• Title/Summary/Keyword: Infants and children

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White matter injury following rotavirus infection in neonates: new aspects to a forgotten entity, 'fifth day fits'?

  • Yeom, Jung Sook;Park, Chan-Hoo
    • Clinical and Experimental Pediatrics
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    • 제59권7호
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    • pp.285-291
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    • 2016
  • That rotavirus infection can cause neurological symptoms in young children has been well established. However, it is surprising why rotavirus infection has been overlooked as a cause of neonatal seizures for many years, despite significant research interest in neonatal rotavirus infection. Neonates are the age group most vulnerable to seizures, which are typically attributed to a wide range of causes. By contrast, because rotavirus infection is usually asymptomatic, it has been difficult to identify an association between this virus and neonatal seizures. The conventional wisdom has been that, although neonates are commonly infected with rotavirus, neurological complications are rare in this age. However, recent studies using diffusion-weighted imaging (DWI) have suggested a connection between rotavirus infection and neonatal seizures and that rotavirus infection can induce diffuse white matter injury without direct invasion of the central nervous system. The clinical features of white matter injury in rotavirus-infected neonates include the onset of seizures at days 4-6 of life in apparently healthy term infants. The recent findings seem to contradict the conventional wisdom. However, white matter injury might not be a completely new aspect of rotavirus infection in neonates, considering the forgotten clinical entity of neonatal seizures, 'fifth day fits'. With increased use of DWI in neonatal seizures, we are just starting to understand connection between viral infection and white matter injury in neonates. In this review, we discuss the historical aspects of rotavirus infection and neonatal seizures. We also present the clinical features of white matter injury in neonatal rotavirus infection.

AHP분석을 통한 교통약자의 도로시설 이용특성에 관한 연구 (A Study on the Road Facilities Use Characteristics of the Transportation Vulnerable by AHP Analysis)

  • 김민제;이영우
    • 대한교통학회지
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    • 제33권3호
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    • pp.276-283
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    • 2015
  • 각 도시에서는 급증하는 자동차로 인해 보행자의 영역은 줄어들고 있고 보행자를 위한 도로시설의 개선은 향상되지 못하고 있어 보행자는 위험한 교통환경에 노출되고 있다. 이러한 열악한 보행환경은 비교통약자에게도 위험하지만 교통약자에게는 더욱 치명적인 위험요소가 될 수 있다. 본 연구에서는 교통약자의 교통안전을 향상시키고 보행환경을 개선하기 위해 교통약자 유형별로 도로시설 이용특성을 분석하였다. 본 연구의 방법은 교통약자를 대상으로 기존 도로의 보행시설을 이용할 때 느낀 정량적, 정성적 사항에 대한 설문조사를 실시하고 이를 바탕으로 정량적, 정성적 요소를 모두 고려한 의사결정방법인 계층 분석적 의사결정방법(AHP)을 이용한 연구를 수행하였다. 제3계층 분석결과 고령자나 장애인의 경우 일부 유사한 특성을 나타내고 있었으며 차량진출입, 도로의 기울기나 포장불량이 높은 순위의 불편요소로 나타났다. 영유아동반자의 경우 승강기가 없는 육교와 지하도가 1순위로 나타나 고령자, 장애인과 다소 차이가 있는 것으로 분석되었다.

유아 언어학습에 대한 하이퍼망 메모리 기반 모델 (Hypernetwork Memory-Based Model for Infant's Language Learning)

  • 이지훈;이은석;장병탁
    • 한국정보과학회논문지:컴퓨팅의 실제 및 레터
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    • 제15권12호
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    • pp.983-987
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    • 2009
  • 유아들의 언어습득에 있어서 중요한 점 하나는 학습자에 대한 언어환경의 노출이다. 유아가 접하는 언어환경은 부모와 같은 인간뿐만 아니라 각종 미디어와 같은 인공적 환경도 포함되며, 유아는 이러한 방대한 언어환경을 탐색하면서 언어를 학습한다. 본 연구는 대용량의 언어 데이터 노출이 영향을 미치는 유아언어학습을 유연하고 적절하게 모사하는 인지적 기제에 따른 기계학습 방식을 제안한다. 유아의 초기 언어학습은 문장수준의 학습과 생성 같은 행동들이 수반되는데, 이는 언어 코퍼스에 대한 노출만으로 모사가 가능하다. 모사의 핵심은 언어 하이퍼망 구조를 가진 기억기반 학습모델이다. 언어 하이퍼망은 언어구성 요소들 간의 상위차원 관계 표상을 가능케 함으로써 새로운 데이터 스트림에 대해 유사구조의 적용과 이용을 도모하여 발달적이고 점진적인 학습을 모사한다. 본 연구에서는 11 개의 유아용 비디오로부터 추출한 문장 32744개를 언어 하이퍼망을 통한 점진적 학습을 수행하여 문장을 생성해 유아의 점진적, 발달적 학습을 모사하였다.

