• Title/Summary/Keyword: Improving design

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Effect of coadministration of enriched Korean Red Ginseng (Panax ginseng) and American ginseng (Panax quinquefolius L) on cardiometabolic outcomes in type-2 diabetes: A randomized controlled trial

  • Jovanovski, Elena;Smircic-Duvnjak, Lea;Komishon, Allison;Au-Yeung, Fei (Rodney);Sievenpiper, John L.;Zurbau, Andreea;Jenkins, Alexandra L.;Sung, Mi-Kyung;Josse, Robert;Li, Dandan;Vuksan, Vladimir
    • Journal of Ginseng Research
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    • v.45 no.5
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    • pp.546-554
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    • 2021
  • Background: Diabetes mellitus and hypertension often occur together, amplifying cardiovascular disease (CVD) risk and emphasizing the need for a multitargeted treatment approach. American ginseng (AG) and Korean Red Ginseng (KRG) species could improve glycemic control via complementary mechanisms. Additionally, a KRG-inherent component, ginsenoside Rg3, may moderate blood pressure (BP). Our objective was to investigate the therapeutic potential of coadministration of Rg3-enriched Korean Red Ginseng (Rg3-KRG) and AG, added to standard of care therapy, in the management of hypertension and cardiometabolic risk factors in type-2 diabetes. Methods: Within a randomized controlled, parallel design of 80 participants with type-2 diabetes (HbA1c: 6.5-8%) and hypertension (systolic BP: 140-160 mmHg or treated), supplementation with either 2.25 g/day of combined Rg3-KRG + AG or wheat-bran control was assessed over a 12-wk intervention period. The primary endpoint was ambulatory 24-h systolic BP. Additional endpoints included further hemodynamic assessment, glycemic control, plasma lipids and safety monitoring. Results: Combined ginseng intervention generated a mean ± SE decrease in primary endpoint of 24-h systolic BP (-3.98 ± 2.0 mmHg, p = 0.04). Additionally, there was a greater reduction in HbA1c (-0.35 ± 0.1% [-3.8 ± 1.1 mmol/mol], p = 0.02), and change in blood lipids: total cholesterol (-0.50 ± 0.2 mmol/l, p = 0.01), non-HDL-C (-0.54 ± 0.2 mmol/l, p = 0.01), triglycerides (-0.40 ± 0.2 mmol/l, p = 0.02) and LDL-C (-0.35 ± 0.2 mmol/l, p = 0.06) at 12 wks, relative to control. No adverse safety outcomes were observed. Conclusion: Coadministration of Rg3-KRG + AG is an effective addon for improving BP along with attaining favorable cardiometabolic outcomes in individuals with type 2 diabetes. Ginseng derivatives may offer clinical utility when included in the polypharmacy and lifestyle treatment of diabetes. Clinical trial registration: Clinicaltrials.gov identifier, NCT01578837;

A Study of Effects of Laminaria japonica Extract on Improvement of Hair Damage (다시마 추출물의 손상모발 개선효과에 관한 연구)

  • Kim, Ju-Sub;Jeon, Yong-Han
    • Journal of the Korean Applied Science and Technology
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    • v.38 no.4
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    • pp.986-993
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    • 2021
  • This study was aimed to investigate the improvement effects of kelp extract on the damaged hair by manufacturing hair quality improving formulation adding kelp extract and applying that in the damaged hair. With respect to the study materials, the formulation was manufactured with different strengths of kelp extract including 0, 2, 4, and 6 grams, adding perm base material. The manufactured formulation was applied to the decolored sample hair of Level 8 and its effects were measured and compared before and after its application. Tensile strength, absorbance using methylene blue, and gloss were measured as the tools to show the improvement effects of hair quality. To check the reliability of the results, statistical analysis was performed. Tensile strength showed to be increased in the Level 8 samples applied by the formulations containing 4- and 6-gram strength. Absorbance using methylene blue showed to be decreased in all the samples after the application, based on the absorbance results before and after the application. No difference was found in all the samples on the gloss. In conclusion, this study revealed that kelp extract could improve the damaged hair. Further studies are required to check the improvement effects on the damaged hair with multiple types of extracts and study methods.

Flexible Unit Floor Plan of a Modular House Considering the Production System (생산 시스템을 고려한 모듈러주택의 가변형 평면계획 연구)

  • Lee, Ji-Eun
    • Land and Housing Review
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    • v.12 no.3
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    • pp.67-78
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    • 2021
  • After World War II, modular housing was developed as a means of quickly and efficiently meeting the housing supply demand. For the past 30 plus years, efforts have been made to improve modular housing in South Korea and to increase their competitiveness in the housing market. This study investigated modular houses based on a steel framed rahem structure which provides a flexible floor plan where walls are easily reconfigured to create rooms of various sizes and functions. Similar to the factory production methods used in the automotive industry, the modular housing industry can also benefit by standardizing such aspects as building components, manufacturing and construction methods, materials, process management, and floor plans. This study examined the feasibility of using a 3m × 3m module for developing various floor plans which are easy to produce and transport. Each 3m × 3m module can be configured to meet different living needs resulting in a complete home when multiple modules are connected. The module configurations can be varied to meet ground transportation and crane limitations. This study found that a 3m × 3m steel framed modular unit is a promising step towards providing residents with plans that meet their living preferences while improving and increasing the supply of modular houses.

