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Is the association of continuous metabolic syndrome risk score with body mass index independent of physical activity? The CASPIAN-III study

  • Heshmat, Ramin;shafiee, Gita;Kelishadi, Roya;Babaki, Amir Eslami Shahr;Motlagh, Mohammad Esmaeil;Arefirad, Tahereh;Ardalan, Gelayol;Ataie-Jafari, Asal;Asayesh, Hamid;Mohammadi, Rasool;Qorbani, Mostafa
    • Nutrition Research and Practice
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    • v.9 no.4
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    • pp.404-410
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    • 2015
  • BACKGROUND/OBJECTIVES: Although the association of body mass index (BMI) with metabolic syndrome (MetS) is well documented, there is little knowledge on the independent and joint associations of BMI and physical activity with MetS risk based on a continuous scoring system. This study was designed to explore the effect of physical activity on interactions between excess body weight and continuous metabolic syndrome (cMetS) in a nationwide survey of Iranian children and adolescents. SUBJECTS/METHODS: Data on 5,625 school students between 10 and 18 years of age were analyzed. BMI percentiles, screen time activity (STA), leisure time physical activity (LTPA) levels, and components of cMetS risk score were extracted. Standardized residuals (z-scores) were calculated for MetS components. Linear regression models were used to study the interactions between different combinations of cMetS, LTPA, and BMI percentiles. RESULTS: Overall, 984 (17.5%) subjects were underweight, whereas 501 (8.9%) and 451 (8%) participants were overweight and obese, respectively. All standardized values for cMetS components, except fasting blood glucose level, were directly correlated with BMI percentiles in all models (P-trend < 0.001); these associations were independent of STA and LTPA levels. Linear associations were also observed among LTPA and standardized residuals for blood pressure, high-density lipoprotein, and waist circumference (P-trend < 0.01). CONCLUSIONS: Our findings suggest that BMI percentiles are associated with cMetS risk score independent of LTPA and STA levels.

Method's to introduce ROKN Nuclear Propulsion Submarines (한국형 원자력 추진 잠수함 도입방안)

  • Jang, Jun-Seop
    • Strategy21
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    • s.42
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    • pp.5-52
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    • 2017
  • Debates about introducing nuclear submarines have been a main issue in Korea. The highest officials and the government has started to think seriously about the issue. Yet there were no certain decision to this issue or any agreements with US but it is still necessary to review about introducing nuclear submarines, the technologies and about the business. The reason for such issues are the highest officials of Korea to build nuclear submarine, nK's nuclear development and SLBM launching. ROKN's nuclear submarine's necessity will be to attack(capacity to revenge), defend(anti-SSBN Operation) and to respond against neighboring nation's threat(Russia, Japan, China). Among these nations, US, Russia (Soviet Union), Britain, France had built their submarines in a short term of time due to their industrial foundation regarding with nuclear propulsion submarines. However China and India have started their business without their industrial foundation prepared and took a long time to build their submarines. Current technology level of Korea have reached almost up to US, Russia, Britain and France when they first built their nuclear propulsion submarines since we have almost completed the business for the Changbogo-I,II and almost up to complete building the Changbogo-III which Korea have self designed/developed. Furthermore Korea have reached the level where we can self design large nuclear reactors and the integrated SMART reactor which we can call ourselves a nation with worldwide technologies. If introducing the nuclear submarine to the Korea gets decided, first of all we would have to review the technological problems and also introduce the foreign technologies when needed. The methods for the introduction will be developments after loans from the foreign, productions with technological cooperations, and individual production. The most significant thing will be that changes are continuous and new instances are keep showing up so that it is important to only have a simple reference to a current instances and have a review on every methods with many possibilities. Also developing all of the technologies for the nuclear propulsion submarines may be not possible and give financial damages so there may be a need to partially introduce foreign technologies. For the introduction of nuclear propulsion submarines, there must be a resolution of the international regulations together with the international/domestics resistances and the technological problems to work out for. Also there may be problem for the requirement fees to solve for and other tough problems to solve for. However nuclear submarines are powerful weapon system to risk everything above. This is an international/domestically a serious agenda. Therefore rather than having debates based on false facts, there must be a need to have an investigations and debates regarding the nation's benefits and national security.