유소아 기도 이물의 임상 양상과 환기형 기관지 내시경술의 결과 : 서울대 병원의 경험 120례 (Clinical Analysis for 120 Cases with Pediatric Airway Foreign Bodies)

  • 차원재;최효근;문성중;하정훈;성명훈;김광현
    • 대한기관식도과학회지
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    • 제12권2호
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    • pp.26-30
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    • 2006
  • Backgroud and Objectives: Inhalation of foreign bodies in respiratory tract can be fatal to infants and child. After ventilating bronchoscopy technique was widelyused, most of the pediatric airway foreign bodies could be managed effectively. In this study, we aimed to analyze clinicalfeatures and outcomes of ventilating bronchoscopic removal of pediatric airway foreign bodies. Materials and Methods: One hundred twenty cases of ventilating bronchoscopy for pediatric airway foreign bodies at Seoul National University Hospital for the past 15 years were analyzed retrospectively. Results: In 120 cases, sex ratio (male: female) was 2.2:1 and mean age was 27.0 months. Most frequent type of airway foreign was peanut (60.2%). One hundred thirteen patients, in whom a foreign body was confirmed in the airway, were successfully managed by ventilating bronchoscopy. Delayed diagnosis and management made a significantly long postoperative hospital stay. Conclusion: Great care must be given when feeding young children, especially younger than 36 months, with nuts. Early intervention with ventilating bronchoscopy following a clinical suspicion is critical to successful treatment.

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Outcome of Alagille Syndrome Patients Who Had Previously Received Kasai Operation during Infancy: A Single Center Study

  • Lee, Hwa Pyung;Kang, Ben;Choi, So Yoon;Lee, Sanghoon;Lee, Suk-Koo;Choe, Yon Ho
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • 제18권3호
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    • pp.175-179
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    • 2015
  • Purpose: Infants with Alagille syndrome (AGS) are occasionally misdiagnosed as biliary atresia and subsequently undergo Kasai operation. The purpose of this study was to investigate the outcome of patients with AGS who had previously received Kasai operation during infancy. Methods: This retrospective study was conducted at the Department of Pediatrics, Samsung Medical Center. We compared the prognosis and mortality between those who had undergone Kasai operation during infancy (Kasai group) and those who had not (non-Kasai group). Results: Among the 15 children with AGS, five had received Kasai operation, while 10 had not. All subjects in the Kasai group revealed neonatal cholestasis, while 70% of the non-Kasai group showed neonatal cholestasis. Liver transplantation was performed in 100% (5/5) among the Kasai group, and 20.0% (2/10) among the non-Kasai group (p=0.007). Mortality was observed in 60.0% (3/5) among the Kasai group, and 10.0% (1/10) among the non-Kasai group (p=0.077). Conclusion: Although overall mortality rate did not significantly differ between the two groups, the proportion of patients receiving liver transplantation was significantly higher in the non-Kasai group. The relatively worse outcome in AGS patients who had received Kasai operation may be due to the unfavorable influences of Kasai operation on the clinical course of AGS, or maybe due to neonatal cholestasis, irrespective of the Kasai operation.

Antiviral activity of Herba Patrinea (a Chinese medicinal herb) against respiratory syncytial virus in vitro

  • Li, Hong-Yuan;Li, Shan-Shan;Liu, Dian-Li;Dong, Yan-Mei;Tian, Wen-Jing
    • Advances in Traditional Medicine
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    • 제3권2호
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    • pp.106-110
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    • 2003
  • Respiratory syncytial virus (RSV) has long been considered an important cause of severe lower respiratory tract infection in infants and young children throughout the world. Unfortunately, no effective treatment of RSV exists. Therefore, New agents are needed to reduce the impact of RSV. We have studied the anti-viral effect of traditional Chinese midicinal herbs for over ten years and find Herba Patrinea (a Chinese medicinal herb) has the anti-RSV effect in vitro. In this study, the Herba Patrinea was extracted with hot water, condensed and sterilized. The cytotoxicity of the aqueous extract was tested by adding the diluted extract directly to HeLa cells and its effect on anti-RSV was estimated by the CPEI assay. As a result, the median cytotoxic concentration $(CC_{50})$ of Herba Patrinea was 32 mg/ ml by morphological observation, the median effective concentration (50% effective concentration, $EC_{50}$) of the Herba Patrinea against replication of the Long strain of RSV in HeLa cells were 1.25 mg/ml. The selectivity index $(SI=CC_{50}/EC{50})$ is 25.6. Moreover, Herba Patrinea gave a dose-dependent response in inhibiting RSV. In time of addition experiment, Herba Patrinea inhibited replication of RSV in HeLa cells when it was added at 0h, 2h, and 4h after virus infection. In summary, the results of this study suggest Herba Patrinea may be a novel anti-RSV drug and it is worthy of further studying.

