• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
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• 제1권2호
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• pp.53-61
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• 1996

The activation of operation department can be defined as man power, the space, energy and organization in the operation department. In this paper, we clarified the activation index of operation department and verified the relation between the activation index and the management index related to in patients. In addition, we studied the effect of the activation index on the construction and management of the operation department. As a result, we can find the followings. 1. The number of operation as the activation index of operation department regardless of the size of hospitals in Japan is smaller than in Korea and Taiwan. 2. Based on the study of the correlation between the activation index and the operation index connected to inpatient, it is found the activation of operation department is affected by average lengh of stay of inpatient. 3. It is found that plan of operation has been practically made on the basis of the number of beds. Howerver, the activation index of operation department should be utilized on the basis of the number of operation.

• 한국정밀공학회지
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• 제22권1호
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• pp.183-192
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• 2005

This study compared cerebral lateralization index based on the area of neural activation with that based on the intensity of neural activation. For this purpose, 8 right-handed male college students (the mean age - 23.5 years) and 10 right-handed male college students (the mean age - 25.1 years) participated respectively in researches on visuospatial and verbal task brain function. Functional brain images were taken from 3T MRI using the single-shot EPI method. The result of measuring cerebral lateralization index based on the area of neural activation suggested that the right hemisphere is dominant in visuospatial tasks and the left one is in verbal tasks. However, the dominance is not sufficient to locate the exact part of the brain for these tasks. When cerebral lateralization index was computed based on the intensity of neural activation, it was derived that the area of cerebral lateralization closely related to visuospatial tasks is the superior parietal lobe, and the area of cerebral lateralization closely related to verbal tasks is the inferior and middle frontal lobes. Thus, cerebral lateralization index by area based on the intensity of neural activation as proposed by this study can determine the dominance of the cerebrum by area, so is helpful for accurate and quantitative determination of cerebral lateralization.

• 한국화재소방학회논문지
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• 제34권3호
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• pp.35-42
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• 2020

성능위주 소방설계(PBD)의 안전성 평가 과정에서 화재모델링의 신뢰성 확보를 위해서는 화재감지기 작동시간의 정확한 예측성능이 요구된다. 본 연구는 대표적 화재모델인 FDS에 적용되는 정온식 열감지기의 주요 입력인자인 감지기 작동온도와 RTI의 측정을 목표로 한다. 이를 위해 화재감지기 실험 장치인 Fire detector evaluator (FDE)가 적용되었으며, 제품 인지도 조사를 통해 선정된 국내 10종의 정온식 감지기가 고려되었다. 결과적으로 감지기의 제조사별로 작동온도와 RTI는 상당한 차이가 있는 것으로 확인되었으며, 측정된 DB가 적용된 FDS의 감지기 작동시간은 보다 정확한 예측이 가능함을 확인하였다. 최종적으로 신뢰성이 확보된 정온식 열감지기의 작동온도와 RTI의 DB가 제공되었다.

• Archives of Pharmacal Research
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• 제22권6호
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• pp.533-541
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• 1999

Many conventional anticancer drugs display relatively poor selectivity for neoplastic cells, in particular for solid tumors. Furthermore, expression or development of drug resistance, increased glutathione transferases as well as enhanced DNA repair decrease the efficacy of these drugs. Research efforts continue to overcome these problems by understanding these mechanisms and by developing more effective anticancer drugs. Cyclophosphamide is one of the most widely used alkylating anticancer agents. Because of its unique activation mechanism, numerous bioreversible prodrugs of phosphramide mustard, the active species of cyclophosphamide, have been investigated in an attempt to improve the therapeutic index. Solid tumors are particularly resistant to radiation and chemotherapy. There has been considerable interest in designing drugs selective for hypoxic environments prevalent in solid tumors. Much of the work had been centered on nitroheterocyclics that utilize nitroreductase enzyme systems for their activation. In this article, recent developments of anticancer prodrug design are described with a particular emphasis on exploitation of selective metabolic processes for their activation.

• 동아시아식생활학회지
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• 제20권1호
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• pp.54-59
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• 2010

Basil is known to contain six types of polyphenols that engage in physiological activation; protocateuic acid, caffeic acid, chlorogenic acid, courmaric acid, rosmarinic acid and quercetin. In this study, the antioxidants in eight types of basil were evaluated. Specifically, the antioxidative activation of basil was evaluated based on the relationship between active oxygen scavenging (DPPH radical-scavenging), which was used as an index showing the content and functionality of the polyphenol compounds in basil, and $Fe^{2+}$/ascorbate (FTC) and 2-thiobarbituric acid (TBA). The total polyphenol content of the different types basil occurred in the following order: Dark-opal> Lettuce> Bush> Greek> Lemon> Sweet> Geno> Holy. The highest content Dark-opal was 173.3 mg, which was about three times greater than the lowest content Holy, which was 49.85 mg. In addition, DPPH radical-scavenging by Dark-opal 51%, which was the highest scavenging activity occurred in the folling order: Dark-opal> Lettuce> Bush> Greek> Lemon> Sweet> Geno> Holy. The antioxidative activation values measured using the FTC and TBA were the same as the value obtained using the DPPH method. Finally, the level of antioxidative activation measured using FTC, TBA and DPPH methods showed that the higher the content of polyphenol substance was, the stronger the antioxidative activation became.