Analysis of Land Use Change Using RCP-Based Dyna-CLUE Model in the Hwangguji River Watershed (RCP 시나리오 기반 Dyna-CLUE 모형을 이용한 황구지천 유역의 토지이용변화 분석)

  • Kim, Jihye;Park, Jihoon;Song, Inhong;Song, Jung-Hun;Jun, Sang Min;Kang, Moon Seong
    • Journal of Korean Society of Rural Planning
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    • v.21 no.2
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    • pp.33-49
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    • 2015
  • The objective of this study was to predict land use change based on the land use change scenarios for the Hwangguji river watershed, South Korea. The land use change scenario was derived from the representative concentration pathways (RCP) 4.5 and 8.5 scenarios. The CLUE (conversion of land use and its effects) model was used to simulate the land use change. The CLUE is the modeling framework to simulate land use change considering empirically quantified relations between land use types and socioeconomic and biophysical driving factors through dynamical modeling. The Hwangguji river watershed, South Korea was selected as study area. Future land use changes in 2040, 2070, and 2100 were analyzed relative to baseline (2010) under the RCP4.5 and 8.5 scenarios. Binary logistic regressions were carried out to identify the relation between land uses and its driving factors. CN (Curve number) and impervious area based on the RCP4.5 and 8.5 scenarios were calculated and analyzed using the results of future land use changes. The land use change simulation of the RCP4.5 scenario resulted that the area of urban was forecast to increase by 12% and the area of forest was estimated to decrease by 16% between 2010 and 2100. The land use change simulation of the RCP8.5 scenario resulted that the area of urban was forecast to increase by 16% and the area of forest was estimated to decrease by 18% between 2010 and 2100. The values of Kappa and multiple resolution procedure were calculated as 0.61 and 74.03%. CN (III) and impervious area were increased by 0-1 and 0-8% from 2010 to 2100, respectively. The study findings may provide a useful tool for estimating the future land use change, which is an important factor for the future extreme flood.

Distribution and Characteristics of Plants Resources in Mt. Jo-bong (Yangyang-gun, Gangwon-do) (조봉(강원, 양양) 식물자원의 분포와 특성)

  • Han, Jun-Soo;Cheon, Kyeong-Sik;Kim, Kyung-Ah;Ok, Gil-Hwan;Jung, Hee-Jin;Yoo, Ki-Oug
    • Korean Journal of Plant Resources
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    • v.26 no.1
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    • pp.119-142
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    • 2013
  • This study was carried out to investigate the distribution and characteristics of plants resources in Mt. Jo-bong (Yangyang-gun, Gangwon-do) from April, 2011 to October, 2012. The vascular plants were summarized as 500 taxa; 92 families, 296 genera, 434 species, 6 subspecies, 49 varieties, and 11 forma. Among the investigated 500 taxa, 13 Korean endemic, 14 rare plants, 1 endangered and 75 specially designated plants by Ministry of Environment were included. The naturalized plants were 32 taxa and percent of naturalized plant species and urbanization index were estimated 6.4% and 10%, respectively. Usefulness of plants of 500 taxa listed consists of 193 taxa (38.6%) of edible plants, 155 taxa (31.0%) of medicinal plants, 86 taxa (17.2%) of pasture plants, 58 taxa (11.6%) of ornamental plants, 16 taxa (3.2%) of timber plants, 14 taxa (2.8%) of fiber plants, 4 taxa (0.8%) of industrial plants and 2 taxa (0.4%) of miscellaneous plants.

