• BMB Reports
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• v.53 no.5
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• pp.241-247
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• 2020

As an intracellular degradation system, autophagy is an essential and defensive cellular program required for cell survival and cellular metabolic homeostasis in response to various stresses, such as nutrient deprivation and the accumulation of damaged organelles. In general, autophagy flux consists of four steps: (1) initiation (formation of phagophore), (2) maturation and completion of autophagosome, (3) fusion of autophagosomes with lysosomes (formation of autolysosome), and (4) degradation of intravesicular components within autolysosomes. The number of genes and reagents that modulate autophagy is increasing. Investigation of their effect on autophagy flux is critical to understanding the roles of autophagy in many physiological and pathological processes. In this review, we summarize and discuss ways to analyze autophagy flux quantitatively and qualitatively with the use of imaging tools. The suggested imaging method can help estimate whether each modulator is an inhibitor or a promoter of autophagy and elucidate the mode of action of specific genes and reagents on autophagy processes.

• Proceedings of the Optical Society of Korea Conference
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• 2007.07a
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• pp.259-260
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• 2007

In this paper, we propose a novel computational integral imaging reconstruction (CIIR) method using round-type mapping model. Proposed CIIP method can overcome problems of non-uniformly reconstructed images caused from the conventional method and improve the resoulution of 3-D images. To show the usefulness of the proposed method, both computational experiment and optical experiment are carried out and their results are presented.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.19 no.3
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• pp.659-666
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• 2015

In this paper, we propose a novel reconstruction method of spatially filtered 3D images in integral imaging based on parallel lens array. The parallel lens array is composed of two lens arrays, which are positioned side by side through longitudinal direction. Conventional spatial filtering method by using convolution property between periodic functions has drawback that is the limitation of the position of target object. this caused the result that the target object should be located on the low depth resolution region. The available spatial filtering region of the spatial filtering method is depending on the focal length and the number of elemental lens in the integral imaging pickup system. In this regard, we propose the parallel lens array system to enhance the available spatial filtering region and depth resolution. The experiment result indicate that the proposed method outperforms the conventional method.

• 한국정보디스플레이학회:학술대회논문집
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• 2006.08a
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• pp.1322-1325
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• 2006

Integral imaging is a three-dimensional display method which has full parallax and continuous viewpoints. However, we found an error between the depth expressed by integral imaging and the depth perceived by the observer through binocular disparity. We analyze the depth perception errors of the threedimensional image constructed by integral imaging.

• The Korean Journal of Nuclear Medicine
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• v.39 no.2
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• pp.146-149
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• 2005

Various stem cells or progenitor cells are being used to treat cardiovascular disease in ischemic heart disease, stem ceil therapy is expected to regenerate damaged myocardium. To evaluate effects of stem cell treatment, the method to image stem cell location, distribution and differentiation is necessary. Optical imaging, MRI, nuclear imaging methods have been used for tracking stem cells. The methods and proglems of each imaging technique are reviewed.

• Korean Journal of Radiology
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• v.22 no.2
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• pp.243-252
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• 2021

Objective: To compare and correlate the findings of intravoxel incoherent motion (IVIM) magnetic resonance (MR) imaging and arterial spin labeling (ASL) imaging in characterizing parotid gland tumors. Materials and Methods: We retrospectively reviewed 56 patients with parotid gland tumors evaluated by MR imaging. The true diffusion coefficient (D), pseudo-diffusion coefficient (D^*), and fraction of perfusion (f) values of IVIM imaging and tumor-to-parotid gland signal intensity ratio (SIR) on ASL imaging were calculated. Spearman rank correlation coefficient, chi-squared, Mann-Whitney U, and Kruskal-Wallis tests with the post-hoc Dunn-Bonferroni method and receiver operating characteristic curve assessments were used for statistical analysis. Results: Malignant parotid gland tumors showed significantly lower D than benign tumors (p = 0.019). Within subgroup analyses, pleomorphic adenomas (PAs) showed significantly higher D than malignant tumors (MTs) and Warthin's tumors (WTs) (p < 0.001). The D^* of WTs was significantly higher than that of PAs (p = 0.031). The f and SIR on ASL imaging of WTs were significantly higher than those of MTs and PAs (p < 0.05). Significantly positive correlation was found between SIR on ASL imaging and f (r = 0.446, p = 0.001). In comparison with f, SIR on ASL imaging showed a higher area under curve (0.853 vs. 0.891) in discriminating MTs from WTs, although the difference was not significant (p = 0.720). Conclusion: IVIM and ASL imaging could help differentiate parotid gland tumors. SIR on ASL imaging showed a significantly positive correlation with f. ASL imaging might hold potential to improve the ability to discriminate MTs from WTs.