• 로봇학회논문지
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• 제19권2호
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• pp.203-212
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• 2024

Simultaneous motion is essential in the activities of daily living (ADL). For motion intention recognition, surface electromyogram (sEMG) and corresponding motion label is necessary. However, this process is time-consuming and it may increase the burden of the user. Therefore, we propose a simultaneous motion recognition framework using data augmentation based on muscle activation model. The model consists of multiple point sources to be optimized while the number of point sources and their initial parameters are automatically determined. From the experimental results, it is shown that the framework has generated the data which are similar to the real one. This aspect is quantified with the following two metrics: structural similarity index measure (SSIM) and mean squared error (MSE). Furthermore, with k-nearest neighbor (k-NN) or support vector machine (SVM), the classification accuracy is also enhanced with the proposed framework. From these results, it can be concluded that the generalization property of the training data is enhanced and the classification accuracy is increased accordingly. We expect that this framework reduces the burden of the user from the excessive and time-consuming data acquisition.

• 대한의용생체공학회:의공학회지
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• 제28권1호
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• pp.55-65
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• 2007

This paper sought to investigate pupil size variability, pupil size parameters in terms of time domain and frequency domain, the autonomic activity change induced by posture change, degree of sleepiness and cognitive task (math task). With a specially designed pupil image acquisition system in the dark room, these three kinds of experiments were performed to induce a dominant state of sympathetic or parasympathetic activation. Electrocardiogram and pupil size were measured in all the experiments. Based on three experiments, we calculated heart rate variability. In the pupil size analysis, we calculated the mean and standard deviation of pupil size (in time domain), and proposed several frequency bands that exhibit different autonomic activation between different sessions. The results indicate that in terms of heart rate variability, posture change exhibited significant differences but not between sleepiness level, or between cognitive task. Pupil sizes differed only during the postures. And we found some frequency bands that correlated with autonomic activation in each experiment. While heart rate variability reflects posture change that need cardiac control, pupil size variability reflects not only posture induced autonomic activation but sleepiness and cognitive load, which is processed in the brain, in time and frequency domain parameter.

• Journal of Trauma and Injury
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• 제37권2호
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• pp.97-105
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• 2024

Purpose: Massive transfusion protocols (MTPs) implementation improves clinical outcomes of the patient's resuscitation with hemorrhagic trauma. Various predictive scoring system have been used and studied worldwide to improve clinical decision. However, such research has not yet been studied in Korea. This systematic review aimed to assess the predictors of MTPs activation in patients with trauma in Korea. Methods: The PubMed, Embase, Cochrane Library, Research Information Sharing Service databases, KoreaMed, and KMbase were searched from November 2022. All studies conducted in Korea that utilized predictors of MTPs activation in adult patients with trauma were included. Results: Ten articles were eligible for analysis, and the predictors were assessed. Clinical assessments such as systolic and diastolic blood pressure, shock index (SI), prehospital modified SI, modified early warning system (MEWS) and reverse SI multiplied by the Glasgow Coma Scale (rSIG) were used. Laboratory values such as lactate level, fibrinogen degradation product/fibrinogen ratio, and rotational thromboelastometry (ROTEM) were used. Imaging examinations such as pelvic bleeding score were used as predictors of MTPs activation. Conclusions: Our systematic review identified predictors of MTPs activation in patients with trauma in Korea; predictions were performed using tools that requires clinical assessments, laboratory values or imaging examinations only. Among them, ROTEM, rSIG, MEWS, SI, and lactate level showed good effects for predictions of MTPs activation. The application of predictors for MTP's activation should be individualized based on hospital resource and skill set, also should be performed as a clinical decision supporting tools.

• 한국멀티미디어학회논문지
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• 제19권9호
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• pp.1698-1709
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• 2016

These days, anyone can easily product and share their own content through a web service such as blogs and SNS. However, contents are being operated separately because of the space limitation in individual SNS. Therefore, it is hard to search contents efficiently in individual SNS. To solve this problem, this paper propose a "Private Contents Management and Sharing Service with Voluntary Sharing Economy System." The system is in part [Input], [Save] and it provides a way to collect the content that are scattered on the Internet based on the creation of personal index. It also proposes a more systematic content management and sharing by creating and updating the website standard index by introducing an index Coordinator concept. Furthermore in [Use] section, by providing a portion of the index as the primary search results, it avoid unclassified content list which was simply collected by users. In conclusion, unlike previous studies, this system will contribute to the acquisition and management of interspersed content and ultimately contribute to the shared activation by preventing secondary processing and unauthorized processing to the original article.

• 정보관리학회지
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• 제22권2호
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• pp.23-39
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• 2005

본 연구의 목적은 국내에서 구축되고 있는 참고문헌 데이터베이스의 현황을 분석하여 문제점을 밝히고, 이들 문제점을 토대로 정보원으로서의 기능과 평가도구로서의 기능을 적절하게 수행할 수 있는 참고문헌 데이터베이스를 구축하기 위한 활성화 방안을 제언하는데 있다. 이를 위하여 국내에서 구축되는 참고문헌 데이터베이스 가운데 전문연구정보센터에서 구축하는 참고문헌 DB, 한국과학기술정보연구원의 KSCI, 학술진흥재단의 KCI. 대한의학회의 KoMCI를 연구대상으로 분석하였다. 이를 근거로 국내 참고문헌 데이터베이스 구축 사업을 위한 방안을 도출하여 제시하였다. 이들 자료는 참고문헌DB 구축을 위한 제도 및 정책, 기술적 방향을 제시하는데 근거자료로 활용할 수 있을 것이다.