국내 주요 정수장 수돗물의 퍼클로레이트 검출현황 (Occurrence of Perchlorate in Drinking Water in Korea)

  • 김현구;김정화;이연희
    • 한국물환경학회지
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    • 제23권6호
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    • pp.822-828
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    • 2007
  • Perchlorate is an unregulated contaminant but recently many cases of perchlorate contamination have been reported in the US. In Japan, also, a couple of contamination incidents caused by perchlorate occurred. Against this backdrop, investigation on perchlorate was urgent for Korea. Accordingly, perchlorate investigation in tap water and river water was conducted one time a week for seven consecutive weeks at major water sources of Korea including Han River, Guem River, Yeong-san River, and Nak-dong River. Perchlorate was not found at Han River, Guem River, and Yeong-san River. However, all the 4 tap water samples in Nak-dong River recorded high level of perchlorate. Among others, NT1 located at Daegu posted the highest value of $22.3{\mu}g/L$. This level is lower than $24.5{\mu}g/L$, the threshold recommended by US EPA. Still, perchlorate contamination in drinking water can deal a heavy blow to nerve development of infants and children by causing iodine deficiency. At the 1st and 2nd investigations, perchlorate concentration reached $18.7{\sim}95.6{\mu}g/L$ and $4.0{\sim}25.6{\mu}g/L$ respectively, both of which are relatively higher. The high perchlorate concentration in Nak-dong River was possible because of the waste water discharged from LCD manufacturing factory which was located at NS3 in Gumi, Korea. Perchlorate concentration of waste water from the factory was $730{\sim}1,858{\mu}g/L$.

소아환자의 점액종 치료 시 최소침습적 방법: 증례 보고 (Minimally Invasive Techniques for the Treatment of Mucoceles in Young Patients: A Case Series)

  • 김종성;김기민;이제식;김현정;남순현
    • 대한소아치과학회지
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    • 제49권1호
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    • pp.113-120
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    • 2022
  • 구강 점액종은 구강의 소타액선의 병적인 변화로 인해 타액의 축적을 야기하며 발생하는 흔한 외향성 병소이다. 구강 점액종은 대개 증상이 없으며 무통성이며 반투과성의 구상의 파동성 결절모양인 것이 특징이다. 일반적인 구강 점액종의 치료방법으로는 외과적 제거술, 조대술, 냉동절제술, 그리고 스테로이드 주사 등이 있다. 본 증례는 치료 시 협조도를 얻기에 충분하지 못한 영아나 소아환자에서 외과적인 치료 대신에 최소침습적 방법의 일환으로 미세조대술과 봉합법을 사용하여 구강에 발생한 점액종을 성공적으로 치료한 증례를 보고한다. 본 증례를 바탕으로 영유아와 행동조절에 문제가 있는 아동를 대상으로 치료하는 소아치과분야에서 구강 점액종 치료 시 미세조대술과 봉합법은 하나의 대안적 방법이 될 수 있음을 시사한다.

지역 식품을 이용한 이유 보충식의 개발과 이의 영양학적 검토 및 저장성에 관한 연구 (Development and Evaluation of the Supplementary Foods for Korean Infants and Children)

