• Proceedings of the Korean Nuclear Society Conference
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• 2005.05a
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• pp.1004-1005
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• 2005

• Proceedings of the Korean Society of Life Science Conference
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• 2007.10a
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• pp.85.2-85.2
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• 2007

See Full Text

• Proceedings of the PSK Conference
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• 2001.04a
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• pp.167.1-167.1
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• 2001

• Proceedings of the PSK Conference
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• 2001.04a
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• pp.166.1-166.1
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• 2001

• Molecules and Cells
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• v.37 no.5
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• pp.418-425
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• 2014

Extracellular hypotonic stress can affect cellular function. Whether and how hypotonicity affects immune cell function remains to be elucidated. Macrophages are immune cells that play key roles in adaptive and innate in immune reactions. The purpose of this study was to investigate the role and underlying mechanism of hypotonic stress in the function of bone marrow-derived macrophages (BMDMs). Hypotonic stress increased endocytic activity in BMDMs, but there was no significant change in the expression of CD80, CD86, and MHC class II molecules, nor in the secretion of TNF-${\alpha}$ or IL-10 by BMDMs. Furthermore, the enhanced endocytic activity of BMDMs triggered by hypotonic stress was significantly inhibited by chloride channel-3 (ClC-3) siRNA. Our findings suggest that hypotonic stress can induce endocytosis in BMDMs and that ClC-3 plays a central role in the endocytic process.

• 한국균학회소식:학술대회논문집
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• 2009.10a
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• pp.38-40
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• 2009

• Proceedings of the Microbiological Society of Korea Conference
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• 2008.05a
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• pp.71-71
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• 2008

• Proceedings of the Korean Nuclear Society Conference
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• 2005.10a
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• pp.864-865
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• 2005

• IMMUNE NETWORK
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• v.13 no.5
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• pp.177-183
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• 2013

Development of nano-sized carriers including nanoparticles, nanoemulsions or liposomes holds great potential for advanced delivery systems for cancer immunotherapy, as such nanostructures can be used to more effectively manipulate or deliver immunologically active components to specific target sites. Successful development of nanotechnology based platform in the field of immunotherapy will allow the application of vaccines, adjuvants and immunomodulatory drugs that improve clinical outcomes for immunological diseases. Here, we review current nanoparticle-based platforms in the efficacious delivery of vaccines in cancer immunotherapy.

• Proceedings of the Zoological Society Korea Conference
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• 2001.10a
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• pp.264.1-264
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• 2001

No Abstract, See Full Text