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Feasibility, Safety, and Follow-up Angiographic Results of Endovascular Treatment for Non-Selected Ruptured Intracranial Aneurysms Under Local Anesthesia with Conscious Sedation

  • Kang, Jongsoo;Kang, Chul-Hoo;Roh, Jieun;Yeom, Jeong A;Shim, Dong-Hyun;Kim, Young Soo;Lee, Sang Won;Kim, Young-Soo;Park, Kee Hong;Kim, Chang-Hun;Kim, Soo-Kyoung;Choi, Nack-Cheon;Kwon, Oh-Young;Kang, Heeyoung;Baik, Seung Kug
    • Journal of Neurocritical Care
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    • v.11 no.2
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    • pp.93-101
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    • 2018
  • Background: At most centers, general anesthesia (GA) has been preferred for endovascular treatment (EVT) of ruptured intracranial aneurysms (RIAs). In this study, we analyzed procedural results, clinical outcomes, and follow-up angiographic findings for patients undergoing EVT for RIA under local anesthesia (LA) with conscious sedation (CS). Methods: We retrospectively evaluated 308 consecutive patients who underwent EVT for RIAs at a single institution between June 2009 and February 2017. EVT under LA with CS was considered for all patients with aneurysmal subarachnoid hemorrhage, regardless of Hunt and Hess (HH) scale score. Results: EVT was performed for 320 aneurysms in 308 patients with subarachnoid hemorrhages. The mean patient age was $55.5{\pm}12.6$ years. Moderate (III) and poor (IV, V) HH grades were observed in 75 (24.4%) and 77 patients (25%), respectively. Complete occlusion immediately after EVT was achieved for 270 (84.4%) of 320 aneurysms. Thromboembolic complications and intraprocedural ruptures occurred in 25 (7.8%) and 14 cases (4.3%), respectively. The morbidity rate at discharge (as defined by a modified Rankin scale score of 3 or greater) was 27.3% (84/308), while the mortality rate was 11.7% (36/308). Follow-up angiographic results were available for 210 (68.1%) of 308 patients. Recanalization was observed in 64 (29.3%) of 218 aneurysms in 210 patients. Conclusion: Based on our experience, EVT for RIAs under LA with CS was feasible, regardless of the clinical grade of the subarachnoid hemorrhage. Complication rates and follow-up angiographic results were also comparable to those observed when GA was used to perform the procedure.

Floristic Study of Juwangsan National Park in Korea (주왕산국립공원의 관속식물상)

  • Jang, Hyun-Do;Leem, Hyosun;Han, Seahee;So, Soonku
    • Korean Journal of Plant Resources
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    • v.32 no.4
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    • pp.379-406
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    • 2019
  • A floristic study on the vascular plants from Juwangsan National Park was conducted 13 times in total, from March to October 2017. Based on the voucher specimens and pictures, it was revealed that the vascular plants in this region comprised 758 taxa: 112 families, 399 genera, 672 species, 4 subspecies, 72 varieties, and 10 forma. Among these plants, 221 taxa were recorded for the first time from this region. The taxa in category II of endangered plants designated by the Korean Ministry of Environment were two taxa, including Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. and Epilobium hirsutum L. The rare plants numbered 5 taxa designated by National Institute of Biological Resources were also found. 20 taxa of Korean endemic plants including Corydalis alata B.U.Oh & W.R.Lee, Iris odaesanensis Y.N.Lee, and Scrophularia cephalantha Nakai were investigated in this region. 40 taxa of floristic regional indicator plants in the 3rd to the 5th degrees were identified. Naturalized plants of 55 taxa were recorded, and 3 taxa of ecosystem disturbance plants, which were Ambrosia artemisiifolia L., Aster pilosus Willd., and Lactuca scariola L., also found.

Accuracy of one-step automated orthodontic diagnosis model using a convolutional neural network and lateral cephalogram images with different qualities obtained from nationwide multi-hospitals

