• Journal of Animal Science and Technology
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• v.64 no.4
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• pp.752-769
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• 2022

Wheat gluten is an increasingly common ingredient in poultry diets but its impact on the small intestine in chicken is not fully understood. This study aimed to identify effects of high-gluten diets on chicken small intestines and the variation of their associated transcriptional responses by age. A total of 120 broilers (Ross Strain) were used to perform two animal experiments consisting of two gluten inclusion levels (0% or 25%) by bird's age (1 week or 4 weeks). Transcriptomics and histochemical techniques were employed to study the effect of gluten on their duodenal mucosa using randomly selected 12 broilers (3 chicks per group). A reduction in feed intake and body weight gain was found in the broilers fed a high-gluten containing diet at both ages. Histochemical photomicrographs showed a reduced villus height to crypt depth ratio in the duodenum of gluten-fed broilers at 1 week. We found mainly a significant effect on the gene expression of duodenal mucosa in gluten-fed broilers at 1 week (289 differentially expressed genes [DEGs]). Pathway analyses revealed that the significant DEGs were mainly involved in ribosome, oxidative phosphorylation, and peroxisome proliferator-activated receptor (PPAR) signaling pathways. These pathways are involved in ribosome protein biogenesis, oxidative phosphorylation and fatty acid metabolism, respectively. Our results suggest a pattern of differential gene expression in these pathways that can be linked to chronic inflammation, suppression of cell proliferation, cell cycle arrest and apoptosis. And via such a mode of action, high-gluten inclusion levels in poultry diets could lead to the observed retardation of villi development in the duodenal mucosa of young broiler chicken.

• Journal of Environmental Impact Assessment
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• v.29 no.4
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• pp.286-297
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• 2020

This research studied human health risk assessment of PAHs (Polycyclic Aromatic Hydrocarbons) in road dust sediments collected from 6 sites in four different cities in Korea. PAHs are well known to be human carcinogens and toxic compounds that are commonly generated from incomplete combustion of fuels and energy products. Such compounds which is absorbed by atmospheric suspended dust can be emitted into air in gaseous form and often deposited on road dust sediments. The PAHs which is deposited on sediment particles can also be re-dispersed by vehicles or winds on the road surface. It can be harmful for humans when exposed via breathing, ingestion and dermal contact. This study examined human health risk assessment of PAHs in deposited road dust sediments. Results showed that the excess cancer risk estimates were above 1.0×10-6 at main traffic roads and resident area in Ulsan city. According to the result of deterministic risk assessment, dermal-contact was the major pathway, while the contribution of the risk from inhalation was less than 1%. The probabilistic risk assessment showed similar levels of cancer risk derived from the deterministic risk assessment. The result of sensitivity analysis reveal that exposure time is the most contributing factor (69%). Since the values of carcinogenic risk assessment were higher than 1.0 × 10^-6, further detailed monitoring and refined risk assessment for PAHs may be required to identify more reliable and potential cancer risks for those who live in the study locations in Ulsan city.

• Clean Technology
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• v.24 no.2
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• pp.146-153
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• 2018

The water footprint is an important component of the Single Market for Green Product initiative based on the EU's Roadmap to a Resource Efficient Europe. In July 2014, the EU has established the International Standard for Water Footprint (ISO 14046) and Korea has complied with the Korean Industrial Standard (KS I ISO 14046) in April 2015. If a certification system based on the international standard (ISO 14046) is introduced, developing countries such as India and Vietnam, which are not equipped with bases, can become a trade barriers in exporting, so Korea should establish a strategy to reverse them. On the other hand, water footprints are designed to take into account local environmental impacts when compared to similar footprints (eg, carbon footprint) using LCA, so that products manufactured and manufactured in Korea will have an impact on domestic waters Should be considered. Therefore, the method of the water footprint should conform to the standard for compatibility with other countries. In order to consider the domestic water condition, it is necessary to identify suitable indicator or factor for estimating water footprint on Korea. For this purpose, this study analyzed the water footprint estimation study conducted at domestic and foreign based on international standards and through the analysis of statistical data related to domestic water resources, we confirmed the applicability of the water footprint methodology in Korea.

• Journal of Wetlands Research
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• v.15 no.1
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• pp.105-114
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• 2013

Recently, Due to Climate change, extreme rainfall occurs frequently. In many preceding studies, Because of extreme hydrological events changes, it is expected that peak flood Magnitude and frequency of drainage infrastructures changes. However, at present, probability rainfall in the drainage facilities design is assumed to Stationary which are not effected from climate change and long-term fluctuation. In the future, flood control safety standard should be reconsidered about the valid viewpoint. In this paper, in order to assess impact of climate change on drainage system, Future climate change information has been extracted from RCP 8.5 Climate Change Scenario for IPCC AR5, then estimated the design rainfall for various durations at return periods. Finally, the design flood estimated through the HEC-HMS Model which is being widely used in the practices, estimated the effect of climate change on the Design Flood of Mihochen basin. The results suggested that the Design Flood increase by climate change. Due to this, the Flood risk of Mihochen basin can be identified to increase comparing the present status.

