• IMMUNE NETWORK
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• 제22권6호
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• pp.46.1-46.25
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• 2022

T-helper-17 (Th17) cells and related IL-17-producing (type17) lymphocytes are abundant at the epithelial barrier. In response to bacterial and fungal infection, the signature cytokines IL-17A/F and IL-22 mediate the antimicrobial immune response and contribute to wound healing of injured tissues. Despite their protective function, type17 lymphocytes are also responsible for various chronic inflammatory disorders, including inflammatory bowel disease (IBD) and colitis associated cancer (CAC). A deeper understanding of type17 regulatory mechanisms could ultimately lead to the discovery of therapeutic strategies for the treatment of chronic inflammatory disorders and the prevention of cancer. In this review, we discuss the current understanding of the development and function of type17 immune cells at the intestinal barrier, focusing on the impact of microbiota-immune interactions on intestinal barrier homeostasis and disease etiology.

• 대한토목학회논문집
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• 제31권5A호
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• pp.369-378
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• 2011

본 논문은 RC(Reinforced Concrete), SC(Steel-Plate Concrete) 격납구조에 대한 대형 민항기 충돌에 관한 응답해석을 Hydrocode인 Autodyn-3D를 통해 수행하였다. 이전에 연구된 대부분의 항공기 충돌 해석에서의 충격 하중은 국부적인 부분(동체면적의 약 2배)에 대해 Riera의 충격하중함수를 적용하는 방법을 이용하여왔다. 하지만, 본 논문에서는 실제 Boeing 767과 유사한 모델을 구현하여 대상 구조체에 직접 충돌 시켜 나타나는 현상을 비교 분석 하였으며, 항공기 모델은 강성벽(Rigid Target)에 대해 항공기를 충돌 시켰을 시 발생되는 충돌하중이력곡선과, Riera 함수를 이용한 충돌하중이력곡선과의 비교를 통하여 검증하였다. 항공기 충돌 시, SC 격납구조에 대한 충돌저항능력 및 응답, 안전성 효과를 평가 하기 위해 무근 콘크리트(Plain Concrete:PC), 철근 콘크리트(Reinforced Concrete:RC), 철근 콘크리트와 완전 부착된 내부 Liner Plate(CLP:Containment Liner Plate), 그리고 SC 격납구조에 대한 해석을 수행하였다. 따라서 항공기 충돌과 같은 비정상충격하중이 RC구조와 SC구조에 가해질 경우에 대한 거동 예측이 가능하며, 보수적인 안전성이 요구되는 RC 원전 격납건물에 SC구조를 적용하면 상대적인 안전성 증대 효과를 기대 할 수 있을 것으로 보여진다.

• 대한기계학회논문집A
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• 제38권10호
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• pp.1125-1131
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• 2014

복합 구조물의 충격 진동 특성을 이용한 취약성 분석 기법을 제안하였다. 프레임 요소로 구성된 구조물의 충격 거동을 파악하기 위해서 스펙트럴요소법을 적용하였다. 티모센코 보함수를 이용해 고속충돌에 의한 고주파 성분을 포함하는 충격파 전파 특성을 시뮬레이션하였다. 구조물의 결합부분에서는 종방향과 횡방향 파동의 상호 작용을 고려한 파동 전달을 해석하였다. 충격력이 구조물에 작용할 경우 주파수 및 시간 응답을 얻고 전체 구조물에서 충격에너지 전파 특성을 파악하였다. 구조물의 위치별로 계산된 최대가속도 크기와 시스템을 구성하는 주요 부품의 허용 가속도 기준에 의한 취약확률 함수를 정의하고 시스템의 취약 확률을 계산하였다. 제안된 취약성 분석 절차를 이용해 3 차원 전투 차량의 충격 응답을 얻고 충격에 취약한 구조물 위치를 파악하였다.

• Coupled systems mechanics
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• 제13권4호
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• pp.293-310
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• 2024

This paper investigates the dynamic response of structures during earthquakes and provides a clear understanding of soil-structure interaction phenomena. It analyses various parameters, comprising ground shear wave velocity and structure properties. The effect of soil impedance function form on the structural response of the system through the use of springs and dashpots with two frequency cases: independent and dependent frequencies. The superstructure and the ground were modeled linearly. Using the substructure method, two different approaches are used in this study. The first is an analytical formulation based on the dynamic equilibrium of the soil-structure system modeled by an analog model with three degrees of freedom. The second is a numerical analysis generated with 2D finite element modeling using ABAQUS software. The superstructure is represented as a SDOF system in all the SSI models assessed. This analysis establishes the key parameters affecting the soil-structure interaction and their effects. The different results obtained from the analysis are compared for each studied case (frequency-independent and frequency-dependent impedance functions). The achieved results confirm the sensitivity of buildings to soil-structure interaction and highlight the various factors and effects, such as soil and structure properties, specifically the shear wave velocity, the height and mass of the structure. Excitation frequency, and the foundation anchoring height, also has a significant impact on the fundamental parameters and the response of the coupled system at the same time. On the other hand, it have been demonstrated that the impedance function forms play a critical role in the accurate evaluation of structural behavior during seismic excitation. As a result, the evaluation of SSI effects on structural response must take into account the dynamic properties of the structure and soil accordingly.

