• 제목/요약/키워드: Il Woo Lee

검색결과 2,885건 처리시간 0.095초

Anti-inflammatory, Antioxidant and Antimicrobial Effects of Artemisinin Extracts from Artemisia annua L.

  • Kim, Wan-Su;Choi, Woo Jin;Lee, Sunwoo;Kim, Woo Joong;Lee, Dong Chae;Sohn, Uy Dong;Shin, Hyoung-Shik;Kim, Wonyong
    • The Korean Journal of Physiology and Pharmacology
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    • 제19권1호
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    • pp.21-27
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    • 2015

  • The anti-inflammatory, antioxidant, and antimicrobial properties of artemisinin derived from water, methanol, ethanol, or acetone extracts of Artemisia annua L. were evaluated. All 4 artemisinin-containing extracts had anti-inflammatory effects. Of these, the acetone extract had the greatest inhibitory effect on lipopolysaccharide-induced nitric oxide (NO), prostaglandin $E_2$ ($PGE_2$), and proinflammatory cytokine ($IL-1{\beta}$, IL-6, and IL-10) production. Antioxidant activity evaluations revealed that the ethanol extract had the highest free radical scavenging activity, ($91.0{\pm}3.2%$), similar to ${\alpha}$-tocopherol (99.9%). The extracts had antimicrobial activity against the periodontopathic microorganisms Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum subsp. animalis, Fusobacterium nucleatum subsp. polymorphum, and Prevotella intermedia. This study shows that Artemisia annua L. extracts contain anti-inflammatory, antioxidant, and antimicrobial substances and should be considered for use in pharmaceutical products for the treatment of dental diseases.

  • https://doi.org/10.4196/kjpp.2015.19.1.21 인용 PDF KSCI