Microarray Analysis of Gene Expression in RAW Cells Treated with Carthami Flos Herbal Acupuncture Solution (홍화약침액(紅花藥鍼液)이 RAW Cell 유전자발현(遺傳子發顯)에 미치는 영향(影響))

  • Kang, Seung-Beom;Kim, Jong-In;Kim, Yong-Seok;Kang, Sung-Keel;Koh, Hyung-Kyun
    • Journal of Acupuncture Research
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    • v.25 no.1
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    • pp.139-154
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    • 2008
  • 목적 : 홍화(紅花)는 활혈거어(活血祛瘀), 해독지통(解毒止痛)의 효능이 있어 관절염, 동맥경화(動脈硬化), 종양(腫瘍), 월경부조(月經不調), 뇌혈전(腦血栓)에 사용되어 왔다. 이에 홍화약침액(紅花藥鍼液)의 분자생물학적 효능 분석을 하고자 Lipopolysaccharide(LPS)로 염증을 유발한 RAW 264.7 cell의 유전자(遺傳子) 발현(發顯)에 미치는 영향을 Microarray를 통하여 관찰하였다. 방법 : RAW cell을 배양하고 홍화약침액(紅花藥鍼液)의 세포 독성을 확인한 후 (1) LPS, (2) 홍화약침액(紅花藥鍼液), (3) 홍화약침액(紅花藥鍼液)과 LPS를 처치했을 때의 유전자 발현양상을 microarray를 이용하여 관찰하였다. 대조군에 비해 2배 이상 발현의 차이가 있는 경우를 유의한 것으로 보았다. 결과 : 8,170개의 유전자 중 (1) LPS를 처치하였을 경우 35개의 유전자에서 발현이 상승되었고, (2) 홍화약침액(紅花藥鍼液)을 처치하였을 경우 11개의 유전자에서 발현이 상승되고 53개의 유전자에서 발현이 억제되었으며, (3) 홍화약침액(紅花藥鍼液)과 LPS를 동시에 처치하였을 경우에는 47개의 유전자에서 발현이 상승되었고 11개의 유전자에서 발현이 억제되었다. LPS 자극으로 발현이 상승되었지만 홍화약침액(紅花藥鍼液)을 처치할 때 발현이 억제되는 유전자는 SUMO1/sentrin specific protease 7(SENP7), Serine(or cysteine) proteinase inhibitor, clade B(ovalbumin), member 7(SERPINB7), M-phase phosphoprotein, mpp8(HSMPP8), Glycogenin 2(GYG2), InaD-like(Drosophila)(INADL), Copine III(CPNE3), Loss of heterozygosity, 11, chromosomal region 2, gene A(LOH11CR2A), Chromosome 9 open reading frame 33(SHC3), NADH dehydrogenase(ubiquinone) 1 beta subcomplex, 2, 8kDa(NDUFB2)로 9개가 있었다. 요약 : 홍화약침액(紅花藥鍼液)이 LPS로 염증을 유발시킨 RAW 264.7 cell의 유전자 발현에 미치는 영향을 Microarray를 통해 분석하였다. 홍화약침액(紅花藥鍼液)이 LPS로 발현을 항진시킨 35개의 유전자 중 9개를 효과적으로 억제하는 것을 확인하여 염증 치료 기전을 시사하는 유용한 자료를 얻을 수 있었으며 홍화약침액(紅花藥鍼液)이 발현을 항진시킨 유전자들을 통해 혈관생성과 종양억제 등 보다 넓은 범위에 대한 연구가 가능할 것으로 사료된다.

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A STUDY ON THE BOND STRENGTH OF REINFORCED INDIRECT COMPOSITE RESINS TO DENIAL ALLOYS (강화형 간접복합레진과 치과용 합금의 결합강도에 관한 연구)