  • Yim, Sunjin;Kim, Sungchul;Kim, Inhwan;Park, Jae-Woo;Cho, Jin-Hyoung;Hong, Mihee;Kang, Kyung-Hwa;Kim, Minji;Kim, Su-Jung;Kim, Yoon-Ji;Kim, Young Ho;Lim, Sung-Hoon;Sung, Sang Jin;Kim, Namkug;Baek, Seung-Hak
    • The korean journal of orthodontics
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    • v.52 no.1
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    • pp.3-19
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    • 2022
  • Objective: The purpose of this study was to investigate the accuracy of one-step automated orthodontic diagnosis of skeletodental discrepancies using a convolutional neural network (CNN) and lateral cephalogram images with different qualities from nationwide multi-hospitals. Methods: Among 2,174 lateral cephalograms, 1,993 cephalograms from two hospitals were used for training and internal test sets and 181 cephalograms from eight other hospitals were used for an external test set. They were divided into three classification groups according to anteroposterior skeletal discrepancies (Class I, II, and III), vertical skeletal discrepancies (normodivergent, hypodivergent, and hyperdivergent patterns), and vertical dental discrepancies (normal overbite, deep bite, and open bite) as a gold standard. Pre-trained DenseNet-169 was used as a CNN classifier model. Diagnostic performance was evaluated by receiver operating characteristic (ROC) analysis, t-stochastic neighbor embedding (t-SNE), and gradient-weighted class activation mapping (Grad-CAM). Results: In the ROC analysis, the mean area under the curve and the mean accuracy of all classifications were high with both internal and external test sets (all, > 0.89 and > 0.80). In the t-SNE analysis, our model succeeded in creating good separation between three classification groups. Grad-CAM figures showed differences in the location and size of the focus areas between three classification groups in each diagnosis. Conclusions: Since the accuracy of our model was validated with both internal and external test sets, it shows the possible usefulness of a one-step automated orthodontic diagnosis tool using a CNN model. However, it still needs technical improvement in terms of classifying vertical dental discrepancies.

CFD Simulations of the Trees' Effects on the Reduction of Fine Particles (PM2.5): Targeted at the Gammandong Area in Busan (수목의 초미세먼지(PM2.5) 저감 효과에 대한 CFD 수치 모의: 부산 감만동 지역을 대상으로)

  • Han, Sangcheol;Park, Soo-Jin;Choi, Wonsik;Kim, Jae-Jin
    • Korean Journal of Remote Sensing
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    • v.38 no.5_3
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    • pp.851-861
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    • 2022
  • In this study, we analyzed the effects of trees planted in urban areas on PM2.5 reduction using a computational fluid dynamics (CFD) model. For realistic numerical simulations, the meteorological components(e.g., wind velocity components and air temperatures) predicted by the local data assimilation and prediction system (LDAPS), an operational model of the Korea Meteorological Administration, were used as the initial and boundary conditions of the CFD model. The CFD model was validated against, the PM2.5 concentrations measured by the sensor networks. To investigate the effects of trees on the PM2.5 reduction, we conducted the numerical simulations for three configurations of the buildings and trees: i) no tree (NT), ii) trees with only drag effect (TD), and iii) trees with the drag and dry-deposition effects (DD). The results showed that the trees in the target area significantly reduced the PM2.5 concentrations via the dry-deposition process. The PM2.5 concentration averaged over the domain in DD was reduced by 5.7 ㎍ m-3 compared to that in TD.

Experimental Study on the Shearing and Crushing Characteristics of Subaqueous Gravels in Gravel Bed River (수중 자갈의 전단 및 파쇄 특성에 관한 실험적 연구)

  • Kim, So-Ra;Jeong, Sueng-Won;Lee, Gwang-Soo;Yoo, Dong-Geun
    • Journal of the Korean earth science society
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    • v.42 no.2
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    • pp.164-174
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    • 2021
  • The study examines the shearing and crushing characteristics of land-derived subaqueous granular materials in a gravel-bed river. A series of large-sized ring shear tests were performed to examine the effect of shear time and shear velocity on the shear stress characteristics of aquarium gravels with a 6-mm mean grain size. Three different shear velocities (i.e., 0.01, 0.1, and 1 mm/sec) were applied to measure the shear stress under the drained (long-term shearing) and undrained (short-term shearing) conditions. Different initial shear velocities, i.e., 0.01→0.1→1 mm/sec and 0.1→0.01→1 mm/sec, were considered in this study. The test results show that the grain crushing effect is significant regardless of drainage conditions. The shear stress of coarse-grained materials is influenced by initial shear velocities, regardless of the drainage conditions. In particular, particle breakage increases as grain size increases. The shearing time and initial shear velocity are the primary influencing factors determining the shear stress of gravels. The granular materials may be broken easily into particles through frictional resistance, such as abrasion, interlocking and fracture due to the particle-particle interaction, resulting in the high mobility of granular materials in a subaqueous environment.