• 한국노년학
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• v.31 no.3
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• pp.831-848
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• 2011

The purpose of this study is to analyse the family caregivers' stress pathways by types of long term care services for the elderly, and then to discuss the findings of analysis. For this research, primary caregivers that provide care the elderly requiring long term care services sanctioned by National Health Insurance Corporation were drawn and surveyed. Among collected data, data for 258 primary caregivers by type of long term care services were used for this study. The results of this study can be summarized as follows. First, on average, the elders that utilize care service in institutions for the elderly were higher proportion of women, older, higher rate of bereavement, more children than the elders that utilize in-home care service, but some cases were vice-versa. Second, the elders that utilize care service in institutions more ADL dependency, higher proportion of severe dementia or severe stroke, higher care rank by National Health Insurance Corporation than the elders that utilize in-home care service on average. Third, primary caregivers with elders that utilize in-home care service were higher proportion of women, older, lower education level, higher rate of spouse and daughter-in-law in relationship with care recipient, less health, lower income than primary caregivers with elders that utilize care service in institutions. Fourth, subjective indicators representing caregivers' reactions to caregiving for the elderly significantly impact on caregivers' stress(ie, depression), and pathway of caregivers' stress are differentiated by type of long term care services. Fifth, stressors that have direct impacts on depression as caregiving family are differentiated by type of long term care services. Therefore, policies or programs to reduce negative mental health or stress of caregivig families should be designed differently by reflecting pathway of various stressors and stress by use types of long term care services for the elderly.

• Journal of Wetlands Research
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• v.18 no.4
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• pp.432-447
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• 2016

The increased frequency of drought and flood due to climate change was a global problem. In particular, drought was recognized as a serious environmental, ecological, social, and economic disaster. Therefore, it is necessary to study the measures to prevent it. In this study, we will estimate the meteorological drought index in the Han River Basin and analyze the impact of climate change on drought. The change of the meteorological drought occurrence due to climate change in the Han River separated by the common drought and severe drought was analyzed using the Representative Concentration Pathways (RCPs) scenarios provided by the Intergovernmental Panel on Climate Change (IPCC). The years 1973 - 2010 were selected for analysis in the current period. Using the scenario, we separated the future period (Target I: 2011 - 2039, Target II: 2040 - 2069, Target III : 2070 - 2099). The number of occurrences of less than -1.0 and -1.5 standard precipitation index were analyzed by SPI 3, 6, 12. Looking at the results, trends in rainfall in the Han River was expected to increase from the current figures, the occurrence of drought is predicted to decline in the future. However, the number of drought occurrence was analyzed to increase toward long-term drought. The number of severe drought occurrences was usually larger than the common drought estimated. Additional studies may be considered in addition to the agricultural drought, hydrological drought, socio-economic drought. This will be done by using efficient water management. The results can be used as a basis for future drought analysis of the Han River.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.12
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• pp.6311-6318
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• 2012

Background: HER2/neu overexpression due to gene amplification is an important factor in breast cancer, modifying the sensitivity to anti-HER2 monoclonal antibody therapy. The clinical significance of HER2 expression in non small cell lung carcinoma (NSCLC) is currently under evaluation. The tumor suppressor gene PTEN negatively regulates the HER2/PI3K/Akt signalling pathway. The purpose of this study was to evaluate the role of simultaneous alteration in HER2 and PTEN protein expression in relation to biological behaviour of NSCLCs. Materials and Methods: Protein expression was determined by immunohistochemistry in sixty-one (n=61) NSCLC cases along with CISH for HER2 gene analysis and detection of chromosome 17 aneuploidy. Patients were followed-up for a period of 34 to 41 months after surgery. Results: HER2 overexpression (2+/3+score) was detected in 17 (27.9%) patients while loss of PTEN expression was observed in 24 (39.3%) cases, low expression in 29 (47.6%) and overexpression in 8 (13.1%). Simultaneous HER2 overexpression and PTEN low/loss of expression were correlated with metastasis (71.4% vs 36.2% p=0.03). Analysis in the subgroup of 22 patients of pTNM stage III with lymph node status N1 or N2 revealed that there was a relationship between the number of positive regional lymph node groups and simultaneous deregulation of the two genes (p=0.04). Multivariate analysis determined that HER2 overexpression was associated with an increasing risk of developing metastases (OR: 4.3; 95%CI: 1.2-15.9; p: 0.03) while PTEN overexpression was associated with lower risk (OR: 0.1; 95%CI: 0.1, 1.0; p: 0.05). Conclusions: Simultaneous HER2/PTEN deregulation is a significant genetic event that leads to a more aggressive phenotype of NSCLC.

