• Journal of applied mathematics & informatics
• /
• 제29권5_6호
• /
• pp.1117-1127
• /
• 2011

In this paper, a class of more general delayed viral infection model with lytic immune response is proposed by Song et al.[1] ([Journal of Mathematical Analysis Application 373 (2011), 345-355). We derive the basic reproduction numbers $R_0$ and $R_0^*$ 0 for the viral infection, and establish that the global dynamics are completely determined by the values of $R_0$ and $R_0^*$. If $R_0{\leq}1$, the viral-free equilibrium $E_0$ is globally asymptotically stable; if $R_0^*{\leq}1$ < $R_0$, the immune-free equilibrium $E_1$ is globally asymptotically stable; if $R_0^*$ > 1, the chronic-infection equilibrium $E_2$ is globally asymptotically stable by using the method of Lyapunov function.

• 약학회지
• /
• 제46권1호
• /
• pp.52-57
• /
• 2002

Effects of the butanl fraction of Astragali Radix (BFAR) on the cellular and nonspecific immune responses were investigated in ICR mice. Mice were divided into 4 groups and BFAR at doses of 5, 25 and 125 mg/kg u ere administered orally to mice daily for 3 weeks, and the normal animals were given vehicle. The results of this study are summarized as follows; the relative weight of thymus was greatly increased by BFAR treatment, compared with that in mormal mice. However, the body weight gain was not affected. Delayed-type hypersensitivity (DTH) reaction to sheep red blood cells (SRBC) for cellular immunity was significantly enhanced by BFAR treatment, compared with those in normal mice. In these mice, BFAR also dose-dependently increased activities of phagocyte and natural killer (NK) cells as well as the number of leukocyte resulted from nonspecific immunity Thus, these results demonstrate that BFAF treatment results in a significant increase in both cellular and nonspecific immune responses to antigen in concentrations that enhance humoral immune function.

• Clinical and Experimental Reproductive Medicine
• /
• 제38권4호
• /
• pp.179-185
• /
• 2011

The ultimate function of the endometrium is to allow the implantation of a blastocyst and to support pregnancy. Cycles of tissue remodeling ensure that the endometrium is in a receptive state during the putative 'implantation window', the few days of each menstrual cycle when an appropriately developed blastocyst may be available to implant in the uterus. A successful pregnancy requires strict temporal regulation of maternal immune function to accommodate a semi-allogeneic embryo. To preparing immunological tolerance at the onset of implantation, tight temporal regulations are required between the immune and endocrine networks. This review will discuss about the action of steroid hormones on the human endometrium and particularly their role in regulating the inflammatory processes associated with endometrial receptivity.

• IMMUNE NETWORK
• /
• 제22권6호
• /
• pp.46.1-46.25
• /
• 2022

T-helper-17 (Th17) cells and related IL-17-producing (type17) lymphocytes are abundant at the epithelial barrier. In response to bacterial and fungal infection, the signature cytokines IL-17A/F and IL-22 mediate the antimicrobial immune response and contribute to wound healing of injured tissues. Despite their protective function, type17 lymphocytes are also responsible for various chronic inflammatory disorders, including inflammatory bowel disease (IBD) and colitis associated cancer (CAC). A deeper understanding of type17 regulatory mechanisms could ultimately lead to the discovery of therapeutic strategies for the treatment of chronic inflammatory disorders and the prevention of cancer. In this review, we discuss the current understanding of the development and function of type17 immune cells at the intestinal barrier, focusing on the impact of microbiota-immune interactions on intestinal barrier homeostasis and disease etiology.

• 정신신체의학
• /
• 제3권1호
• /
• pp.3-10
• /
• 1995

A comparison was made between the effect of subjective stress and that of objective stress on immune function in male medical college students. Interaction between perceived stress, psychopathology and natural killer-cell(NK) activity was assessed during an exam period, non-exam period, and vacation. No significant difference was found in NK activity among these three periods, but scores of perceived stress related to unusual happenings during an exam period and related to interpersonal relationship during vacation were found to have significantly positive correlation with NK activity, respectively. In psychopathology, only scores of anxiety during an exam period had significantly positive correlation with NK activity. These results suggest that immune function is more likely to be affected by subjective stress than objective stress and that subjective stress such as some perceived stress and subclinical level of anxiety may positively affect immune function.

