• Journal of Acupuncture Research
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• 제28권4호
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• pp.93-103
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• 2011

Objectives : The aim of this study was to observe the effect of Needle-embedding therapy on sequelae of peripheral facial palsy. Methods : 27 patients with sequelae of peripheral facial palsy were treated with Needle-embedding therapy. Yanagihara score, number of symptoms, symptoms score were compared between before and after treatment to evaluate the effect of Needle-embedding therapy. Results : After treatment, Yanagihara score, number of symptoms, symptom score were significantly decreased(p<0.05). Conclusions : Needle-embedding therapy could be effective to improve symptoms of sequelae of peripheral facial palsy patients.

• Journal of Electrical Engineering and Technology
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• 제3권3호
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• pp.331-336
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• 2008

Electric load components have different characteristics according to the variation of voltage and frequency. This paper presents the load modeling of an electric locomotive by the parameter identification method. The proposed method for load modeling is very simple and easy for application. The proposed load model of the electric locomotive is represented by the combination of the loads that have static and dynamic characteristics. This load modeling is applied to the KTX in Korea to verify the effectiveness of the proposed method. The results of proposed load modeling by the parameter identification follow the field measurements very exactly.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.220-221
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• 2003

Bacterial infection is a very complex process in which both pathogens and host cells play crucial roles, and the host cells undergo drastic changes in their physiology, releasing various proteins in response to the pathogenic infection. Human airway epithelial surface serves as a first line of defense against microorganisms and the external environment. It is well known that bronchial epithelial cells secrete various chemokines and cytokines such as IL-6 and IL-8 to cope with various respiratory pathogens. (omitted)

• 한국생명과학회:학술대회논문집
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• 한국생명과학회 2006년도 제47회 학술심포지움 및 추계국제학술대회
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• pp.93.2-93.2
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• 2006

• 천문학회보
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• 제34권1호
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• pp.188.2-188.2
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• 2009

• 대한전기학회:학술대회논문집
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• 대한전기학회 2007년도 제38회 하계학술대회
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• pp.27-28
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• 2007

본 논문은 배전계통을 운영함에 있어서 배전자동화 시스템의 가장 중요한 기능인 정전복구 기능에 대해서 현재의 중앙집중 방식에서 분산형으로 보다 효율적인 처리를 위한 알고리즘을 제안하였다. 분산형으로 처리하기 위하여 단말장치들을 Intelligent 기능에 능동 자율학습 기능을 보완할 수 있는 Multi-Agent 기법을 알고리즘에 도입하였다. 기존의 agent 기법을 응용한 연구는 적용 대상이 불분명한데 반해 본 논문에서는 적용 대상도 분명하고 현재 계통에도 바로 적용이 가능한 알고리즘을 제안하였다. 또한 Multi-Agent 기반 분산형 정전복구 시스템의 약점이라 할 수 있는 통신망 보안에 대해서 위협사례들을 분석하고, 이 위협들에 대한 보안알고리즘 적용방안을 제시하였다. 본 논문에서 제시한 알고리즘들을 PC 기반으로 예제계통을 꾸며 그 성능을 입증하였다.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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• pp.111.1-111.1
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• 2003

Bacterial infection is a very complex process in which both pathogens and host cells play crucial roles, and the host cells undergo drastic changes in their physiology, releasing various proteins in response to the pathogenic infection. Human airway epithelial surface serves as a first line of defense against microorganisms and the external environment. It is well known that bronchial epithelial cells secrete various chemokines and cytokines such as IL-6 and IL-8 to cope with various respiratory pathogens. (omitted)

• 대한한의학회지
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• 제27권4호
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• pp.1-11
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• 2006

