• Geomechanics and Engineering
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• 제23권5호
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• pp.405-418
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• 2020

Deep excavation may have impact on the adjacent tunnels. It is obvious that the excavation will adversely affect and even damage the existing tunnels if the induced deformation exceeds the capacity of tunnel structures. It hence creates a high necessity to predict tunnel displacement induced by nearby excavation to ensure the safety of tunnel. In this paper, a simplified method to evaluate the heave of the underlying tunnel induced by adjacent excavation is presented and verified by field measurement results. In the proposed model, the tunnel is represented by a series of short beams connected by tensile springs, compressional springs and shear springs, so that the rotational effect and shearing effect of the joints between lining rings can be captured. The proposed method is compared with the previous modelling methods (e.g., Euler-Bernoulli beam, a series of short beams connected only by shear springs) based on a field measured longitudinal deformation of subway tunnels. Results of these case studies show a reasonable agreement between the predictions and observations.

• Earthquakes and Structures
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• 제9권1호
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• pp.127-143
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• 2015

In conventional seismic design, structures are assumed to be fixed at the base. To reduce the impact of earthquake loading, while at the same time providing an economically feasible structure, minor damage is tolerated in the form of controlled plastic hinging at predefined locations in the structure. Uplift is traditionally not permitted because of concerns that it would lead to collapse. However, observations of damage to structures that have been through major earthquakes reveal that partial and temporary uplift of structures can be beneficial in many cases. Allowing a structure to move as a rigid body is in fact one way to limit activated seismic forces that could lead to severe inelastic deformations. To further reduce the induced seismic energy, slip-friction connectors could be installed to act both as hold-downs resisting overturning and as contributors to structural damping. This paper reviews recent research on the concept, with a focus on timber shear walls. A novel approach used to achieve the desired sliding threshold in the slip-friction connectors is described. The wall uplifts when this threshold is reached, thereby imparting ductility to the structure. To resist base shear an innovative shear key was developed. Recent research confirms that the proposed system of timber wall, shear key, and slip-friction connectors, are feasible as a ductile and low-damage structural solution. Additional numerical studies explore the interaction between vertical load and slip-friction connector strength, and how this influences both the energy dissipation and self-centring capabilities of the rocking structure.

• 한국복합재료학회:학술대회논문집
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• 한국복합재료학회 2004년도 춘계학술발표대회 논문집
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• pp.95-102
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• 2004

변형률과 파손신호를 동시에 계측하기 위하여 이중복조기를 갖는 광섬유 브래그 격자센서시스템을 제안하였다. 이중복조기는 가변 패브리-페로 필터를 사용하여 변형률과 같이 변화가 큰 저주파신호를 측정하는 복조기와 수동 마흐-젠더 간섭계를 사용하여 파손신호나 충격신호와 같이 미세한 크기의 고주파 신호를 측정하는 복조기로 구성된다. 제안된 광섬유 브래그 격자센서시스템을 이용하여 인장하중을 받는 직교적층 복합재 구조물의 변형률과 파손신호를 동시에 계측할 수 있었다. 하나의 광섬유브래그격자센서로 측정한 변형률과 파손신호를 분석한 결과, 복합재 시편의 90도 층에서 모재균열이 발생할 때 급격한 변형률 변이가 유발되고, 최대 수백킬로헤르쯔에 이르는 주파수 성분을 가진 진동신호가 발생함을 알 수 있었다.

• 국제초고층학회논문집
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• 제10권4호
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• pp.323-334
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• 2021

Concrete structures may rarely collapse in fire incidents but fire induced damage to structural members is inevitable as a result of material degradation and thermal expansion. This requires certain repairing measures to be applied to restore the performance of post-fire members. A brief review on investigation of post-fire damage of concrete material and concrete structural members is presented in this paper, followed by a review of post-fire repair research regarding various types of repairing techniques (FRP, steel plate, and concrete section enlargement) and different type of structural members including columns, beams, and slabs. Particularly, the fire scenarios adopted in these studies leading to damage are categorized as three levels according to the duration of gas-phase temperature above 600℃ (t₆₀₀). The repair effectiveness in terms of recovered performance of concrete structural members compared to the initial undamaged performance has been summarized and compared regarding the repairing techniques and fire intensity levels. The complied results have shown that recovering the ultimate strength is achievable but the stiffness recovery is difficult. Moreover, the current fire loading scenarios adopted in the post-fire repair research are mostly idealized as constant heating rates or standard fire curves, which may have produced unrealistic fire damage patterns and the associated repairing techniques may be not practical. For future studies, the realistic fire impact and the system-level structural damage investigation are necessary.

