. The WHO has declared this outbreak a pandemic. Currently, there are no approved vaccines or antiviral drugs that prevent SARS-CoV-2 infection. Drugs already approved for clinical use would be ideal candidates for rapid development as COVID-19 treatments. In this work, we screened 1,473 FDA-approved drugs to identify inhibitors of SARS-CoV-2 infection using cell-based assays. The antiviral activity of each compound was measured based on the immunofluorescent staining of infected cells using anti-dsRNA antibody. Twenty-nine drugs among those tested showed antiviral activity against SARS-CoV-2. We report this new list of inhibitors to quickly provide basic information for consideration in developing potential therapies.