• 상하수도학회지
• /
• 제34권2호
• /
• pp.149-159
• /
• 2020

Cured-in-place-pipe(CIPP) is the most adopted trenchless application for sewer rehabilitation to extend the life of the existing sewer without compromising both direct construction and indirect social costs especially applied in the congested urban area. This technology is globally and domestically known to be the most suitable for partial and full deteriorated pipe structure rehabilitation in a sewer system. The typical design of CIPP requires a significant thickness of lining to support loading causing sewage flow interruption and increasing material cost. This paper presents development of a high strength glass fiber composite lining material for the CIPP application and structural test results. The test results exhibit that the new glass fiber composite lining material has 12 times of flexural strength, 6.2 times of flexural modulus, and 0.5 Creep Retention Factor. These test results can reduce lining design thickness 35% at minimum. Even though taking into consideration extra materials such as outer and inner films for actual field applications, the structural capacity of the composite material significantly increases and it reduces 20 percent or more line thickness as compared to the conventional CIPP. We expect that the newly developed CIPP lining material lowers material costs and minimizes flow capacity reduction, and fully replaceable to the conventional CIPP lining materials.

• Radiation Oncology Journal
• /
• 제6권2호
• /
• pp.259-262
• /
• 1988

만성 골수성 백혈병 치료에 있어서 비장의 방사선 조사는 화학요법에 반응이 없거나, 비종대가 심하여 비장 절제술을 시행할 수 없는 환자 그리고 통증을 동반한 비종대 환자에서 증상완화를 위하여 사용되고 있다. 가톨릭의대 성모병원 방사선과에서는 만성 골수성 백혈병에 있어 비장의 방사선 조준시 초음파를 이용하여 치료범위를 정하는 새로운 방법을 개발하여 이에 보고하는 바이다. 이 방법의 장점은 기존의 방사선 조준기를 사용하여 결정하는 방사선치료범위보다 작으며 비장만을 정확하게 포함 할 수 있으므로 효과적 인 비 장 조사 및 주변 장기의 방사선 보호, 그리고 부작용 등을 감소시킬 수 있다.

• Journal of Pharmaceutical Investigation
• /
• 제41권6호
• /
• pp.355-362
• /
• 2011

This work was performed to investigate the protective effect of ethanol extract (AEx) from acorn (Quercus acutissima CARR.) against allergic mediated responses in asthma model cells and mice. The AEx inhibited antigen-stimulated cytokine production such as interleukin (IL)-4, IL-13 and tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) and AEx also inhibited intracellular reactive oxygen species (ROS) generation against IgE-mediated allergic response in rat basophilic leukaemia RBL-2H3 cells. The ovalbumin (OVA)-sensitized mice were orally administered with AEx (100 or 300 mg/kg) and authentic tannic acid (75 mg/kg) every day for 15 days. Increased TNF-${\alpha}$ production by OVA-sensitization/challenge was significantly reduced by administration of AEx. The serum triglyceride levels of asthma mice were significantly reduced after feeding for 15 days with tannic acid or AEx. The mice fed with tannic acid or AEx also exhibited a significant reduction in body weights compared to those of asthma control group. The AEx increased the heme oxygenase (HO)-1 mRNA expression in the asthma model mice and showed DPPH radical scavenging activity. These results indicate that AEx protects against IgEmediated allergic and OVA-induced asthmatic responses via direct and indirect antioxidant activities. Reduced triglyceride and body weights may provide additional protective benefits of AEx on allergic asthma.

• 한국환경복원기술학회지
• /
• 제11권2호
• /
• pp.123-132
• /
• 2008

The problems caused by new biological organisms in Ogasawara Island of Japan include : (1) loss of native species' habitats and extinction of native species due to the multiplication of invasive species; (2) reduction of native species and confusion in the food chain in result of invasive species' predation; (3) confusion in genes due to hybridization of new and native plants; and (4) destruction of ecosystem and erosion of earth due to rapid increase of invasive species. The natural ecosystem of preserved areas in Korea is constantly confused and destroyed by new animals and plants, but Korea does not has any solutions because new animals and plants rarely affect human lives. Invasive species are manually introduced by humans and are considered disasters caused by humans. Korea is in desperate need of campaigns as the general public does not understand the seriousness of the destruction and confusion of natural ecosystem caused by new biological organisms and their indirect/direct influences on humans. It is necessary to evaluate the biological characteristics, ecological influence, and harms of invasive species in preserved areas to establish a system to manage invasive species and plan the priority removal of species that are highly harmful and locally distributed. Manual removal and suppression of new biological organisms that cause problems is effective, but it takes cost, effort, and time. Therefore, we would need to research and develop the most efficient and effective techniques and measures to manage invasive species in our ecosystem.

