• 동의생리병리학회지
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• 제19권5호
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• pp.1272-1280
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• 2005

The study was performed by examining the effects of fermented liquid of Crataegi Fructus on the lipid profile improvement in rats fed high fat diets. Sprague-Dawley rats of weighting $180.0{\pm}30g$ were randomly divided into five groups : basal diet (Normal control group, NCG), only high fat diet (High fat control group, HFC), high fat diet and supplemented with 1.69 mg/100 g body weight, 3.38 mg/100 g body weight, 6.76 mg/100 g body weight by fermented liquid of Crataegi Fructus - HFL, HFM, HFH group). These experimental diets were fed for 6 weeks. The fermented liquid of Crataegi Fructus fed groups had more significantly decreased in the levels of serum total cholesterol, triglyceride, LDL-cholesterol and atherogenic index than the high fat control group, while the HDL-cholesterol was higher when compared to the normal control group. Total lipid, total cholesterol, triglyceride, LDL-cholesterol contents in liver were decreased in high fat experimental groups. But the degree of increment was reduced by administration of fermented liquid of Crataegi Fructus. while the fermented liquid of Crataegi Fructus fed group had ore significantly increased in the level of HDL-cholesterol than the high fat control group. The singularity of the unsaturated fatty acid contents attracted our attention. Especially, the polyunsaturated fatty acid compositions were 36.36%, 34.70%, 20.31%in serum, liver and fecal of fermented liquid of Crataegi Fructus fed groups, respectively. These results imply that the fermented liquid of Crataegi Fructus can be used as possible food resources and medicinal food materials.

• 대한융합한의학회지
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• 제5권2호
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• pp.11-16
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• 2023

Objectives: The purpose of this study was to investigate the anti-obesity effects of the aqueous extract of Schizandra chinensis (SC) in menopausal mice. Methods: To induce menopausal obesity, female mice were ovariectomized (OVX) and fed a high-fat diet (HFD; 60% fat, 28% carbohydrates, 14% protein) for 12 weeks. The mice were divided into 6 groups (n = 8): NOR (sham-operated and vehicle-treated), HFD+OVX (vehicle-treated), E2 (17-beta estradiol 50 ㎍/kg-treated), SC1 (1 mg/kg SC-treated), SC10 (10 mg/kg SC-treated), and SC100 (100 mg/kg SC-treated). Samples were orally administered for 6 weeks, after which all experimental mice were sacrificed. Body weight, feeding efficiency, white adipose tissue weight, adipocyte diameter, and fat vacuoles in liver were analyzed. Results: By treating with SC extract, the body weight and feeding efficiency of mice were significantly decreased. The weight of visceral fat tissues was decreased in the SC10 and SC100 groups. Histopathology showed that fat cell diameters of white adipose tissue were also decreased in the SC10 and SC100 groups. Additionally, SC extract regenerated the hepatocyte damage and decreased the size and number of follicular adipocytes Conclusion: In summary, these results suggest that SC has inhibitory effects against menopausal obesity. Schizandra chinensis may be a potential alternative for obesity among female menopausal diseases.

• 대한한방내과학회지
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• 제27권2호
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• pp.305-315
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• 2006

Objectuves : The purpose of this study was to investigate the effects of Cheunghyeoltang(CHT) and Gami-Cheunghyeoltang(GCHT) on the obesity in rats. Methods : After we divided rats into four different groups, we Provided to normal group general diet and distilled water, to control group high fat diet and distilled water, to CHT group high fat diet and CHT and to GCHT group with high fat diet and GCHT for 9 weeks. Afterward we check the change of body weight, the concentration of AST, ALT, total cholesterol, HDL-cholesterol, LDL-cholesterol, the Atherogenic index and the gene expression of leptin in rats. Results : The increase of body weight were suppressed significantly in the CHT group and GCHT group in comparision with control group, the serum ALT showed significant decrease in the GCHT group in comparison with control group, the serum total cholesterol showed significant decrease in the CHT and GCHT group in comparison with control group, the atherogenic index(AI) showed significant decrease in the GCHT group in comparison with control group and the serum leptin showed increase of gone expression in the GCHT group in comparison with control group. Conclusions : According to the experimental results, it is suggested that CHT is effective to the suppression of body weight's increase, the improvement of hyperlipidemia and the activation of leptin's gene expression, GCHT is effective to the suppression of body weight's increase, the improvement of hyperlipidemia, the decrease of arteriosclerosis and the activation of leptin's gene expression. Therefore CHT and GCHT seem to be applicable to obesity, arteriosclerosis and hyperlipidemia in clinical practice.