• 아태비즈니스연구
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• 제13권3호
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• pp.183-208
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• 2022

Purpose - The main purpose of this study is to widely investigate the impact of recent pandemic crises on the synchronization of the world capital markets through 25 stock indices from major developed countries. Design/methodology/approach - This study collects 25 stock indices from major developed countries and the time period is between January 5, 2001 and February 24, 2022. The data sets used in the study include finance.yahoo.com and Investing.com.. The Granger causality analysis, unit-root test, VAR analysis, and forecasting error variance decomposition were hired in order to analyze the data. Findings - First, there are significant inter-relations among 25 countries around recent major pandemic crises(such as SARS, A(H1N1), MERS, and COVID19), which is consistent result with previous literature. Second, COVID19 shows much stronger impact on the world-wide synchronization than other pandemics. Third, the return volatility of each stock market varies, unit root tests show that daily stock index data are unstable while daily stock index returns are stable, and VAR(Vector Auto Regression) analyses presents significant inter-relations among 25 capital markets. Fourth, from the impulse response function analyses, we find that each market affects the other markets for short term periods, about 2~4 days, and no long term effect was not found. Fifth, Granger causality tests show one-side or two-sides synchronization between capital markets and we estimate, through forecasting error variance decomposition method, that the explanatory portions of each capital market on other markets vary from 10 to 80%. Research implications or Originality - The above results all together show that pandemic crises have strong effects on the synchronization of world capital markets and imply that these synchronizations should be carefully considered both in the investment decisions by individual investors and in the financial and economic policies by governments.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2002년도 춘계학술대회 논문집
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• pp.791-794
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• 2002

On this study, the dynamic response of vibration absorber was operated by finite element analysis and this paper proposed the optimum value of spring constant and damping coefficient for three types of impact absorber. Also the reaction farce of piston which is the objective function was proposed by the optimum design and the model which has the optimum value among the reaction forces was shown.

• 상하수도학회지
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• 제30권5호
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• pp.481-489
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• 2016

Method of characteristic(MOC) has been widely used as a transient analysis technique for pressurized pipeline systems. There are substantial studies using MOC for the water hammer triggered through instantaneous valve closures, pump stoppage and pump startup for pipelines systems equipped with a centrifugal pump. Considering restrictions of MOC associated with courant number condition for complicated pipeline systems, an impulse response method(IRM) was developed in the frequency domain. this study implements the impact of centrifugal pump using transfer function in frequency domain approach. Using pump performance curve and the affinity law, this study formulated transfer functions which relate complex pressure head at upstream of pump system to that of downstream location. Simulations of simple reservoir-pump-valve system using IRM with formulated transfer function were similar to those obtained through MOC.

• 산경연구논집
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• 제8권1호
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• pp.5-13
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• 2017

Purpose - In this article, a dynamic model like a VAR is an appropriate choice for estimating the possible interrelationship between ownership structure and firm performance as a dynamic process. Research design, data, and methodology - Data of this work are collected from Chinese stock exchange including 350 Chinese-listed firms during the period of 1999-2012. We hypothesize that this interrelationship dynamically exists between ownership structure and firm performance. To examine the correlation, a panel Vector Auto-regression (PVAR) approach generated by GMM method is utilized to test the possible dynamic relation embedded in corporate governance. Another two dynamic analysis solutions such as orthogonalized impulse-response function and variance decomposition are also used simultaneously. Results - Findings of this study indicate the evidence that dynamically endogenous relationship exists between ownership structure and firm performance. Further, there is a dynamical correlation between investment and performance. Impulse response and variance decomposition illustrate that impact of a shock to variables themselves is the main source for their variability. Conclusions - The conclusion in this study is that there is a bidirectional and inter-temporal effect between proportion of ownership and corporate performance for a long run in accordance with impulse response function. Overall, our results suggest that corporate governance in China is more market oriented.

• 대한조선학회논문집
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• 제46권2호
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• pp.155-164
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• 2009

In this paper, a spectral finite element method for a rectangular sandwich plate with viscoelastic core having the Levy-type boundary conditions has been plated. The sandwich plate consists of two isotropic and elastic face plates with a surfaced-bonded viscoelastic core. For the analysis, the in-plane and transverse energy in the face plates and only shear energy in the core are considered, respectively. To account for the frequency dependent complex shear modulus of the viscoelastic core, the Golla-Hughes-McTavish model is adopted. To evaluate the validity and accuracy of the proposed method, the frequency response function and dynamic responses of the sandwich plate with all edges simply supported subject to an impact load are calculated and compared with those calculated by a finite element method. Though these calculations, it is confirmed that the proposed method is very reliable and efficient one for vibration analysis of a rectangular sandwich plate with viscoelastic core having the Levy-type boundary conditions.

• ETRI Journal
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• 제38권4호
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• pp.634-644
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• 2016

Channel-based radio-frequency fingerprinting such as a channel impulse response (CIR), channel transfer function (CTF), and frequency coherence function (FCF) have been recently proposed to improve the accuracy at the physical layer; however, their empirical performance, advantages, and limitations have not been well reported. This paper provides a comprehensive empirical performance evaluation of RF location fingerprinting, focusing on a comparison of received-signal strength, CIR-, CTF-, and FCF-based fingerprinting using the weighted k-nearest neighbor pattern recognition technique. Frequency domain channel measurements in the IEEE 802.11 band taken on a university campus were used to evaluate the accuracy of the fingerprinting types and their robustness to human-induced motion perturbations of the channel. The localization performance was analyzed, and the results are described using the spatial and temporal radio propagation characteristics. In particular, we introduce the coherence region to explain the spatial properties and investigate the impact of the Doppler spread in time-varying channels on the time coherence of RF fingerprint structures.