• Asian Pacific Journal of Cancer Prevention
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• 제15권3호
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• pp.1163-1169
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• 2014

Astragalus, a commonly used traditional Chinese medicine, has exhibited antitumor actions in patients. In this study, in vitro and in vivo antitumor effects of astragalus and synergistic antitumor efficacy in combination with pterostilbene were investigated. Melanoma cells were treated with pterostilbene (Pt), graduated doses of astragalus injection (AI), or these in combination. Cell viability was measured using a MTT assay. Released nucleosomes and caspase activity were measured using enzyme-linked immunosorbent assay. Growth inhibition in vitro and in vivo was also assessed. Analysis of variance and t tests were used for statistical analysis. Significant reduction (p<0.05) in cellular proliferation were observed with AI and AI-Pt in a time- and concentration-dependent manner. Apoptosis and caspase-3/7 activity were significantly increased by AI and AI-Pt treatment (p<0.05). In vivo, AI inhibited melanoma tumor growth, with inhibition rates ranging from 36.5 to 62.3%, by inducing apoptosis via up-regulation Bax expression and the Bax/Bcl-2 ratio and down-regulating Bcl-2 expression. AI significantly inhibits the growth of melanoma in vitro and in vivo by inducing apoptosis. These data suggest that combined treatment of astragalus with pterostilbene enhances antitumor efficacy.

• 대한간호학회지
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• 제38권4호
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• pp.533-540
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• 2008

Purpose: This study was designed to examine the effects of a weight control program on body weight and the sense of efficacy for control of dietary behavior in psychiatric inpatients. Methods: A quasi-experimental design was used. Data were collected from March 1 to September 30, 2007. Female mentally ill patients in closing psychiatry ward of H University Hospital participated in the study (16 persons in the experimental group and 13 in the control group). Results: The weight control program including diet therapy, exercise, education and behavior modification therapy decreased the rate of weight gain in female mentally ill patients taking atypical anti psychotics, and effectively increased a sense of efficacy for control of dietary behavior. Conclusion: Weight control program had a positive effect as a nursing intervention to decrease obesity and to increase the sense of efficacy for control of dietary behavior of psychiatric inpatients in psychiatric inpatients.

• 한국간호교육학회지
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• 제15권2호
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• pp.311-320
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• 2009

Purpose: This study was done to investigate the factors associated with a mothers' caring behavior in health promotion of children with disabilities. Methods: Data were collected by using self-reported questionnaires from 371 mothers who had a 3-12 year old child with a disability from July 14 to 31, 2008. Data were analyzed by descriptive statistics, t-test, one-way ANOVA, and hierarchical multiple regression analysis with the SPSS program. Results: There were significant differences on the mothers' caring behavior according to children's negative and hyperactive behavior, mothers' perceived burden, parenting efficacy, and social support. Children's characteristics explained 5.1% of mothers' caring behavior. The power of explanation ($R^2$) was 16.6% by adding mother's characteristics including mother's job, burden, parenting efficacy, satisfaction and stigma, and increased to 23.5% by adding social support. Conclusion: These results showed that mothers' caring behavior for their children's health promotion could be influenced by children's behavior problems, mothers' perception of burden, parenting efficacy, and social support. It suggests that health promotion programs for children with disabilities should focus on lowering subjective burden and enhancing mother's efficacy as a type of social support.

• Biomolecules & Therapeutics
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• 제4권1호
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• pp.68-77
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• 1996

Efficacy and general pharmacology of recombinant human erythropoietin (rHu-EPO), were investigated. Efficacy studies were conducted in normal, cisplatin- and acute hemorrhage-induced anemic rats. Normal and anemic animals were treated intravenously with rHu-EPO for 5 days and the changes in the numbers of red blood cells (RBC), hemoglobin (Hb), hematocrit (Hct) and reticulocytes (Ret) were examined. In normal rats, rHu-EPO significantly increased RBC, Hb, Hct and Ret at doses of 50∼ 1250 IU/kg/day. Cisplatin-induced anemic rats showed significant increase of RBC, Hb, Hct and Ret in a dose-dependent manner after administration of rHu-EPO (50∼200 lU/kg/day). And in acute hemorrhage-induced anemic rats, rHu-EPO(4∼100 Iu/kg/day) accelerated recovery of anemia with significant increase in Ret. These changes disappeared gradually after cessation of the treatment. The general pharmacological effects of rHu-EPO were investigated in mice, rats, guinea-pigs, rabbits and cats. rHu-EPO had no influences on central nervous, cardiovascular, gastrointestinal and blood coagulation system. It also had no influence on the contraction of phrenic nerve-diaphragm preparation. rHu-EPO produced significant increase of urine volume at a dose of 7000 IU/kg. These results suggest that rHu-EPO might be useful for the therapy of anemia without serious side effect.

• 한국의류학회지
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• 제32권7호
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• pp.1149-1159
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• 2008

This study aims at examining how male college students' extent of mass media exposure affects their sociocultural attitude toward appearance and appearance orientation. It also investigates how these variables show difference depending on the individual's self-efficacy. For the study, data were collected from 397 male students by means of stratified random sampling. The results are as follows: 1. Male college students 'sociocultural attitude toward appearance was shown in two factors of appearance internalization and appearance awareness. Appearance orientation was shown in two factors of interest in appearance and interest in body weight. 2. Male college students were exposed to mass media in order of videos, movies, TV entertainment shows, music and movie magazines. The influence of video media was strong. 3. Male college students' extent of mass media exposure exerted indirect influence through sociocultural attitude toward appearance rather than exerting direct influence on appearance orientation. 4. Male college students' appearance orientation varied depending on the extent of self-efficacy, and higher self-efficacy showed higher appearance orientation and appearance attitude. Especially the group with higher self-efficacy showed higher appearance attitude when the extent of exposure to mass media increased.