Analysis of Research Trends in Elder Abuse Using Text Mining : Academic Papers from 2004 to 2021. (텍스트 마이닝 분석을 통한 노인학대 관련 연구 동향 분석 : 2004년~2021년까지 발행된 국내 학술논문을 중심으로)

  • Youn, Ki-Hyok
    • Journal of Internet of Things and Convergence
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    • v.8 no.4
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    • pp.25-40
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    • 2022
  • This study aimed to understand the increasing number of elder abuses in South Korea, where entry into the super-aged society is imminent, by implementing text mining analysis. Korean Academic journals were obtained from 2004, the establishment year of the senior care agency, to 2021. We performed natural language processing of the titles, keywords, and abstracts and divided them into three segments of periods to identify latent meanings in the data. The results illustrated that the first section included 81 papers, the second 64, and the third 104 respectively, averaging 13.8 annually, which increased its numbers from 2014 until the decrease below the annual average in 2020. Word frequency demonstrated that the common keywords of the entire segments were 'elder abuse,' 'elders,' 'influences,' 'factors,' 'recognition,' 'family,' 'society,' 'prevention plans,' 'experiences,' 'abused elders,' 'abuse prevention,' 'depression,' etc., in consecutive order. TF-IDF indicated that 'influences,' 'recognition,' 'society,' 'prevention plans,' 'abuse prevention,' 'experiences,' 'depression,' etc., were the common keywords of all divisions. Network text analysis displayed that the commonly represented keywords were 'elder abuse,' 'elders,' 'influences,' 'factors,' 'characteristics,' 'recognition,' 'family,' 'prevention plans,' 'society,' 'abuse prevention,' and 'experiences' in the entire sections. concor analysis presented that the first segment consisted of 5 groups, the second 7, and the third 6. We suggest future directions for elder abuse research based on the results.

Experimental assessment of thermal radiation effects on containment atmospheres with varying steam content

  • R. Kapulla;S. Paranjape;U. Doll;E. Kirkby;D. Paladino
    • Nuclear Engineering and Technology
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    • v.54 no.11
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    • pp.4348-4358
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    • 2022
  • The thermal-hydraulics phenomena in a containment during an accident will necessarily include radiative heat transfer (i) within the gas mixture due to the high radiative absorption and emission of steam and (ii) between the gas mixture and the surrounding structures. The analysis of some previous PANDA experiments (PSI, Switzerland) demonstrated the importance of the proper modelling of radiation for the benefit of numerical simulations. These results together with dedicated scoping calculations conducted for the present experiments indicated that the radiative heat transfer is considerable, even for a very low amount of steam (≈2%). The H2P2 series conducted in the large-scale PANDA facility at the Paul-Scherrer-Institut (PSI) in the framework of the OECD/NEA HYMERES-2 project is intended to enhance the understanding of thermal radiation phenomena and to provide a benchmark for corresponding numerical simulations. Thus, the test matrix was tailored around the two opposite extremes: either gas compositions with small steam content such that radiative heat transfer phenomena can be neglected. Or gas mixtures containing larger amounts of steam, so that radiative heat transfer is expected to play a dominant role. The H2P2 series consists of 5 experiments designed to isolate the radiation phenomena from convective and diffusive effects as much as possible. One vessel with a diameter of 4 m and a height of 8 m was preconditioned with different mixtures of air / steam at room and elevated temperatures. This was followed by the build-up of a stable helium stratification at constant pressure in the upper part of the vessel. After that, helium was injected from the top into the vessel which leads to an increase of the vessel pressure and a corresponding elevation-dependent and transient rise of the gas temperature. It is shown that even the addition of small amounts of steam in the initial gas atmosphere considerably impacts the radiative heat transport throughout all phases of the experiments and markedly influences i) the monitored gas peak temperature, ii) the temperature history during the compression and iii) the following relaxation phase after the compression was stopped. These PANDA experiments are the first of its kind conducted in a large scale thermal-hydraulic facility.

A Study of Influential Factors on Health Promoting Behaviors of the Elderly: Focusing on Senior Citizens Living in Seoul (노인의 건강증진행위 영향요인에 관한 연구: 서울지역 거주노인을 중심으로)

  • Kim, Hyesook;Junsoo, Hur
    • 한국노년학
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    • v.30 no.4
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    • pp.1129-1143
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    • 2010
  • The purposes of this study were to investigate the major determinants influencing on health promoting behaviors(HPB) of the elderly living in Seoul. The conceptual framework of the study was Pender's health promoting model and the ecological perspectives. The study was conducted with 495 elderly persons whom 60 years old. For the analysis of data, descriptive statistics and hierarchical regression were used for the statistical analysis with SPSS program. The results were as following: 1) The mean score of the HPB was 3.11(SD=0.41). 2) Hierarchical regression analysis found that ModelIV accounted for 55.7% of the variance in HPB. 3) The Major determinants on HPB among the elderly persons were prior related perceived benefits of action, social support, perceived self-efficacy, community environment, perceived health status, education, and age. In conclusions, first, we should develop to various levels of educational and supportive programs for the HPB among the elderly persons. Second, we should examine more with environment, the accessibility to senior welfare agencies. Third, we should be organized the self-help groups for the elderly persons to improve health promoting behaviors. Fourth, the government should established more secure environment for the HPB, and find better solutions that are provided by various social welfare agencies connected with the coordination of the services in the local communities. Finally, we should develop professional education training programs of the HPB for the practitioners in the field of Gerontological Social Work.

