• 설비공학논문집
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• 제22권12호
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• pp.881-890
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• 2010

As Influenza A virus(H1N1) has been spreading more rapidly around globe, the study on the airborne disease which is transimitted through the respiratory system is on the rise. In this study, the multizone simulation of the public building against bioviolence is performed in the case of unexpected spread of microbial contaminants, such as bioviolence agent, Influenza A, Smallpox, B. anthrax and transport and control characteristics of above three kinds of bioviolence agents are evaluted. Results suggest that Influenza A and Smallpox which has small mean diameter can be more removable than B. anthrax by using high UVGI grade condition and B. anthrax which has large mean diameter can be more removable than Influenza A and Smallpox by using high filter grade condition. Results also suggest that installing a combined air treatment system is more effective to reduce the damage and engineers will use immune building technology for removing the bioviolence agents effectively.

• Genomics & Informatics
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• 제20권1호
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• pp.11.1-11.20
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• 2022

Vibrio harveyi belongs to the Vibrio genus that causes vibriosis in marine and aquatic fish species through double-stranded DNA virus replication. In humans, around 12 Vibrio species can cause gastroenteritis (gastrointestinal illness). A large amount of virus particles can be found in the cytoplasm of infected cells, which may cause death. Despite these devastating complications, there is still no cure or vaccine for the virus. As a result, we used an immunoinformatics approach to develop a multi-epitope vaccine against most pathogenic hemolysin gene of V. harveyi. The immunodominant T- and B-cell epitopes were identified using the hemolysin protein. We developed a vaccine employing three possible epitopes: cytotoxic T-lymphocytes, helper T-lymphocytes, and linear B-lymphocyte epitopes, after thorough testing. The vaccine was developed to be antigenic, immunogenic, and non-allergenic, as well as having a better solubility. Molecular dynamics simulation revealed significant structural stiffness and binding stability. In addition, the immunological simulation generated by computer revealed that the vaccination might elicit immune reactions in the actual life after injection. Finally, using Escherichia coli K12 as a model, codon optimization yielded ideal GC content and a higher codon adaptation index value, which was then included in the cloning vector pET2+ (a). Altogether, our experiment implies that the proposed peptide vaccine might be a good option for vibriosis prophylaxis.

• 한국정보통신학회논문지
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• 제10권1호
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• pp.88-95
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• 2006

PID 제어기는 구조가 간단하고 적용이 용이하다는 장점으로 인하여 널리 사용되고 있는 제어방식이다. 이러한 선형 PID 제어기는 시스템의 파라메터가 변화가 있거나 부하 특성이 비 선형적으로 변화할 때에 적절한 이득과 성능을 얻기 어려워 고성능 제어 특성을 기대하기 어렵다. 본 연구에서는 세포성 면역 반응과 경사감소학습에 기초하여 비선형 PID 제어기를 설계하고, 설계된 제어기의이득과 비선형 함수의 파라메터들을 실시간 적응적으로 학습할 수 있는 학습 알고리즘을 개발하고, 이를 제어시스템에 적용하였다. 제안된 비선형 PID 제어기는 비선형 직류 모터 시스템의 파라메터들이 변화하거나 주파수가 다른 추종 명령에 대하여, 적응적으로 이득을 변화 시키며 추종함을 보였다.

• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2005년도 추계종합학술대회
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• pp.701-704
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• 2005

PID 제어기는 구조가 간단하고 적용이 용이하다는 장점으로 인하여 널리 사용되고 있는 제어방식이다. 이러한 선형 PID 제어기는 시스템의 파라메터가 변화가 있거나 부하 특성이 비선형적으로 변화할 때에 적절한 이득과 성능을 얻기 어려워 고성능 제어 특성을 기대하기 어렵다. 본 연구에서는 세포성 면역 반응과 경사감소학습에 기초하여 비선형 PID 제어기를 설계하고, 설계된 제어기의 이득과 비선형 함수의 파라메터들을 실시간 적응적으로 학습할 수 있는 학습 알고리즘을 개발하고, 이를 제어시스템에 적용하였다. 제안된 비선형 PID 제어기는 비선형 직류 모터 시스템의 파라메터들이 변화하거나 주파수가 다른 추종 명령에 대하여, 적응적으로 이득을 변화 시키며 추종함을 보였다.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2003년도 ICCAS
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• pp.1272-1277
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• 2003