• 약학회지
• /
• 제48권1호
• /
• pp.41-46
• /
• 2004

Mancozeb, a polymeric complex of zinc and manganese salts of ethylene bisthiocarbamate (EBDC), is used widely in agriculture as fungicides, insecticides, and herbicides. Mancozeb can be occupationally and environmentally exposed to human and has been reported to induce estrogenic activity, therein it is considered as an endocrine disrupter, We investigated the effects of acute exposure of Mancozeb on the immune function in mice. After single oral administration of Mancozeb to female ICR mice, the immunopathological parameters (body- and organ-weight, splenic cellularity hematological parameters), mitogen (Con A, PHA+IL-2, LPS)-induced splenocyte proliferation (SP) and splenic IgM plaque forming cell (PFC). WBC and splenic cellularity were decreased, but liver-, kidney-, and spleen-weight were increased when compared with control group. Splenic IgM PFC against SRBC was slightly lowered. Mitogen-induced proliferation of spleen cells from Mancozeb-treated mice was not signifcantly changed ex vivo, however, SP in vitro were significantly lowered in concentration dependent manner. These results indicate that Mancozeb could affect the immune function in mice.

• 한국식품영양과학회지
• /
• 제27권5호
• /
• pp.920-927
• /
• 1998

The purpose of this study was to investigate the correlation between serum component and immune function in Korean female college students according to the body mass index. There were significant increased in weight, body fat, LBM, TBW, WHR in subjects as their BMI increase(p<0.001). It was found obese group had higher levels of serum components such as total cholesterol, LDL-cholesterol and Cu levels than those of the normal group. There was a significant positive correlation between HDL-cholesterol level and NK cell number(p<0.01), between A/G ratio and T lympocytes number(p<0.05), between Cu levels and B lympocytes(p<0.01) in normal group. There was a significant positive correlation between TG level and CD4/8 ratio(p<0.001), between and IgG(p<0.001) in obese group.

• Tuberculosis and Respiratory Diseases
• /
• 제87권1호
• /
• pp.22-30
• /
• 2024

Tumor immune evasion is a complex process that involves various mechanisms, such as antigen recognition restriction, immune system suppression, and T cell exhaustion. The tumor microenvironment contains various immune cells involved in immune evasion. Recent studies have demonstrated that granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) induce immune evasion in lung cancer by modulating neutrophils and myeloid-derived suppressor cells. Here we describe the origin and function of G-CSF and GM-CSF, particularly their role in immune evasion in lung cancer. In addition, their effects on programmed death-ligand 1 expression and clinical implications are discussed.

• IMMUNE NETWORK
• /
• 제20권1호
• /
• pp.4.1-4.17
• /
• 2020

Tregs have a role in immunological tolerance and immune homeostasis by suppressing immune reactions, and its therapeutic potential is critical in autoimmune diseases and cancers. There have been multiple studies conducted on Tregs because of their roles in immune suppression and therapeutic potential. In tumor immunity, Tregs can promote the development and progression of tumors by preventing effective anti-tumor immune responses in tumor-bearing hosts. High infiltration of Tregs into tumor tissue results in poor survival in various types of cancer patients. Identifying factors specifically expressed in Tregs that affect the maintenance of stability and function of Tregs is important for understanding cancer pathogenesis and identifying therapeutic targets. Thus, manipulation of Tregs is a promising anticancer strategy, but finding markers for Treg-specific depletion and controlling these cells require fine-tuning and further research. Here, we discuss the role of Tregs in cancer and the development of Treg-targeted therapies to promote cancer immunotherapy.

• 제어로봇시스템학회:학술대회논문집
• /
• 제어로봇시스템학회 2001년도 ICCAS
• /
• pp.115.5-115
• /
• 2001

This paper suggests that the immune algorithm can effectively be used in tuning of a multivariable system. Then artificial immune network always has a new paraller decentralized processing mechanism for various situations, since antibodies communication to each other among different species of antibodies/B-cells through the simulation and suppression chains among antibodies that form a large-scaled network. In addition to that, the structure of the network is not fixed, but varies continuously. That is, the artificial immune network flexibly self-organizes according to dynamic changes of external environment (meta-dynamics function). However, up to the present time, models based on the conventional crisp approach ...