• Molecules and Cells
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• 제43권2호
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• pp.107-113
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• 2020

The Runt-related transcription factors (RUNX) transcription factors have been known for their critical roles in numerous developmental processes and diseases such as autoimmune disorders and cancer. Especially, RUNX proteins are best known for their roles in hematopoiesis, particularly during the development of T cells. As scientists discover more types of new immune cells, the functional diversity of RUNX proteins also has been increased over time. Furthermore, recent research has revealed complicated transcriptional networks involving RUNX proteins by the current technical advances. Databases established by next generation sequencing data analysis has identified ever increasing numbers of potential targets for RUNX proteins and other transcription factors. Here, we summarize diverse functions of RUNX proteins mainly on lymphoid lineage cells by incorporating recent discoveries.

• 대한의생명과학회지
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• 제29권1호
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• pp.11-25
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• 2023

In hepatocellular carcinoma (HCC), chromosome 4 open-reading frame 47 (C4orf47) has not been so far investigated for its prognostic value or association with infiltrating immune cells. We performed bioinformatics analysis on HCC data and analyzed the data using online databases such as TIMER, UALCAN, Kaplan-Meier plotter, LinkedOmics, and GEPIA2. We found that C4orf47 expression in HCC was higher compared to normal tissues. High C4orf47 expression was associated with a worse prognosis in HCC. The correlation between C4orf47 and infiltrating immune cells is positively associated with CD4+T cells, B cells, neutrophils, macrophages, and dendritic cells in HCC. Moreover, high C4orf47 expression was correlated with a poor prognosis of infiltrating immune cells. Analysis of C4orf47 gene co-expression networks revealed that 12501 genes were positively correlated with C4orf47, whereas 7200 genes were negatively correlated. The positively related genes of C4orf47 are associated with a high hazard ratio in different types of cancer, including HCC. Regarding the biological functions of C4orf47 gene, it mainly regulates RNA metabolic process, DNA replication, and cell cycle. The C4orf47 gene may play a prognostic role by regulating the global transcriptome process in HCC. Our findings demonstrate that high C4orf47 expression correlates with poor prognosis and tumor-infiltrating immune cells in HCC. We suggest that C4orf47 is a novel prognostic biomarker and potential immune therapeutic target for HCC.

• 생명과학회지
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• 제34권5호
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• pp.356-364
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• 2024

림프절은 인체에 침입한 감염원에 대하여 면역반응을 일으키는 곳이다. 림프절은 스트로마세포에 의해 뚜렷하게 구획화되어 있다. 스트로마세포들은 면역세포의 이동, 활성화, 분화를 야기하기 위해 상호작용을 위해 미세환경을 제공한다. FRC는 림프절의 T zone에서 3차원 구조물을 형성하여 면역세포의 통로를 제공한다. FRC는 림프절 구조, 면역세포 리쿠르트, 면역세포와의 상호작용, 항원제시 등을 촉진시키는 역할을 한다. 염증반응 동안, FRC는 면역세포들의 면역반응을 조절하기 위해 국부적이며 분비성 물질을 통해 면역반응을 조절하고 있다. 본문 면역반응 조절을 위해 FRC가 면역반응의 setup, support 그리고 suppress 단계로 3부분에 관여하여 면역반응을 조절하고 있는 것으로 나누어 설명하였다. 전체적으로 FRC는 T 세포생물학적 효율성 증대를 위해 기능을 하는 것으로 보인다. 더불어, FRC는 식작용을 통해 선천성 면역반응에 영향을 미치고 있는 것으로 나타났다. 따라서 FRC는 림프절에서 면역반응의 immune gate-keepers로써 위치적 역할을 하는 것으로 사료된다. 전체적으로 FRC는 선천성면역과 적응면역의 조절기능에 대한 내용으로 설명하다. 이러한 협력적 피드백 루프는 염증반응 동안 림프절의 기능을 유지하는데 기여를 할 것으로 사료된다.

• IMMUNE NETWORK
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• 제1권1호
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• pp.26-31
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• 2001

Background : Follicular dendritic cells (FDCs) play key roles during T cell-dependent humoral immune responses by allowing antigen-specific B cells to survive, proliferate, and differentiate within the FDC networks of secondary follicles, i.e., germinal centers (GC). Methods: A novel monoclonal antibody, 3C8, was generated by immunizing with an FDC line HK, in order to understand the molecular signals involved in the FDC-B cell interactions in the microenvironment of the GC. Results: The 3C8 antibody did not bind to mononuclear cells, including T cells, B cells, and monocytes. Murine L929 and human skin fibroblasts exhibited no or little reactivity to 3C8. However, 3C8 specifically recognized HK cells by flowcytometry. Furthermore, the antigen recognized by 3C8 was restricted to the GC of the human tonsil. Dendritic networks of the GC were intensely stained by 3C8, but cells outside the GC were not. Conclusion: Our results suggest that the antigen 3C8 may play some unique role on FDCs during the GC reactions.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제11권10호
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• pp.4680-4697
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• 2017

In future, since the user experience plays a more and more important role in the development of today's communication systems, quality of experience (QoE) becomes a widely used metric, which reflects the subjective experience of end users for wireless service. In addition, the energy efficiency is an increasingly important problem with the explosive growth in the amount of wireless terminals and nodes. Hence, a QoE-aware energy efficiency maximization based joint user access selection and power allocation approach is proposed to solve the problem. We transform the joint allocation process to an optimization of energy efficiency by establishing an energy efficiency model, and then the optimization problem is solved by chaotic clone immune algorithm (CCIA). Numerical simulation results indicate that the proposed algorithm can efficiently and reliably improve the QoE and ensure high energy efficiency of networks.

