• The Korean Journal of Pain
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• v.28 no.1
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• pp.4-10
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• 2015

Etifoxine (etafenoxine, $Stresam^{(R)}$) is a non-benzodiazepine anxiolytic with an anticonvulsant effect. It was developed in the 1960s for anxiety disorders and is currently being studied for its ability to promote peripheral nerve healing and to treat chemotherapy-induced pain. In addition to being mediated by $GABA_A{\alpha}2$ receptors like benzodiazepines, etifoxine appears to produce anxiolytic effects directly by binding to ${\beta}2$ or ${\beta}3$ subunits of the $GABA_A$ receptor complex. It also modulates $GABA_A$ receptors indirectly via stimulation of neurosteroid production after etifoxine binds to the 18 kDa translocator protein (TSPO) of the outer mitochondrial membrane in the central and peripheral nervous systems, previously known as the peripheral benzodiazepine receptor (PBR). Therefore, the effects of etifoxine are not completely reversed by the benzodiazepine antagonist flumazenil. Etifoxine is used for various emotional and bodily reactions followed by anxiety. It is contraindicated in situations such as shock, severely impaired liver or kidney function, and severe respiratory failure. The average dosage is 150 mg per day for no more than 12 weeks. The most common adverse effect is drowsiness at the initial stage. It does not usually cause any withdrawal syndromes. In conclusion, etifoxine shows less adverse effects of anterograde amnesia, sedation, impaired psychomotor performance, and withdrawal syndromes than those of benzodiazepines. It potentiates $GABA_A$ receptor-function by a direct allosteric effect and by an indirect mechanism involving the activation of TSPO. It seems promising that non-benzodiazepine anxiolytics including etifoxine will replenish shortcomings of benzodiazepines and selective serotonin reuptake inhibitors according to animated studies related to TSPO.

• Journal of the Korean Society for Railway
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• v.14 no.1
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• pp.57-65
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• 2011

The estimation of traffic safety and passenger comfort when the train is running on the bridge is a estimation unique to the railway bridge. The standards for such estimation are included in the Eurocode, the Shinkansen design criteria, and the design guideline of the Honam High-speed railway. The items are bridge responses including vertical displacement of bridge, vertical acceleration, and slab twist. In principle, a direct estimation based on the train responses has to take place. However, the estimation based on the bridge responses can be seen as an indirect estimation procedure for the convenience of the bridge designer. First, it is general practice that traffic safety can be verified as a derailment coefficient or wheel load decrement The general method of estimating passenger comfort is to calculate the acceleration within the train car-body. Various international indexes have been presented for this method. In the present study, traffic safety and passenger comforts are estimated directly by bridge/train interaction analysis. The acceleration and wheel load decrement are obtained for the estimation of traffic safety and passenger comforts of a suspension bridge which has main span length of 300m. Also, the consideration of seismic load with simultaneous action of moving train is done for bridge/train/earthquake interaction analysis.

• Korean Journal of Social Welfare
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• v.38
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• pp.234-254
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• 1999

Volunteering has been defined as a form of altruistic helping behavior directed at improving other's welfare. Volunteering is, however, also identified as a type of collective action for community welfare. In this regard, this study tests whether neighborhood member's network and collective identity are more important determinants to explain participation in volunteer work than altruistic or normative motivation. This study estimates a model in which volunteering is determined by empathy, normative beliefs, neighborhood networks(friendship, contacts, and integration), and identity as a neighborhood member. This study shows that empathy, normative beliefs, and collective identity as a neighborhood member have significant impacts on participation in volunteer work. In addition, this study reveals that neighborhood member's network has an indirect impact on volunteering through identity as a neighborhood member. These results suggest that neighbor-hood community member's ties and collective identity are important sources for community welfare and collective volunteer work.