• BMB Reports
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• 제56권11호
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• pp.612-617
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• 2023

Pleiotropic regulator 1 (PLRG1), a highly conserved element in the spliceosome, can form a NineTeen Complex (NTC) with Prp19, SPF27, and CDC5L. This complex plays crucial roles in both pre-mRNA splicing and DNA repair processes. Here, we provide evidence that PLRG1 has a multifaceted impact on cancer cell proliferation. Comparing its expression levels in cancer and normal cells, we observed that PLRG1 was upregulated in various tumor tissues and cell lines. Knockdown of PLRG1 resulted in tumor-specific cell death. Depletion of PLRG1 had notable effects, including mitotic arrest, microtubule instability, endoplasmic reticulum (ER) stress, and accumulation of autophagy, ultimately culminating in apoptosis. Our results also demonstrated that PLRG1 downregulation contributed to DNA damage in cancer cells, which we confirmed through experimental validation as DNA repair impairment. Interestingly, when PLRG1 was decreased in normal cells, it induced G1 arrest as a self-protective mechanism, distinguishing it from effects observed in cancer cells. These results highlight multifaceted impacts of PLRG1 in cancer and underscore its potential as a novel anti-cancer strategy by selectively targeting cancer cells.

• Structural Engineering and Mechanics
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• 제33권2호
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• pp.113-136
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• 2009

The seismic induced interaction between multistory structures with unequal story heights (inter-story pounding) is studied taking into account the local response of the exterior beam-column joints. Although several parameters that influence the structural pounding have been studied sofar, the role of the joints local inelastic behaviour has not been yet investigated in the literature as key parameter for the pounding problem. Moreover, the influence of the infill panels as an additional parameter for the local damage effect of the joints on the inter-story pounding phenomenon is examined. Thirty six interaction cases between a multistory frame structure and an adjacent shorter and stiffer structure are studied for two different seismic excitations. The results are focused: (a) on the local response of the critical external column of the multistory structure that suffers the hit from the slab of the adjacent shorter structure, and (b) on the local response of the exterior beam-column joints of the multistory structure. Results of this investigation demonstrate that the possible local inelastic response of the exterior joints may be in some cases beneficial for the seismic behaviour of the critical column that suffers the impact. However, in all the examined cases the developing demands for deformation of the exterior joints are substantially increased and severe damages can be observed due to the pounding effect. The presence of the masonry infill panels has also been proved as an important parameter for the response of the exterior beam-column joints and thus for the safety of the building. Nevertheless, in all the examined inter-story pounding cases the presence of the infills was not enough for the total amelioration of the excessive demands for shear and ductility of the column that suffers the impact.

• Advances in aircraft and spacecraft science
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• 제4권1호
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• pp.37-52
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• 2017

Gas turbines operating in dusty or sandy environment polluted with micron-sized solid particles are highly prone to blade surface erosion damage in compressor stages and molten sand attack in the hot-sections of turbine stages. Commercial/Military fixed-wing aircraft engines and helicopter engines often have to operate over sandy terrains in the middle eastern countries or in volcanic zones; on the other hand gas turbines in marine applications are subjected to salt spray, while the coal-burning industrial power generation turbines are subjected to fly-ash. The presence of solid particles in the working fluid medium has an adverse effect on the durability of these engines as well as performance. Typical turbine blade damages include blade coating wear, sand glazing, Calcia-Magnesia-Alumina-Silicate (CMAS) attack, oxidation, plugged cooling holes, all of which can cause rapid performance deterioration including loss of aircraft. The focus of this research work is to simulate particle-surface kinetic interaction on typical turbomachinery material targets using non-linear dynamic impact analysis. The objective of this research is to understand the interfacial kinetic behaviors that can provide insights into the physics of particle interactions and to enable leap ahead technologies in material choices and to develop sand-phobic thermal barrier coatings for turbine blades. This paper outlines the research efforts at the U.S Army Research Laboratory to come up with novel turbine blade multifunctional protective coatings that are sand-phobic, sand impact wear resistant, as well as have very low thermal conductivity for improved performance of future gas turbine engines. The research scope includes development of protective coatings for both nickel-based super alloys and ceramic matrix composites.