• ETRI Journal
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• 제38권6호
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• pp.1153-1162
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• 2016

This paper addresses the resource allocation (RA) problem in multi-cell cognitive radio networks. Besides the interference power threshold to limit the interference on primary users PUs caused by cognitive users CUs, a proportional fairness constraint is used to guarantee fairness among multiple cognitive cells and the impact of imperfect spectrum sensing is taken into account. Additional constraints in typical real communication scenarios are also considered-such as a transmission power constraint of the cognitive base stations, unique subcarrier allocation to at most one CU, and others. The resulting RA problem belongs to the class of NP-hard problems. A computationally efficient optimal algorithm cannot therefore be found. Consequently, we propose a suboptimal RA algorithm composed of two modules: a subcarrier allocation module implemented by the immune algorithm, and a power control module using an improved sub-gradient method. To further enhance algorithm performance, these two modules are executed successively, and the sequence is repeated twice. We conduct extensive simulation experiments, which demonstrate that our proposed algorithm outperforms existing algorithms.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제8권1호
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• pp.74-90
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• 2014

Routing in mobile wireless sensor networks (MWSNs) is an extremely challenging issue due to the features of MWSNs. In this paper, we present a novel bio-inspired trusted routing protocol (B-iTRP) based on artificial immune system (AIS), ant colony optimization (ACO) and Physarum optimization (PO). For trust mechanism, B-iTRP monitors neighbors' behavior in real time and then assesses neighbors' trusts based on AIS. For routing strategy, each node proactively finds routes to the Sink based on ACO. When a backward ant is on the way to return source, it senses the energy residual and trust value of each node on the discovered route, and calculates the link trust and link energy of the route. Moreover, B-iTRP also assesses the availability of route based on PO to maintain the route table. Simulation results show how B-iTRP can achieve the effective performance compared to existing state-of-the-art algorithms.

• 한국지능시스템학회논문지
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• 제14권4호
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• pp.402-410
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• 2004

본 논문에서는 복잡하고 비선형적인 시스템을 위하여 최적 면역 알고리즘의 개선된 클론선택에 기반을 둔 최적FNN 설계방법을 제안한다. FNN은 퍼지추론의 간략 추론과 학습방법으로는 오류역전파 알고리즘을 하였고 멤버쉽함수의 파라미터, 학습률 및 모멘텀 계수들을 선정하기 위하여 개선된 클론 선택을 사용하는 방법을 도입하였다. 제안한 알고리즘은 생체의 면역반응에 기초를 둔 면역알고리즘의 클론선택을 기본으로 분화율을 조절하여 성능을 개선하였다. 그 과정을 통하여 다양한 항체들을 생성하고 목적함수나 제한조건과 같은 항원들에 대하여 가장 높은 친화도를 가지는 항체를 최적 항체로 선택하였다. 제안된 알고리즘의 성능을 평가하기 위하여 가스로공정과 교통경로선택 공정을 사용한다.

• Journal of Communications and Networks
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• 제17권1호
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• pp.40-46
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• 2015

In a mobile ad hoc network (MANET), communication between mobile nodes occurs without centralized control. In this environment the mobility of a node is unpredictable; this is considered as a characteristic of wireless networks. Because of faulty or malicious nodes, the network is vulnerable to routing misbehavior. The resource constrained characteristics of MANETs leads to increased query delay at the time of data access. In this paper, AntHocNet+ Security (ANTSEC) framework is proposed that includes an enhanced cooperative caching scheme embedded with artificial immune system. This framework improves security by injecting immunity into the data packets, improves the packet delivery ratio and reduces end-to-end delay using cross layer design. The issues of node failure and node malfunction are addressed in the cache management.

• Journal of Ecology and Environment
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• 제48권3호
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• pp.256-262
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• 2024

Background: Research investigating the relationship between latitude and network specialization plant-pollinator networks present conflicting results. While some studies indicate a positive link between latitude and network specialization, particularly in tropical regions, others suggest contradictory trends, with specialization declining towards lower latitudes. These studies underscore the intricate nature of ecological specialization in plant-pollinator networks and the need for further studies in this field to gain a more nuanced understanding of the underlying mechanisms driving these patterns. In this study, we explore the relationship between plant-pollinator network specialization and latitude using a global dataset comprising 93 plant-pollinator networks. Results: Our analysis revealed a significant relationship with latitude mostly in the Southern Hemisphere, particularly concerning metrics such as connectance and nestedness. However, notably, we found no association with H2, a metric immune to the size, shape, or sampling effects of the network and considered highly suitable for measuring network specialization in both Hemispheres. Conclusions: The absence of latitudinal trends in network specialization (H2) in both Hemispheres in this study imply that the mutual attraction between plants and pollinators remains relatively stable across various latitudes. Our comparison with prior research highlights the diversity of conclusions regarding how latitude influences plant-pollinator networks. While our results are consistent with certain studies, indicating no direct impact of latitude on network specialization, discrepancies persist.