  • 안경미;문수재;최홍식;곽동경
    • Journal of Nutrition and Health
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    • 제18권4호
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    • pp.259-271
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    • 1985
  • The purpose of this study was to develop supplementary foods for infants and young children in order to improve their nutritional status. Three formulas composed of rice, soybeans, fish, dry skim milk and sesame in varying proportions were studied. The three formulas, $RS_{1}S_{2}$, $RFS_{1}S_{2}$, and $RMS_{1}S_{2}$, were consisted of Rice(R), Soybean$(S_{1})$, Sesame$(S_{2})$ (60 : 35 : 5) , Rice, Fish(F), Soybean, Sesame (60 : 10 : 25 : 5) , and Rice, Dry Skin Milk (M), Soybean, Sesame (60 : 10 : 25 : 5), respectively. A proximate analysis and amino acid determination were made on the developed formulas. In the animal assay, growth rate, PER and FER were evaluated and biochemical analyses were also carried out. A storage test and the cost evaluation were also conducted. The summarized results are as follows : 1) The proximate composition of the three formulas were 7.3-7.4% of moisture, 15.9-21.5% of crude protein, 7.8-9.6% of crude fat and 2.5-2.8% ash. 2) The result of amino acid analysis showed that the 1st limiting amino acids of $RS_{1}S_{2}$ and $RFS_{1}S_{2}$ were lysine (amino acid score, 76.6) and threonine (amino acid score, 93.3), and that of $RMS_{1}S_{2}$ and the commercially prepared formula were sulfur containing amino acids (amino acid score, 82.0 and 54.4). When the contents of the amino acids of the three formulas were compared with mother's milk and cow's milk, the balance of the amino acid of each formula was superior to mother's milk but inferior to cow's milk. 3) In the animal assay, the growth rate of all groups increased gradually during the experimental period. 4) The C- PER, which was corrected on the basis of the casein PER of 2.5 was 2.99, 3.38 and 3.10 in the $RS_{1}S_{2}$, $RFS_{1}S_{2}$ and $RMS_{1}S_{2}$ respectively. The C- PER of $RFS_{1}S_{2}$ and $RMS_{1}S_{2}$ were Significantly (P<.05) higher than that of the casein. 5) The FER of the casein, $RS_{1}S_{2}$, $RFS_{1}S_{2}$, and $RMS_{1}S_{2}$ were 0.37, 0.39, 0.43 and 0.39, respectively. The FER of $RFS_{1}S_{2}$ and $RMS_{1}S_{2}$ were also significantly (P<.05) higher than that of the casein. 6) The concentrations of hematocrit, hemoglobin, total protein and albumin in the serum of the rats of all groups were not significantly different among groups. 7) The storage stability test showed that the total plate count (TPC), the coliforms count and the bacterial spore count in the ingredients were quiet low. However, after 30 and 60 days storage, the count in $RFS_{1}S_{2}$ increased and were higher at room temperature than refrigerated temperature. 8) In the cost evaluation, the cost of the developed formulas was \1,826-2,626 / kg. This was less than that of the commercially prepared formula (\3,300-4,073 / kg) and that of the imported formula (\4,250-8,720 / kg).

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만 2세 이하 자녀를 둔 취업모의 육아지원 서비스 이용 과정 (The Process of Utilizing Childcare Support Services for Working Mothers with Children under Age 2 in South Korea)

  • 김은지;한주연;도승이;최은수;박준하
    • 한국심리학회지 : 문화 및 사회문제
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    • 제30권3호
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    • pp.267-298
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    • 2024
  • 육아지원 서비스는 여성의 원만한 사회 진출과 커리어 발전, 웰빙 향상을 위해 중요하다. 본 논문은 국내 만 2세 이하 자녀를 둔 취업모 10명의 인터뷰를 바탕으로, 근거이론분석 방법을 사용하여 육아지원 서비스 이용 과정과 심리적 경험, 일-가정 양립 계획을 탐색하였다. 분석 결과, 육아지원 서비스 이용 전 결정 과정, 육아지원 서비스 이용 중 경험, 향후 일-가정 양립 계획 범주가 도출되었다. 서비스 이용 전 결정 과정은 육아지원 서비스 정보 탐색, 선택 시 가족과의 대화, 서비스 제안과 결정의 주체, 육아지원 서비스 최종 결정의 범주로 이루어졌다. 서비스 이용 중 경험은 경제적 부담, 산후 경력에 변화, 일-가정 양립에서 기대와 실제의 차이, 삶의 질 영향 요인, 남편과의 가사 및 육아 분담이 도출되었다. 향후 일-가정 양립 계획에서는 커리어 발전 희망, 커리어 유지 희망, 커리어 일시 중단 및 축소 희망, 향후 커리어에 대한 생각이 미정의 범주가 도출되었다. 마지막으로, 향후 일-가정 양립 계획에 따라 서비스 이용 과정과 경험에서 차이가 있는지 알아보았다. 본 연구는 취업모의 일-가정 양립과 웰빙을 위한 다차원적 지원과 여성의 향후 커리어에 대한 불확실성을 줄이는 것이 필요함을 시사한다.