• Journal of Korean Society of Forest Science
• /
• v.78 no.3
• /
• pp.302-313
• /
• 1989

To investigate the effects of forest fire on the change of vegetation and soil conditions by the lapse of time, the 5th soil survey and vegetation analysis were carried out in July of 1988 at the rocky areas of Mt. Kwanak, where ground fire broke out 5 years ago. Three-year increasing trends of organic matter content, the value of pH, and total nitrogen content stabilized after the restoration of the vegetation. By the comparison of the occurrences of the species for 5 years after the forest fire, woody and herbaceous plants were categorized into 4 groups, i,e., invasive, sensitive, tolerant, and neutral species to the forest fire. Although such diversity indices as the species diversity and similarity index indicate that the restoration of damaged vegetation to the original species composition was proceeded for the period, the restoration of vegetation to the original crown closure and tree growth was not proceeded yet.

• Korean Journal of Veterinary Research
• /
• v.59 no.1
• /
• pp.17-24
• /
• 2019

Animal models of osteoarthritis (OA) have played a key role in understanding the etiology of OA and in the development of new therapeutic strategies. Although pigs have an advantage as an animal disease model due to their similarity to humans, there are few studies on the induction of OA in minipigs. Therefore, this study aimed to characterize disease progression of OA in total medial meniscectomy (TMM)-operated skeletally mature minipigs, up to day 180 postoperatively. There were no significant alterations in vital signs or hematological indices throughout the observation period. However, clinical manifestations of OA in the medial femoral condyles of TMM-operated minipigs were progressive, depending on postoperative duration, with respect to osteophytes formation and roughened surfaces on radiological observation, cartilage erosion under macroscopic examination, and severe cartilage defects including fibrillation, vertical fissures, and cartilage denuding on histopathological observation, with the highest score indicating late-stage OA on day 180 and without indicating apparent variation between subjects. In particular, the lateral femoral condyles were also degenerated, possibly due to localization of weight-bearing from both menisci to the lateral meniscus. Therefore, TMM in minipigs is suitable for reproducible induction of degenerative changes in the femorotibial joints that closely resemble late-stage OA, and is suitable for use in further research.

• Bulletin of the Korean Chemical Society
• /
• v.31 no.5
• /
• pp.1355-1360
• /
• 2010

In order to search new inhibitors against farnesyl protein transferase (FPTase), a series of 2,3-bis-benzylidenesuccinaldehyde derivatives (1-29) were synthesized and their inhibition activities ($pI_{50}$) against FPTase were measured. From based on the reported results that the inhibitory activities of dimers 2,3-bis-benzylidenesuccinaldehydes were higher than those of monomers cinnamaldehydes, 3D-QSARs on FPTase inhibitory activities of the dimers (1-29) were studied quantitatively using comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) methods. The statistical qualities of the optimized CoMFA model II ($r^2{_{cv.}}$= 0.693 and $r^2{_{ncv.}}$= 0.974) was higher than those of the CoMSIA model II ($r^2{_{cv.}}$ = 0.484 and $r^2{_{ncv.}}$ = 0.928). The dependence of CoMFA models on chance correlations was evaluated with progressive scrambling analyses. And the inhibitory activity exhibited a strong correlation with steric factors of the substrate molecules. Therefore, from the results of graphical analyses on the contour maps and of predicted higher inhibitory active compounds, it is suggested that the structural distinctions and descriptors that contribute to inhibitory activities ($pI_{50}$) against FPTase will be able to applied new inhibitor design.

• Bulletin of the Korean Chemical Society
• /
• v.34 no.8
• /
• pp.2387-2393
• /
• 2013

Benzotriazole is an important synthetic auxiliary for potential clinical applications. A series of benzotriazoles as potential antiproliferative agents by inhibiting histone deacetylase (HDAC) were recently reported. Three-dimensional quantitative structure-activity relationship (3D-QSAR), including comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA), were performed to elucidate the 3D structural features required for the antiproliferative activity. The results of both ligand-based CoMFA model ($q^2=0.647$, $r^2=0.968$, ${r^2}_{pred}=0.687$) and CoMSIA model ($q^2=0.685$, $r^2=0.928$, ${r^2}_{pred}=0.555$) demonstrated the highly statistical significance and good predictive ability. The results generated from CoMFA and CoMSIA provided important information about the structural characteristics influence inhibitory potency. In addition, docking analysis was applied to clarify the binding modes between the ligands and the receptor HDAC. The information obtained from this study could provide some instructions for the further development of potent antiproliferative agents and HDAC inhibitors.

• Imaging Science in Dentistry
• /
• v.52 no.4
• /
• pp.393-398
• /
• 2022

Purpose: This study proposed a generative adversarial network (GAN) model for T2-weighted image (WI) synthesis from proton density (PD)-WI in a temporomandibular joint(TMJ) magnetic resonance imaging (MRI) protocol. Materials and Methods: From January to November 2019, MRI scans for TMJ were reviewed and 308 imaging sets were collected. For training, 277 pairs of PD- and T2-WI sagittal TMJ images were used. Transfer learning of the pix2pix GAN model was utilized to generate T2-WI from PD-WI. Model performance was evaluated with the structural similarity index map (SSIM) and peak signal-to-noise ratio (PSNR) indices for 31 predicted T2-WI (pT2). The disc position was clinically diagnosed as anterior disc displacement with or without reduction, and joint effusion as present or absent. The true T2-WI-based diagnosis was regarded as the gold standard, to which pT2-based diagnoses were compared using Cohen's ĸ coefficient. Results: The mean SSIM and PSNR values were 0.4781(±0.0522) and 21.30(±1.51) dB, respectively. The pT2 protocol showed almost perfect agreement(ĸ=0.81) with the gold standard for disc position. The number of discordant cases was higher for normal disc position (17%) than for anterior displacement with reduction (2%) or without reduction (10%). The effusion diagnosis also showed almost perfect agreement(ĸ=0.88), with higher concordance for the presence (85%) than for the absence (77%) of effusion. Conclusion: The application of pT2 images for a TMJ MRI protocol useful for diagnosis, although the image quality of pT2 was not fully satisfactory. Further research is expected to enhance pT2 quality.

