• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.6
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• pp.508-519
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• 2020

This study empirically investigated the influence of entrepreneurship and technological commercialization capabilities of domestic small and medium-sized manufacturing enterprises on financial performance by mediating technological performance. To achieve this, a survey was administered to their hands-on workers in charge of R&D. The survey results were analyzed through the structural equation model as follows. Entrepreneurship had an effect on technological and financial performance. Technology commercialization capability had an effect on technological performance. However, technological commercialization capabilities were evaluated to be inferior to financial performance, which can be interpreted as financial performance being judged as different between individuals or organizations in terms of technological commercialization capabilities. Technological performance had an effect on financial performance. Technological performance played a mediating role in the effects of entrepreneurship and technology commercialization capability on financial performance. Consequently, it is very important for entrepreneurship and technology commercialization capability to develop new products and improve corporate performance with insufficient financial status or operating system completion.

• Journal of the Institute of Electronics and Information Engineers
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• v.49 no.9
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• pp.328-334
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• 2012

Continuous fetal heart beat monitoring has assisted clinicians in assuring fetal well-being during antepartum and intrapartum. Fetal heart rate (FHR) is an important parameter of fetal health during pregnancy. The Doppler ultrasound is one of very useful methods that can non-invasively measure FHR. Although it has been commonly used in clinic, inaccurate heart rate reading has not been completely resolved.. The objective of this study is to improve detection algorithm of FHR from Doppler ultrasound signal with simple method. We modified autocorrelation function to enhance signal periodicity and adopted adaptive window size and shifted for data segment to be analysed. The proposed method was applied to real measured data, and it was verified that beat-to-beat FHR estimation result was comparable with the reference fetal ECG data. This simple and effective method is expected to be implemented in the embedded system.

• Reproductive and Developmental Biology
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• v.41 no.4
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• pp.65-70
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• 2017

Alpha-linolenic acid (ALA) is one of n-3 polyunsaturated fatty acids and found mainly in the chloroplasts. Many studies have been reported that intracellular reactive oxygen species (ROS) in mammalian oocytes were reduced by supplementation of ALA in in vitro maturation (IVM) medium. Based on these reports, we expected that ALA acts as an antioxidant during IVM of porcine oocytes. Therefore, the objective of this study was to investigate the antioxidant effect of ALA supplementation during IVM in porcine oocytes. The cumulus-oocyte complexes (COCs) were incubated in IVM medium containing $200{\mu}m$ $H_2O_2$ or $H_2O_2$ with $50{\mu}m$ ALA for 44 h. Nuclear maturation stage of oocytes was evaluated using aceto-orcein method. For measurement of oxidative stress state, intracellular ROS and glutathione (GSH) levels were measured using carboxy-DCFDA and cell tracker red, respectively. In results, oocytes in metaphase-II (MII) stage development was significantly reduced in $H_2O_2$ group compared to non-treated control group $61.84{\pm}1.42%$ and 80.00%, respectively; p<0.05) and it was slightly recovered by treatment of ALA ($69.76{\pm}1.67%$; p<0.05). The intracellular GSH levels was decreased in $H_2O_2$ groups compared with control groups, but it was enhanced by ALA treatment (p<0.05). On the contrary, $H_2O_2$ treatment increased intracellular ROS level in oocytes and $H_2O_2$-induced ROS was decreased by treatment of ALA (p<0.05). Our findings suggested that ALA treatment under oxidative stress condition improve oocyte maturation via elevated GSH and reduced ROS levels in oocytes. Therefore, these results suggest that ALA have an antioxidative ability and it could be used as antioxidant in in vitro production system of porcine embryo.

• Development and Reproduction
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• v.9 no.2
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• pp.105-114
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• 2005

Embryonic stem(ES) cells have tremendous potential as a cell source for cell-based therapies. Realization of that potential will depend on our ability to understand and manipulate the factors that influence cell fate decision and to develop methods for getting enough cell numbers for clinical applications. Hematopoiesis has been widely studied, and hematopoietic differentiation from ES cells is a good model to study lineage commitment. In this study, we investigated stemness and compared the efficiency of hematopoietic differentiation using two different mouse embryonic stem cell lines TC-1 and B6-1. Although the two cell lines showed known stem cell properties with minor differences, the embryoid body formation efficiency in methylcellulose was much higher in TC-1 than B6-1. When measured potentials of hematopoietic differentiation using functional(colony-forming cell) and phenotypic(specific marker expression) assays, we found that TC-1 can differentiate into hematopoietic cells in methylcellulose culture but B6-1 cannot. These results imply that we can improve the efficiency of hematopoietic cell differentiation by selection of proper cell lines and this may be also applied in the differentiation of human embryonic stem cells.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.5
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• pp.485-494
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• 2020

This study analyzed the relationship between communication perception and job performance in general hospital nurses in order to provide basic data for efficient personnel and hospital management. For this purposes, data were collected from August 5 to 23, 2019, targeting 392 nurses from 14 general hospitals in Gwangju and Jeonnam and t-test, variance analysis, post hoc analysis, Correlations analysis and multi-regression analysis were conducted. In analyzing the differences between demographical and health characteristics and job performance, there were statistically significant differences in age, working years, salary, satisfaction, locations, health status, health education, chronic diseases and depression. In respect to communication perception and job performance of nurses, age of 30 and job satisfaction (moderate satisfaction and dissatisfaction) had a negative effect, locations had a positive effect, and horizontal communication had the greatest effect on job performance. There was a relation between downward, informal and upward communication and job performance, and the determination coefficient was 45.2%. Based on these results, this study suggested that for higher job performance, we should improve working environment, enhance job satisfaction, organize nursing organization culture with active horizontal, downward, informal and upward communication and develop an efficient personnel management system.