• 항공우주시스템공학회지
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• 제17권6호
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• pp.35-45
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• 2023

본 논문에서는 항공기용 차폐 케이블의 구조에 따른 간접낙뢰의 영향성을 분석하고, 차폐력 향상을 위한 차폐 케이블 구조를 분석하였다. 항공기에서 케이블은 부품 중에 가장 많은 비중을 차지하고 있고, 항공기 프레임과 전자기기들이 연결되어 있어 영향을 많이 줄 수 있다. 특히, 간접낙뢰 노이즈는 항공 전자기기 오동작 및 손상을 발생시킬 수 있어, 차폐 케이블을 활용하여 간접낙뢰 노이즈로 인한 피해를 줄일 수 있다. 항공기용 차폐 케이블의 차폐층 유무, 내심, 절연체 등의 케이블 구조에 따른 간접낙뢰 영향성 분석을 진행하였다. 또한, 간접낙뢰 공인 규격인 RTCA DO-160G Sec. 22를 적용하여 시뮬레이션 및 실험하여 검증하였다.

• Journal of Microbiology and Biotechnology
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• 제34권4호
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• pp.812-827
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• 2024

Phloroglucinol (PG) is one of the abundant isomeric benzenetriols in brown algae. Due to its polyphenolic structure, PG exhibits various biological activities. However, the impact of PG on anagen signaling and oxidative stress in human dermal papilla cells (HDPCs) is unknown. In this study, we investigated the therapeutic potential of PG for improving hair loss. A non-cytotoxic concentration of PG increased anagen-inductive genes and transcriptional activities of β-Catenin. Since several anagen-inductive genes are regulated by β-Catenin, further experiments were performed to elucidate the molecular mechanism by which PG upregulates anagen signaling. Various biochemical analyses revealed that PG upregulated β-Catenin signaling without affecting the expression of Wnt. In particular, PG elevated the phosphorylation of protein kinase B (AKT), leading to an increase in the inhibitory phosphorylation of glycogen synthase kinase 3 beta (GSK3β) at serine 9. Treatment with the selective phosphoinositide 3-kinase/AKT inhibitor, LY294002, restored the increased AKT/GSK3β/β-Catenin signaling and anagen-inductive proteins induced by PG. Moreover, conditioned medium from PG-treated HDPCs promoted the proliferation and migration of human epidermal keratinocytes via the AKT signaling pathway. Subsequently, we assessed the antioxidant activities of PG. PG ameliorated the elevated oxidative stress markers and improved the decreased anagen signaling in hydrogen peroxide (H₂O₂)-induced HDPCs. The senescence-associated β-galactosidase staining assay also demonstrated that the antioxidant abilities of PG effectively mitigated H₂O₂-induced senescence. Overall, these results indicate that PG potentially enhances anagen signaling and improves oxidative stress-induced cellular damage in HDPCs. Therefore, PG can be employed as a novel therapeutic component to ameliorate hair loss symptoms.

• KCI Concrete Journal
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• 제14권1호
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• pp.23-29
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• 2002

Recent construction activities have given rise to civil petitions associated with vibration-induced damages or nuisances. To mitigate unfavorable effects of construction activities, the measures to reduce or isolate from vibration need to be adopted. In this research, a vibration-mitigated concrete, which is one of the active measures for reducing vibration in concrete structures, was investigated. Concrete was mixed with vibration-reducing materials (i.e. latex, rubber power, plastic resin, and polystyrofoam) to reduce vibration and tested to evaluate dynamic material properties and structural characteristics. Normal and high strength concrete specimens with a certain level of damage were also tested for comparisons. In addition, recycling tires and plastic materials were added to produce a vibration-reducing concrete. A total of 32 concrete bars and eight concrete beams were tested to investigate the dynamic material properties and structural characteristics. Wave measurements on concrete bars showed that vibration-mitigated concrete has larger material damping ratio than normal or high strength concrete. Styrofoam turned out to be the most effective vibration-reducing mixture. Flexural vibration tests on eight flexural concrete beams also revealed that material damping ratio of the concrete beams is much smaller than structural damping ratio for all the cases.