A Study on Usage Behaviors and Place Attachment of Urban SSamji Park as a Neighborhood Space - Focused on Hanpyeong Park and Hanpyeom Park located in Capital Area- (근린공간으로서 도심지 쌈지공원의 이용행태와 장소애착에 관한 연구 - 수도권 지역의 한평공원 및 한뼘공원을 중심으로 -)

  • Park, Hoon
    • Asia-pacific Journal of Multimedia Services Convergent with Art, Humanities, and Sociology
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    • v.9 no.7
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    • pp.707-722
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    • 2019
  • The concept of neighborhood parks has been used as the principle of forming a community in our society going through modern and contemporary times. The concept of neighborhood parks equipped with physical facilities has been discussed constantly regarding the roles and meanings of them. This study focuses on pocket parks which have been playing roles in improving environment through regeneration and forming regional communities based on that as neighborhood facilities. This author carried out field investigation on total 72 Hanpyeong Park and Hanpyeom Parks formed in the capital area and examined the significance of planning them and also their utility and residents and users' attachment to them through a survey. In this process, this researcher has been able to draw following conclusions. First, according to the demographic characteristics of users, there is significant difference found by groups in terms of their place attachment to the parks. This implies that difference in the major types of residences supplied these days influences their intention to experience ecological space. Second, according to their educational background, there is significant difference found by groups regarding their place attachment to the parks. Third, according to user behavior, there are differences found in their place attachment to the parks and also detailed differences found by groups in terms of the frequency of use and duration of stay.

Feasibility Study of Fuel Property for Fuel Processing Design on Ship and Warship (선박의 연료품질 기반 군용선박의 연료품질 적용가능성 분석)

  • Hwang, Gwang-Tak
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.22 no.4
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    • pp.281-286
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    • 2021
  • The International Maritime Organization recently proposed a policy to establish a preemptive response strategy for exhaust gas pollution on board ships according to the recent strengthening of the sulfur content regulations. Discussions on improving the fuel oil quality and reducing emissions are also ongoing. Fuel oil quality information, which is one of the main concerns internationally, is increasing as the sulfur content standard is being applied from the current 3.5% to 0.5% by 2020. From the perspective of shipping companies and recipients, the essential quality of fuel oil is also requested for domestic and international fuel oil information, basic properties, correlation information between characteristics for application of solid ships and ships. The current standard for the basic quality of fuel oil is generally used, but the nature and composition of the fuel oil are very complex, and the interpretation of the basic quality is complicated because there are many cases outside the scope of the basic standard. Various factors were analyzed for the basic quality of fuel oil in terms of the basic quality of fuel oil, optimization of operation in ships, and fuel efficiency in ships. Moreover, the possibility of applying the standard according to the dilution was suggested.

A Liability for Damage caused by Drug (의약품 부작용과 손해배상)

  • Song, Jinsung
    • The Korean Society of Law and Medicine
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    • v.21 no.3
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    • pp.77-116
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    • 2020
  • The use of drugs that reflect the experiences and achievements of modern science has given human being the benefits of treating diseases and improving health conditions. However, in addition to the benefits of those, medicines have inherently inevitable adverse reactions. Many countries are taking measures such as market entry regulations or post-marketing surveillance to minimize damage caused by drug side effects, but the occurrence of side effects cannot be eliminated. Although the damage is force majeure, in some cases, the doctor who prescribed the drug or the pharmacist who administered the drug may have to compensate for the damage. The liability depends on whether the side effects were known in advance, the type of medicine, etc. On the other hand, in some cases, drug manufacturer may have to take liability for the side effect itself. As it is not easy for victims to be compensated for damages in those cases, many countries, including Korea, are setting to protect victims through the Product Liability Act. Drugs are also one of the product, so liability set by the Product Liability Act may apply. Even before the enactment and enforcement of the Product Liability Act, damage caused by drug has occurred. To resolve them, precedents have developed case law, which have many similarities with the Product Liability Act, but also have differences. Damage caused by drug manufactured prior to the enforcement of the Product Liability Act may occur in the future. In this context, the legal principles of the case laws will remain valid and be applied. This is an important reason to review the case law of precedents.