• Journal of KIISE:Software and Applications
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• v.35 no.3
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• pp.179-188
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• 2008

An important issue in multiagent reinforcement learning is how an agent should team its optimal policy through trial-and-error interactions in a dynamic environment where there exist other agents able to influence its own performance. Most previous works for multiagent reinforcement teaming tend to apply single-agent reinforcement learning techniques without any extensions or are based upon some unrealistic assumptions even though they build and use explicit models of other agents. In this paper, basic concepts that constitute the common foundation of multiagent reinforcement learning techniques are first formulated, and then, based on these concepts, previous works are compared in terms of characteristics and limitations. After that, a policy model of the opponent agent and a new multiagent reinforcement learning method using this model are introduced. Unlike previous works, the proposed multiagent reinforcement learning method utilize a policy model instead of the Q function model of the opponent agent. Moreover, this learning method can improve learning efficiency by using a simpler one than other richer but time-consuming policy models such as Finite State Machines(FSM) and Markov chains. In this paper. the Cat and Mouse game is introduced as an adversarial multiagent environment. And effectiveness of the proposed multiagent reinforcement learning method is analyzed through experiments using this game as testbed.

• Journal of Acupuncture Research
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• v.34 no.4
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• pp.153-158
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• 2017

Background: Hominis placenta (HP) is used in Korean medicine to tonify qi and blood, and enrich yin and tonify yang. HP has been reported to have therapeutic effects. Methods: A survey of international and Korean electronic databases was conducted using the search terms "hominis placenta pharmacopuncture" and "hominis placenta extract". The search was limited to material published up to May 31, 2017. Results: A total of 83 studies were included in this systematic review: 50 were clinical studies, 25 were basic studies, and 8 were other types of study. Among clinical studies, the most frequently treated disease groups were musculoskeletal diseases and nervous system diseases. In vitro studies were conducted mainly on anti-inflammatory, analgesic, and anti-cell necrosis models. Most of the in vivo studies were performed in rheumatoid arthritis or diabetic complications models. Conclusion: HP pharmacopuncture has effects in the treatment of various diseases. Further large-scale randomized controlled trials are needed to improve the level of evidence for HP pharmacopuncture. It would be helpful if future in vitro and in vivo studies could identify the mechanism of action of HP pharmacopuncture.

• Journal of the Korean Data and Information Science Society
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• v.27 no.3
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• pp.749-761
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• 2016

The purpose of this study was to investigate the effects of emotional regulation between clinical practice stress and nursing professionalism in nursing students. Participants were 192 nursing students and data were collected from September to November, 2015. This study has shown that nursing professionalism is negatively associated with clinical practice stress (r=-.40, p<.001) and positively associated with emotional regulation (r=.55, p<.001). In addition, a negative correlation has been found significant between emotional regulation and clinical practice stress (r=-.20, p<.001). In a final model of hierarchial multiple regression, professor support (${\beta}=.19$, p<.01), satisfaction with nursing as a major (${\beta}=.14$, p<.05), clinical practice stress (${\beta}=-.19$, p<.01) and emotional regulation (${\beta}=.32$, p <.001) were associated with nursing professionalism. In this study, we also have shown that emotional regulation does not play a moderating role on the relationship between clinical practice stress and nursing professionalism. The results of this study suggests that, in order to improve nursing professionalism, it is important to promote support system, develop clinical-practice-stress-relief programs, and enhance emotional regulation training for nursing students.

• Child Health Nursing Research
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• v.19 no.3
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• pp.159-167
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• 2013

Purpose: The purpose of this study is to find out preschool children's health status and their mothers' health management in the vulnerable classes. Methods: The assessment tool was developed, taken into consideration existing studies, materials produced by the customized visiting health care system, and review of visiting nurses of health centers and related experts. Data were collected January to February 2010 from 259 mothers by visiting nurses, and analyzed using SAS program for descriptive statistics. Results: Body weight less than 3 percentile was found for 5.0% children and over 97 percentile for 7.7%. Atopy was found in 17.8% children, no hand-washing after toileting and before meal in 30.9% and 36.7% respectively, no breakfast in 15.8%, and irregular meal in 32.0%. Sex education was made by 45.7% mothers, regular dental check by 56.6%, and hearing and eyesight test by 61.1% and 66.8% respectively. Home environment for upbringing is 34.3 in the scale of 41, and accident prevention 17.5 in the scale of 22. Conclusion: It is necessary to make an intervention on children's weight, personal sanitation and meal time in the vulnerable classes. Mothers need to be educated for appropriate health care, and home environments to improve upbringing and accident prevention.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.35 no.2
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• pp.353-359
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• 2015

This study introduces a resource recycling system in urban apartment complex using four different technologies. The four technologies, called 4G, include a production technology for reclaimed water (Green water), a biogas production technology from organic waste (Green biogas), a reuse technology of rainwater (Green rainwater), and urban agropark (Green pyramid). Green water is the technology for producing the reclaimed water from wastewater, rainwater and underground water, and the average concentrations of BOD, SS, T-N and coliform of reclaimed water were 7.8mg/L, ND (not detected), 4.9mg/L and ND, respectively. Green biogas is the technology for producing biogas and effluent after treating organic wastes (e.g. food waste and night soil) discharged from households, and the average production rates of hydrogen and methane were $0.33m^3/m^3/d$ and $0.24m^3/m^3/d$, respectively. Green pyramid, agricultural farm operated by biogas and reclaimed water, provides a healthy and recreational space for residents, and plant growth rates using treated water and reclaimed water showed height of 1.32cm and weight of 112.8g. Therefore, 4G technologies can improve the recycling rate and treatment efficiencies of waste and wastewater in an apartment complex.