• Asian-Australasian Journal of Animal Sciences
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• v.32 no.3
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• pp.320-333
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• 2019

Objective: The Shanghai Holstein cattle breed is susceptible to severe mastitis and other diseases due to the hot weather and long-term humidity in Shanghai, which is the main distribution centre for providing Holstein semen to various farms throughout China. Our objective was to determine the genetic mechanisms influencing economically important traits, especially diseases that have huge impact on the yield and quality of milk as well as reproduction. Methods: In our study, we detected the structural variations of 1,092 Shanghai Holstein cows by using next-generation sequencing. We used the DELLY software to identify deletions and insertions, cn.MOPS to identify copy-number variants (CNVs). Furthermore, we annotated these structural variations using different bioinformatics tools, such as gene ontology, cattle quantitative trait locus (QTL) database and ingenuity pathway analysis (IPA). Results: The average number of high-quality reads was 3,046,279. After filtering, a total of 16,831 deletions, 12,735 insertions and 490 CNVs were identified. The annotation results showed that these mapped genes were significantly enriched for specific biological functions, such as disease and reproduction. In addition, the enrichment results based on the cattle QTL database showed that the number of variants related to milk and reproduction was higher than the number of variants related to other traits. IPA core analysis found that the structural variations were related to reproduction, lipid metabolism, and inflammation. According to the functional analysis, structural variations were important factors affecting the variation of different traits in Shanghai Holstein cattle. Our results provide meaningful information about structural variations, which may be useful in future assessments of the associations between variations and important phenotypes in Shanghai Holstein cattle. Conclusion: Structural variations identified in this study were extremely different from those of previous studies. Many structural variations were found to be associated with mastitis and reproductive system diseases; these results are in accordance with the characteristics of the environment that Shanghai Holstein cattle experience.

• Korean Journal of Social Welfare Studies
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• v.40 no.1
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• pp.323-351
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• 2009

The purpose of this study is to investigate which factors affect working women's intention of second childbirth and what paths that determine this intention exist. Especially, this study focused on the influence of 'values regarding children' on intention of second childbirth of working women, and divided 'values regarding children' into 'individualistic value regarding children'and 'group-oriented value regarding children'. Findings from this study are as follows. First, the research model of this study was appropriate to explain the intention of second childbirth in working women with a child by measurement model analysis and structural model analysis. Second, it appeared that the factor which directly determined the intention of second childbirth in working women with a child was 'values regarding children', and the impact of 'individualistic values regarding children' was stronger than that of 'group-oriented values regarding children'between the two. Third, 'Economic resource'factor and 'service'factor affected 'intention of second childbirth' indirectly through other factors. Fourth, the level of public and private service resources for reconciling work and family life is affected by the level of economic resources. Finally, it appeared that 'values regarding children' could be formed or changed by working women's environmental condition like public and private service resources to support reconciling work and family life. Based on these findings, this study proposed that it should be important to form values regarding children positively by improving environmental condition for reconciling work and family life to increase childbirth intention of working women.

• Quality Improvement in Health Care
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• v.30 no.1
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• pp.120-131
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• 2024

Purpose: This study aimed to evaluate the impact of implementing a clinical pathways (CPs) on the clinical outcomes and costs of patients undergoing breast cancer surgery. Methods: This retrospective cohort study included patients who were newly diagnosed with primary breast cancer at the Samsung Medical Center between 2014 and 2019 (N=8482; 2931 patients in the pre-path and 5551 patients in the post-path). Clinical outcomes included reoperation during hospitalization, readmission, and emergency room visits within 30 days of discharge. The cost data for each unit were obtained from an activity-based management accounting system. We performed an interrupted time series analysis. Results: The post-path period showed a significantly shorter hospital length of stay (LOS) than the pre-path period (6.3 days in pre-path vs. 5.0 days in post-path; -1.3 days' difference; p=.001), and fewer reoperations during hospitalization and within 30 days after discharge than the pre-path period. After adjusting for inflation rates and relative value scores, the model demonstrated savings of $146 per patient in the post-path for total costs, and $537 per patient for patient out-of-pocket costs (p=.001). Conclusion: CPs can help reduce costs without compromising the quality of care by reducing the number of reoperations, readmissions, and complications.