Objectives : We investigated the effect of Dohongsamul-tang (DHSMT) on the production of various cytokines in lipopolysaccaride (LPS) stimulated peripheral mononuclear cells (PBMCs) from CI patients. Methods: Cell viability was determined using MTT assay. ELISA was carried out for investigating $TNF-{\alpha}$, $IL-1{\beta}$, IL-6, IL-8, IL-4, and $TGF-{\beta}$ 1 Results : The amount of tumor necrosis factor (TNF)-${\alpha}$, interleukin (IL)-$1{\beta}$, IL-6, IL-8, IL-4, and transforming growth factor(TGF)-${\beta}$ 1 in PBMC culture supernatant significantly increased in the LPS treated cells compared to unstimulated cells. We show that DHSMT inhibited the production of TNF-${\alpha}$, IL-1${\beta}$, IL-6, IL-8, and IL-4 induced by LPS in a dose dependent manner. The maximal inhibition rate of the TNF-${\alpha}$, IL-1${\beta}$, IL-6, IL-8, and IL-4 production by pretreatment of DHSMT (1.0mg/ml) was 38.52 ${\pm}$ 2.5% (P < 0.01), 44.02 ${\pm}$ 3.5% (P < 0.05), 45.32 ${\pm}$ 2.3% (P < 0.01), 42.30 ${\pm}$ 3.1% (P < 0.05), and 49.70　${\pm}$　3.1%(P ＆lt; 0.05), respectively. On the other hand, DMSMT significantly increased the LPS-induced TGF-${\beta}$ 1 production(P<0.05). Conclusions : Taken together. these results suggest that DHSMT might have regulatory effects on cytokine production, which might explain its beneficial effect in the treatment of CI.

• Biomolecules & Therapeutics
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• 제16권2호
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• pp.126-131
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• 2008

Immunosuppressive therapy after organ transplantation is routinely used to prevent rejection of the organ, because this decreases the risk of adverse events, infection, and malignancies. Recently, ursodeoxycholic acid (UDCA), which is isolated from the dried bile of adult Chinese bears, has been shown to reduce the incidence and severity of acute rejection of liver allograft during early phase of liver transplantation. Therefore, in this study, we investigated the effect of UDCA on the proliferation of splenocytes exposed to PMA plus ionomycin. Our results demonstrated that UDCA decreased the splenocytes' proliferation in a dose-dependent manner. The decreased cell proliferation was accompanied with the decreased secretion of cytokines such as IL-2, IFN-${\gamma}$ and TNF-${\alpha}$. In addition, the pretreatment of UDCA on splenocytes stimulated with PMA plus ionomycin decreased the mRNA levels of cytokines (IL-2, IFN-${\gamma}$ and TNF-${\alpha}$) and costimulatory molecules (B7.2 and PD-L1). These results suggest the beneficial effect of UDCA on organ transplantation by decreasing lymphocyte proliferation.

• Archives of Pharmacal Research
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• 제26권5호
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• pp.383-388
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• 2003

Bee venom is used as a traditional medicine for treatment of arthritis. The anti-inflammatory activity of the n-hexane, ethyl acetate, and aqueous partitions from bee venom (Apis mellifera) was studied using cyclooxygenase (COX) activity and pro-inflammatory cytokines (TNF-$\alpha and IL-1\beta$) production, in vitro. COX-2 is involved in the production of prostaglandins that mediate pain and support the inflammatory process. The aqueous partition of bee venom showed strong dose-dependent inhibitory effects on COX-2 activity ($IC_{50} = 13.1 \mu$ g/mL), but did not inhibit COX-1 activity. The aqueous partition was subfractionated into three parts by molecular weight differences, namely, B-F1 (above 20 KDa), B-F2 (between 10 KDa and 20 KDa) and BF-3 (below 10 KDa). B-F2 and B-F3 strongly inhibited COX-2 activity and COX-2 mRNA expression in a dose-dependent manner, without revealing cytotoxic effects. TNF-$\alpha and IL-1\beta$ are potent pro-inflammatory cytokines and are early indicators of the inflammatory process. We also investigated the effects of three subfractions on TNF-$\alpha and IL-1\beta$ production using ELISA method. All three subfractions, B-F1, B-F2 and B-F3, inhibited TNF-$\alpha and IL-1\beta$production. These results suggest the pharmacological activities of bee venom on anti-inflammatory process include the inhibition of COX-2 expression and the blocking of pro-inflammatory cytokines (TNF-$\alpha and IL-1\beta$) production.