  • Yoon, Dong-Joo;Shin, Sang-Wan;Lim, Ho-Nam;Suh, Kyu-Won
    • The Journal of Korean Academy of Prosthodontics
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    • v.37 no.5
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    • pp.620-639
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    • 1999
  • Indirect composite resins are used as an popular effective esthetic material in prosthetic dentistry, often with metallic substructure that provides support for restorations. Recently, new indirect composite resins as a substitute of ceramic have been developed. These resins provide good esthetics, with a wide range of hue and chroma. And the flexural strength of those is in the range of 120-150MPa, Which is higher than that of feldspathic Ceramic, and similar th that of Dicor. Although it has many merits, one of the major clinical problems of composite resins is the bond failure between metal and resin due to insufficient interfacial bond strength. The purpose of this study was to evaluate shear bond strength of the reinforced indirect composite resin to dental alloys. Three different composite resin systems($Artglass^{(R)},\;Sculpture^{(R)},\;Targis^{(R)}$) as test groups and ceramic($VMK\;68^{(R)}$) as control group were bonded to Ni-Cr-Be alloy($Rexillium\;III^{(R)}$) and gold alloy(Deva 4). All specimens were stored at $^37{\circ}C$ distilled water for 24 hours and the half of specimens were thermocycled 2000 times at temperature from $5^{\circ}C\;to\;60^{\circ}C$. The shear bond strengths of reinforced indirect composite resins to dental alloys were measured by using the universal testing machine, and modes of debonding were observed by stereoscope and scanning electron microscope. The results were as follows: 1 The shear bond strengths of reinforced indirect composite resins to dental alloys were approximately half those of ceramic to dental alloys(P<0.01). 2. There was no significant difference between the shear bond strength of several reinforced indirect composite resins to metal. 3. Alloy type did not affect on the shear bond strengths of resin to metal, but the shear bond strengths of ceramic to gold alloys were higher than those of ceramic to Ni-Cr alloys(P<0.05). 4. The shear bond strengths of Artglass and Targil to gold alloys were significantly decreased after thermocycling treatment(P<0.01). 5. Sculpture showed cohesive, adhesive, and mixed failure modes, but Artglass and Targis showed adhesive or mixed failures. And ceramic showed cohesive and mixed failures.

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The registration and approval of Oriental Medical devices for the entry into U.S. market (한방의료기기의 미국 시장 진출을 위한 심사제도 소개)

  • Oh, Ji Yun;Choi, Yu Na;Jo, Su Jeong;Jung, Chan Yung;Cho, Hyun Seok;Lee, Seung Deok;Kim, Kap Sung;Kim, Eun Jung
    • Journal of Acupuncture Research
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    • v.32 no.4
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    • pp.91-102
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    • 2015
  • Objectives : The Oriental medical device industry is expected to continue to experience significant growth. It should increase its global market share rather than focusing on the domestic market. Countries around the world self-regulate their domestic market, so this study aims to aid in the development of a particular overseas market by introducing the U.S.(the largest market) medical device registration and approval process. Methods : For an understanding of the US medical device licensing process, we researched the relevant regulatory organization (FDA), the history, definition and classification of medical devices, the approval and 510(k) submission process related to substantial equivalence, IEC 60601-1 Edition 3, usability tests, and so on. Results : Medical devices in the United States are assigned to one of three regulatory classes: Class I, Class II and Class III, based on the level of control necessary to assure the safety and effectiveness of the device. If a company's device is classified as Class II and if it is not exempt, a 510k will be required for marketing. 1) A 510(k) is a premarket submission made to the FDA to demonstrate that the new device to be marketed is "substantially equivalent" to a legally marketed device (predicate device) 2) The IEC 60601-1 Edition 3 preparation process, which contains information related to usability, is expensive and time-consuming but a critical requirement. Conclusions : Although the U.S. market has high barriers to entry, access to this, large overseas market will encourage development of the Oriental medical device industry and commercial value enhancement is expected.