• Journal of information and communication convergence engineering
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• v.12 no.4
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• pp.208-214
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• 2014

In this paper, in order to solve the problems of a narrow viewing angle and the flip effect in a three-dimensional (3D) integral imaging display, we propose an improved system by using an eye tracking method based on the Kinect sensor. In the proposed method, we introduce two types of calibration processes. First process is to perform the calibration between two cameras within Kinect sensor to collect specific 3D information. Second process is to use a space calibration for the coordinate conversion between the Kinect sensor and the coordinate system of the display panel. Our calibration processes can provide the improved performance of estimation for 3D position of the observer's eyes and generate elemental images in real-time speed based on the estimated position. To show the usefulness of the proposed method, we implement an integral imaging display system using the eye tracking process based on our calibration processes and carry out the preliminary experiments by measuring the viewing angle and flipping effect for the reconstructed 3D images. The experimental results reveal that the proposed method extended the viewing angles and removed the flipping images compared with the conventional system.

• Journal of information and communication convergence engineering
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• v.13 no.4
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• pp.275-279
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• 2015

There are several methods to record three dimensional (3D) information of objects such as lens array based integral imaging, synthetic aperture integral imaging (SAII), computer synthesized integral imaging (CSII), axially distributed image sensing (ADS), and axially distributed stereo image sensing (ADSS). ADSS method is capable of recording partially occluded 3D objects and reconstructing high-resolution slice plane images. In this paper, we present a computational method for depth extraction of partially occluded 3D objects using ADSS. In the proposed method, the high resolution elemental stereo image pairs are recorded by simply moving the stereo camera along the optical axis and the recorded elemental image pairs are used to reconstruct 3D slice images using the computational reconstruction algorithm. To extract depth information of partially occluded 3D object, we utilize the edge enhancement and simple block matching algorithm between two reconstructed slice image pair. To demonstrate the proposed method, we carry out the preliminary experiments and the results are presented.

• Journal of Biomedical Engineering Research
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• v.24 no.3
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• pp.217-231
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• 2003

Coded excitation with complementary Golay sequences is an effective means to increase the SNR and penetration of ultrasound imaging. in which the two complementary binary codes are transmitted successively along each scan-line, reducing the imaging frame rate by half. This method suffers from low frame rate particularly when multiple transmit focusing is employed, since the frame rate will be further reduced in proportion to the number of focal zones. In this paper. a new ultrasound imaging technique based on simultaneous multiple transmit focusing using modified orthogonal Golay codes is proposed to improve lateral resolution with no accompanying decrease in the imaging frame rate, in which a pair of orthogonal Golay codes focused at two different focal depths are transmitted simultaneously. On receive, these modified orthogonal Golay codes are separately compressed into two short pulses and individually focused. These two focused beams are combined to form a frame of image with improved lateral resolution. The Golay codes were modified to improve the transmit power efficiency (TPE) for practical imaging. Computer simulations and experimental results show that the proposed method improves significantly the lateral resolution and penetration of ultrasound imaging compared with the conventional method.

• Journal of the Optical Society of Korea
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• v.7 no.4
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• pp.234-239
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• 2003

Objective methods to assess quantitatively port wine stain (PWS) blanching in response to laser therapy are needed to improve laser therapeutic outcome. Previous studies have attempted to assess objectively PWS color based on point measurement devices. To date, these approaches have typically been limited by a number of factors such as small test area and need for contact. To address these issues, a polarization spectral imaging system and an image analysis method have been developed to evaluate quantitatively erythema and melanin content distribution in skin. The developed polarization spectral imaging system minimizes artifacts such as glaring, shadowing, and non-uniform illumination that interfere with image fidelity. Furthermore, the image analysis method has been employed to get images of skin melanin and erythema indices from the acquired color images for quantitative analysis. Finally, using PWS patient color image, the effectiveness in laser treatment of PWS was evaluated by calculating relative erythema index image that is the relative erythema index of PWS region to the normal region. The developed device and analysis method appears to be a simple and effective method for quantitative analysis of PWS blanching.