• Korean Journal of Medicinal Crop Science
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• v.19 no.4
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• pp.287-299
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• 2011

Pharmacological effects of Panax ginseng have been demonstrated in cardiovascular system, endocrine secretion and immune system, together with antitumor, anti-stress and anti-oxidant activities. Modern scientific data show protective effect of ginseng against bone marrow cell death, increased survival rate of experimental animals, recovery of hematopoietic injury, immunopotentiation, reduction of damaged intestinal epithelial cells, inhibition of mutagenesis and effective protection against testicular damages, caused by radiation exposure. And also, ginseng acts in indirect fashion to protect radical processes by inhibition of initiation of free radical processes and thus reduces the radiation damages. The research has made much progress, but still insufficient to fully uncover the action mechanism of ginseng components on the molecule level. This review provides the usefulness of natural product, showing no toxic effects, as an radioprotective agent. Furthermore, the further clinical trials on radioprotection of ginseng need to be highly done to clarify its scientific application. The effective components of ginseng has been known as ginsenosides. Considering that each of these ginsenosides has pharmacological effect, it seems likely that non-saponin components might have radioprotective effects superior to those of ginsenosides, suggesting its active ingredients to be non-saponin series. These results also show that the combined effects of saponin and non-saponin components play an important role in the radioprotective effects of ginseng.

• Journal of Korea Society of Digital Industry and Information Management
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• v.14 no.2
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• pp.91-105
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• 2018

The purpose of this study is to examine an immoral effectiveness decrease by information access monitoring between ethical dilemma and unethical information-sharing behavior. Firms are raising the demand of confidential information management and are highlighting the ethical awareness of organizational members. The individuals in organization are concerned information sharing for future-oriented social networking. To prevent their immoral behavior, Firms should consider investing the information access monitoring. This system is aiming at log verification of movement, storage and deletion on information and will reduce an ethical conflict and unethical behavior on employees. I used the structural equation methodology for this empirical study. The research model constructs the voluntary and involuntary dilemma of information sharing on the two independent-variables, the unethical information behavior and the improper networking reinforcement on the two dependent-variables and the information access monitoring the one mediating-variables. This model tests the power effect of direct path, indirect path and total path. According to the study, the two ethical dilemma of information sharing provided a high influence to the unethical sharing action and to the inappropriate social networking strengthens. However, the mediating role of information access monitoring shows the effect weakens of independent and dependent variables. Thus, the mediating variables appeared to be important for the controlling role of an unethical behavior and improper social networking. Ultimately, The firms will need to invest the information access monitoring for a compulsory ethics behavior of organizational members. In addition, this can hinder networking enhancements for future opportunistic behaviors.

• Journal of Dairy Science and Biotechnology
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• v.35 no.4
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• pp.270-285
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• 2017

Among milk proteins, caseins are not subjected to chemical changes during heat treatment of milk; however, whey proteins are partially denatured following heat treatment. The degree of whey protein denaturation by heat treatment is decreased in the order of high temperature short time (HTST) > low temperature long time (LTLT) > direct-ultra-high temperature (UHT) > indirect-UHT. As a result of heat treatment, several changes, including variations in milk nitrogen, interactions between beta-lactoglobulin and k-casein, variations in calcium sulfate and casein micelle size, and delay of milk coagulation by chymosin action, were observed. Lysine, an important essential amino acid found in milk, was partially inactivated during heat treatment. Therefore, the available amount of lysine decreased slightly (1~4% decrease) after heat treatment, However, the influence of heat treatment on the nutritional value of milk was negligible. Nutritional value and nitrogen balance did not differ significantly between UHT and LTLT in milk. In conclusion, our results showed that heat treatment of milk did not alter protein quality. Whey proteins denatured to a limited extent during the heat treatment process, and the nutritional value and protein quality were unaffected by heat treatment.