• 대한본초학회지
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• 제31권2호
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• pp.13-19
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• 2016

Objectives : The present study was designed to evaluate the protective effect of Allium tuberosum (AT) extract on atherosclerosis in LDL receptor knockout (LDLr KO) mouse fed western diet.Methods : The AT was extracted 70% ethanol. The experimental groups were divided with four groups of LDLr KO mice, one group fed a normal diet and the others fed a Western diets for 8weeks. Two Western diet groups were orally administered AT extract at dosage of 100 and 300 mg/kg body weight. The body weight and food intake were measured every day. We measured levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and Glucose in serum. Also, effect of AT extract performed using H&E staining.Results : The AT treatment groups showed decrease in body weight and food efficiency in comparison with control group. Blood biochemistry parameters such as TG, TC, LDL, and glucose levels were increased in control group, while AT treatment groups were reduced. Also, the increased levels of ALT and AST were improved by AT extract. We confirmed that the weights of liver, kidney, subcutaneous fat, epididymal fat, kidney leaf fat, and intraabdominal fat were change in LDLr KO mice treated AT extract. In addition, histopathological changes in liver and aorta were similar to normal group.Conclusions : Based on these results, the AT extract is considered to make prevention of atherosclerosis through reduction and functional improvement of the liver and vascular endothelial cells in the body fat accumulation and lipid content in LDLr ko mouse model.

• 운동영양학회지
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• 제23권3호
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• pp.22-28
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• 2019

[Purpose] The purpose of this study was to investigate the effect of diet plus exercise training and detraining for 12 weeks on body composition, aerobic performance, and stress-related variables in obese women. [Methods] Twenty-five women in their 20s-40s with 30% body fat and body mass indices above 25 kg/m² were divided into HR_LT (heart rate at lactate threshold) and HR_LT + 5% groups. Dietary intervention of 70% recommended dietary allowance (RDA) and exercise treatment composed of aerobic exercises on a bicycle (30 min) and treadmill (30 min) were then performed. These interventions were performed three times a week for 12 weeks. [Results] Dietary intake was significantly decreased, while daily activity significantly increased within the 12-week intervention period, and this effect was sustained after 12 weeks of detraining. Exercise training based on dietary intake and daily activity presented a significantly decreased weight and % body fat, improvement of aerobic performance, and a significant increase in heart rate variability (HRV) (e.g., average of all RR intervals and the square root mean squared differences of successive RR intervals) as stress-related variables. It was also confirmed that the improvement of body composition and stress-related variables were maintained even after detraining. [Conclusion] Our results suggest that 70% RDA of dietary intervention and exercise training corresponding to HR_LT and HR_LT + 5% for 12 weeks were effective in improving body composition and aerobic performance, and relieving stress. In particular, enhanced HRV persisted for up to 12 weeks after the end of exercise training in obese women.

• Journal of Applied Biological Chemistry
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• 제66권
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• pp.328-337
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• 2023

We investigated the effects of single and combined administrations of Lactobacillus species (L. plantarum, LP; L. gasseri, LG; L. casei, LC) on blood lipid metabolism and obesity in mice fed a high-fat diet (HFD). The mice were continuously supplemented with LP, LP/LG, or LP/LG/LC, along with HFD, for 12 weeks. The consumption of HFD led to significant increases in body weight, total cholesterol, and triglyceride levels compared to the normal control group. However, administration of LP, LP/LG, or LP/LG/LC to HFD-fed mice reduced body weight gain and showed a tendency to suppress the levels of total cholesterol, triglycerides, and LDL-cholesterol, while increasing HDL-cholesterol levels. The HFD group exhibited increased abdominal fat weight and larger adipocytes in the epididymal adipose tissue compared to the NC group. However, the administered probiotics led to a significant reduction in adipocyte size with decreasing tendency in abdominal fat weight compared with the HFD group. Additionally, the deposition of giant vesicular fat cells in the liver of the HFD group considerably decreased in the probiotic-administered group. Microbiome analysis revealed an imbalance in intestinal microbes in the HFD group, characterized by lower Bacteroidetes and higher Proteobacteria ratios. However, probiotic administration tended to restore the microbial distribution by controlling the abundance of Bacteroidetes and Proteobacteria, resulting in decreased Firmicutes/Bacteroidetes and Proteobacteria/Bacteroidetes ratios. These results suggest that single and combined administration of LP and other probiotics holds enormous potential in reducing obesity in HFD-fed mice as they regulate lipid metabolism, reduce adipocyte size, and restore the balance of intestinal microbes.

