• Archives of Pharmacal Research
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• 제27권10호
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• pp.985-989
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• 2004

A functional divergency oriented synthetic approach to the azoninone (9-membered lactams), key intermediate for the indolizidine alkaloids library, using amide enolate induced aza-Claisen rearrangement has been achieved.

• Bulletin of the Korean Chemical Society
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• 제24권12호
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• pp.1832-1834
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• 2003

• Bulletin of the Korean Chemical Society
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• 제17권3호
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• pp.212-214
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• 1996

• Bulletin of the Korean Chemical Society
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• 제32권spc8호
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• pp.2867-2868
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• 2011

• 한국생명과학회:학술대회논문집
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• 한국생명과학회 2005년도 국제학술심포지움 The 44th Annual Meeting of Korean Society for Life Science
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• pp.111-111
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• 2005

• Bulletin of the Korean Chemical Society
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• 제29권10호
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• pp.1998-2004
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• 2008

Two synthetic pathways to substituted hexahydroimidazo[1,2-a]pyridines, which may serve as precursors of aza-alkaloids, were investigated. The first involves the condensation of a bisnucleophilic enediaminoester and a biselectrophile. The second involves attachment to nitrogen of the carbon chain skeleton required to form the six-memberd ring, before formation of the enediaminoester. Several substituted hexahydroimidazo[1,2- a]pyridines were synthesized via these two approaches.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1998년도 Proceedings of UNESCO-internetwork Cooperative Regional Seminar and Workshop on Bioassay Guided Isolation of Bioactive Substances from Natural Products and Microbial Products
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• pp.167-168
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• 1998

Swainsonine is a toxic indolizidine alkaloid found in the plant, Swainsona species (Dorling, 1978; Colgate, 1979). It is a potent inhibitor of the glycoprotein processing pathway in the Golgi apparatus. Specifically, it inhibits mannosicase II resulting in abherrant high mannose glycans. Recent studies showed that swainsonine prevents metastasis of tumor cells and it inhibits solid growth tumor, at least partially (Goss et al., 1994; Baptista et al, 1994).

• Archives of Pharmacal Research
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• 제20권6호
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• pp.545-549
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• 1997

Effects of swainsonine (SW;8${\alpha}$, ${\beta}$-indolizidine-${\alpha}$, $2{\alpha}$8-triol from Locoweed) on the humoral immune responses of lipopolysaccharide (LPS) wer studied in ICR mice. Mice were divided into 4 groups (10 mice/group), and LPS was given to each mouse 1 hr after i.p. injection with 3.7 mg/kg of swainsonine, by i.p. injection twice a week for 14 days at a dose of 2 mg/kg. Humoral immune responses were evaluated by hemagglutination (HA) titer and splenic plaque forming cells (PFC). The results of this study were summarized as follows: Mice administrated each of LPS and SW showed significant enhancement of the weight ratios of spleen to body, HA titer, 2-mercaptoethanol-resistant HA(MER-HA) titer and PFC compared with those in controls. However, the LPS plus SW treatment decreased HA titer, MER-HA titer and PFC corresponding to humoral immunity, as compared with those in the mice treated with LPS alone. These findings indicated that LPS significantly enhanced humoral immune responses, but their enhancement effects were lowered somewhat by SW.

• 약학회지
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• 제42권1호
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• pp.75-81
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• 1998

Effects of swainsonine (SW: 8${\alpha}$, ${\beta}$-indolizidine-1alpha, 2${\alpha}$, 8${\beta}$-triol from Locoweed) on the cellular and nonspecific immune responses of lipopolysaccharide (LPS) wer e studied in ICR mice. Mice were divided into 4 groups (10mice/group), and LPS was given to each mouse 1 hr after i.p. injection with 3.7mg/kg of SW by i.p. injection twice a week for 14 days at a dose of 2mg/kg. Immune responses of the delayed-type hypersensitivity response (DTH) to sheep red blood cells (s-RBC), phagocytic activity and natural killer (NK) cell activity were evaluated. LPS treatment didn`t affect NK cell activity, phagocytic activity, DTH to s-RBC compared with those in controls, and phagocytic activity of sareoma 180 tumor bearing mice. However, circulating leukocytes were significantly decreased. Combinaton of LPS and SW increased circulating leukocytes significantly compared vath that in LPS alone, and DTH to s-RBC, NK cell activity and phagocytic activities of normal and sarcoma tumor bearing mice were not affected. These findings indicate that SW didn`t affected the cellular immune responses suppressed by LPS but significantly increased circulating leukocytes.

• 대한화학회지
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• 제54권3호
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• pp.261-268
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• 2010

이 총설 논문에서는 천연물 합성에서 새로운 합성전략으로 이용될 수 있는 세가지 합성방법에 대해 간단히 소개하고자 한다. 소개된 첫 번째 방법으로는 Grubbs에 의해 개발된 루테늄 카벤 촉매 고리 전이 복분해 반응을 이용한 합성방법으로 이 방법을 이용하여 알켄기로 치환된 사이클로알켄들을 열역학적으로 더 안정한 알켄기 치환 사이클로알켄으로 전환시킬 수 있어 새로운 유기합성과정으로 소개되었다. 두 번째 Grubbs에 의해 보고된 루테늄 카벤 촉매 다이엔아인 복분해 반응을 이용한 합성방법으로 이 합성방법을 이용한 과정들은 다이엔아인 화합물들을 접합 두고리 콘쥬게이트 다이엔 화합물들을 합성할 수 있게 한다. 마지막으로 새로 개발된 피리디늄 염의 광-전자고리화반응을 이용한 4-아미노사이클로팬텐-3,5-다이올 유도체 화합물들을 합성할 수 있는 방법을 소개하였다. 이 총설에서 루테늄 카벤 촉매 고리전이와 다이엔인 복분해 반응들을 함께 연결 이용하여 폴리하이드록시 인돌리지딘 알카로이드들과 레파디포르민과 실린드리신 알카로이드들을 피리듐 염 광화학 반응법을 통해 합성한 과정들을 상세히 소개하고 있다.