• 대한전기학회논문지:시스템및제어부문D
• /
• 제55권7호
• /
• pp.335-343
• /
• 2006

We have designed the system that measure one channel ECG by two electrode and extract real-time EDR with more related resipiration and comportable to subject by using conductive textile. On the assumption that relation between RL electrode and potential measurement electrode is coupled with RC connected model, we designed RL drive output to feedback two electrode for reduction of common mode signal. The conductive textile which was used for two ECG electrode was offered more comfort during night sleep in bed than any other method using attachments. In the method of single-lead EDR, R wave point or QRS interval area could be used for EDR estimation in traditional method, it is, so to speak, the amplitude modulation(AM) method for EDR. Alternatively, R-R interval could be used for frequency modulation(FM) method based on Respiratory Sinus Arrhythmia(RSA). For evaluation of performance on AM EDR and FM EDR from 14 subject, ECG lead III was measured. Each EDR was compared with both temperature around nose(direct measurement of respiration) and respiration signal from thoracic belt(indirect measurement of respiration) on mean squared error(MSE), cross correlation(Xcorr), and Coherence. The upsampling interpolation technique of multirate signal processing is applied to interpolating data instead of cubic spline interpolation. As a result, we showed the real-time EDR extraction processing to be implemented at micro-controller.

• Parasites, Hosts and Diseases
• /
• 제51권2호
• /
• pp.147-154
• /
• 2013

To control coccidiosis without using prophylactic medications, a DNA vaccine targeting the gametophyte antigen Gam56 from Eimeria maxima in chickens was constructed, and the immunogenicity and protective effects were evaluated. The ORF of Gam56 gene was cloned into an eukaryotic expression vector pcDNA3.1(zeo)+. Expression of Gam56 protein in COS-7 cells transfected with recombinant plasmid pcDNA-Gam56 was confirmed by indirect immunofluorescence assay. The DNA vaccine was injected intramuscularly to yellow feathered broilers of 1-week old at 3 dosages (25, 50, and $100{\mu}g/chick$). Injection was repeated once 1 week later. One week after the second injection, birds were challenged orally with $5{\times}10^4$ sporulated oocysts of E. maxima, then weighed and killed at day 8 post challenge. Blood samples were collected and examined for specific peripheral blood lymphocyte proliferation activity and serum antibody levels. Compared with control groups, the administration of pcDNA-Gam56 vaccine markedly increased the lymphocyte proliferation activity (P<0.05) at day 7 and 14 after the first immunization. The level of lymphocyte proliferation started to decrease on day 21 after the first immunization. A similar trend was seen in specific antibody levels. Among the 3 pcDNA-Gam56 immunized groups, the median dosage group displayed the highest lymphocyte proliferation and antibody levels (P<0.05). The median dosage group had the greatest relative body weight gain (89.7%), and the greatest oocyst shedding reduction (53.7%). These results indicate that median dosage of DNA vaccine had good immunogenicity and immune protection effects, and may be used in field applications for coccidiosis control.

• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• 제11권sup1호
• /
• pp.83-92
• /
• 2008

Helicobacter pylori is the causative agent of chronic gastritis and has a role in the pathogenesis of peptic ulcer diseases, and gastric cancer. There have been reports suggesting a close link between these gastroduodenal disorders and a state of vitamin C deficiency. In this paper, the past, present and future perspectives on H. pylori infection and vitamin C will be discussed under the following view points. Since the ecological niche of H. pylori is the mucus layer and intercellular junctions of the gastric epithelium, the various kinds of host inflammatory cells motivated by the local and systemic immune responses cannot eliminate the microorganisms. When the invading foreign body is not removed, despite full activation of defense mechanisms, adverse consequences of the immune responses develop on the host gastric mucosa. The reasons for the body vitamin C depletion could be explained as follows; 1) the increased vitamin C consumption by increased oxygen free radical production through the prolonged hypersensitivity reactions in the gastric mucosa, 2) the increased vitamin C oxidation by the nitrite which is formed from nitrate reduction by the intragastric bacteria proliferated in the hypochlorhydric gastric cavity, 3) the strong ${\gamma}$-glutamyltranspeptidase activity of H. pylori which depletes the glutathiones in gastric mucosa. Depletion of glutathiones in the stomach favors irreversible oxidative destruction of ascorbic acid. Both persistent inflammatory burdens in the stomach by H. pylori and resultant vitamin C depletions synergistically and uninhibitedly might aggravate the hypothetical sequence of gastric carcinogenesis: atrophic gastritis${\rightarrow}$intestinal metaplasia${\rightarrow}$dysplasia${\rightarrow}$gastric adenocarcinoma. High intake of vitamin C could reverse the hypothetical sequence of the gastric carcinogenesis via direct and indirect effects on H. pylori and host-parasite relationships.