• Biomolecules & Therapeutics
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• 제6권3호
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• pp.312-316
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• 1998

Efficacy and in vivo bioassay of recombinant human erythropoietin (rho-EPO), was investigated. Efficacy studies were conducted in normal, and cisplatin-induced anemic rats. Normal and anemic animals were treated intravenously with rhu-EPO for 5 days, and the changes in the number of red blood cells (RBC), hemoglobin concentration (Hb), hematocrit value (Hct) and percentage reticulocyte value (Ret, reticulocyte/RBC) were examined. In normal rats, rho-EPO significantly increased RBC, Hb, Hct and Ret at the doses of 50∼ 1,250 lU/kg/day in a dose-dependent fashion. Cisplatin-induced anemic rats showed significant increase of RBC, Hb, Hct and Ret after administration of rho-EPO (50-200 lU/kg/day) in a dose-dependent manner. These changes of hematological parameters disappeared gradually after cessation of the treatment. The in vivo bioassay results in polycythemic mice showed that rho-EPO had 90% of bioactivity compared to NIBSC standard rhu-EPO. These results suggest that rho-EPO might be useful for the therapy of anemia originated from renal failure and chemotherapy-induced anemia.

• KSBB Journal
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• 제20권2호
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• pp.129-132
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• 2005

본 연구는 헛개열매 추출물의 pH를 산성으로 조절한 산 가수분해 방법에 의하여 헛개열매 추출물에 배당체 형태로 존재하는 알코올분해 효능을 가진 생리활성물질 ((+)-dihydromyricetin)의 양을 증가시켰다. 반응온도 $80^{\circ}C$, 반응시간 4hr, 반응 pH 2.0에서 $124\%$의 알코올분해 효능이 증가하여 최적임을 알 수 있었다. 산 가수분해 전 후에 생리활성물질인 (+)-dihydromyricetin의 양이 $30\%$ 증가함을 알 수 있었으며, 또한 헛개열매 추출물에 포함되어 있는 고분자 물질이 분해됨을 확인할 수 있었다.

• 대한가정학회지
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• 제50권1호
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• pp.79-88
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• 2012

The purpose of this study was to examine the interaction effects of children's academic self-efficacy and to test their anxiety coping style in terms of their test anxiety. We conducted a questionnaire survey with 193 sixth-graders in an elementary school. The results of this study are summarized as follows. First, the children were more worried about emotionality to test anxiety, and used problem-focused coping significantly more frequently than emotion-focused coping. In addition, female children demonstrated more emotionality and worry about test anxiety and used emotion-focused coping for test anxiety more frequently. Second, emotionality was higher when emotion-focused coping was used. In the case where the level of problem-focused coping was high, emotionality was higher when academic self-efficacy was high. Children's worry was lower when the level of problem-focused coping was high and when the level of emotion-focused coping was low. In female children, however, worry increased when the level of problem-focused coping was low and the level of emotion-focused coping was high.

• Physical Therapy Rehabilitation Science
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• 제11권4호
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• pp.391-399
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• 2022

Objective: This study aimed to investigate the effects of fall-prevention exercise programs on fall efficacy, depression and health-related quality of life in elderly. Design: a randomized controlled trial Methods: A total of 57 participants over 65-years-old have been allocated to control and experimental groups. The experimental group received 8 weeks of fall-prevention exercises that included strengthening of lower extremities, balance and gait training. They received the exercises twice a week for 50 minutes as a group.Both groups were assessed using Modified Falls Efficacy Scale (MFES), Geriatric Depression Scale (GDS), and 36-Item Short-Form Health Survey (SF-36) prior and post to the intervention. The control group also received the same exercise program after the post evaluation. Results: The experimental group showed overall improvement in MFES, GDS, and physical components of SF-36 (p<0.05). The MFES was significantly increased in the experimental group after the intervention (p<0.05). The GDS was significantly decreased in the experimental group after the intervention (p<0.05). The SF-36, only physical Function, Role limitations due to physical health, general health, and energy and fatigue categories were improved in the experimental group after the intervention (p<0.05). Conclusions: The results showed 8 weeks of fall-prevention exercise programs can increase fall efficacy and physical related quality of life while reducing depression of elderly over 65.

• 한국융합학회논문지
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• 제8권1호
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• pp.163-171
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• 2017

본 연구는 융복합기반 핵심기본간호술 교육이 저학년 간호학생의 자기효능감, 수행자신감 및 전공만족도에 미치는 효과를 검정하기 위한 단일군 전후설계(One group pretest-posttest design)연구이다. 대상자는 일개 대학교 간호학과에 재학 중인 2학년 학생 80명이었다. 실험처치 및 자료 수집은 2016년 3월 2일부터 4월 15일까지 시행되었다. 교육 전과 후에 구조화된 설문지를 이용하여 자기효능감, 수행자신감 및 전공만족도를 평가하였으며, 교육 후 수행능력을 평가하였다. 수집된 자료는 SPSS 21 프로그램의 빈도분석, 기술통계 및 paired t-test를 이용하여 분석하였다. 연구 결과 교육 후 자기효능감(p=.045), 수행자신감(p<.001) 및 전공만족도(p=.018) 모두 유의하게 증가되어, 융복합기반 핵심기본간호술 교육이 저학년 간호학생의 자기효능감, 수행자신감 및 전공만족도 향상에 효과적인 것으로 나타났다.