This paper presents a method for combining classifier which is constructed by fuzzy and neural network classifiers and uses classifier fusion algorithms and selection algorithms. The input space of combing classifier is divided by the extended hyperbox region proposed in this paper to guarantee non-overlapped data property. To fuse the fuzzy classifier and the neural network classifier, we propose the fusion parameter for the overlapped data. In addition, the adaptive learning algorithm also proposed to maximize classifier performance. Finally, simulation examples are given to illustrate the effectiveness of the method.

• 산업공학
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• 제16권2호
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• pp.149-155
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• 2003

The focus of this study is to investigate how personal display systems - a VDU (Visual Display Unit) and an HMD (Head Mounted Display) physiologically affect the body in virtual environments, and to evaluate differential effects of using the VDU and the HMD on physiological responses to mental stressful tasks (virtual reality flight simulation). As physiological variables, autonomic measures (heart rate, blood pressure), immune cells (leukocyte, neutrophil, lymphocyte), and hormones (catecholamine) were measured before and after experiments. Physiological data were measured in order to compare a level of mental stress on the VDU and the HMD. Increments in blood pressure (systolic (p<0.05), diastolic (p<0.1)), norepinephrin (catecholamine) (p<0.005), and neutrophils (p<0.2) of the group using the HMD showed a significant difference with the group using the VDU. Although, the heart rate was not statistically significant between two environments, differences of them quietly increased on the HMD more than on the VDU.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2001년도 하계학술대회 논문집 A
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• pp.161-163
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• 2001

In this paper, a method for optimal design of PID controller using the immune algorithm(IA) has been proposed to improve the stability of A.C.-D.C. power system. To design optimal PID controller, formulation of AC-DC system equation, selection of stability analysis model, formulation immune algorithm and application model of optimal PID controller are proposed in order of the paper. In case of various disturbance, computer simulations have been performed and the proposed IA-PID controller has been compared with base controller which is conventional control technique for dynamics. From simulation results, it is demonstrated that proposed IA-PID controller has good dynamic responses about the disturbance of power system and reliability as compared with the base control.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1988년도 추계학술대회 논문집 학회본부
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• pp.159-163
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• 1988

The purpose of this paper is to investigate the effects of alpha particles on the memory circuits such as a sense amplifier and bit lines. Sense amplifiers column alpha particle hits have been simulated for a mega bit DRAM using SPICE, a circuit simulation program. The energy of alpha particle and the substrate concentration are found to strongly influence the likehood of soft errors. Our results may be useful for the designing of alpha particle immune sense amplifiers.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2001년도 ICCAS
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• pp.89.6-89
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• 2001

In Vehicle Information and Communication System (VICS), which is an active field of Intelligent Transport System (ITS), information of traffic congestion is sent to each vehicle at real time. However, a centralized navigation system is not realistic to guide millions of vehicles in a megalopolis. Autonomous distributed systems should be more flexible and scalable, and also have a chance to focus on each vehicle´s demand. This paper proposes a sub-optimal route planning mechanism of vehicles in urban areas using the non-network type immune system. Simulation is carried out using a cellular automaton model. This system announces a sub-optimal route to drivers in real time using VICS.

• Journal of applied mathematics & informatics
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• 제18권1_2호
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• pp.95-112
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• 2005

This work concerns the stabilization of uninfected steady state of an ordinary differential equation system modeling the interaction of the HIV virus and the immune system of the human body. The control variable is the drug dose, which, in turn, affects the rate of infection of $CD4^{+}$ T cells by HIV virus. The feedback controller is constructed by a variant of the receding horizon control (RHC) method. Simulation results are discussed.