• Safety and Health at Work
• /
• 제10권4호
• /
• pp.393-399
• /
• 2019

Objective: This study investigates the impact of multimorbidity on work through a literature review of longitudinal studies. Methods: A systematic review was carried out in the databases Lilacs, SciELO, PAHO, PubMed/Medline, Scopus, Web of Science, and Cochrane. There were no restrictions regarding the year of publication or language to maximize the identification of relevant literature. The quality of studies was assessed by the protocol STrengthening the Reporting of OBservational studies in Epidemiology (STROBE). Results: An initial database search identified 7522 registries, and at the end of the analysis, 7 manuscripts were included in the review. Several studies have demonstrated direct and indirect impacts of multimorbidity on the health of workers. For this, the number of missed days due to health-related issues was evaluated, as well as the reduction in work productivity of the unhealthy worker, vulnerability of the worker with multimorbidity regarding higher indices of dismissal and recruitment difficulties, and incidence of early retirement and/or receipt of benefits due to disabilities. Conclusions: Multimorbidity has a negative impact on work, with damages to quality of life and work productivity, worsening the absenteeism/presenteeism indices, enhancing the chances of temporary or permanent leaves, and lowering employability and admission of individuals with multimorbidity.

• Biomolecules & Therapeutics
• /
• 제6권4호
• /
• pp.389-394
• /
• 1998

Cyclosporine (CsA) is a major immunosuppressive drug used widely to prevent organ allograft rejection. fits potential organotoxicity by prolonged use is known to cause both direct tissue damage and indirect pharmacokinetic interactions with other drugs. This study was performed to determine the effect of nicardipine (NCP) on the pharmacokinetic parameters of CsA in Sprague-Dawley rats. Each rat was administered with CsA in saline-treated group or in NCP-treated group which was pretreated with NCP (5 mg/kg/12 hours, i.p.) for 6 days. The plasma CsA concentration were analyzed by reversed HPLC: UV system at 0.5, 1, 2, 4, 6, and 8 hours after bolus injection of CsA (10 mg/kg). Pharmacokinetic parameters (mean$\pm$ SD, n=7) such as initial plasma concentration (C(0)), mean residence time (MRT), steady-state volume of distribution (Vdss), terminal half-life (t$\frac{1}{2}$($\beta$)) and plasma clearance (CLp) of CsA in each groups (saline-group vs NCP-group) were determined as follows: C(0) (5.66$\pm$ 1.98 vs 17.98$\pm$2.36, p<0.01); Vdss (2.68$\pm$ 1.6 vs 0.94 $\pm$ 0.25, p<0.01); CLp (0.53 $\pm$0.18 vs 0.21 $\pm$0.06, p<0.01). Therefore, Our results indicate that nicardipine significantly affects the pharmacokinetic parameters of cyclosporme, especially C(0), Vdss, and CLp in NCP-treated group. We suggest that the significant pharmacokinetic interaction between cyclosporine and nicardipine should be considered and cyclosporine level should be closely monitored and dosage reduction made as necessary in clinical situation that was coadministered with CsA and NCP.

• 한국생활과학회지
• /
• 제24권6호
• /
• pp.795-809
• /
• 2015

The suicide rate in South Korea has been the highest among the OECD countries for more than 10 years. In addition, the suicide rate among the rural elderly is much higher than that of the elderly in urban areas and that of younger generations. The purpose of this study was to examine the general tendencies of family ties, community consciousness and suicide ideation of the rural elderly in Korea. Also, this study aimed to verify the mediating effect of community consciousness between family ties and suicidal ideation. The data for this study came from 283 elderly people (over 65 years old) living in 11 villages in South Korea. The data was gathered from July to August 2013. Baron and Kenny's (1986) step based regression from the SPSS Win 18.0 program was used to analyze this data. This study also utilized the Sobel-test. The results of this study are as follows. First, the suicidal ideation of the respondents had a lower score than the median score. However, the magnitude of suicidal ideation was still significant. Second, this study found that family ties and community consciousness have both direct and indirect effects on the reduction of suicidal ideation. Lastly, this study examined the mediating effects of community consciousness. The findings of this study are of great significance because they reconfirmed the importance of establishing a social safety net in local communities to replace adult children who have relocated to urban areas.