• Proceedings of the Korean Information Science Society Conference
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• 2011.06c
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• pp.176-179
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• 2011

본 연구에서는 T-Test와 Genetic Algorithm을 사용해 Luminex 사용 환경에서 난소암을 진단할 수 있는 바이오마커의 조합을 찾고 Cancer와 Normal간의 분류 성능을 평가해 보았다. 바이오마커는 혈액, 체액 내의 특정 질환 여부나 상태를 나타내는 단백질, DNA들의 지표 물질이다. 정상인과는 다른 분포를 가진 성분이 환자의 혈액이나 체액에서 발견되면 이를 토대로 질병유무와 상태를 판단할 수 있다. 난소암을 진단할 수 있는 바이오마커 조합을 찾기 위해 T-Test와 Genetic Algorithm를 사용하여 분류성능이 좋은 바이오마커 조합을 각각 선별해 보았고, 선별된 각각의 마커조합을 선형분류기(LDA)를 사용해 평균 민감도, 특이도, 정확도를 비교해 보았다. 실험데이터는 두 곳의 병원에서 제공받은 총 58명(Cancer 27명, Normal 31명)의 혈청에서 21 종류의 바이오마커 데이터를 Luminex-PRA를 통해 얻었다. 본 연구에서는 T-Test로 만들어진 마커조합이 Genetic algorithm으로 만들어진 마커조합 보다 더 좋은 민감도, 특이도, 분류정확도를 보여주었다.

• Proceedings of the Korean Information Science Society Conference
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• 2011.06c
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• pp.180-183
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• 2011

본 논문에서는 진단 검사 의학 분야에서 통계적 지식이나 도구사용능력이 부족한 임상의학자들을 위해 개발된 통계적 데이터 분석 시스템을 소개한다. 개발된 시스템은 질병진단에 필요한 다중 바이오마커 데이터를 Luminex장비를 통하여 측정한 후, 분석이 용이한 형태로 변환하는 시각화 기술과 데이터에 내재된 패턴을 찾아내어 유용한 지식을 생성하는 데이터 마이닝 기술을 포함한다. 주요 모듈로는 마커선택, 데이터 시각화, 마커 평가 모듈로 구성되며 MATLAB을 기반으로 개발되었다.

• The Journal of Internal Korean Medicine
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• v.28 no.2
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• pp.262-274
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• 2007

Objective : It has been reported that two-repeats ($IL1RN^{\ast}2$) of interleukin-1 receptor antagonist (IL-1Ra) gene is associated with ischemic stroke, and that Ala allele of the common Pro12Ala polymorphism in $PPAR-{\gamma}2$ isoform is associated with reduced risk for type 2 DM and its complications. The aim of the present study is to assess the association of IL-1Ra and $PPAR-{\gamma}2$ Pro12Ala polymorphism with the presence of ischemic stroke in the case of diabetic and non-diabetic patients. Methods : Genomic DNA was obtained from 373 healthy subjects, 157 DM subjects without ischemic stroke (known DM duration ${\ge}10$ years) and 302 ischemic stroke patients (including with DM). IL-1Ra polymorphism was analysed by polymerase chain reaction (PCR), and $PPAR-{\gamma}2$ polymorphism by restriction fragment length polymorphism after PCR. Results : $IL1RN^{\ast}1/IL1RN^{\ast}2$ genotype was associated with significantly increased risk for DM (OR=2.86, P = 0.0008) and ischemic stroke (OR=2.74, P = 0.0016). Pro/Ala genotype was associated with the reduced risk for DM (OR=0.53, P = 0.0491) and ischemic stroke (OR=0.38, P = 0.0039). They were also associated with the reduced risk for ischemic stroke in the DM patients compared with DM without ischemic stroke (OR=0.25, P = 0.0321). Conclusions : $IL1RN^{\ast}2$ allele could be an accelerating factor, not a predictive marker for ischemic stroke in type 2 DM. The Pro/Ala genotype of $PPAR-{\gamma}2$ Pro12Ala polymorphism may be associated with reduced risk for ischemic stroke with type 2 DM. Therefore it could be a useful predictive marker for ischemic stroke in Korean type 2 DM.

• Journal of Embryo Transfer
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• v.33 no.2
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• pp.69-73
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• 2018

This study was conducted to examine the influences of two human chorion gonadotrophins (hCGs) being injected into young or aged (45- to 65-week old) outbred (ICR) mice on developmental capacity of oocytes retrieved. In vitro-culture and parthenogenetic activation of oocytes retrieved were employed for the assessment. Superovulation was determined as being induced when more than 25 oocytes were retrieved. No aged mice were superovulated, while in contrast, 67-100% were superovulated in the 6- to 8-week-old (young) mice. In the aged, hCG injection yielded better retrieval (5 vs. 13 to 14.8 oocytes/mouse). Overall, no significant difference between two hCGs was detected but between the young and aged, significant differences in maturational arrest (0% vs. 39% MI arrest and 46% vs. 15% degeneration) and developmental capacity (24% vs. 46% 8-cell embryo development) were detected. In conclusion, hCG injection contributes to increasing oocyte retrieval from aged outbred mice, but the kinds of gonadotrophin influenced the efficiency of hyperstimulation induction in specific ages.

• ETRI Journal
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• v.27 no.1
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• pp.102-105
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• 2005

In this letter, we present a layered structure of the Korean terrestrial Digital Multimedia Broadcasting (TDMB) transmission system for multimedia broadcasting service and introduce a device called the Ensemble Remultiplexer which is designed to remultiplex the Ensemble Transport Interface (ETI) for T-DMB service. This letter describes the remultiplexing process of the Ensemble Remultiplexer.

• 대한핵의학회:학술대회논문집
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• 2004.11a
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• pp.405.2-405.2
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• 2004

• The Plant Pathology Journal
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• v.17 no.6
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• pp.375.4-376
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• 2001

• 대한예방의학회:학술대회논문집
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• 2005.10a
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• pp.354-354
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• 2005

• 한국가스학회:학술대회논문집
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• 2004.11a
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• pp.173-177
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• 2004

• Proceedings of the Zoological Society Korea Conference
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• 1998.10b
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• pp.160.1-160
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• 1998

No Abstract, See Full Text