• Journal of Korean Medicine Rehabilitation
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• v.28 no.4
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• pp.125-130
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• 2018

This case report was conducted to introduce the use of miniscalpel-acupuncture for the treatment of hand osteoarthritis. A-76-year old female patient who had pain on both hands due to osteoarthritis was treated with miniscalpel-acupuncture for 7 weeks. The main outcome were the Numeral Rating Scale (NRS) and the grip strength by dynamometer. After miniscalpel-acupuncture treatment, NRS was decreased and the strength of grasp was increased. The result of this study suggests that the treatment of miniscalpel-acupuncture may be effectively used to decrease pain and increase grip strength of patients who suffer from hand osteoarthritis. Further research is necessary by the reason of the limited sample size of this study.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2022.09a
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• pp.119-119
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• 2022

The coronavirus disease 2019 (COVID-19) pandemic may be stressful for people. Public health actions, such as social distancing, can make people feel isolated and lonely and can increase stress and anxiety. As a result, there is a growing interest towards various materials to relieve stress. Thus, the present study aimed to investigate the anti-stress effects of ethanol extract of Ziziphus jujuba in PC12 cells treated with corticosterone and its underling mechanisms. Furthermore, the viability of the cells, the apoptosis of the cells, the level of phosphorylation of extracellular signal-regulated kinases (p-ERKs) expression were measured by MTT assay, LDH assay, Hoechst staining assay and western blotting. Our results showed that the extract of Ziziphus jujuba reversed corticosterone-induced damage in PC12 cells, which increased cell viability, decreased LDH release, and attenuated corticosterone-induced apoptosis as compared with the corticosterone-treated group. Therefore, these data suggest that the extract of Ziziphus jujuba could be a good candidate for development as a functional food supplement in the improve the anti-stress effect.

• The Journal of Korean Medicine
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• v.44 no.3
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• pp.39-46
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• 2023

Objectives: This research aims to analyze the relationship between Daeseunggi-tang and sepsis in literature. Methods: The main treatment symptoms of Daeseunggi-tang presented in Sanghanron and GeumGweyoryak, the symptoms of Ju-hwang and Nae-ham which correspond to sepsis in Korean Medicine, the symptoms of sepsis presented in the related papers including international guideline and diagnosis criteria of spesis were compared and analyzed. Results: The main treatment symptoms of Daeseunggi-tang were very similar to the symptoms of sepsis, and were almost identical to the symptoms of Ju-hwang and Nae-ham (especially Hwa-ham, Gu-ham), which are the Korean medicine descriptions of sepsis. Conclusions: Based on the above research results, it seems to be possible to use Daeseunggi-tang for the treatment of sepsis.

• Korean Journal of Food Science and Technology
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• v.45 no.5
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• pp.628-635
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• 2013

We investigated the effects of water extracts of unripe black raspberry (UBR) and red ginseng (RG) on cholesterol synthesis, 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase activity, and expression of low-density lipoprotein (LDL) or high-density lipoprotein (HDL)-related genes in HepG2 and Caco-2 (human hepatoma and intestinal cell lines, respectively). Our results showed that cholesterol synthesis and HMG-CoA reductase activity in HepG2 cells were inhibited by UBR and RG. Further, co-treatment with UBR and RG had a greater effect than did treatment with either UBR or RG. In Caco-2 cells, treatment with UBR and RG increased the expression of LDL-regulated genes, such as LDL receptor and SREBP-2, and also upregulated the level of HDL-associated ABCA1. Moreover, co-treatment with UBR and RG appeared to be more effective than treatment with either UBR or RG. Taken together, our results indicate that UBR and RG regulate the level of HDL-associated ABCA1 via signaling pathway, thereby preventing cholesterol synthesis.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.12
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• pp.6089-6097
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• 2012

This study suggested a method of detecting an incident inside tunnel by using camera that is installed within the tunnel. As for the proposed incident detection method, a static object, travel except vehicles, smoke, and contra-flow were detected by extracting the moving object through using the real-time background image differencing after receiving image from the camera, which is installed inside the tunnel. To detect the moving object within the tunnel, the positive background image was created by using the moving information of the object. The incident detection method was developed, which is strong in a change of lighting that occurs within the tunnel, and in influence of the external lighting that occurs in the entrance and exit of the tunnel. To examine the efficiency of the suggested method, the experimental images were acquired from Marae tunnel and Expo tunnel in Yeosu of Jeonnam and from Unam tunnel in Imsil of Jeonbuk. Number of images, which were used in experiment, included 20 cases for static object, 20 cases for travel except vehicles, 4 cases for smoke, and 10 cases for contra-flow. As for the detection rate, all of the static object, the travel except vehicles, and the contra-flow were detected in the experimental image. In case of smoke, 3 cases were detected. Thus, excellent performance could be confirmed. The proposed method is now under operation in Marae tunnel and Expo tunnel in Yeosu of Jeonnam and in Unam tunnel in Imsil of Jeonbuk. To examine accurate efficiency, the evaluation of performance is considered to be likely to be needed after acquiring the incident videos, which actually occur within tunnel.

