• Journal of Pharmaceutical Investigation
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• v.17 no.1
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• pp.1-14
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• 1987

To increase the bioavailability of norfloxacin, inclusion complex of antimicrobial agent norfloxacin with ${\beta}-Cyclodextrin$ was prepared and studied by the solubility method, spectrophotometric methods(UV, IR, $^1H-NMR$), differential thermal analysis, powder X-ray diffractometry, the physical properties, the antimicrobial activity, DNA binding and in situ recirculation technique. The conclusions are summerized as following; 1) The inclusion complexation was identified by means of solubility, spectrophotometry(UV, IR, NMR), DTA and X-ray diffraction. 2) The molar ratio of $norfloxacin-{\beta}-cyclodextrin$ complex was 1 : 1. 3) The stability constant of $norfloxacin-{\beta}-cyclodextrin$ complex was $21.5\;M^{-1}$, and both true and apparent partition coefficients of the inclusion complex were larger than those of norfloxacin. 4) The time required to dissolve 60% $(T_{60}%)$ of the inclusion complex was 120 min. in distilled water and in the artificial intestinal juice, while norfloxacin did not reach to 60% dissolution within 120 min. 5) The antimicrobial activity of the inclusion complex against Pseudomonas aeruginosa, Klebsiella pneumoniae and Staphylococcus aureus showed no significant difference compared to that of norfloxacin alone. 6) Studies on binding properties between the inclusion complex and norfloxacin alone to DNA according to equilibrium dialysis showed no significant differency. 7) In situ absorption rates (Ka) of inclusion complex and norfloxacin alone were 0.229 and $0.102hr^{-1}$, respectively.

• Polymer(Korea)
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• v.39 no.2
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• pp.261-267
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• 2015

The inclusion complexes (ICs) between polylactic acid (PLA) and ${\beta}$-cyclodextrin (CD) were prepared by co-precipitation method in this work. The orthogonal experiments were designed to investigate the influence of different factors on the formation of inclusion complexes. The results suggested that the optimum scheme of inclusion compounds could be obtained when the feeding ratio of CD to PLA (wt%) was 20:1, stirring speed was 6 kr/min and the stirring time was 30 min. The structures and properties of the inclusion complexes were characterized by $^1H$ NMR, FTIR, DSC, FT-Raman, XRD and TGA. The DSC results demonstrated that the crystallization behavior of the inclusion complexes nearly disappeared. It was found that ${\beta}$-CD-PLA inclusion complex had a better thermal stability compared with the neat PLA. The model of the inclusion complexes was proposed on the basis of XRD, $^1H$ NMR and DSC results.

• The Journal of Asian Finance, Economics and Business
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• v.8 no.3
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• pp.943-952
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• 2021

The Covid-19 pandemic situation has changed all medical priorities. This has put pressure on the World's health sector, which also affects the economy of the whole world. This study aims to study how Islamic work ethics affects the relationship between spiritual leadership and organizational inclusion practices in the health care sector of Pakistan in the COVID-19 situation. This is a mix-method study. Data collected of 158 practicing doctors through survey-based questionnaire and interview was conducted from 30 doctors dealing with direct coronavirus. The organizational inclusion practices variable is used for the first time in a quantitative approach in this study. The reliability and validity of organizational inclusion practices are checked by Adanco, SPSS, and SmartPLS software. For this purpose, data on inclusion practices was also collected from the banking and education sector. Results show that spiritual leadership significantly relates to Islamic work ethics also has a positive connection between spiritual leadership and organizational inclusion practices. Still, Islamic work ethics as a moderator has an insignificant impact on the relationship between spiritual and organizational inclusion practices. Also, from the result, it is verified that the organizational inclusion practices variable is valid and reliable for further studies.

• Structural Engineering and Mechanics
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• v.63 no.3
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• pp.329-345
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• 2017

This paper devoted to study dynamic interaction between crack and inclusion or void by developing the eXtended Finite Element Methods (XFEM). A novel XFEM approximation is presented for these structures containing multi discontinuities (void, inclusion, and crack). The level set methods are used so that elements that include a crack segment, the boundary of a void, or the boundary of an inclusion are not required to conform to discontinuous edges. The investigation covers the effects of a single circular or elliptical void / stiff inclusion, and multi stiff inclusions on the crack propagation path under dynamic loads. Both the void and the inclusion have a significant effect on the dynamic crack propagation path. The crack initially curves towards into the void, then, the crack moves round the void and propagates away the void. If a large void lies in front of crack tip, the crack may propagate into the void. If an enough small void lies in front of crack tip, the void may have a slight or no influence on the crack propagation path. For a stiff inclusion, the crack initially propagates away the inclusion, then, after the crack moves round the inclusion, it starts to propagate along its original path. As ${\delta}$ (the ratio of the elastic modulus of the inclusion to that of the matrix) increases, a larger curvature of the crack path deflection can be observed. However, as ${\delta}$ increases from 2 to 10, the curvature has an evident increase. By comparison, the curvature has a slight increase, as ${\delta}$ increases from 10 to 1000.