• Bulletin of the Korean Chemical Society
• /
• v.32 no.1
• /
• pp.251-262
• /
• 2011

Human ether-a-go-go related gene (hERG) potassium channel blockade, an undesirable side effect which might cause sudden cardiac death, is one of the major concerns facing the pharmaceutical industry. The purpose of this study is to develop an in silico QSAR model which uncovers the structural parameters of T-type calcium channel blockers to reduce hERG blockade. Comparative molecular similarity indices analysis (CoMSIA) was conducted on a series of piperazine and benzimidazole derivatives bearing methyl 5-(ethyl(methyl)amino)-2-isopropyl-2-phenylpentanoate moieties, which was synthesized by our group. Three different alignment methods were applied to obtain a reliable model: ligand based alignment, pharmacophore based alignment, and receptor guided alignment. The CoMSIA model with receptor guided alignment yielded the best results : $r^2$ = 0.955, $q^2$ = 0.781, $r^2_{pred}$ = 0.758. The generated CoMSIA contour maps using electrostatic, hydrophobic, H-bond donor, and acceptor fields explain well the structural requirements for hERG nonblockers and also correlate with the lipophilic potential map of the hERG channel pore.

• Journal of Forest and Environmental Science
• /
• v.37 no.3
• /
• pp.243-250
• /
• 2021

Information on butterflies in the Niger Delta Region is relatively scanty because monitoring of their activities and distribution has not been fully documented and these are paramount to establish their conservation protocols. The study therefore aimed at evaluating the species richness distribution pattern, and relative abundance of butterflies in the University of Port Harcourt. The University Park was purposively selected for this study. The park was stratified into three different habitat types (secondary forest, farmland, and residential/garden). A sampling of each stratum was done three times; twice in the morning between 8:00 am and 12:00 pm as well as once in the evening between 4:00 pm and 6:00 pm along a 100 m line transects for 16 months (May 2017-August 2018). Data collected were analyzed for species diversity indices, evenness, and similarity index. A total of 1,932 individual butterflies belonging to 28 species, 18 genera, and five 5 families were identified in the study area. Species diversity and evenness were higher on farmland (1-D=0.909; H'=2.615; E=0.833), and least in the residential area/gardens (1-D=0.744; H'=1.975; E=0.659). The family Nymphalidae (39.0%) had the highest number of species occurrence while Hesperidae (0.4%) had the lowest composition. Anthene larydas (24.12%) had the highest relative abundance in the entire study area, followed by Acraea serena (17.49%). The study, therefore, recommends continuous monitoring of butterfly species diversity and composition also in other regions.

• KSCE Journal of Civil and Environmental Engineering Research
• /
• v.29 no.3B
• /
• pp.311-317
• /
• 2009

Similarity indices between sampling sites are calculated and cluster analysis of fish community is carried out by UPGMA based on investigating fish fauna and water environment. The restoration indicators as target species of Wonju stream are selected Cottus poecilopus, Zacco temmincki, and Zacco platypus along upper, middle, and lower streams, respectively. For better habitat suitability, low flow increasing and induced water quality improving must be secured by sewer system rearrangement and watershed management. Composite habitat suitability of Zacco temmincki as target species at middle stream of Wonju stream improve significantly by low flow increasing, which is very important factor to improve habitat suitability. The changes of hydraulics of depth and velocity govern the habitat suitability in general, but the effects are not significant. Low flow increasing with the change of 10% reducing of lower channel improves the composite habitat suitability of 0.37~0.78 to their origin of 0.1~0.25, which represent the channel restoration scheme of Wonju stream for enhancing the habitat suitability of fish community.

• Journal of Life Science
• /
• v.24 no.8
• /
• pp.813-819
• /
• 2014

The spatial distribution of geographical distances at five natural populations of Camellia japonica in Busan, Korea was studied. The four plots (Mollundae, Gadeok-do, Du-do, and Jwiseum) of C. japonica were uniformly distributed in the forest community and only one plot (Amnam-dong) was aggregately distributed in the forest community. Morisita index is related to the patchiness index showed that the plot $20m{\times}50m$ had an overly steep slope when the area was larger than $20m{\times}20m$, which indicated that the degree of aggregation increased significantly with increasing quadrat sizes, while the patchiness indices did not change from the plot $5m{\times}10m$ to $10m{\times}10m$. The spatial structure was quantified by Moran's I, a coefficient of spatial autocorrelation. Ten of the significant values (76.9%) were positive, indicating similarity among individuals in the first 4 distance classes (80 m), i.e., pairs of individuals with dissimilarity characteristics can separate by more than 100 m.

• Journal of The Korean Society of Agricultural Engineers
• /
• v.64 no.1
• /
• pp.51-63
• /
• 2022

Up-to-date statistics of crop cultivation status is essential for farm land management planning and the advancement in remote sensing technology allows for rapid update of farming information. The objective of this study was to develop a classification model of rice paddy or winter crop fields based on NDWI, NDVI, and HSV indices using Sentinel-2 satellite images. The 18 locations in central Korea were selected as target areas and photographed once for each during summer and winter with a eBee drone to identify ground truth crop cultivation. The NDWI was used to classify summer paddy fields, while the NDVI and HSV were used and compared in identification of winter crop cultivation areas. The summer paddy field classification with the criteria of -0.195