• The Journal of the Petrological Society of Korea
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• v.16 no.3
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• pp.101-115
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• 2007

The CHIME (chemical Th-U-total Pb isochron method) dating on monazite was carried out for two foliated granites from a dextral ductile shear zone in the vicinity of Gangjin area, which is considered to be a southern extension of Sunchang shear zone. The result gives emplacement age of the medium-grained biotite granite and the coarse-grained biotite granite as $183.6{\pm}2.2Ma$(MSWD=0.21) and $171.7{\pm}4.0Ma$(MSWD=0.57), respectively. Microtextures of quartz and feldspar observed in the foliated granite are almost identical with those reported in Jurassic (ca 180 Ma) foliated granites from the Imsil-Namwon area of the Sunchang shear zone, and they constraint that the ductile deformation took place at temperature condition of $300{\sim}550^{\circ}C$. Assuming cooling curves of the foliated granites in this study are similar with those of Jurassic foliated granites from Imsil-Namwon area, dextral ductile shear in the Gangjin area would take place between 172 Ma and 150 Ma, about 10 Ma later than the previous estimation based on CHIME monazite ages.

• Korean Journal of Agricultural Science
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• v.4 no.2
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• pp.199-214
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• 1977

These studies were conducted to obtain basic information of the rice blast resistance in comparision with blast occurrence patterns in the blast nursery test in Korea. One hupdred and twenty nine rice varieties including several blast differential varieties and 30 combinations of pedigree lines were tested at six different locations, Suweon, Chulweon, Chuncheon, Iri, Jinan, Imsil, and Milyang, in 1976~1977. The results obtained are summarized as follows: 1. When blast resistance was tested using three sets of differential varieties at six locations, prevalent races were different depending on the location and differential variety set tested. 2. There were regional differences in blast disease reation among Japonica rice varieties and among Indica${\times}$Japonica crosses. 3. At Suweon blast disease reactions of pedigree lines were different from that at Imsil. 4. Three varietal groups were made depending on the develpment of rice blast in the nursery test. 5. In general, highly resistant varieties to rice leaf blast were also resistant to neck blast, but there were exceptions.

• Journal of the Korean Society of Food Science and Nutrition
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• v.43 no.10
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• pp.1491-1499
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• 2014

We examined the effects of unripe black raspberry (UBR) and red ginseng (RG) extracts on cholesterol improvement in C57BL/6J mice fed a HCD (high cholesterol diet) for 12 weeks. Hepatic total lipid and total cholesterol contents were significantly induced in hyperlipidemic mice. However, supplementation with UBR, RG and simvastatin effectively reduced these lipid profiles. Further, UBR and co-treatment with UBR and RG increased expression of LDL receptor, SREBP2, and SR-B1 mRNA compared with HCD. The ApoB/ApoA1 ratio was reduced by co-treatment with UBR and RG compared to treatment with UBR. In addition, histopathologic evaluation showed that co-treatment with UBR and RG suppressed lipid accumulation as well as FAS and leptin expression in plasma. These results indicate that co-treatment with UBR and RG may be useful for the prevention of hypercholesterolemia.

• Research in Plant Disease
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• v.17 no.1
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• pp.86-89
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• 2011

Phytophthora blight and anthracnose disease caused by Phytophthora capsici and Collectotrichum gloeosporioides are the most important devastating diseases of red pepper plants, worldwide. Five different bacterial isolates were isolated from the red pepper rhizosphere and non-rhizosphere soil and subsequently tested for antagonistic activity against P. capsisi and C. gloeosporioides. The area of the inhibition zone was taken as a measure for antagonistic activity. Among the 5 isolates tested, S54 exhibited a maximum antagonistic activity under in vitro and in vivo conditions. In greenhouse studies the isolate has successfully reduced the disease symptom. Protect value was 80.8% (Phytophthora blight) and 81.9% (Anthrancnose disease), whereas the infection rate of control plants was 21.3% and 23.2%. Based on the 16S rDNA sequence and API 50CHB Kit analysis the most effective isolate was identified as Bacillus subtilis. The results of the study indicate that the stratin S54 could be used as an potential biological control of Phytophthora blight and anthracnose disease of red pepper.

• The Korea Journal of Herbology
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• v.26 no.4
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• pp.39-47
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• 2011

Objective: The roots, leaves, flowers, stems and seeds of Cirsium japonicum var. ussuriense are often used in treatment of human diseases such as hemorrhage, blood congestion and inflammation. Focusing our attention on natural and bioavailable sources of antioxidants and anti-inflammation, we undertook to investigate the antioxidant and anti-inflammatory properties of Cirsium japonicum var. ussuriense used as a folk medicine in Korea. Methods: The extracts of the leaves, stems, flowers, seeds and roots from C. japonicum var. ussuriense were prepared by extracting with water or 80% ethanol. Total flavonoids and polyphenols were measured by a colorimetric assay. The free radical scavenging activity of the extract was analyzed by the DPPH (1,1-diphenyl-2-picryl hydrazyl), ABTS (2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) and Griess reagent assay. An oxidative product of nitric oxide (NO), was measured in the culture medium by the Griess reaction. The level of prostaglandin $E_2$ ($PGE_2$) was measured by enzyme-linked immunosorbent assay. The expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) were measured by Western blot analysis. Results: Total flavonoid and polyphenol amounts of the leaves (CLE) and flowers (CFE) showed higher than those of the seed extract (CSE), stem extract (CSTE) and roots (CRE). CLE and CFE also showed the high antioxidant activities such as DPPH, NO-like and ABTS radical scavenging activity. An antioxidant activities of these water extracts showed higher than those of 80% ethanol extracts. We investigated the anti-inflammatory effects of CLE on lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. CLE significantly suppressed the levels of the inflammatory mediators such as NO and prostaglandin $E_2$ ($PGE_2$) in dose dependant. Furthermore, the levels of iNOS and COX-2 protein expressions were markedly suppressed by the treatment with CLE extract in a dose dependent manner. Conclusions: These results suggest that CLE water extract has a higher anoxidant and anti-inflammatory activity, these properties may contribute to the oxidative and inflammatory related disease care.