2003 Asia Pacific Microwave Conference (2003아시아 태평양 마이크로파 학술회의)

  • 김동일;이혁재;박동철;명로훈;윤상원;조영기;남상욱;윤영중;이해영
    • Proceedings of the Korea Electromagnetic Engineering Society Conference
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    • 2004.01a
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    • pp.1-226
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    • 2004
  • I. Title APMC'03(2003 Asia Pacific Microwave Conference) II. Objecuve $\bigcirc$Investigation of new trend in the field of microwave engineering $\bigcirc$Establishment of R&D track for wireless and high speed communication III. Scope of investigation $\bigcirc$R&D trend in various microwave engineering areas-Solid state Devices and circuits-Electromagnetic Field Theory-EMI&EMC-Phased & Active Array Antennas-Scattering & Propagation $\bigcirc$Discussions with various technical topics-New research & development topics-Establishment of wireless & high speed communications IV. Results During the conference, very active academic exchange were possible between Korean and foreign microwave engineering scholars. It was also possible to introduce the level and activities of Korean microwave engineering researches to foreign countries. Also, it was good opportunity to contact foreign scholars and researchers for valuable academic discussion using technical paper presentations and inquiries.

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Surgical Results for Perforated Gastric Cancer (천공성 위암의 수술 방법과 치료 결과)

  • Lee, Moon-Soo;Chae, Man-Kyu;Kim, Tae-Yun;Cho, Gyu-Seok;Kim, Sung-Yong;Baek-Moo-Jun;Chung-Il-Kwon;Park, Kyung-Kyu;Kim, Chang-Ho;Song-Ok-Pyung;Cho, Moo-Sik
    • Journal of Gastric Cancer
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    • v.2 no.2
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    • pp.85-90
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    • 2002
  • Purpose: Perforated gastric cancer (PGC) is rare and occurs in $1\∼4\%$ of all gastric cancers. Possible dissemination of tumor cells at the time of perforation of the gastric carcinoma has been a matter of concern. The intraoperative determination of what kind of operation should be done and how extensive the lymphnode dissection should be still remains controversial. The purpose of this study is to evaluate the factors influencing the survival and to determine the optimal treatment for PGC. Materials and Methods: A total of 42 patients were operated on for a perforated gastric carcinoma at Soonchunhyang University Chunan Hospital from 1983 to 2000. the age and the sexes of the patients, the location of perforation, the diameter of perforation, the histologic type of the tumor, the depth of wall invasion, the absence or presence of lymph node metastasis / distant metastasis, the stage of disease, the type of operation, and the outcomes were examined. Statistically significant differences were analyzed by using Fisher's exact test. Results: The stage distributions according to the UICC classification were 1 case of stage I, 6 cases of stage II, 17 cases of stage III, and 11 cases of stage IV. An emergency gastrectomy was done in 26 patients ($61.9\%$), with a 5-yr survival rate of $44\%$. The survival of patients was significantly influenced by the depth of wall invasion, the lymphnode metastasis, distant metastasis, the stage of disease, and the type of operation. Conclusions: an emergency gastrectomy is the treatment of choice for most patients with resectable PGC. Choosing more a optimistic surgical approach for potentially curative cases of PGC should be one way to increase the patient's survival rate.

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Adsorption and Storage of Hydrogen by Nanoporous Adsorbents (나노세공체 흡착제에 의한 수소 흡착 및 저장)

  • Jhung, Sung Hwa;Chang, Jong-San
    • Applied Chemistry for Engineering
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    • v.18 no.2
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    • pp.99-110
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    • 2007
  • Efficient and inexpensive hydrogen storage is an essential prerequisite for the utilization of hydrogen, one of the new and clean energy sources for $21^{st}$ century. In this review, several storage techniques are briefly reviewed and compared. Especially, adsorption/storage via physisorption at low temperature, by using nanoporous adsorbents, is reviewed and evaluated for further developments. The adsorption over a porous material at low temperature is currently investigated deeply to fulfill the storage target. In this review, several characteristics needed for the high hydrogen adsorption capacity are introduced. It may be summarized that following characteristics are necessary for high storage capacity over porous materials: i) high surface area and micropore volume, ii) narrow pore size, iii) strong electrostatic field, and iv) coordinatively unsaturated sites, etc. Moreover, typical results demonstrating high storage capacity over nanoporous materials are summarized. Storage capacity up to 7.5 wt% at liquid nitrogen temperature and 80 atm is reported. Competitive adsorbents that are suitable for hydrogen storage may be developed via intensive and continuous studies on design, synthesis, manufacturing and modification of nanoporous materials.