• Journal of Physiology & Pathology in Korean Medicine
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• v.21 no.3
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• pp.736-740
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• 2007

Acanthopanax sessiliflorus SEEM extracts(AS) have been used to treat patient with diseases including cancer in Oriental countries. Recently, AS was known to have anti-cancer and immuno-stimulating activites. For these reasons, we investigated the effects of AS following gamma-ray irradiation on cytotoxicity for solid tumor cell line (S-180) and immune-potentiating ability such as proliferation of thymocytes and splenocytes. Finally we also investigated tumor weight and survival rate in tumor bearing mice. In our results, Treatment with AS suppressed proliferation of solid tumor cells (S-180) effectively. Treatment with AS accelerated thymocyte and splenocyte proliferation in tumor bearing mice. In addition, Treatment with AS reduced tumor weight and prolonged life of tumor bearing mice. In conclusion, we demonstrate that AS following gamma-ray irradiation is useful to treat patients with cancer, and also demonstrate that AS have both direct cytotoxic ability for cancer cells and indirect immune-stimulating action for thymocytes and splenocytes.

• 한국사회복지학회:학술대회논문집
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• 1999.04a
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• pp.294-313
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• 1999

Volunteering has been defined as a form of altruistic helping behavior directed at improving other's welfare. Volunteering is, however, also identified as a type of collective action for community welfare. In this regard, this study tests whether neighborhood member's network and collective identity are more important determinants to explain participation in volunteer work than altruistic or normative motivation. This study estimates a model in which volunteering is determined by empathy, normative beliefs, neighborhood networks(friendship, contacts, and integration), and identity as a neighborhood member. This study shows that empathy, normative beliefs, and collective identity as a neighborhood member have significant impacts on participation in volunteer work. In addition, this study reveals that neighborhood member's network has an indirect impact on volunteering through identity as a neighborhood member. These results suggest that neighborhood community member's ties and collective identity are important sources for community welfare and collective volunteer work.

• Journal of Ginseng Research
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• v.47 no.3
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• pp.385-389
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• 2023

Background: Ginseng has been used as a traditional medicine for treatment of many diseases and for general health maintenance. Previously, we showed that ginseng did not demonstrate estrogenic property in ovariectomized mouse model. However, it is still possible that disruption of steroidogenesis leading to indirect hormonal activity. Methods: The hormonal activities were examined in compliance with OECD guidelines for detecting endocrine disrupting chemicals: test guideline (TG) No. 456 (an in vitro assay method for detecting steroidogenesis property) and TG No. 440 (an in vivo short-term screening method for chemicals with uterotrophic property). Results: Korean Red Ginseng (KRG) and ginsenosides Rb1, Rg1, and Rg3 did not interfere with estrogen and testosterone hormone synthesis as examined in H295 cells according to TG 456. KRG treatment to ovariectomized mice did not show a significant change in uterine weight. In addition, serum estrogen and testosterone levels were not change by KRG intake. Conclusion: These results clearly demonstrate that there is no steroidogenic activity associated with KRG and no disruption of the hypothalamic-pituitary-gonadal axis by KRG. Additional tests will be performed in pursuit of cellular molecular targets of ginseng to manifest mode of action.

• Korean Journal of Family Social Work
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• no.58
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• pp.5-36
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• 2017

This study aims to empirically analyze whether the women's cognitive attitude toward gender role, which is formed through social norms, enforces the gender division of housework. In this study, 4,435 married women aged 18-59 years from the 5th wave dataset of Korean Longutudinal Survey of Women and Family Data were selected for analysis. Using the Structural Equation Model(SEM), we examine the direct effect of "attitude toward behavior" and "subjective norm" on the domestic working hours and whether those two independent variables, such as "attitude toward behavior" and "subjective norm," influence the mediator variable "Behavior Intention" which in turn affect the dependent variable. The study reveals that "attitude toward the gender division of housework" has a statistically significant direct effect on the domestic working hours as well as an indirect effect operating through "behavior intention." And"subjective norm "has only a statistically significant indirect effect on the domestic working hours, operating through "behavior intention." Despite the fact that many women are now aware that various work-life balance policies are avaliable to mitigate the gender inequality of domestic works, it is proven that the gender division of housework becomes worse. The reason behind this is not only because there exist some problems in implementing the institutions themselves, but also because women's deeply internalized self-perception of gender role based on the traditional patriarchal culture somehow exacerbates the gender division of housework. Hence, in order to instill a progressive change in gender division of housework, it is important for women to try to change the way they perceive the stereotypical gender roles as well as for men to treat women equally.