The Effect of the Flipped Learning on Learning motivation, Academic self-efficacy and Critical Thinking Disposition of Nursing Students (플립러닝 교수-학습법이 간호대학생의 학습동기, 학업적 자기효능감 및 비판적 사고성향에 미치는 효과)

  • Lee, Oi Sun;Noh, Yoon Goo
    • Journal of Digital Convergence
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    • v.17 no.3
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    • pp.253-260
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    • 2019
  • This study was conducted to test the effects of flipped learning on learning motivation, academic self-efficacy and critical thinking disposition for undergraduate nursing students. This study used a one group pre-post test design. Participants were 88 nursing students. The flipped learning was provided for 4 times(8 hours) in adult nursing. Data were collected between March 5 and June 8, 2018. Data were analyzed by frequencies, paried t-test using SPSS/WIN 23.0. The results showed that learning motivation (t=12.7, p<.001) was significantly lower than levels before flipped learning, academic self-efficacy (t=-3.01, p<.001) was significantly higher than levels before flipped learning and critical thinking disposition (t=-.51, p=.606) was higher than levels before flipped learning but was no significantly. The study findings suggest that the flipped learning has proven to be influential educational program for improving the academic self-efficacy, critical thinking disposition of nursing students. The flipped learning was an effective teaching program for nursing students. But Learning motivation is decreased, It is necessary to develop flipped learning that can improve learning motivation.

Effects of a Computer-based Cognitive Rehabilitation Therapy on Mild Dementia Patients in a Community (지역사회 경증치매환자를 대상으로 한 전산화 인지재활 치료(COMCOG) 효과)

  • Jeong, Won-Mee;Hwang, Yun-Jung;Youn, Jong Chul
    • 한국노년학
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    • v.30 no.1
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    • pp.127-140
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    • 2010
  • This study aims to understand the effects of a Computer - based Cognitive Rehabilitation Therapy(CBCRT) evidence based on mild dementia patients' ability to activities daily living(ADL), cognitive function and measure of occupational performance and to suggest basic data for a cognitive rehabilitation therapy for dementia patients. Method : A CBCRT was applied two times a week for 5 weeks to 14 mild dementia patients who visited Yongin Center for Managing Dementia in Gyeongi-do between February and August 2009. Based on frame of reference for Visual-Perception a CBCRT was applied at home. Moreover, a one group pretest-post test design was, which is a quasi-experiment and research, also applied in order to verify the effects of the rehabilitation therapy on the subjects' ability to ADL, cognitive function and occupational performance skills. Results: A significant effect was confirmed (p<.05) from the CBCRT which Assessment of Motor and Process Skills(AMPS) processing skills and cognitive function and occupational performance skills. Neither was found any significant effect in improving motor skills from AMPS. Conclusion: It seems that a CBCRT based on evidence and has an effect on the improvement of the ability to ADL and cognitive function of mild dementia patients living in a community. The present author hopes that, in the future, more cognitive rehabilitation programs will be developed to improve the functions of mild dementia patients living in a community.

Research of Usability Test on Disabled Welfare Vehicle for Guardians and Passengers of Disabled People (장애인 보호자 및 탑승자를 대상으로 한 장애인 복지차량 사용성 평가 연구)

  • Rhee, Kun Min;Kim, Dong Ok
    • 재활복지
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    • v.20 no.3
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    • pp.141-161
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    • 2016
  • This research is to anticipate problems of Ray's disabled experiment welfare vehicles for 17 drivers with disability, improving them. In addition it is to provide the criteria for ergonomic design based on perspective of drivers with disability by investigating 18 items of usability test. The results are as follows. First, satisfaction degree of Ray, disabled experiment welfare vehicle, was shown to be 3.88 which is higher than normal vehicles whose degree is 3.20. This showed that the disabled experiment welfare vehicle is the one with much improvement. Second, so as to develop a welfare vehicle it needs to take into account some factors including rear slope, wheelchair locker, seat belt, safety grip, and high roof. Third, in case of rear slope, high roof and width of manual or automatic wheel chairs should be considered and motor-operated device should also be taken into account for safety lockers, which make a wheelchair firmly fixed. Moreover, motor-operated seat and rear slope can be chosen for either of the disabled and the elderly.

Development and Effect Analysis of Pregnancy Recognition Improvement Program (임신 인식 개선 프로그램 개발 및 효과 분석)

  • Kim, Jungae;Kim, Ju-ok
    • The Journal of the Convergence on Culture Technology
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    • v.4 no.4
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    • pp.77-87
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    • 2018
  • The study was a mixed design study that analyzed the effects of developing and applying a program to improve pregnancy recognition for severe low fertility. The study period was from April 1, 2018, to October 26, 2018, and the participants included 16 women of 19~21 age who lived in M City and M Gun. The process of program development is based on Dorothy Johnson 's theory of behavior system to induce change of perception, and reference literature review and national policy report. The program developed through the literature was finally developed by examining the experts panel discussion after deriving causes and alternatives for low fertility from 25 fertility women. The contents of program consist of three areas. Quantitative research results were analyzed using Shapiro Wilk and Wilcoxon sign rank using SPSS 18.0, and qualitative research results were analyzed using focus group. As a result of study, the perception of pregnancy increased significantly (P<0.01) with statistical significance as pre-experimental (M=3.21, SD=.342), post-experimental (M=4.46, SD=.398) and the result of content analysis appeared three themes as , , . In conclusion, the program was effective in improving the recognition of pregnancy for young women.