Identification of Autoantigens in Pediatric Gastric Juices

  • Hee-Shang Youn;Jin-Su Jun;Jung Sook Yeom;Ji Sook Park;Jae-Young Lim;Hyang-Ok Woo;Jung-Wook Yang;Seung-Chul Baik;Woo-Kon Lee;Ji-Hyun Seo
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.27 no.1
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    • pp.15-25
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    • 2024
  • Purpose: This study aimed to investigate the presence of autoantigens in the gastric juices of children. Methods: Gastric juice and serum samples were obtained from 53 children <15 years of age who underwent gastric endoscopy. Among these, 8, 22, and 23 participants were in the age groups 0-5, 6-10, and 11-15 years, respectively. These samples were analyzed using two-dimensional electrophoresis (2-DE), immunoblot analysis, and matrix-assisted laser desorption ionization-time of-flight mass spectrometry. Furthermore, we reviewed the histopathological findings and urease test results and compared them with the results of 2-DE and immunoblot analysis. Results: There were no statistically significant differences in urease test positivity, grades of chronic gastritis, active gastritis, or Helicobacter pylori infiltration of the antrum and body among the three age groups. Three distinct patterns of gastric juice were observed on 2-DE. Pattern I was the most common, and pattern III was not observed below the age of 5 years. Histopathological findings were significantly different among active gastritis (p=0.037) and H. pylori infiltration (p=0.060) in the gastric body. The immunoblots showed large spots at an approximate pH of 3-4 and molecular weights of 31-45 kDa. These distinct, large positive spots were identified as gastric lipase and pepsin A and C. Conclusion: Three enzymes, which are normally secreted under acidic conditions were identified as autoantigens. Further investigation of the pathophysiology and function of autoantigens in the stomach is required.

Impact of Skeletal Muscle Loss and Visceral Obesity Measured Using Serial CT on the Prognosis of Operable Breast Cancers in Asian Patients

  • Mi-ri Kwon;Eun Sook Ko;Min Su Park;Woo Kyoung Jeong;Na Young Hwang;Jae-Hun Kim;Jeong Eon Lee;Seok Won Kim;Jong Han Yu;Boo-Kyung Han;Eun Young Ko;Ji Soo Choi;Ko Woon Park
    • Korean Journal of Radiology
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    • v.23 no.2
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    • pp.159-171
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    • 2022
  • Objective: This study aimed to investigate the impact of baseline values and temporal changes in body composition parameters, including skeletal muscle index (SMI) and visceral adipose tissue area (VAT), measured using serial computed tomography (CT) imaging on the prognosis of operable breast cancers in Asian patients. Materials and Methods: This study retrospectively included 627 Asian female (mean age ± standard deviation [SD], 53.6 ± 8.3 years) who underwent surgery for stage I-III breast cancer between January 2011 and September 2012. Body composition parameters, including SMI and VAT, were semi-automatically calculated on baseline abdominal CT at the time of diagnosis and follow-up CT for post-treatment surveillance. Serial changes in SMI and VAT were calculated as the delta values. Multivariable Cox regression analysis was used to evaluate the association of baseline and delta SMI and VAT values with disease-free survival. Results: Among 627 patients, 56 patients (9.2%) had breast cancer recurrence after a median of 40.5 months. The mean value ± SD of the baseline SMI and baseline VAT were 43.7 ± 5.8 cm2/m2 and 72.0 ± 46.0 cm2, respectively. The mean value of the delta SMI was -0.9 cm2/m2 and the delta VAT was 0.5 cm2. The baseline SMI and VAT were not significantly associated with disease-free survival (adjusted hazard ratio [HR], 0.983; 95% confidence interval [CI], 0.937-1.031; p = 0.475 and adjusted HR, 1.001; 95% CI, 0.995-1.006; p = 0.751, respectively). The delta SMI and VAT were also not significantly associated with disease-free survival (adjusted HR, 0.894; 95% CI, 0.766-1.043; p = 0.155 and adjusted HR, 1.001; 95% CI, 0.989-1.014; p = 0.848, respectively). Conclusion: Our study revealed that baseline and early temporal changes in SMI and VAT were not independent prognostic factors regarding disease-free survival in Asian patients undergoing surgery for breast cancer.