• 한국산학기술학회논문지
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• 제17권6호
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• pp.226-232
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• 2016

본 연구는 비만 노인여성을 대상으로 아쿠아로빅 운동을 적용한 후 신체조성 및 혈중지질의 개선효과를 알아보고 노인운동프로그램에 관한 다각적인 기초자료를 제공하는데 목적이 있다. 실험참가자들 (n=31)은 12주 동안 주 3회 60분의 아쿠아로빅 운동을 Borg의 운동자각도 12-13의 강도로 실시하였다. 신체조성은 inbody의 생체전기저항분석법을 사용하여 측정하였고 채혈된 혈액에서 혈중지질 (고밀도지단백(HDL), 저밀도지단백(LDL), 중성지방(TG)와 총콜레스터롤(TC))을 분석하였다. 자료의 분석은 대응 t-test를 이용하였고 유의수준은 0.05로 설정하였다. 아쿠아로빅 운동 후 체지방량과 허리둘레는 유의하게 감소하였고 (p < 0.05) 혈중지질 중 LDL (p < 0.05), TG (p < 0.001), 그리고 TC (p < 0.05)은 유의하게 감소하였다. 이상과 같은 결과를 볼 때 아쿠아로빅 운동은 신체조성과 혈중지질에 긍정적인 방향으로 변화시켰으며, 지방대사의 활용을 높여 지질분해의 향상과 신체조성을 증진시키고 고지혈증의 위험성을 낮출 것으로 생각된다. 따라서 아쿠아로빅 운동이 지상에서의 유산소 운동 및 저항 운동을 대체할 수 있는 유용한 운동이라 할 수 있다.

• 대한통합의학회지
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• 제3권2호
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• pp.17-28
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• 2015

Purpose: The purpose of this study was intended to investigate the effect on the body composition of the dormitory-type middle school students by implementing the complexed exercise program. Method: As subjects of the study, the dormitory-type middle school students in Chungbuk, divided into 2 grade experimental group(N=46), 3 grade control group(N=49). Group-specific arbitration method, was applied to complexed exercise program (experimental group) and running group (control group). Each training courses 30 minutes 5times weekly, examined the changes in body composition to examine a total of 6-week course effectively. Result: The results were compared with change of Height, Muscle mass, Fat mass, Lean body mass and BMI. Experimental group were significant(p<.05) compared to the control group. Height, Weight, Muscle mass, Fat mass, and BMI of control group wasn't significant(p>.05). Also there were significant difference(p<.05) between groups on Height, Muscle mass, Fat mass and Lean body mass post-test measure. Conclusion: Looking in total from the above results, it is suggested that it is possible to complexed exercise program 6 weeks improves body composition of the dormitory-type middle school students. Therefore, it is possible that the application of complexed exercise program is to effective in improvement of body composition of the dormitory-type middle school students.

• 혜화의학회지
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• 제9권1호
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• pp.503-511
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• 2000

This case study was done on a 37 year old female patient at the department for rehabilitation in Bundang Cha Oriental hospital who was treated for 70 days by traditional Acupuncture and Herbal medicine therapy as well as fasting with saengshig(生食), air bath(風浴) and cold-hot-bath(冷溫浴) for skin revitalisation, furthermore by Doinangyo and exercise for improvement of general condition and colon-hydrocleansing. The results are as following: 1. The body weigth was reduced by 14.5kg from 87.4kg to 72.9kg 2. The obesity degree reduced from 159% to 133% 3. The BMI reduced from 33.3 to 27.8 4. The WHR reduced from 0.96 to 0.88 5. The amount of body fat reduced by 7.7kg from 27.2kg to 19.5kg 6. The fat distribution of the abdomen reduced from 0.92 to 0.85 7. The percent body fat was reduced from 31.1% to 26.7 % 8. Except of a mild systemic pruritus the clinical symtoms like kneepain, fatigue, chilling, headache, indigestion, menorrhalaia improved significantly.

• Physical Therapy Rehabilitation Science
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• 제10권3호
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• pp.320-327
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• 2021

Objective: The community has implemented a variety of exercise programs for the elderly population. However, studies comparing changes in the cardiovascular system through body composition and blood analysis after applying aqua aerobic exercise are insufficient. The purpose of this study was to investigate the effect of a 12 weeks aqua exercise on body composition and cardiovascular index in elderly women. Design: Non-equivalence pre-post design. Methods: Thirty elderly women were assigned to aquarobic group(n=15) and control group(n=15). The aquarobic exercise was 60 minutes per every session, 2times per week, for 12weeks. Weight, skeletal muscle mass, body fat percentage, total cholesterol, triglyceride, HDL cholesterol, and LDL cholesterol were measured before and after the exercise program. Paired and independent t-tests were performed using SPSS program. Results: The result showed was weight(p<0.05), body fat percentage(p<0.05), total cholesterol(p<0.05), triglyceride(p<0.05), HDL cholesterol(p<0.05), and LDL cholesterol(p<0.05) were significantly decreased and skeletal muscle mass(p>0.05) was not significantly increased after aquatic exercise program. Conclusions: According to the study result, aqua exercise program made a positive effect in the improvement of obesity and cardiovascular function in elderly women. Therefore, we suggest that you actively consider implementing the Aquarobic exercise program when operating the community health promotion program in the future. In addition, in future studies, comparative studies according to various ages and genders and studies on the effects of aqua aerobic exercise as a community exercise program for chronically illness patients are needed.