• Honam Mathematical Journal
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• v.32 no.1
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• pp.113-129
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• 2010

Inclusion and exclusion is used in many papers to count certain objects exactly or asymptotically. Also it is used to derive the Bonferroni inequalities in probabilistic area [6]. Inclusion and exclusion on finitely many types of properties is first used in R. Meyer [7] in probability form and first used in the paper of McKay, Palmer, Read and Robinson [8] as a form of counting version of inclusion and exclusion on two types of properties. In this paper, we provide a proof for inclusion and exclusion on finitely many types of properties in counting version. As an example, the asymptotic number of general cubic graphs via inclusion and exclusion formula is given for this generalization.

• Journal of Pharmaceutical Investigation
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• v.15 no.1
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• pp.15-21
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• 1985

The inclusion of ${\alpha}-cyclodextrin$ and ${\beta}-cyclodextrin$ with flurbiprofen in aqueous phase was investigated by UV absorption and circular dichroism spectroscopies. The inclusion complex in solid powder form were made by the freeze-drying and coprecipitation methods in molar ratio 1:1. The inclusion complex formation was confirmed by infrared absorption spectroscopy. The freeze-drying method was successful in obtaining the inclusion compounds compared with the coprecipitation method. The dissolution of solid flurbiprofen inclusion complex was examined in comparison with those of flurbiprofen alone. The inclusion complex obtained by freeze-drying method increased the dissolution rate.

• Korean Journal of Child Studies
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• v.13 no.2
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• pp.53-64
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• 1992

The purpose of the present research was to investigate developmental trends in children's class-inclusion performance and to examine the influence of task characteristics(provision or deprivation of quantitative information and perceptual information) on a class-inclusion task. The subjects of this study were 96 children, 12boys and 12girls at each age level. 5, 6. 7 and 8 years of age. The experimental materials consisted of 12 stimulus boards which were constructed on the basis of picture cards used by Judd and Mervis(1979) and Lane and Hodkin(1985). The class-inclusion tasks were individually administered by the researcher. The data were analyzed by the statistical methods of t-test, one-way ANOVA and Duncan multiple range test. The results showed that (1) There were significant age differences in children's class-inclusion performance. That is, children's performance scores on the class-inclusion task increased with age.: (2) There were significant task characteristics differences in children's class-inclusion performance. That is, children performed better on the deprivation of quantitative information task than on the provision of quantitative information task.

• International Journal of Computer Science & Network Security
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• v.23 no.4
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• pp.103-110
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• 2023

Financial inclusion is the safe and timely access of formal financial services to people at affordable costs. Various barriers of legacy financial system hinder the involvement of all segments of populations in the financial sector. The journey from financial exclusion to financial inclusion has to be achieved with the implementation of technological breakthroughs. Covid-19 has also raised the need for technology in all sectors of the economy. This research paper introduces the concept of intelligent financial inclusion which is the provision of financial services to people with the help of intelligent systems. This intelligent system will take the concepts from the human mind, cognitive sciences, and artificial intelligence tools and techniques. For achieving the optimal level of financial inclusion, economies must shift their financial sector from traditional means to intelligent financial systems. In this way, intelligent financial inclusion will achieve the target of involving all people in the financial sector.

• Journal of Pharmaceutical Investigation
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• v.25 no.4
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• pp.283-289
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• 1995

The aim of this study is to increase the solubility and dissolution rate of clonixin by inclusion complex formation. Inclusion complexes of clonixin, a non-steroidal antiinflammatory drug, with ${\beta]-cyclodextrin$ were $2-hydrolrypropyl-{\beta]-cyclodextrin$ were prepared by freeze drying method. Inclusion complex formation of clonixin with cyclodextrins was determined by UV, IR and DSC. The apparent stability constants were calculated from the phase solubility diagrams. Dissolution rate and solubility of clonixin in water markedly increased by the complex formation.

• Journal of the Korean Applied Science and Technology
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• v.32 no.3
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• pp.451-460
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• 2015

An enantioselective recognition of D- and L-tryptophan (Trp)-b-cyclodextrin (CD) inclusion complex was performed using electrochemical and FT-Raman spectroscopic analysis. From the electrochemical analysis, the selectivity coefficient ($K_{DL}$) of b-CD inclusion complexes was found higher than that of the D- and L-Trp in phosphate buffered saline (PBS, pH=7.0) solution. The percentage of enantioselectivity ($I_{%{ee}}$) for peak current of D-Trp-b-CD inclusion complexes was observed higher than that of L-Trp-b-CD inclusion complexes in PBS solution. From Raman spectroscopy, chemical shift difference (D, $cm^{-1}$) for the C=C stretch, ring vibration, and ring breathing of D-Try-b-CD inclusion complex were observed higher than that of L-Trp-b-CD inclusion complex. The electrochemical and Raman spectroscopic analyses were found very useful for chiral detection of racemic amino acid in the presence of b-CD.