• Title/Summary/Keyword: Il-Young Ahn

Search Result 766, Processing Time 0.029 seconds

Evaluation of Anti-Colitic Effect of Chung-Jang-Hwan (C-mix) in Mice

  • Lee, Ho-Yong;Ahn, Young-Tae;Park, Se-Hoon;Ahn, Young-Min;Shim, Jae-Jung;Lee, Jung-Hee;Lee, Jeong-Sang;Surh, Young-Joon;Huh, Chul-Sung;Kim, Dong-Hyun
    • Biomolecules & Therapeutics
    • /
    • v.19 no.1
    • /
    • pp.52-58
    • /
    • 2011
  • The inhibitory effect of Chung-Jang-Hwan (C-mix) consisted of Geranium nepalense subsp. thunbergii, Saururus chinensis, and Rubus coreanus were investigated in dextran sulfate sodium (DSS)-induced colitic mice by microarray analysis. Treatment with Cmix improved colitic symptoms, including colon shortening and myeloperoxidase activity. Treatment with DSS alone upregulated the expression levels of inflammation-related genes, including IL-$1\beta$, IL-6, CCL2, CCL4, CCL5, CCL7, CCL8, CCL24, CXCL1, CXCL2, CXCL5, CXCL9 and CXCL10, and other colitis-related genes such as COX-2, PAP, MMP family, S100a8, S100a9 and DEFA1 in mice. However, treatment with C-mix inhibited the expression levels of inflammation-associated genes induced by DSS. The increased expression levels of COX-2 and IL-$1\beta$, representative inflammatory genes, were confirmed by a quantitative realtime polymerase chain reaction analysis. These results indicate that C-mix may ameliorate colitis by the inhibitory regulation of inflammation-associated genes.

Protective effects of Ginsan against Cyclophosphamide-induced immunosuppression in mice

  • Shim, Ji-Young;Ahn, Ji-Yeon;Han, Young-Soo;Jung, In-Sung;Yun, Yeon-Sook;Song, Jie-Young
    • Proceedings of the PSK Conference
    • /
    • 2003.04a
    • /
    • pp.206.1-206.1
    • /
    • 2003
  • The immunomodulator Ginsan has been found previously by us to stimulate the secretion of high levels of IL -1. IL -6 and TNF-alpha in irradiated mice. These cytokines are known to induce proliferation and differentiation of hematopoietic progenitor cells from the spleen and bone marrow and to protect mice from DNA-damaging agents. The present studies were evaluated as a cytoprotective agent against toxicity of the alkylating drugs. (omitted)

  • PDF

Improved Modular Inversion over GF(p)

  • Choi, Jong-Hwa;Kim, Yong-Dae;Ahn, Young-Il;You, Young-Gap
    • International Journal of Contents
    • /
    • v.3 no.2
    • /
    • pp.40-43
    • /
    • 2007
  • This paper proposed a new modular inverse algorithm based on the right-shifting binary Euclidean algorithm. For an n-bit numbers, the number of operations for the proposed algorithm is reduced about 61.3% less than the classical binary extended Euclidean algorithm. The proposed algorithm implementation shows substantial reduction in computation time over Galois field GF(p).